Aesthetic surgery journal. Open forum最新文献

{"title":"The Use of a Proprietary Near-Infrared Laser to Enhance Wound Healing: A Preliminary Preclinical and Clinical Study.","authors":"Graeme E Glass, András Mérai, Szabolcs Molnár, Paul Clayton","doi":"10.1093/asjof/ojaf009","DOIUrl":"10.1093/asjof/ojaf009","url":null,"abstract":"<p><strong>Background: </strong>Nonthermal light energy has been used to enhance wound healing. This is known as photobiomodulation. Although preclinical evidence is largely based on laser light, light-emitting diodes (LEDs) form the mainstay of clinical studies owing to the lack of available lasers for nonclinical use. However, it is speculated the 2 technologies exhibit dissimilar biological responses.</p><p><strong>Objectives: </strong>The influence of a new, commercially available near-infrared laser device on the gene expression profile of human skin relative to an equivalent, near-infrared LED device was evaluated. Additionally, the wound healing potential of the device was examined in practice.</p><p><strong>Methods: </strong>Defatted human skin was exposed to the laser (3), LED (3), or negative control (3) for 5 days. On Day 6, skin samples were biopsied for ribonucleic acid extraction and gene expression assays run for 107 genes of interest. Twenty patients with chronic wounds were randomized to receive standard wound care ± laser therapy 3 times weekly for 4 weeks, and wounds were analyzed for healing.</p><p><strong>Results: </strong>The laser altered expression of 45 genes. Highly up-regulated genes (>5-fold change) included those implicated in wound healing and antiaging, whereas highly down-regulated genes included those implicated in inflammation and extracellular matrix integrity. The LED device altered expression of only 1 gene relative to negative controls. The laser reduced mean wound area by 78% and healed 4 of 10 wounds completely. In contrast, 8 of 10 of those receiving standard care exhibited no change.</p><p><strong>Conclusions: </strong>A proprietary near-infrared laser exhibited superior ability to influence gene expression in healthy skin than an equivalent LED device and induced the healing of chronic wounds.</p><p><strong>Level of evidence 2 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Commentary on: The Role of Nasal Fat Preservation in Upper Lid Surgery and Assessment With the FACE-Q Questionnaire: Innovations in Upper Blepharoplasty.","authors":"","doi":"10.1093/asjof/ojaf007","DOIUrl":"https://doi.org/10.1093/asjof/ojaf007","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/asjof/ojae097.].</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf007"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxical Adipose Hyperplasia of Submental Region After Cryolipolysis Treated With Deep-Plane Neck Lift: A Case Report.","authors":"Heather M Zimmerman, J Simon Ivey","doi":"10.1093/asjof/ojaf008","DOIUrl":"10.1093/asjof/ojaf008","url":null,"abstract":"<p><p>Cryolipolysis is a technique to reduce adipose tissue with localized cooling. Paradoxical adipose hyperplasia (PAH) is a known risk of this procedure and presents with a voluminous swelling in the treated region, generally occurring 2 to 4 months after. Most cases of PAH are noted in the umbilical region, and it has been infrequently noted in the submental region. The researchers of previous reports have noted liposuction or excision as proposed treatments. In this study, the authors report on a case of PAH after 2 sessions of cryolipolysis to the submental region, which was treated with deep-plane neck lift (DPNL) for total correction. Intraoperative removal of sub- and supraplatysmal fibrotic fat, glandular material, and muscle was utilized for optimal results. The patient had total correction of the deformity and maintained results at several months postoperatively. This case would have been poorly treated with liposuction because of the dense structural material and fibrotic subplatysmal fat noted intraoperatively. Patients undergoing cryolipolysis for adipose reduction of the submental region should be counseled on the risk of PAH, and DPNL should be evaluated further as the standard for correction of this condition.</p><p><strong>Level of evidence 5 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf008"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Efficacy and Safety of a Hyaluronic Acid-Based Dermal Filler With Tri-Hyal Technology to Enhance Lip Volume.","authors":"Philippe Kestemont, Ferial Fanian, Philippe Garcia, Anne Grand-Vincent, Laurent Benadiba, Henry Delmar, Isaac Bodokh, Patrick Brun, Frédéric Braccini, Christophe Desouches, Jérôme Paris, Ismahane Guimiot, Catherine Salomon, Patrick Trévidic","doi":"10.1093/asjof/ojae110","DOIUrl":"https://doi.org/10.1093/asjof/ojae110","url":null,"abstract":"<p><strong>Background: </strong>Interventions to enhance lip volume and shape are common aesthetic procedures to counter signs of aging.