Advances in ophthalmology practice and research最新文献

{"title":"Real-world assessment of second-generation trabecular micro-bypass stents in open-angle glaucoma patients","authors":"Vishal Vohra ,&nbsp;Indira Madgula ,&nbsp;Harshika Chawla","doi":"10.1016/j.aopr.2024.09.002","DOIUrl":"10.1016/j.aopr.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>To assess the safety and efficacy of iStent inject placement in individuals with glaucoma with open angles in real world clinical settings.</div></div><div><h3>Methods</h3><div>A review was conducted on the medical records of individuals who received iStent inject implants starting from March 2018. The analysis focused on reductions in intraocular pressure (IOP) and glaucoma medication usage. Safety assessments encompassed intraoperative and postoperative issues, additional surgeries, and improvements in best-corrected visual acuity (BCVA).</div></div><div><h3>Results</h3><div>Analysis of 55 eyes of 48 patients that underwent iStent implantation revealed a mean age of 77 years (range: 51–97). The initial average intraocular pressure (IOP) in these eyes was 20.2 ​± ​6.4 ​mm Hg. Following surgery, IOP decreased by ​≥ ​20% compared to preoperative levels in 21 eyes (43.8%) over the 12-month follow-up period. Notably, there was a significant reduction in medication usage by the 12-month mark (<em>P</em> ​&lt; ​0.0042). Among the evaluated eyes, 9 exhibited a response to steroids, 3 had stents that were improperly positioned, 5 had stents that were over implanted, and 1 eye experienced an episode of iris prolapse.</div></div><div><h3>Conclusions</h3><div>The findings from the 12-month follow-up of iStent inject implants in standard clinical settings demonstrate a notable decrease in both intraocular pressure (IOP) and medication usage in eyes with concurrent open-angle glaucoma.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 16-21"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An anatomical study of the medial wall, lateral wall, roof, and floor of the Filipino orbit","authors":"Lorenzo Angelo R. Santos,&nbsp;Reynaldo M. Javate","doi":"10.1016/j.aopr.2024.10.002","DOIUrl":"10.1016/j.aopr.2024.10.002","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 73-77"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing eyes with artificial tears: A simple and effective strategy to combat screen-related asthenopia and dry eye symptoms","authors":"Ning Wang ,&nbsp;Jinjin Min ,&nbsp;Xiaojing Fan ,&nbsp;Xiuming Jin","doi":"10.1016/j.aopr.2024.07.001","DOIUrl":"10.1016/j.aopr.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>The widespread use of various video display terminals (VDTs) always had a detrimental impact on ocular health. Prolonged use of smartphones has been one of the leading causes of dry eye (DE) and asthenopia. Therefore, the purpose of this study is to find a simple and effective strategy to combat screen-related DE and asthenopia.</div></div><div><h3>Methods</h3><div>A group of healthy participants aged 18 and above were randomly assigned to three groups and tasked with a 2 h smartphone reading task. After 1 ​h of usage, each group adopted different methods of rest: no rest (Group A), a 10 min eye-closed rest (Group B), or a 10 min eye-closed joint artificial tears rest (Group C). Ophthalmological examinations and questionnaires were administered to all participants before and after the 2 h reading task.</div></div><div><h3>Results</h3><div>90 qualified volunteers, including 29 males and 61 females, were randomly assigned to three groups. Group A demonstrated a significant increase in the severity of DE and asthenopia as evidenced by all the evaluated indices. On the other hand, Group C did not exhibit any notable change in DE and asthenopia symptoms, with an improvement in corneal fluorescein staining (CFS) results (<em>P</em> ​&gt; ​0.05) when compared to the pre-reading values. Group B showed a significant increase in ocular surface disease index (OSDI) (<em>P</em> ​≤ ​0.05) and a decrease in critical flicker frequency (CFF) (<em>P</em> ​≤ ​0.05).</div></div><div><h3>Conclusions</h3><div>Close-eye rest with artificial tears may be a convenient and effective prevention strategy for screen-related DE and asthenopia.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 58-65"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decline in US–China science: Can ophthalmology remain collaborative?","authors":"Kevin Y. Huang ,&nbsp;Parth A. Patel ,&nbsp;Austin Huang,&nbsp;Allen C. Ho,&nbsp;Jost B. Jonas,&nbsp;Xiaodong Sun,&nbsp;Youxin Chen,&nbsp;Yingfeng Zheng,&nbsp;Yih-Chung Tham,&nbsp;Christina Y. Weng,&nbsp;Tien Yin Wong","doi":"10.1016/j.aopr.2024.11.002","DOIUrl":"10.1016/j.aopr.2024.11.002","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 13-15"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel RP1 truncating mutation that causes autosomal dominant retinitis pigmentosa (ADRP)","authors":"Wei Wu ,&nbsp;Ying Zhang ,&nbsp;Jingjie Xu ,&nbsp;Hua Jiang ,&nbsp;Xiangjun Chen","doi":"10.1016/j.aopr.2024.08.005","DOIUrl":"10.1016/j.aopr.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Retinitis pigmentosa (RP) is a genetically and clinically heterogeneous group of hereditary degenerative disorders affecting approximately one in every 4000 people worldwide. Abnormalities in the retina's photoreceptors can cause night blindness or even complete vision loss. Retinitis Pigmentosa 1 (RP1), also known as the oxygen-regulated protein-1, is a microtubule-associated protein (MAP) that organizes the outer segment of the photoreceptor. Besides, mutations in the <em>RP1</em> gene are associated with dominant or recessive form of RP. This study aims to identify the potential pathogenic genes in Chinese RP patients and to elucidate the association relationship between the mutant gene and the phenotypes.