Aesthetic surgery journal. Open forum最新文献

{"title":"A Single-Center, Blinded, Placebo-Controlled Study Evaluating Cosmetic Efficacy and Safety of a Novel Topical GLPSGLT in Glucagon-Like Peptide-1 Analog-Treated Patients.","authors":"Alec Semersky, Sydney Pryor, Caitlin Barwood-Parent, Mike Lee, Karen Copeland, Julius Few","doi":"10.1093/asjof/ojaf030","DOIUrl":"10.1093/asjof/ojaf030","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are widely used for Type 2 diabetes and weight management but may adversely affect skin quality, resulting in dermal thinning, decreased elasticity, and accelerated aging-a phenomenon referred to as \"GLP-1 Face.\" A novel topical serum, GLPSGLT (Aforé LLC), was developed to counteract these effects using a proprietary blend of a bioavailable retinoic acid derivative, peptides, and botanical agents to support keratinocyte function and dermal repair. The authors of the study aim to evaluate the safety and efficacy of GLPSGLT serum in improving facial skin quality in patients undergoing GLP-1 RA or SGLT-2 therapy. In this split-face, double-blind pilot study, 7 female patients (median age 55) on stable GLP-1 RA/SGLT-2 therapy applied GLPSGLT serum to one side of the face and placebo to the other, twice daily for 6 weeks. Assessments at baseline, Day 21, and Day 42 included the Global Ranking Scale (GRS), standardized photography reviewed by a blinded physician, and a 26-item patient-satisfaction questionnaire. Treated sides showed statistically significant improvements across all 13 GRS domains vs placebo (<i>P</i> < .0001), particularly in hydration, surface roughness, pigmentation, vasculature, visible pores, and static wrinkles. The blinded reviewer correctly identified the treated side in all cases. Patients reported greater satisfaction with skin texture, firmness, radiance, and hydration. No adverse events were reported. GLPSGLT serum significantly improved skin quality in GLP-1 RA/SGLT-2-treated patients and was well-tolerated, warranting further investigation in larger, histologically assessed cohorts.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf030"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Collaboration and Safety in Aesthetic Plastic Surgery: The Role of the AlliedPro Program.","authors":"Sachin M Shridharani","doi":"10.1093/asjof/ojaf029","DOIUrl":"10.1093/asjof/ojaf029","url":null,"abstract":"","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf029"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Analysis of Age-Related Trends in Biostimulatory Response to Combined Calcium Hydroxylapatite-Carboxymethylcellulose and Microfocused Ultrasound With Visualization Treatments.","authors":"Amanda Doyle, Iris Looi, Paul Chu, Keith A Martinez, Alec D McCarthy","doi":"10.1093/asjof/ojaf023","DOIUrl":"https://doi.org/10.1093/asjof/ojaf023","url":null,"abstract":"<p><strong>Background: </strong>Biostimulators and energy-based devices are increasingly used in combination to address visible signs of aging. Previous research demonstrated that pairing microfocused ultrasound with visualization (MFU-V) and hyperdiluted calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) enhances dermal elastin synthesis and improves aesthetic outcomes up to 120 days posttreatment. However, the impact of patient age on the histological response to these treatments remains unclear.</p><p><strong>Objectives: </strong>To explore whether age influences the biostimulatory response to combined hyperdiluted CaHA-CMC and MFU-V treatments in healthy adults aged 39 to 62 years.</p><p><strong>Methods: </strong>This secondary analysis leveraged data from a 12-patient, IRB-approved clinical study in which patients received 2 combination treatment protocols: Group A (MFU-V followed by hyperdiluted CaHA-CMC) and Group B (hyperdiluted CaHA-CMC followed by MFU-V). Biopsies obtained before and 120 days after completion of treatments were stained for elastin and quantitatively assessed. Linear regression analyses assessed correlations between age and changes in elastin staining intensity and area coverage.</p><p><strong>Results: </strong>No significant correlation was found between patient age and changes in dermal elastin intensity or area. In subgroup analyses, neither protocol showed a significant age-dependent difference in elastin intensity. Although 1 subgroup (Group B) revealed a marginal correlation between age and elastin area, the pooled data did not support age as a significant predictor of biostimulatory response.</p><p><strong>Conclusions: </strong>This exploratory analysis suggests that within the studied age range, patient age may not significantly influence the histological response to combined CaHA-CMC and MFU-V treatments. Larger, statistically powered studies are needed to validate these findings and further investigate age-related effects.</p><p><strong>Level of evidence 5 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf023"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Large-Volume Liposuction on Inflammatory Cytokine Interleukin-6 Levels: A Cross-Sectional Study.","authors":"Hüseyin Kandulu","doi":"10.1093/asjof/ojaf021","DOIUrl":"https://doi.org/10.1093/asjof/ojaf021","url":null,"abstract":"<p><strong>Background: </strong>Liposuction is a widely performed surgical procedure for fat removal, showing increasing popularity for body sculpting purposes. Surgical interventions typically trigger an inflammatory response, but in the context of overweight and obesity, excess adipose tissue can perpetuate systemic inflammation. Adipose tissue, recognized as an endocrine organ, secretes adipokines, influencing metabolic and inflammatory processes. Interleukin-6 (IL-6) is a key cytokine involved in inflammation, notably elevated in obese individuals.