{"title":"TOC","authors":"","doi":"10.1016/S2667-3762(24)00066-0","DOIUrl":"10.1016/S2667-3762(24)00066-0","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages iii-iv"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xincen Hou , Alexander C. Rokohl , Xueting Li , Yongwei Guo , Xiaojun Ju , Wanlin Fan , Ludwig M. Heindl
{"title":"Global incidence and prevalence in uveal melanoma","authors":"Xincen Hou , Alexander C. Rokohl , Xueting Li , Yongwei Guo , Xiaojun Ju , Wanlin Fan , Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.10.001","DOIUrl":"10.1016/j.aopr.2024.10.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The most common intraocular cancer in adults is uveal melanoma (UM). This study aimed to investigate and report the incidence and prognosis of UM in different regions of the world.</div></div><div><h3>Methods</h3><div>We retrieved relevant data on UM from the PubMed database and analyzed its global incidence and prognosis. All data was obtained from a national population-based registry, with publication dates ranging from 2013 to 2023.</div></div><div><h3>Results</h3><div>The incidence rates of UM vary across different regions: in the United States, rates were 5.1 per million (1993–2008) and 5.2 per million (1973–2013); in Canada, rates ranged from 3.34 per million (1992–2010) to 5.09 per million (2011–2017); in Republic of Korea, the rate was 0.42 per million (1999–2011); in New Zealand, it was 5.56 per million (2000–2020); in Australia, it was 7.6 per million (1982–2014); and in Europe, rates ranged from 3.1 to 5.8 per million (1995–2002). Among European countries, Sweden (5.6 per million (1960–2009)), Germany (6.41 per million (2009–2015)), Poland (6.67 per million (2010–2017)), and the United Kingdom (10 per million (1999–2010)).</div></div><div><h3>Conclusions</h3><div>The most common site of occurrence for UM is in the choroid. Limited data suggest a stable trend in UM incidence rates across the included countries, but significant differences in incidence rates exist among different countries and regions, with notably lower rates in Asian countries compared to Europe, North America, and Oceania. In general, the incidence rate in males is slightly higher compared to that in females.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 226-232"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rekha Gyanchand, B. Mamatha, Salma Mohd Iqbal Tabani, Rajan Sharma, Ashok Sharma
{"title":"Clinical outcome of sequential bilateral pediatric penetrating keratoplasty (PKP) in patients with corneal dystrophies in South India","authors":"Rekha Gyanchand, B. Mamatha, Salma Mohd Iqbal Tabani, Rajan Sharma, Ashok Sharma","doi":"10.1016/j.aopr.2024.09.003","DOIUrl":"10.1016/j.aopr.2024.09.003","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 216-219"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrzej Grzybowski , Laura Kapitanovaite , Reda Zemaitiene
{"title":"An updated systematic review of pharmacological treatments for presbyopia","authors":"Andrzej Grzybowski , Laura Kapitanovaite , Reda Zemaitiene","doi":"10.1016/j.aopr.2024.09.001","DOIUrl":"10.1016/j.aopr.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Presbyopia, a common age-related condition affecting near vision, impacts over a billion people worldwide. The aim of this paper is to review the main reports and results of clinical trials, comparing the newest pharmacological treatment options for presbyopia, their mechanisms of action, and possible side effects.</div></div><div><h3>Main text</h3><div>Pharmacological approaches, involving eye drops that target the underlying mechanisms of presbyopia, have gained growing interest. Two key pharmacological agents in this field are miotics and lens softeners. Miotics enhance near vision temporarily by creating a pinhole effect, though they may cause side effects and are under further investigation for long-term use with ongoing research also exploring the potential benefits of combining them with other drugs to improve outcomes and reduce adverse reactions. Lens softeners, on the other hand, aim to restore the flexibility of the lens, addressing one of the primary causes of presbyopia. Despite early trials, further development of lens softeners has been suspended. A notable advancement in this field is the recent FDA approval of 1.25% and 0.4% pilocarpine, a miotic agent, for presbyopia treatment. This milestone highlights the growing interest in pharmacological solutions for presbyopia, with several new drugs and their combinations currently being investigated for potential FDA approval.</div></div><div><h3>Conclusions</h3><div>pharmacological treatments, particularly miotics like pilocarpine, represent a promising alternative to conventional methods for managing presbyopia. Continued research into these treatments, especially combinations of drugs, may offer more effective and convenient options for presbyopia patients in the future.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 220-225"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xueting Li , Alexander C. Rokohl , Xiaojun Ju , Yongwei Guo , Xincen Hou , Wanlin Fan , Ludwig M. Heindl