</div></div><div><h3>Methods</h3><div>Multiple ophthalmic examinations, whole-exome sequencing, sanger sequencing, and <em>in silico</em> analysis were performed to evaluate the clinical features and pathogenic genes in a five-generation Chinese family diagnosed with RP.</div></div><div><h3>Results</h3><div>Our findings revealed a novel truncating mutation c.2015_2018del p. (Lys672Argfs∗9) in <em>RP1</em> that may result in the translation of a protein with deleterious effects on photoreceptors. Therefore, resulting in autosomal dominant retinitis pigmentosa (ADRP).</div></div><div><h3>Conclusions</h3><div>This study broaden the range of genetic mutations associated with <em>RP1</em> in ADRP and make a valuable contribution to the ongoing endeavors aimed at characterizing the molecular aspects of Chinese ADRP. Future studies would pay more attention in determining the characterization of the mutantations in <em>RP1</em> gene and the relationship between genotype and phenotype in RP patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 41-48"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome of sequential bilateral pediatric penetrating keratoplasty (PKP) in patients with corneal dystrophies in South India","authors":"Rekha Gyanchand,&nbsp;B. Mamatha,&nbsp;Salma Mohd Iqbal Tabani,&nbsp;Rajan Sharma,&nbsp;Ashok Sharma","doi":"10.1016/j.aopr.2024.09.003","DOIUrl":"10.1016/j.aopr.2024.09.003","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 216-219"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning-based image analysis for assessing the extent of abduction in abducens nerve palsy patients before and after strabismus surgery","authors":"Ziying Zhou ,&nbsp;Shengqiang Shi ,&nbsp;Xiajing Tang ,&nbsp;Zhaoyang Xu ,&nbsp;Juan Ye ,&nbsp;Xingru Huang ,&nbsp;Lixia Lou","doi":"10.1016/j.aopr.2024.06.004","DOIUrl":"10.1016/j.aopr.2024.06.004","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to propose a novel deep learning-based approach to assess the extent of abduction in patients with abducens nerve palsy before and after strabismus surgery.</div></div><div><h3>Methods</h3><div>This study included 13 patients who were diagnosed with abducens nerve palsy and underwent strabismus surgery in a tertiary hospital. Photographs of primary, dextroversion and levoversion position were collected before and after strabismus surgery. The eye location and eye segmentation network were trained via recurrent residual convolutional neural networks with attention gate connection based on U-Net (R2AU-Net). Facial images of abducens nerve palsy patients were used as the test set and parameters were measured automatically based on the masked images. Absolute abduction also was measured manually, and relative abduction was calculated. Agreements between manual and automatic measurements, as well as repeated automatic measurements were analyzed. Preoperative and postoperative results were compared.</div></div><div><h3>Results</h3><div>The intraclass correlation coefficients (ICCs) between manual and automatic measurements of absolute abduction ranged from 0.985 to 0.992 (<em>P</em>＜0.001), and the bias ranged from −0.25 ​mm to −0.05 ​mm. The ICCs between two repeated automatic measurements ranged from 0.994 to 0.997 (<em>P</em>＜0.001), and the bias ranged from −0.11 ​mm to 0.05 ​mm. After strabismus surgery, absolute abduction of affected eye increased from 2.18 ​± ​1.40 ​mm to 3.36 ​± ​1.93 ​mm (<em>P</em>＜0.05). The relative abduction was improved in 76.9% patients (10/13) after surgery (<em>P</em>＜0.01).</div></div><div><h3>Conclusions</h3><div>This image analysis technique demonstrated excellent accuracy and repeatability for automatic measurements of ocular abduction, which has promising application prospects in objectively assessing surgical outcomes in patients with abducens nerve palsy.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 202-208"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in the treatment of squamous cell carcinoma over the past decade: A bibliometric analysis","authors":"Xueting Li ,&nbsp;Alexander C. Rokohl ,&nbsp;Xiaojun Ju ,&nbsp;Yongwei Guo ,&nbsp;Xincen Hou ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.08.001","DOIUrl":"10.1016/j.aopr.2024.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to identify research trends and hot spots in the treatment of Squamous Cell Carcinoma (SCC) over the past decade using bibliometric analysis.</div></div><div><h3>Methods</h3><div>Data were extracted from the Web of Science Core Collection, including Science Citation Index Expanded (SCI-Expanded), Social Sciences Citation Index (SSCI), and Emerging Sources Citation Index (ESCI). The data underwent manual cleaning to remove inaccuracies and irrelevancies, followed by transformation into an analyzable format via the VOSviewer software. This tool facilitated the visualization of co-occurrence networks and keyword maps, highlighting the relationships and the prominence of research themes.