</p><p><strong>Objectives: </strong>The aim of this study is to understand the impact of liposuction on IL-6 levels and its correlation with different follow-up points.</p><p><strong>Methods: </strong>This cross-sectional study involved patients undergoing liposuction between January and December 2023. Exclusion criteria included metabolic or chronic diseases. IL-6 levels were measured preoperatively and at 1, 3, and 6 months postsurgery. Data on liposuction volume, BMI, and demographic variables were collected.</p><p><strong>Results: </strong>Twenty-seven patients participated, predominantly female (21/6) with a mean age of 36.42 years. Significant reductions in BMI were observed postoperatively, with a notable increase in IL-6 levels immediately postsurgery followed by a decline at 1 month. IL-6 levels remained stable and were significantly lower than the baseline preoperative levels on the third and sixth follow-up visits.</p><p><strong>Conclusions: </strong>Liposuction induces a temporary inflammatory response, as evidenced by elevated IL-6 levels postsurgery, which subsequently normalize within the first month. Although liposuction may offer short-term improvements in inflammatory response, larger studies are needed to understand its long-term impact on inflammation and metabolic health.</p><p><strong>Level of evidence 2 risk: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf021"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide-1 Receptor Agonists: Friend or Foe of Aesthetic Medicine?","authors":"Ashton J Rosenbloom, Thomas P Gasbeck, Lana S Mamoun, Mary Ziegler, Alan D Widgerow","doi":"10.1093/asjof/ojaf022","DOIUrl":"https://doi.org/10.1093/asjof/ojaf022","url":null,"abstract":"","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf022"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Canadian Outpatient Ambulatory Surgery Centers Safe? An Assessment of 2596 Consecutive Aesthetic Surgery Patients.","authors":"Natalia Ziolkowski, John Milkovich, Jamil Ahmad, Elizabeth Benakopoulos, Frank Lista, Ryan E Austin","doi":"10.1093/asjof/ojaf020","DOIUrl":"https://doi.org/10.1093/asjof/ojaf020","url":null,"abstract":"<p><strong>Background: </strong>Ambulatory surgery centers (ASCs) with same-day discharge criteria are the most common setting for aesthetic surgery in Canada. However, to date, no study has reviewed the safety of outpatient aesthetic surgery performed in the Canadian ASC setting.</p><p><strong>Objectives: </strong>The purpose of this study was to evaluate the overall safety profile of aesthetic surgery in ASCs, to determine how often in-hospital resources were utilized following outpatient aesthetic surgery, and to examine how predictor variables impact adverse outcomes in this setting.</p><p><strong>Methods: </strong>A retrospective chart review of 2596 consecutive patients who underwent aesthetic surgery over a 40-month period at a single Canadian ASC was performed. Data extracted included demographics, operative details, and postoperative complications.</p><p><strong>Results: </strong>A total of 2581 patients met inclusion criteria. The majority of patients were female (91.2%) with a mean age of 37.6 years (range, 18-85 years). Most patients had a BMI in the normal weight range (56.3%), and 70.0% were classified as American Society of Anesthesiologists Class I score. Patients predominantly underwent breast/chest surgery (60.3%) with a procedure duration under 2 h (59.2%). Mean postanesthesia care unit time was 109 min (range, 72-420 min). In total, 10 patients (0.4%) utilized hospital resources in the postoperative period, with 3 (0.1%) direct hospital transfers from the ASC. No patients underwent reoperation in the hospital setting. Overall, 67 (2.4%) patients experienced complications that were managed within the ASC setting. Combined procedures (<i>P</i> = .1367), lipoaspirate volume (<i>P</i> = .53) and procedure duration (<i>P</i> = .92) were not associated with an increased risk of adverse outcomes.</p><p><strong>Conclusions: </strong>Aesthetic surgery in the ASC setting is safe, with a low associated complication rate. Utilization of hospital resources in the postoperative period is rare.</p><p><strong>Level of evidence 4 risk: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf020"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle-Free Jet Injectors and Their Potential Applications in Plastic Surgery: A Review.","authors":"Neil M Vranis, Spero Theodorou","doi":"10.1093/asjof/ojaf019","DOIUrl":"https://doi.org/10.1093/asjof/ojaf019","url":null,"abstract":"<p><p>Needle-free jet injector (NFJI) devices offer an alternative to traditional needle-syringe injection for administration of medications, vaccines, and other fluids. They are already in clinical use around the world for vaccines and insulin administration. NFJIs have reproducibly demonstrated improvement in speed of drug absorption and efficacy; however, this technology has yet to prevail in the plastic surgery industry. Plastic surgeons have experimented with this technology to inject botulinum toxin for palmar hyperhidrosis, steroids for keloids/hypertrophic scars, and local anesthesia. A review was conducted to identify studies published in the last 10 years, indexed on PubMed, involving NFJI devices. Original articles that included ex vivo experimentation, animal studies, and human trials were included. Review articles, mathematical modeling theoretical articles, and nonmedical applications of jet injectors were excluded. A total of 767 identified articles were screened. Once exclusion criteria were applied, there were 115 articles remaining. The majority of the studies were conducted on human patients (<i>n</i> = 62, 53.9%), followed by ex vivo, small, and large animal models. Subcategories of investigations included device efficacy, mechanics, safety, and patient preferences. In conclusion, NFJI are a viable, safe, and potentially more efficacious delivery system compared with traditional needle-syringe techniques for the delivery of medications, vaccines, and other injectable fluids. Patient preference and pain were improved with NFJI. These devices have significant potential clinical applications in the plastic and dermatologic fields.