{"title":"Global research trends in the treatment of squamous cell carcinoma over the past decade: A bibliometric analysis","authors":"Xueting Li , Alexander C. Rokohl , Xiaojun Ju , Yongwei Guo , Xincen Hou , Wanlin Fan , Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.08.001","DOIUrl":"10.1016/j.aopr.2024.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to identify research trends and hot spots in the treatment of Squamous Cell Carcinoma (SCC) over the past decade using bibliometric analysis.</div></div><div><h3>Methods</h3><div>Data were extracted from the Web of Science Core Collection, including Science Citation Index Expanded (SCI-Expanded), Social Sciences Citation Index (SSCI), and Emerging Sources Citation Index (ESCI). The data underwent manual cleaning to remove inaccuracies and irrelevancies, followed by transformation into an analyzable format via the VOSviewer software. This tool facilitated the visualization of co-occurrence networks and keyword maps, highlighting the relationships and the prominence of research themes.</div></div><div><h3>Results</h3><div>A total of 46448 authors from 7374 institutions across 108 countries contributed to the literature, reflecting a broad international effort. The study documented a consistent increase in SCC-related publications up to 2020, with some variability in subsequent years. Notably, the United States, Germany, China, the United Kingdom, and France were predominant in this research area. The University of Texas MD Anderson Cancer Center and the University of Pittsburgh were leading contributors in terms of publication volume and citation impact. Key journals included ‘Oral Oncology’ and ‘Clinical Cancer Research’, which were central to the dissemination of high-impact research. Our keyword analysis identified three major research clusters focused on molecular mechanisms, clinical treatment strategies, and emerging interests in immunotherapeutic approaches.</div></div><div><h3>Conclusions</h3><div>The extensive collaboration and the increasing publication trend underscore the growing global commitment to advancing SCC treatment. The high level of engagement from top institutions and the concentration of research in influential journals reflect the field's dynamic evolution towards innovative and effective treatment modalities. This study provides a valuable overview for researchers, guiding future studies towards areas of high impact and emerging trends in SCC treatment. The findings advocate for enhanced focus on personalized medicine and combination therapies, which are poised to improve outcomes for SCC patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 209-215"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding parental hurdles in accessing strabismus treatment","authors":"Omna Chawla , Anupam Singh , Himani Pal , Sanjeev Kumar Mittal , Srishti Sharma , Mittali Khurana , Pooja Kumari , Barun Kumar","doi":"10.1016/j.aopr.2024.08.004","DOIUrl":"10.1016/j.aopr.2024.08.004","url":null,"abstract":"<div><h3>Purpose</h3><p>To explore the parental factors that impede early intervention for strabismus and thus identify strategies for improving access to specialized care.</p></div><div><h3>Methods</h3><p>This hospital-based cross-sectional study included 110 parents of children under 19 years with strabismus receiving treatment at the squint clinic of a tertiary health care center in north India. A pre-validated survey questionnaire was administered to the participants, that had a section about the socio-demographics of the participants, another section addressed the parental knowledge about strabismus about diagnosis, and the need for an eye examination. It also sought information about referral source, the felt need for squint examination, and reasons for not seeking treatment.</p></div><div><h3>Results</h3><p>A total of 110 parents/guardians of strabismus patients (59 exotropes and 51 esotropes) were interviewed using a survey questionnaire. Parents themselves identified 80% of cases, and a substantial link (<em>P</em> < 0.0001) was found between the education status of parents and the age of identification of strabismus. Fear of surgical outcomes (41.79%) was a significant barrier to timely surgery with a higher percentage of parents expressing fear of surgical outcomes (<em>P</em> = 0.025). The cost of surgery (34.33%) and the non-availability of facilities (23.88%) also delayed the intervention.