</p><p><strong>Objectives: </strong>This study aimed to assess the efficacy of Art Filler Lips (AFL), with or without retouching, at restoring lip shape and volume, tolerability, and persistence over 18 months.</p><p><strong>Methods: </strong>During this open-label study, AFL (≤2.0 mL) was injected into the upper, lower, and/or both red lips and borders at baseline (D0). Patients were evaluated at D21, when, if necessary, retouching was performed. Patients were evaluated at D42, D90, D180, D270, D360, D450, and D540. The primary assessment was based on evaluation at D21 using the Medicis Lip Fullness Scale (MLFS). Satisfactory volume restoration was defined as an improvement of ≥1 point vs D0. Secondary outcomes were adverse events (AEs), and investigator and patient satisfaction rates based on Global Aesthetic Improvement Scores.</p><p><strong>Results: </strong>Among 73 patients (97% females; 54.4 ± 10.5 years), 56% of lips were injected without any retouch. Mean MLFS scores either for upper and lower lips separately or together, significantly improved by D21 for the patients without retouching or D42 for those with (all <i>P</i> < .0001). At D21/42, 99% of upper lips, 94% of lower lips, and 96% of both lips showed satisfactory volume restoration. This proportion declined between D21/42 and D540. The most reported immediate AEs were swelling, sensitivity, and pain and were mild to moderate, lasting for <2 weeks.</p><p><strong>Conclusions: </strong>AFL is well tolerated and produces a sustained objective and subjective lip volume restoration and shape.</p><p><strong>Level of evidence 4 risk: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojae110"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Split-Face Comparison of Two Hyaluronic Acid Fillers: Intersection of Rheology and Tissue Behavior in Midface Rejuvenation.","authors":"Steven F Weiner, Jessica A Hicks, Thu Nguyen, Matthew Meckfessel","doi":"10.1093/asjof/ojaf006","DOIUrl":"https://doi.org/10.1093/asjof/ojaf006","url":null,"abstract":"<p><strong>Background: </strong>Hyaluronic acid (HA) fillers are one of the most popular aesthetic treatments for midface volumization, achieving optimal aesthetic improvements. Given the variety of HA filler products available, it is important for injectors to understand how their rheological properties can influence behavior in tissues.</p><p><strong>Objectives: </strong>To evaluate and compare (1) product integration and dynamic support and (2) lifting capacity of 2 rheologically different HA fillers (HA Contour [HA_CON] and HA Voluma [HA_JVOL]) through ultrasound and clinical photography.</p><p><strong>Methods: </strong>Randomized, split-face study (<i>n</i> = 11) comparing 2 midface HA fillers over a 12-month period with initial injection along the zygomatic arch at Day 0 and optional touch-up at Month 1. Eligible patients were aged 22 to 65 years with midface volume loss and contour deficiency. Assessments included ultrasound (neutral and smiling), clinical photography with 3D volume change (lifting capacity) analyses, and adverse event reporting. Volume change was assessed at 2 regions: midface and infraorbital hollow (IOH).</p><p><strong>Results: </strong>With similar average total injection volumes, both fillers had comparable lifting capacity in the midface (HA_CON: ≥2.07 mL and HA_JVOL: ≥2.08 mL; <i>P</i> > .05) and IOH (HA_CON: ≥0.45 mL and HA_JVOL: ≥0.57 mL; <i>P</i> > .05) areas for up to 12 months. Ultrasound showed that HA_CON integrated into the tissue, stretching and elongating during a smiling expression, whereas HA_JVOL did not integrate as much, with aggregates consistent in size and shape during both neutral and smiling expressions through 12 months. No adverse events were reported during the study.</p><p><strong>Conclusions: </strong>HA_CON demonstrated a similar duration of lifting capacity (volumization) as HA_JVOL but had more distributed product integration and flexibility to support dynamic expressions through 12 months.</p><p><strong>Level of evidence 3 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf006"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Neuromodulator Use for Optimization of Facial Scars and Blepharoplasty and Brow Lift Outcomes.","authors":"Manoj T Abraham, Solomon Husain, Anni Wong, Sunder Gidumal, Ebrahim Elahi, Ellen Marmur, Matthew DelMauro","doi":"10.1093/asjof/ojaf005","DOIUrl":"10.1093/asjof/ojaf005","url":null,"abstract":"<p><strong>Background: </strong>There are many published studies that indicate neuromodulators help improve surgical outcomes and the appearance of facial scars.</p><p><strong>Objectives: </strong>To determine the prevalence of neuromodulator use as an adjunct for facial scar treatment as well as blepharoplasty and brow lift surgeries across surgical subspecialties.