Aesthetic surgery journal. Open forum最新文献

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A Decade in Focus: Examining Lessons Learned From Office-Directed Injectables in an Academic Practice. 十年聚焦:在学术实践中研究办公室定向注射的经验教训。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf013
Vidhya Nadarajan, Bhavana Thota, Anca Dogaroiu, Lauren Kim, Amor Niksic, Victoria Peters, Tuong-Vi Cindy Ngo, Jennifer Barillas, Jeffrey Kenkel
{"title":"A Decade in Focus: Examining Lessons Learned From Office-Directed Injectables in an Academic Practice.","authors":"Vidhya Nadarajan, Bhavana Thota, Anca Dogaroiu, Lauren Kim, Amor Niksic, Victoria Peters, Tuong-Vi Cindy Ngo, Jennifer Barillas, Jeffrey Kenkel","doi":"10.1093/asjof/ojaf013","DOIUrl":"10.1093/asjof/ojaf013","url":null,"abstract":"<p><strong>Background: </strong>Noninvasive facial rejuvenation procedures have continued to grow in popularity, with botulinum toxin and injectable soft-tissue fillers being the most common.</p><p><strong>Objectives: </strong>The purpose of this study was to evaluate trends in patient cost, provider product preferences, and complications of a single surgeon's 10-year experience with botulinum toxin and soft-tissue fillers. Additionally, this study aimed to quantify the crossover between patients receiving injectables and patients receiving aesthetic surgery.</p><p><strong>Methods: </strong>This was a retrospective analysis utilizing internal/departmental records and Epic charting from January 2013 to January 2023. Botulinum toxin and soft-tissue filler cases were captured using select CPT codes, and patient demographics, complications, and follow-up data were recorded.</p><p><strong>Results: </strong>One thousand three hundred and sixty-eight patients undergoing 5794 injectable cases were assessed. The study population was majority female (89.3%) and Caucasian (78.7%). Injectable cases increased over time, except for a decrease in 2020. Botulinum toxin was most common (59%), followed by fillers (18%), and combination therapy (19%). Common injection sites included the glabella, crow's feet, and forehead for neurotoxins and marionette lines and nasolabial folds for fillers. Complications were rare, with 35 from botulinum toxin and 33 from fillers. Of patients receiving injectables, 19.6% went on to receive an aesthetic surgery, and 0.6% of patients undergoing aesthetic surgery subsequently received injectables.</p><p><strong>Conclusions: </strong>Botulinum toxin and soft-tissue fillers are safe with low complication rates when administered by an experienced provider. These procedures may serve as a starting point for patients pursuing antiaging treatments and an opportunity to establish continuity of care for providers.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf013"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implant-Based Chin Augmentation Vs Osseous Genioplasty: A Systematic Review of Indications and Outcomes. 基于种植体的下颌隆胸与骨性颏成形术:适应症和结果的系统回顾。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-26 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf048
Martin Kauke-Navarro, Leonard Knoedler, Omar Allam, Max Heiland, Samuel Knoedler, Felix J Klimitz, Michael Alperovich, Ali-Farid Safi
{"title":"Implant-Based Chin Augmentation Vs Osseous Genioplasty: A Systematic Review of Indications and Outcomes.","authors":"Martin Kauke-Navarro, Leonard Knoedler, Omar Allam, Max Heiland, Samuel Knoedler, Felix J Klimitz, Michael Alperovich, Ali-Farid Safi","doi":"10.1093/asjof/ojaf048","DOIUrl":"10.1093/asjof/ojaf048","url":null,"abstract":"<p><p>Osseous genioplasty (OG) and implant-based chin augmentation are 2 primary approaches for correcting microgenia. A comprehensive synthesis comparing their outcomes, safety profiles, and patient satisfaction is lacking. In this study, the authors aim to assess the safety and outcome profile of implant-based chin augmentation and OG. A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of PubMed, MEDLINE, Cochrane CENTRAL, and Google Scholar was performed in November 2024, utilizing keywords related to genioplasty, chin implants, and specific implant materials. Inclusion criteria required studies to provide original data on isolated procedures performed at a single institution, ensuring consistency in perioperative management. The authors included 7 single-center studies involving 1126 patients with microgenia (740 underwent OG; 386 received implants). Follow-up durations ranged from 6 months to 6 years. Implant materials included <i>Medpor</i>, silicone, <i>Proplast</i>, and