</p></div><div><h3>Conclusions</h3><p>It is essential to educate parents about the importance of strabismus therapy at an appropriate time, stressing its reconstructive rather than merely cosmetic nature, as there are notable gaps in their knowledge. Also, we need to do away with the fear of surgical outcomes of surgical interventions for strabismus.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 189-193"},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000520/pdfft?md5=af61d93bbb8173147dd3fcf570581767&pid=1-s2.0-S2667376224000520-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research progress on the impact of cataract surgery on corneal endothelial cells","authors":"Chen Yang , Qi An , Han Zhou , Hongyan Ge","doi":"10.1016/j.aopr.2024.08.002","DOIUrl":"10.1016/j.aopr.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><p>Cataracts are a common eye disease and a major cause of blindness in China and worldwide. In China, the incidence of cataracts among people over 60 years old is as high as 80%. Surgery is the primary treatment for various types of cataracts, but such invasive procedures can affect corneal endothelial cells to some extent.</p></div><div><h3>Content</h3><p>Cataract surgery can damage corneal endothelial cells, leading to complications such as corneal edema in mild cases. Severe damage can result in endothelial decompensation, necessitating secondary corneal endothelial transplantation. Preoperative thorough assessment of endothelial status, intraoperative endothelial protection measures, and postoperative active use of medications to prevent further damage to endothelial cells can reduce endothelial cell loss. Factors influencing endothelial cell status include whether the patient has related systemic diseases or ocular conditions, the hardness of the nucleus, the choice of surgical incision, the method of nuclear fragmentation, the type of viscoelastic agent used, the orientation of the phacoemulsification needle bevel, the duration and energy of ultrasound use, the choice of fluid control system, the use of protective auxiliary instruments, the application of intraocular lens scaffold technology, femtosecond laser assistance, and the use of certain medications.</p></div><div><h3>Conclusions</h3><p>Actively regulating the factors affecting corneal endothelial cells to reduce damage related to cataract surgery is crucial. This paper reviews the existing literature on various factors affecting corneal endothelial cells during cataract surgery and explores future developments and research directions.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 194-201"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000507/pdfft?md5=8e0743b0108c76565c02caac03fc1a39&pid=1-s2.0-S2667376224000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TOC","authors":"","doi":"10.1016/S2667-3762(24)00045-3","DOIUrl":"10.1016/S2667-3762(24)00045-3","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages iii-iv"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000453/pdfft?md5=fb90564753531009a4d918164ac6cb5b&pid=1-s2.0-S2667376224000453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha Min Er Yew , Yibing Chen , Jocelyn Hui Lin Goh , David Ziyou Chen , Marcus Chun Jin Tan , Ching-Yu Cheng , Victor Teck Chang Koh , Yih Chung Tham
{"title":"Ocular image-based deep learning for predicting refractive error: A systematic review","authors":"Samantha Min Er Yew , Yibing Chen , Jocelyn Hui Lin Goh , David Ziyou Chen , Marcus Chun Jin Tan , Ching-Yu Cheng , Victor Teck Chang Koh , Yih Chung Tham","doi":"10.1016/j.aopr.2024.06.005","DOIUrl":"10.1016/j.aopr.2024.06.005","url":null,"abstract":"<div><h3>Background</h3><p>Uncorrected refractive error is a major cause of vision impairment worldwide and its increasing prevalent necessitates effective screening and management strategies. Meanwhile, deep learning, a subset of Artificial Intelligence, has significantly advanced ophthalmological diagnostics by automating tasks that required extensive clinical expertise. Although recent studies have investigated the use of deep learning models for refractive power detection through various imaging techniques, a comprehensive systematic review on this topic is has yet be done. This review aims to summarise and evaluate the performance of ocular image-based deep learning models in predicting refractive errors.