</p><p><strong>Methods: </strong>An anonymous electronic survey was distributed to plastic surgeons, facial plastic surgeons, oculoplastic surgeons, and dermatologic surgeons through their respective national societies. The survey assessed demographics, practice characteristics, and practice habits.</p><p><strong>Results: </strong>A total of 276 surgeons responded. Although 96.7% of respondents use neuromodulators in their practice, only 21% utilize neuromodulators for scar optimization, and 12.3% and 25.4% utilize neuromodulators for optimization of blepharoplasty and surgical brow lift outcomes, respectively.</p><p><strong>Conclusions: </strong>Although the use of neuromodulators has been shown to improve the appearance of scars and could enhance outcomes after blepharoplasty and brow lift procedures, its use among respondents was limited.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsular Contracture After Breast Augmentation: A Systematic Review and Meta-Analysis.","authors":"Evan Haas, Neophytos Christodoulou, Murilo Secanho, George Kokosis, Rafael D Malgor, Julian Winocour, Jason W Yu, David W Mathes, Christodoulos Kaoutzanis","doi":"10.1093/asjof/ojaf003","DOIUrl":"10.1093/asjof/ojaf003","url":null,"abstract":"<p><p>Capsular contracture is characterized by the formation of a fibrous capsule around a breast implant after an augmentation mammaplasty, and often results in pain, firmness, and implant distortion. The aim of this meta-analysis was to investigate how implant and surgical characteristics affect rates of capsular contracture after breast augmentation. A systematic review and meta-analysis were performed in PubMed MEDLINE, EMBASE (OvidSP), and Cochrane Library. Comparison groups included smooth vs textured implants; subpectoral vs prepectoral implant placement; saline vs silicone implants. Odds ratios (ORs) were calculated for capsular contracture for each of these groups. The inclusion criteria were met in 24 studies. Smooth implants were associated with significantly higher capsular contracture rates compared with textured implants (OR = 2.80, 95% CI, 1.92-4.08). Subpectoral implant placement demonstrated significantly reduced capsular contracture rates compared with prepectoral placement (OR = 0.35, 95% CI, 0.25-0.50). No significant difference in capsular contracture rates was found between silicone and saline (OR = 0.39, 95% CI, 0.02-6.69). This meta-analysis suggests that textured-surface implants are associated with lower capsular contracture rates than smooth implants following breast augmentation. Additionally, subpectoral implant placement was associated with significantly reduced rates of capsular contracture compared with prepectoral placement. There was no significant difference in capsular contracture rates between saline and silicone implants. However, the absence of large, randomized controlled trials included in this study underscores the need for prospective investigation of the relationship between implant and surgical characteristics and postoperative outcomes.</p><p><strong>Level of evidence 2 risk: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is More Always Better? A Randomized Comparative Clinical Trial About the Impact of Polydioxanone Threads Quantity for Facial Lifting.","authors":"Marcelo Germani, Victor R M Munoz-Lora, Ana C N Carnevali, Adriana Marques Geroldo, Fernanda Fogolin Teixeira, Gabriela Giro","doi":"10.1093/asjof/ojaf002","DOIUrl":"https://doi.org/10.1093/asjof/ojaf002","url":null,"abstract":"<p><strong>Background: </strong>Minimally invasive aesthetic procedures, such as the use of polydioxanone (PDO) threads, are increasingly popular for facial rejuvenation.</p><p><strong>Objectives: </strong>This study investigates the impact of the number of PDO threads on tissue displacement, volume changes, and patient satisfaction.</p><p><strong>Methods: </strong>This randomized controlled trial involved 22 patients seeking facial lifting using PDO threads. Participants were divided into 2 groups: G1 with 3 threads per hemiface and G2 with 6 threads per hemiface. Three-dimensional stereophotogrammetry was used to evaluate volumetric changes and tissue displacement at baseline, 20 days, and 60 days posttreatment. Patient satisfaction was assessed using the Global Aesthetic Improvement Scale (GAIS).</p><p><strong>Results: </strong>Significant volumetric changes were observed over time in both midface and lower face regions (<i>P</i> < .05), but no significant intergroup differences were found (<i>P</i> > .6). Tissue displacement showed statistical significance over time (<i>P</i> = .039) but not between groups (<i>P</i> = .821). GAIS scores did not differ significantly between groups or between patients and specialists. Adverse events were minor and transient, primarily involving pain.