PEEK. Patient satisfaction was high across both cohorts, with a trend toward higher satisfaction rates in the OG group. Complication profiles differed: implants had higher infection rates (up to 23.8%) and dehiscence, whereas OG was associated with transient neurosensory changes (up to 100%), occasionally persisting in 7.4% to 12.5% of patients. Relapse rates were similar but slightly higher for OG (2.63%-27.21%). OG was noted to provide greater soft-tissue predictability (85% bony to soft-tissue translation) than implants (66%). Both procedures are effective for managing microgenia, with distinct strengths and risks. Future studies should explore long-term outcomes and assess custom-fabricated implants to enhance fit, contour, and patient satisfaction. Tailored approaches based on individual patient needs remain critical.</p><p><strong>Level of evidence 3 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf048"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ideal Nasal Angle Preferences Among Japanese People: A Prospective Observational Study on Aesthetic Perception. 日本人的理想鼻角偏好:审美知觉的前瞻性观察研究。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf052
Kohki Okumura, Takahiko Tamura, Yusuke Funakoshi, Hiroo Teranishi
{"title":"Ideal Nasal Angle Preferences Among Japanese People: A Prospective Observational Study on Aesthetic Perception.","authors":"Kohki Okumura, Takahiko Tamura, Yusuke Funakoshi, Hiroo Teranishi","doi":"10.1093/asjof/ojaf052","DOIUrl":"10.1093/asjof/ojaf052","url":null,"abstract":"<p><strong>Background: </strong>The aesthetic ideal of the nose varies across nationalities and cultures, making it challenging to define an \"ideal\" nasal shape in rhinoplasty.</p><p><strong>Objectives: </strong>The authors of this study aimed to provide foundational data for generalizable aesthetic standards for nasal surgery in Japanese individuals.</p><p><strong>Methods: </strong>A randomly selected group of 783 Japanese adults was presented with digitally modified images depicting 12 nasolabial and nasofacial angles. Aesthetic evaluations were conducted using Google Forms or paper surveys. The images were categorized into 3 groups: \"aesthetic,\" \"average,\" and \"not aesthetic.\" Statistical analysis was conducted using JMP software. To minimize bias, the order in which the images were presented was randomized. The Steel-Dwass test was used to assess statistically significant differences between angles.</p><p><strong>Results: </strong>For men, a nasolabial angle of 95° and a nasofacial angle of 33° were rated as aesthetic, whereas for women, a nasolabial angle of 105° and a nasofacial angle of 30° were considered favorable. The results indicate a preference for sharper nasolabial angles in men and slightly obtuse angles in women. When calculating the ideal angles using the weighted average, the ideal nasolabial angle for men was 105° and the ideal nasofacial angle was 30°. For women, the ideal nasolabial and nasofacial angles were 105° and 30°, respectively.</p><p><strong>Conclusions: </strong>The authors of this study highlight sex-specific nasal preferences within the Japanese population and emphasize the importance of tailoring rhinoplasty procedures to demographic factors.</p><p><strong>Level of evidence 5 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf052"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catheter-Assisted Application of Hyaluronidase Combined With Multimodal Treatment After Hyaluronic Acid-Induced Ischemia of the Upper Extremity. 透明质酸诱导的上肢缺血后,导管辅助应用透明质酸酶联合多模式治疗。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf054
Sophie Hasiba-Pappas, Lars-Peter Kamolz, Marianne Brodmann, Leyla Schweiger, Andrej Pal, Thomas Rappl, Raimund Winter
{"title":"Catheter-Assisted Application of Hyaluronidase Combined With Multimodal Treatment After Hyaluronic Acid-Induced Ischemia of the Upper Extremity.","authors":"Sophie Hasiba-Pappas, Lars-Peter Kamolz, Marianne Brodmann, Leyla Schweiger, Andrej Pal, Thomas Rappl, Raimund Winter","doi":"10.1093/asjof/ojaf054","DOIUrl":"10.1093/asjof/ojaf054","url":null,"abstract":"<p><p>In this study, the authors report the case of a 62-year-old female patient who presented with ischemia of the right dominant arm and hand after being injected with hyaluronic acid (HA) in the elbow crease. Imaging showed occlusion of the radial artery, the deep and superficial palmar arch and the common digital arteries, as well as the princeps pollicis artery because of an accidental injection of HA into the brachial artery. The aim of the