</p></div><div><h3>Main text</h3><p>We search on three databases (PubMed, Scopus, Web of Science) up till June 2023, focusing on deep learning applications in detecting refractive error from ocular images. We included studies that had reported refractive error outcomes, regardless of publication years. We systematically extracted and evaluated the continuous outcomes (sphere, SE, cylinder) and categorical outcomes (myopia), ground truth measurements, ocular imaging modalities, deep learning models, and performance metrics, adhering to PRISMA guidelines. Nine studies were identified and categorised into three groups: retinal photo-based (n = 5), OCT-based (n = 1), and external ocular photo-based (n = 3).</p><p>For high myopia prediction, retinal photo-based models achieved AUC between 0.91 and 0.98, sensitivity levels between 85.10% and 97.80%, and specificity levels between 76.40% and 94.50%. For continuous prediction, retinal photo-based models reported MAE ranging from 0.31D to 2.19D, and <em>R</em><sup>2</sup> between 0.05 and 0.96. The OCT-based model achieved an AUC of 0.79–0.81, sensitivity of 82.30% and 87.20% and specificity of 61.70%–68.90%. For external ocular photo-based models, the AUC ranged from 0.91 to 0.99, sensitivity of 81.13%–84.00% and specificity of 74.00%–86.42%, MAE ranges from 0.07D to 0.18D and accuracy ranges from 81.60% to 96.70%. The reported papers collectively showed promising performances, in particular the retinal photo-based and external eye photo -based DL models.</p></div><div><h3>Conclusions</h3><p>The integration of deep learning model and ocular imaging for refractive error detection appear promising. However, their real-world clinical utility in current screening workflow have yet been evaluated and would require thoughtful consideration in design and implementation.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 164-172"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000404/pdfft?md5=e8e8ffa80d96f5702bfab097d34d40cc&pid=1-s2.0-S2667376224000404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziying Zhou , Shengqiang Shi , Xiajing Tang , Zhaoyang Xu , Juan Ye , Xingru Huang , Lixia Lou
{"title":"A deep learning-based image analysis for assessing the extent of abduction in abducens nerve palsy patients before and after strabismus surgery","authors":"Ziying Zhou , Shengqiang Shi , Xiajing Tang , Zhaoyang Xu , Juan Ye , Xingru Huang , Lixia Lou","doi":"10.1016/j.aopr.2024.06.004","DOIUrl":"10.1016/j.aopr.2024.06.004","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to propose a novel deep learning-based approach to assess the extent of abduction in patients with abducens nerve palsy before and after strabismus surgery.</div></div><div><h3>Methods</h3><div>This study included 13 patients who were diagnosed with abducens nerve palsy and underwent strabismus surgery in a tertiary hospital. Photographs of primary, dextroversion and levoversion position were collected before and after strabismus surgery. The eye location and eye segmentation network were trained via recurrent residual convolutional neural networks with attention gate connection based on U-Net (R2AU-Net). Facial images of abducens nerve palsy patients were used as the test set and parameters were measured automatically based on the masked images. Absolute abduction also was measured manually, and relative abduction was calculated. Agreements between manual and automatic measurements, as well as repeated automatic measurements were analyzed. Preoperative and postoperative results were compared.</div></div><div><h3>Results</h3><div>The intraclass correlation coefficients (ICCs) between manual and automatic measurements of absolute abduction ranged from 0.985 to 0.992 (<em>P</em><0.001), and the bias ranged from −0.25 mm to −0.05 mm. The ICCs between two repeated automatic measurements ranged from 0.994 to 0.997 (<em>P</em><0.001), and the bias ranged from −0.11 mm to 0.05 mm. After strabismus surgery, absolute abduction of affected eye increased from 2.18 ± 1.40 mm to 3.36 ± 1.93 mm (<em>P</em><0.05). The relative abduction was improved in 76.9% patients (10/13) after surgery (<em>P</em><0.01).</div></div><div><h3>Conclusions</h3><div>This image analysis technique demonstrated excellent accuracy and repeatability for automatic measurements of ocular abduction, which has promising application prospects in objectively assessing surgical outcomes in patients with abducens nerve palsy.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 4","pages":"Pages 202-208"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}