</p><p><strong>Level of evidence 3 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf019"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Planes in Aesthetic Breast Surgery: Is Subfascial a Misnomer?","authors":"Alexandre Mendonça Munhoz","doi":"10.1093/asjof/ojaf017","DOIUrl":"https://doi.org/10.1093/asjof/ojaf017","url":null,"abstract":"","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf017"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Aesthetic Medicine: Exploring the Intersection of Social Psychology, Technology, and Aesthetic Medicine.","authors":"Steven Dayan, Berno Bucker, Jacques van der Meulen, John St John Blythe, Patricia Ogilvie, Damon Caiazza, Maria Musumeci, Michael Silberberg","doi":"10.1093/asjof/ojaf015","DOIUrl":"https://doi.org/10.1093/asjof/ojaf015","url":null,"abstract":"<p><p>A wealth of information can be garnered from the face, such as current emotional state, perceived overall health, personality traits, and even attributed capabilities. It is well understood within aesthetic medicine that minimally invasive treatments positively influence how a patient feels about themselves from an emotional and physical standpoint; however, a growing body of literature suggests that facial aesthetic treatments can also impact how an individual is perceived by others. First impressions, which are formed within milliseconds of viewing a new face, allow us to intuit information about the person and anticipate their intentions. Multiple theories aim to explain why and how these initial social impressions are formed from relatively simple visual cues, and increasing evidence suggests that augmentation of facial appearance influences how others form first impressions. In this article, we discuss theories underlying the importance of first impressions and how minimally invasive aesthetic treatments can affect first impressions and social attributions. We also discuss how advancements in technology can enhance consultations and how technology may expand the world of aesthetic medicine to patients who had not previously considered engaging with aesthetic treatments.</p><p><strong>Level of evidence 5 diagnostic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf015"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Mapping of Nasal Arteries in Chilean Patients Using Doppler Ultrasound: Clinical Application for Injectables.","authors":"Exequiel Ortiz Middleton, Angela Aguilar","doi":"10.1093/asjof/ojaf016","DOIUrl":"https://doi.org/10.1093/asjof/ojaf016","url":null,"abstract":"<p><strong>Background: </strong>This study aims to assess the anatomical positioning of critical nasal arteries in Chilean patients to improve the safety and efficacy of nonsurgical rhinoplasty procedures.</p><p><strong>Objectives: </strong>Using Doppler ultrasound, the study seeks to provide a precise vascular map that informs injection protocols and minimizes the risk of vascular complications, particularly in high-risk nasal regions.</p><p><strong>Methods: </strong>A cohort of 50 Chilean patients (ages 18-60, BMI 18.5-24.9 kg/m²) with no previous nasal procedures were evaluated. Doppler ultrasound was used to map the nasal vasculature, specifically targeting the dorsal nasal artery (DNA), radix, columella, and facial arteries in the piriform fossa. Key measurements included the depth of each artery relative to the periosteum and the skin surface. Descriptive statistics were used to calculate mean values and standard deviations for arterial distances, and comparative analyses were performed using the Student's <i>t</i> test or Mann-Whitney <i>U</i> test as appropriate, with a significance threshold set at <i>P</i> < .05.</p><p><strong>Results: </strong>The anatomical mapping revealed significant variability in arterial positioning. The DNA was located within 1 mm of the periosteum in 10% of cases, presenting a high risk for vascular complications if not accurately mapped preinjection. The average depth of the facial artery in the piriform fossa was 4.65 ± 0.48 mm on the left side and 4.08 ± 0.53 mm on the right side, with statistically significant differences observed between sides (<i>P</i> < .01). Additionally, the columellar artery showed variability in proximity to the epidermis, averaging 2.42 ± 0.34 mm on the left side and 3.03 ± 0.37 mm on the right (<i>P</i> = .03). These findings underscore the necessity of individualized depth and site adjustments during injections to mitigate risks associated with arterial proximity.</p><p><strong>Conclusions: </strong>This study provides critical insights into nasal vascular anatomy in a Latin American population, highlighting the clinical importance of Doppler ultrasound for preinjection mapping in nonsurgical rhinoplasty. By identifying high-risk areas and statistically significant anatomical variations, this research supports the need for a standardized, evidence-based protocol tailored to individual vascular profiles. The integration of Doppler ultrasound into clinical practice is recommended to enhance patient safety and optimize aesthetic outcomes, establishing a new standard for injectable procedures in high-risk nasal regions.</p><p><strong>Level of evidence 4 risk: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"7 ","pages":"ojaf016"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}