authors is to discuss vascular complications after HA injections and present possible treatment options. Off-label treatment with hyaluronidase was chosen and administered in 2 treatment cycles. The patient received a total of 6000 units of catheter-delivered intra-arterial hyaluronidase and an additional 1500 units applied subcutaneously. A brachial plexus block was placed to promote vasodilatation. Because of severe occlusion, recombinant tissue-type plasminogen activator was administered during the second treatment cycle. Hyperbaric oxygen therapy was carried out for 3 weeks to avoid reocclusion. After the second intra-arterial hyaluronidase injection combined with lysis therapy, full revascularization of the upper extremity was achieved. Follow-up examinations were conducted to monitor sensory and motor recovery. No sequelae were observed. Off-label treatment with high-dose intra-arterial hyaluronidase and adjuvant treatment led to successful restoration of blood circulation after vascular occlusion because of intra-arterial HA injection. <b>Level of Evidence</b>: 5 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf054"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Time-Saving Technique for Ultrasound-Guided Filler Injection: A 3-Year Retrospective Study. 一种省时的超声引导填充物注射新技术:3年回顾性研究。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf061
Danilo Augusto Teixeira
{"title":"A New Time-Saving Technique for Ultrasound-Guided Filler Injection: A 3-Year Retrospective Study.","authors":"Danilo Augusto Teixeira","doi":"10.1093/asjof/ojaf061","DOIUrl":"10.1093/asjof/ojaf061","url":null,"abstract":"<p><strong>Background: </strong>The use of hyaluronic acid (HA) for facial rejuvenation is increasing every year. However, complications can be disastrous because they can cause necrosis, blindness, and stroke. In 2021, the author described a 3-step technique to prevent intravascular injections, but it is time-consuming and difficult to implement.</p><p><strong>Objectives: </strong>The aim of the authors of this article is to propose a quicker and simpler ultrasound-guided filling technique using high-frequency ultrasound to avoid intravascular injections.</p><p><strong>Methods: </strong>The investigator introduced a vascular mapping technique that takes <3 min to identify the position of the arteries to introduce the cannula or needle in a different plane. The investigator retrospectively reviewed 503 patients who were injected with 1109 cc of HA utilizing vascular mapping in different areas of the face to evaluate vascular complications.</p><p><strong>Results: </strong>The most common injection sites were the nasolabial fold (324 cases), marionette lines (157), and lips (106). The chin was injected in 48 patients, the temple in 34, the nose in 26, and the glabella in 23. In 34.7%, 13.2%, and 2.9% of the glabella, nasolabial folds, and temple, respectively, arteries with significant diameters (>0.8 mm) were present at the injection sites. There were no cases of vascular complications.</p><p><strong>Conclusions: </strong>Except for the glabella, only a small percentage of patients have arteries with larger calibers in the injection area. These arteries can be identified before the procedure using quick Doppler ultrasonography (DUS). The use of DUS to map the site of filler injection can help physicians reduce the risk of intravascular injection.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf061"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Late-Onset Pneumothorax and Bilateral Pulmonary Embolism Following Combined Liposuction and Mastopexy: A Case Report and Literature Review. 联合吸脂乳房切除术后迟发性气胸合并双侧肺栓塞1例报告并文献复习。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-14 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf062
Mohamed Badie Ahmed, Fatima Saoud Al-Mohannadi, Albandare Abdulrahman Aldehaimi, Ghanem Aljassem, Abeer Alsherawi
