Advances in laboratory medicine最新文献_第8页

Evaluation of urine albumin-to-creatinine ratio analysis using strip test as a screening method for urinary albumin determination in primary care. 尿白蛋白与肌酐比值分析在初级保健中作为尿白蛋白测定筛查方法的评价。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-05-01 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2024-0068

Paula Liébanas García, Silvia Montolio Breva, Teresa Sans Mateu

{"title":"Evaluation of urine albumin-to-creatinine ratio analysis using strip test as a screening method for urinary albumin determination in primary care.","authors":"Paula Liébanas García, Silvia Montolio Breva, Teresa Sans Mateu","doi":"10.1515/almed-2024-0068","DOIUrl":"10.1515/almed-2024-0068","url":null,"abstract":"Objectives: The determination of urinary albumin, crucial for chronic kidney disease (CKD) diagnosis and monitoring, typically employs quantitative techniques as the gold standard. However, semi-quantitative methods such as urine reagent strips show promise as cost-effective and rapid screening tools. This study aims to evaluate the feasibility of utilizing Meditape UC-11A strips (Sysmex, Kobe, Japan) for albuminuria screening compared to quantitative assays measuring urine albumin-to-creatinine ratio (ACR).Methods: We systematically analyzed 1,627 strip samples using Meditape UC-11A strips whenever quantitative urinary albumin measurement was required. We compared the ACR measured by strip test with the gold standard (quantitative method determined by Atellica, Siemens, Marburg, Germany) and calculated diagnostic indicators. Additionally, we assessed the economic implications based on test prices (€2.88 for quantitative albumin plus creatinine, and €0.93 for a Meditape UC-11A strip).Results: Receiver operator characteristic (ROC) curve analysis was conducted to determine the optimal cut-off point. The concordance rate achieved using the calculated cut-off point was 90.78 %. Using the quantitative test as the gold standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ACR, analyzed using Meditape UC-11A, were 84.2 , 91.9, 62.7, and 97.3 %, respectively. Our findings suggest a potential saving of 81.2 % on quantitative tests during the study period, amounting to €2,291.65.Conclusions: This study supports the use of Meditape UC-11A strips for detecting abnormal levels of albuminuria, thus offering a viable alternative to quantitative measurement methods. Substantial cost savings can be achieved through this approach.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 3","pages":"345-350"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating ctDNA testing for EGFR analysis in advanced non-small cell lung cancer: strategies for clinical laboratories. 将ctDNA检测整合到晚期非小细胞肺癌的EGFR分析：临床实验室策略

IF 1.1

Advances in laboratory medicine Pub Date : 2025-05-01 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0012

Esther Fernández-Galán, Joan Anton Puig-Butillé

{"title":"Integrating ctDNA testing for EGFR analysis in advanced non-small cell lung cancer: strategies for clinical laboratories.","authors":"Esther Fernández-Galán, Joan Anton Puig-Butillé","doi":"10.1515/almed-2025-0012","DOIUrl":"10.1515/almed-2025-0012","url":null,"abstract":"Epidermal growth factor receptor gene (EGFR) molecular testing is essential for guiding targeted therapies in patients with advanced non-small cell lung cancer (NSCLC). Between 15 and 40 % of patients with NSCLC carry mutations in EGFR that are sensitive to tyrosine kinase inhibitors (TKIs). Due to the significant clinical benefits, identifying patients eligible for TKI therapy is crucial for optimizing treatment. While tumor tissue has been considered the gold standard for this testing, adequate material for EGFR molecular study cannot be obtained in up to 30 % of patients. In this context, circulating tumor DNA (ctDNA) analysis offers a guideline-recommended non-invasive method to detect EGFR mutations. Despite its promise, the widespread adoption of ctDNA analysis faces challenges for integration into clinical practice. This review provides a comprehensive synthesis of current knowledge on the clinical utility of EGFR molecular analysis in ctDNA, alongside its relationship with other circulating biomarkers widely implemented in clinical laboratories, such as serum tumor markers (STMs). It delves into the technical considerations, interpretation of results, and other challenges associated with ctDNA analysis, offering valuable insights into its integration into laboratory workflows.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 3","pages":"233-244"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of external quality assessment in extra-analytical phases in clinical laboratories in Spain: a survey by the Spanish Society of Laboratory Medicine (SEQC^ML). 在西班牙临床实验室的分析外阶段使用外部质量评估：西班牙检验医学学会（SEQCML）的一项调查。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-21 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2025-0067

Andrea Caballero Garralda, Immaculada Comas Reixach, Carlos García Miralles, Rubén Gómez Rioja, María Antonia Llopis Díaz, Débora Martínez Espartosa, Reyes Nicolás de Blas, Mariona Panadès Turró, Laura Puigví Fernández, Laura Rodelgo Jiménez, Berta Sufrate-Vergara, Emma Ventura Orriols