</p><p><strong>Conclusions: </strong>The number of PDO threads used did not significantly influence sustained lifting outcomes or patient satisfaction. Initial improvements in volume and tissue displacement diminished by 60 days, suggesting that additional threads do not enhance long-term efficacy. Further studies with longer follow-up are needed to better understand collagen stimulation's potential role in lasting effects.</p><p><strong>Level of evidence 2 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galactocele Following Aesthetic Breast Augmentation: Diagnosis, Management, and Prevention.","authors":"Hiba El Hajj, Dollen Eid, Roland Tohme, Fadi Sleilati","doi":"10.1093/asjof/ojaf001","DOIUrl":"10.1093/asjof/ojaf001","url":null,"abstract":"<p><p>Galactorrhea and galactocele are rare complications following breast augmentation. These conditions can lead to significant patient discomfort and require careful management. This article aims to report 3 cases of galactocele that developed after aesthetic breast augmentation, proposing approaches for diagnosis, management, and prevention of galactocele. Three patients who underwent breast augmentation presented with galactocele. Clinical evaluations included aspiration of fluid collections, imaging studies, and laboratory tests to rule out infections and hormonal imbalances. Surgical interventions were tailored to each case based on patient preferences and clinical findings. In Case 1, a 40-year-old female experienced bilateral swelling 1-month postsurgery. Despite aspiration, symptoms recurred, leading to surgical revision and drainage. The implants were removed at her request. In Case 2, a 37-year-old female developed a unilateral galactocele 3 months postaugmentation after starting Norethisterone. Ultrasound-guided aspiration and surgical drainage were performed, with the implants kept in place. In Case 3, a 36-year-old female presented with wound dehiscence and lactescent discharge 7 months postaugmentation. Emergency surgery was needed for fluid evacuation, but worsening symptoms led to implant removal and drainage of bilateral galactoceles. Effective management of galactocele and galactorrhea postbreast augmentation requires a personalized approach, addressing both clinical presentations and patient-specific factors. Further awareness of these complications is essential for optimizing patient outcomes.</p><p><strong>Level of evidence 5 diagnostic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canada HARMONY Study: Improvements in Patient Satisfaction With Facial Appearance and Psychological Impact of Combined Aesthetic Treatment.","authors":"Jason K Rivers, Vince Bertucci, Channy Muhn, Shannon Humphrey, Nowell Solish, Jean Carruthers, William McGillivray, Meetu Bhogal, Julia K Garcia, Sara Sangha, Stephanie Manson Brown","doi":"10.1093/asjof/ojae130","DOIUrl":"10.1093/asjof/ojae130","url":null,"abstract":"<p><strong>Background: </strong>Panfacial treatment has the potential to positively impact psychosocial and emotional well-being.</p><p><strong>Objectives: </strong>The Canada HARMONY study evaluated the satisfaction and psychosocial impact of comprehensive, multimodal aesthetic treatment of the face and submental area from the patient perspective.</p><p><strong>Methods: </strong>Over 12 months, all patients (<i>N</i> = 58) sequentially received treatment with hyaluronic acid (HA) fillers, onabotulinumtoxinA, and medical-grade skincare products, and eligible patients (<i>n</i> = 13) also received ATX-101. The primary endpoint was the change from baseline on the FACE-Q Satisfaction with Facial Appearance Scale. Secondary endpoints included the following assessments: FACE-Q Expectations of Life Change, Psychological Function, Social Function, Satisfaction with Skin, and Aging Appraisal Scales; Global Aesthetic Improvement Scale (GAIS); and the Periorbital Aesthetic Appearance Questionnaire (PAAQ). Safety was monitored throughout the study.</p><p><strong>Results: </strong>Baseline FACE-Q Expectations of Life Change scores indicated realistic treatment expectations. Significant improvements from baseline were observed on the FACE-Q Satisfaction with Facial Appearance, Psychological Function, Social Function, Satisfaction with Skin, and Aging Appraisal Scales (<i>P</i> < .0001 for all endpoints). Most patients rated \"much improved\" on the GAIS. The mean PAAQ total score significantly improved from baseline by 32.6 (<i>P</i> < .0001). Most patients reported mild-to-moderate injection-site responses, which had a mean time to resolution of <14 days.</p><p><strong>Conclusions: </strong>Panfacial aesthetic treatment consisting of HA fillers, onabotulinumtoxinA, and ATX-101 improved patient-reported satisfaction, psychological function, social function, and aging appraisal across validated measures.</p><p><strong>Level of evidence 5 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojae130"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}