{"title":"A Rare Case of Late-Onset Pneumothorax and Bilateral Pulmonary Embolism Following Combined Liposuction and Mastopexy: A Case Report and Literature Review.","authors":"Mohamed Badie Ahmed, Fatima Saoud Al-Mohannadi, Albandare Abdulrahman Aldehaimi, Ghanem Aljassem, Abeer Alsherawi","doi":"10.1093/asjof/ojaf062","DOIUrl":"https://doi.org/10.1093/asjof/ojaf062","url":null,"abstract":"<p><p>Liposuction, although generally safe, carries risks of rare but serious complications, such as pneumothorax and venous thromboembolism, as illustrated in the case of a 48-year-old woman who developed bilateral pulmonary embolism and left pneumothorax 6 days after vibration amplification of sound energy at resonance-assisted liposuction with mastopexy, despite appropriate thromboprophylaxis. Presenting with dyspnea, chest pain, and leg swelling, computed tomography pulmonary angiography confirmed the diagnoses, which were successfully managed with anticoagulation and conservative measures, highlighting both the potential for delayed complication presentation and the limitations of current prophylaxis protocols. This case underscores the importance of extended postoperative vigilance, particularly for combined respiratory and thromboembolic events, and reinforces the need for meticulous surgical technique, including blunt-tip cannula utilization in thoracic-area procedures, as well as thorough patient counseling about warning signs, because even guideline-compliant prevention may not eliminate risks in susceptible individuals undergoing body contouring surgery. <b>Level of Evidence:</b> 5 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf062"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Tissue Contraction With Helium-Based Plasma Radiofrequency Technology: A Preliminary Report of Initial Ultrasound Findings. 用氦基等离子体射频技术纠正组织收缩:初步超声结果的初步报告。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf057
{"title":"Correction to: Tissue Contraction With Helium-Based Plasma Radiofrequency Technology: A Preliminary Report of Initial Ultrasound Findings.","authors":"","doi":"10.1093/asjof/ojaf057","DOIUrl":"https://doi.org/10.1093/asjof/ojaf057","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/asjof/ojae104.].</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf057"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Ozempic Face" in Plastic Surgery: A Systematic Review of the Literature on GLP-1 Receptor Agonist Mediated Weight Loss and Analysis of Public Perceptions. 整形手术中的“臭氧脸”:对GLP-1受体激动剂介导的体重减轻和公众看法分析的文献系统回顾。
Aesthetic surgery journal. Open forum Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf056
Giulia Daneshgaran, Orr Shauly, Daniel J Gould
{"title":"\"Ozempic Face\" in Plastic Surgery: A Systematic Review of the Literature on GLP-1 Receptor Agonist Mediated Weight Loss and Analysis of Public Perceptions.","authors":"Giulia Daneshgaran, Orr Shauly, Daniel J Gould","doi":"10.1093/asjof/ojaf056","DOIUrl":"10.1093/asjof/ojaf056","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 (GLP-1) receptor agonists have gained popularity after clinical trials demonstrated their weight-loss potential. The term \"Ozempic® face\" has been coined to describe the exaggerated volume loss from semaglutide therapy, resulting in advanced facial aging.</p><p><strong>Objectives: </strong>The authors of this study aim to review plastic surgery publications discussing GLP-1 receptor agonists and characterize the public's perception of the effect of these medications on weight loss.</p><p><strong>Methods: </strong>A systematic review of the PubMed database was conducted to identify articles discussing GLP-1 receptor agonist use in plastic surgery. Articles in non-English languages or on nonhuman subjects were excluded. Bias assessment was completed using standardized checklists. Google Trends was used to track public interest in these medications and their effect on face and body morphology.</p><p><strong>Results: </strong>Twenty-three articles were identified, revealing that (1) several injectable drugs are available for weight loss, (2) GLP-1 receptor agonists cause morphological changes resembling advanced aging, (3) surgical and nonsurgical options exist to address these changes, (4) adverse effects of these medications help guide perioperative management, and (5) important contraindications exist to their use. Online searches for \"Ozempic® face\" were linked to rising searches for \"face filler\" and \"plastic surgeons.\"</p><p><strong>Conclusions: </strong>As the unintended morphological changes of GLP-1 receptor agonists become increasingly reported, so does the public interest in seeking rejuvenation procedures. Although limited by study biases, this systematic review can help the plastic surgery community prepare for the rising needs of this patient population by understanding the risk and benefit profile of GLP-1 receptor agonists and developing clear clinical practice guidelines.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf056"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Could Exosomes be a Promising Therapy to Accelerate Wound Healing and Skin Regeneration in Ischemic Nasal Flaps? 外泌体能否成为促进缺血鼻皮瓣伤口愈合和皮肤再生的有希望的治疗方法?