</div></div><div><h3>Results</h3><div>A total of 46448 authors from 7374 institutions across 108 countries contributed to the literature, reflecting a broad international effort. The study documented a consistent increase in SCC-related publications up to 2020, with some variability in subsequent years. Notably, the United States, Germany, China, the United Kingdom, and France were predominant in this research area. The University of Texas MD Anderson Cancer Center and the University of Pittsburgh were leading contributors in terms of publication volume and citation impact. Key journals included ‘Oral Oncology’ and ‘Clinical Cancer Research’, which were central to the dissemination of high-impact research. Our keyword analysis identified three major research clusters focused on molecular mechanisms, clinical treatment strategies, and emerging interests in immunotherapeutic approaches.</div></div><div><h3>Conclusions</h3><div>The extensive collaboration and the increasing publication trend underscore the growing global commitment to advancing SCC treatment. The high level of engagement from top institutions and the concentration of research in influential journals reflect the field's dynamic evolution towards innovative and effective treatment modalities. This study provides a valuable overview for researchers, guiding future studies towards areas of high impact and emerging trends in SCC treatment. The findings advocate for enhanced focus on personalized medicine and combination therapies, which are poised to improve outcomes for SCC patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 209-215"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated systematic review of pharmacological treatments for presbyopia","authors":"Andrzej Grzybowski ,&nbsp;Laura Kapitanovaite ,&nbsp;Reda Zemaitiene","doi":"10.1016/j.aopr.2024.09.001","DOIUrl":"10.1016/j.aopr.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Presbyopia, a common age-related condition affecting near vision, impacts over a billion people worldwide. The aim of this paper is to review the main reports and results of clinical trials, comparing the newest pharmacological treatment options for presbyopia, their mechanisms of action, and possible side effects.</div></div><div><h3>Main text</h3><div>Pharmacological approaches, involving eye drops that target the underlying mechanisms of presbyopia, have gained growing interest. Two key pharmacological agents in this field are miotics and lens softeners. Miotics enhance near vision temporarily by creating a pinhole effect, though they may cause side effects and are under further investigation for long-term use with ongoing research also exploring the potential benefits of combining them with other drugs to improve outcomes and reduce adverse reactions. Lens softeners, on the other hand, aim to restore the flexibility of the lens, addressing one of the primary causes of presbyopia. Despite early trials, further development of lens softeners has been suspended. A notable advancement in this field is the recent FDA approval of 1.25% and 0.4% pilocarpine, a miotic agent, for presbyopia treatment. This milestone highlights the growing interest in pharmacological solutions for presbyopia, with several new drugs and their combinations currently being investigated for potential FDA approval.</div></div><div><h3>Conclusions</h3><div>pharmacological treatments, particularly miotics like pilocarpine, represent a promising alternative to conventional methods for managing presbyopia. Continued research into these treatments, especially combinations of drugs, may offer more effective and convenient options for presbyopia patients in the future.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 220-225"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the impact of cataract surgery on corneal endothelial cells","authors":"Chen Yang ,&nbsp;Qi An ,&nbsp;Han Zhou ,&nbsp;Hongyan Ge","doi":"10.1016/j.aopr.2024.08.002","DOIUrl":"10.1016/j.aopr.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><p>Cataracts are a common eye disease and a major cause of blindness in China and worldwide. In China, the incidence of cataracts among people over 60 years old is as high as 80%. Surgery is the primary treatment for various types of cataracts, but such invasive procedures can affect corneal endothelial cells to some extent.</p></div><div><h3>Content</h3><p>Cataract surgery can damage corneal endothelial cells, leading to complications such as corneal edema in mild cases. Severe damage can result in endothelial decompensation, necessitating secondary corneal endothelial transplantation. Preoperative thorough assessment of endothelial status, intraoperative endothelial protection measures, and postoperative active use of medications to prevent further damage to endothelial cells can reduce endothelial cell loss. Factors influencing endothelial cell status include whether the patient has related systemic diseases or ocular conditions, the hardness of the nucleus, the choice of surgical incision, the method of nuclear fragmentation, the type of viscoelastic agent used, the orientation of the phacoemulsification needle bevel, the duration and energy of ultrasound use, the choice of fluid control system, the use of protective auxiliary instruments, the application of intraocular lens scaffold technology, femtosecond laser assistance, and the use of certain medications.</p></div><div><h3>Conclusions</h3><p>Actively regulating the factors affecting corneal endothelial cells to reduce damage related to cataract surgery is crucial. This paper reviews the existing literature on various factors affecting corneal endothelial cells during cataract surgery and explores future developments and research directions.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 194-201"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000507/pdfft?md5=8e0743b0108c76565c02caac03fc1a39&pid=1-s2.0-S2667376224000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}