{"title":"Use of external quality assessment in extra-analytical phases in clinical laboratories in Spain: a survey by the Spanish Society of Laboratory Medicine (SEQCML).","authors":"Andrea Caballero Garralda, Immaculada Comas Reixach, Carlos García Miralles, Rubén Gómez Rioja, María Antonia Llopis Díaz, Débora Martínez Espartosa, Reyes Nicolás de Blas, Mariona Panadès Turró, Laura Puigví Fernández, Laura Rodelgo Jiménez, Berta Sufrate-Vergara, Emma Ventura Orriols","doi":"10.1515/almed-2025-0067","DOIUrl":"10.1515/almed-2025-0067","url":null,"abstract":"Objectives: Quality indicators (QIs) are a valuable tool for monitoring and improving extra-analytical phase performance in the clinical laboratory (CL). For that reason, the Spanish Society of Laboratory Medicine (SEQCML) launched its Pre-analytical Phase EQA Program in 2001.Methods: In 2023, a survey was conducted to assess the level of participation in the EQA Program, identify its potential improvements, and enhance the understanding of the collection and estimation processes of the extra-analytical QI.Results: In total, 51 % of respondents (124 responses in total) were enrolled in the program. The primary reason for participating was the need of monitoring of the extra-analytical phases (38 %). In contrast, the main reason for not taking part in the EQA Program was the difficulty in collecting data (32 %). As to potential points for improvement, 56 % considered that QI should be analyzed disaggregated by type of extraction (ambulatory vs. urgent). As many as 86 % of respondents would be interested in participating in a post-analytical phase EQA Program. Most of the suggestions about indicators to be included were related to events regarding temperature and transport times from peripheral extraction sites.Conclusions: Although interest in QIs for pre- and post-analytical phases is growing, the percentage of laboratories that collect data regularly is still limited. The findings of this survey have led the future directions for the EQA Pre-analytical Program, updating and adapting it to the current needs of CLs.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 2","pages":"199-205"},"PeriodicalIF":1.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necesidad de ajustar al IMC los valores límite de los péptidos natriuréticos para un diagnóstico más personalizado de la insuficiencia cardíaca. 需要调整BMI钠肽限值，以更个性化地诊断心力衰竭。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-18 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0060

Damien Gruson, Sergio Bernardini, Marco Perrone

引用次数: 0

Ciencia de datos aplicada a la obtención de estimados de variación biológica. 应用于获得生物变异估计的数据科学。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-03 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2024-0163

Fernando Marques-Garcia, Ana Nieto-Librero, Nerea Gonzalez-García, Xavier Tejedor-Ganduxé, Cristina Martinez-Bravo

引用次数: 0

Uso de la evaluación externa de la calidad en las fases extraanalíticas de los laboratorios clínicos españoles: una encuesta de la Sociedad Española de Medicina de Laboratorio (SEQC^ML). 外部质量评估在西班牙临床实验室分析外阶段的使用：西班牙实验室医学学会（SEQCML）的一项调查。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-03 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2024-0160

Andrea Caballero Garralda, Immaculada Comas Reixach, Carlos García Miralles, Rubén Gómez Rioja, María Antonia Llopis Díaz, Débora Martínez Espartosa, Reyes Nicolás de Blas, Mariona Panadès Turró, Laura Puigví Fernández, Laura Rodelgo Jiménez, Berta Sufrate-Vergara, Emma Ventura Orriols

引用次数: 0

Uso de inteligencia artificial en la predisposición genética a enfermedad crítica por COVID-19: evaluación comparativa de modelos de aprendizaje automático. 人工智能在2019年新冠病毒重病遗传易感性中的应用：机器学习模型的比较评估。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-02 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2024-0129

Salomon Martin Perez, Flora Sanchez Jimenez, Sandra Fuentes Cantero, Marta Jímenez Barragan, Catalina Sanchez Mora, Juan M Borreguero Leon, Teresa Arrobas Velilla, Agustín Valido Morales, Juan A Delgado Torralbo, Antonio León-Justel

引用次数: 0

Data science applied to the assessment of biological variation estimates. 应用于生物变异评估的数据科学。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-01 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2025-0042

Fernando Marques-Garcia, Ana Nieto-Librero, Nerea Gonzalez-García, Xavier Tejedor-Ganduxé, Cristina Martinez-Bravo

{"title":"Data science applied to the assessment of biological variation estimates.","authors":"Fernando Marques-Garcia, Ana Nieto-Librero, Nerea Gonzalez-García, Xavier Tejedor-Ganduxé, Cristina Martinez-Bravo","doi":"10.1515/almed-2025-0042","DOIUrl":"10.1515/almed-2025-0042","url":null,"abstract":"Introduction: Data science is an umbrella term encompassing a set of tools and processes that make it possible to extract new information from structured or unstructured databases. This scientific discipline is gaining relevance in healthcare. In the clinical laboratory, the multiple applications of data science include the development of algorithms for obtaining population-based reference intervals or biological variation (BV) estimates. These algorithms contribute to overcoming the drawbacks of traditional or direct methods.Content: A review was performed of the state-of-the-art in algorithm-based methods for obtaining BV estimates using Real-World Data (RWD) in the field of data science.Summary: A description is provided of the structure of the algorithms currently available for obtaining BV estimates based on the scientific evidence available. An overview is provided of the advantages and drawbacks of direct methods.Outlook: The use of RWD to obtain BV estimates is a novel discipline with a considerable potential for improving our understanding of BV.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 2","pages":"154-159"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cómo manejar las muestras lipémicas para realización de contaje de células sanguíneas (CBC) en los analizadores hematológicos Sysmex. 如何在Sysmex血液学分析仪中处理血脂样本进行血细胞计数（CBC）。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-04-01 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2025-0037

Vanja Radišić Biljak, Lucija Dolovčak, Iva Bakarić, Ana Nikler, Andrea Saračević, Marija Grdić Rajković

引用次数: 0

Diagnóstico de hemoglobinopatías en el laboratorio clínico: hallazgo de una hemoglobina hofu oculta en HPLC. 在临床实验室诊断血红蛋白疾病：发现HPLC中隐藏的hofu血红蛋白。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-03-31 eCollection Date: 2025-06-01 DOI: 10.1515/almed-2024-0081

Maitane Echeverría Urroz, Ana Isabel López Delgado, Raquel Oliveros Conejero, David Álvarez Nistal

引用次数: 0