Aesthetic surgery journal. Open forum Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf060
Jenny Carvajal, Melissa Carvajal
{"title":"Could Exosomes be a Promising Therapy to Accelerate Wound Healing and Skin Regeneration in Ischemic Nasal Flaps?","authors":"Jenny Carvajal, Melissa Carvajal","doi":"10.1093/asjof/ojaf060","DOIUrl":"10.1093/asjof/ojaf060","url":null,"abstract":"<p><p>Severe nasal soft tissue avulsions often involve skin flaps with compromised vascularity. Ischemic changes ranging from epidermolysis to full-thickness necrosis can occur. Angiogenesis is a critical step in wound healing and tissue repair as well as a key factor in skin flap survival. In previous studies, the authors show that angiogenic capacity declines with age, slowing wound healing. Regenerative medicine is rapidly evolving. Stem cell-derived exosomes are gaining popularity in this field, and potential benefits to stimulate angiogenesis and tissue regeneration, accelerating healing, have been demonstrated in preclinical studies. Therapy could hypothetically be targeting exosomes to deliver proangiogenic factors directly to the ischemic skin flap in the early stage of healing, when inflammation and angiogenesis occur. We present the case of a 75-year-old man with a nasal soft tissue partial degloving injury of the dorsum and tip; the avulsed flap was rolled on itself at the nasal tip for 3 h, showing marked signs of venous congestion. The flap was unrolled and repositioned, but venous congestion persisted, evolving into partial tissue necrosis, which was treated with Rosa Damascena stem cell-derived exosomes (RSCEs) on postinjury Days 6, 11, and 16. Wound healing was achieved with complete skin regeneration at 30 days postinjury. In this case, RSCEs were safely utilized to treat a posttraumatic ischemic nasal flap, suggesting their potential as a therapeutic option to support healing and improve outcomes. Randomized, controlled clinical trials are required to validate this preliminary finding. <b>Level of Evidence:</b> 4 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf060"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osseous Genioplasty and Its Impact on Airway Volume-What is the Evidence? 骨性颏成形术及其对气道容积的影响——证据是什么?
Aesthetic surgery journal. Open forum Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI: 10.1093/asjof/ojaf059
Martin Kauke-Navarro, Leonard Knoedler, Lars Stucki, Felix J Klimitz, Omar Allam, Samuel Knoedler, Miguel Carlo Navarro, Paula Flores-Pérez, Albert L Rancu, Max Heiland, Michael Alperovich, Ali-Farid Safi
{"title":"Osseous Genioplasty and Its Impact on Airway Volume-What is the Evidence?","authors":"Martin Kauke-Navarro, Leonard Knoedler, Lars Stucki, Felix J Klimitz, Omar Allam, Samuel Knoedler, Miguel Carlo Navarro, Paula Flores-Pérez, Albert L Rancu, Max Heiland, Michael Alperovich, Ali-Farid Safi","doi":"10.1093/asjof/ojaf059","DOIUrl":"10.1093/asjof/ojaf059","url":null,"abstract":"<p><p>Osseous genioplasty (OG) improves facial aesthetics by 3-dimensionally repositioning the chin and associated soft tissues. Although its effects on airway volumes and obstructive sleep apnea (OSA) have been investigated, the available evidence remains limited. The authors of this study performed a systematic review using the databases PubMed/MEDLINE, Web of Science, Google Scholar, Cochrane, and EMBASE through January 2025. Studies assessing the impact of OG on airway volumes and/or OSA metrics were included. Data on chin advancements, hyoid movements, and related outcomes were extracted. Nine studies met the inclusion criteria. Chin advancement ranged from 4 to 12.5 mm (mean: 7.3 mm), and hyoid advancement ranged from 2.17 to 10 mm (mean: 5.6 mm). Six studies assessed airway changes, with most reporting increases in airway size. Among those, 3 studies quantified volumetric changes. On average, total airway volume increased by 8.5%, with initial volumes averaging 17,956.5 mm<sup>3</sup> and increasing to 19,467.5 mm<sup>3</sup>. The average absolute volume increase was 1511 mm<sup>3</sup>, with the greatest expansion observed in the oropharynx and hypopharynx. Other studies measured linear airway changes, with posterior airway space increasing by a mean of 2.9 mm. One study reported inconsistent results, with some cases demonstrating no significant airway changes postoperatively. These findings suggest a general trend of airway enlargement following intervention. Functional improvements included reductions in apnea-hypopnea index from 27.7 to 12.7 and from 12.4 to 4.4 in 2 studies, along with reported improvements in snoring severity. Genioplasty can enhance airway dimensions and may improve OSA symptoms through forward chin advancement and hyoid elevation. Although outcomes are consistently positive, standardized assessment methods are needed to optimize surgical techniques and evaluate long-term results. <b>Level of Evidence</b>: 4 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf059"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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