Advances in geriatric medicine and research最新文献_第6页

Delirium due to Anticholinergic Drug Burden in Older Persons 老年人抗胆碱能药物负担所致谵妄

Advances in geriatric medicine and research Pub Date : 2020-12-28 DOI: 10.20900/agmr20210004

A. Soldati, M. Cesari

引用次数: 0

The Paradox of Precision Medicine 精准医疗的悖论

Advances in geriatric medicine and research Pub Date : 2020-10-28 DOI: 10.20900/agmr20200026

L. Mosconi, Carole J. Lee, G. Vradenburg, R. Brinton

引用次数: 0

Research Survey Series Shows Effects of COVID-19 Shutdowns on Alzheimer’s Community, with Especially High Stress on Caregivers 研究调查系列显示COVID-19关闭对阿尔茨海默病社区的影响，对护理人员的压力尤其大

Advances in geriatric medicine and research Pub Date : 2020-07-30 DOI: 10.20900/agmr20200020

T. Frangiosa, V. Biggar, M. Comer, Amber Roniger

引用次数: 8

Eliminating Health Disparities Is Essential to Achieving Racial Justice—Alzheimer’s Disease, COVID-19, and Related Comorbidities Disproportionately Impact Minority Communities in the Fight for Health Equity 消除健康差距对实现种族公正至关重要——阿尔茨海默病、COVID-19和相关合并症对少数民族社区争取卫生公平的影响不成比例

Advances in geriatric medicine and research Pub Date : 2020-07-27 DOI: 10.20900/agmr20200019

Stephanie Monroe, D. Satcher

引用次数: 0

Derivation of a Frailty Index from the interRAI-HC to Assess Frailty among Older Adults Receiving Home Care and Assistance (the “fraXity” Study) 由interRAI-HC衍生出虚弱指数以评估接受家居照顾及协助的长者的虚弱程度(“虚弱”研究)

Advances in geriatric medicine and research Pub Date : 2020-04-16 DOI: 10.20900/agmr20200013

C. Ludwig, C. Busnel

{"title":"Derivation of a Frailty Index from the interRAI-HC to Assess Frailty among Older Adults Receiving Home Care and Assistance (the “fraXity” Study)","authors":"C. Ludwig, C. Busnel","doi":"10.20900/agmr20200013","DOIUrl":"https://doi.org/10.20900/agmr20200013","url":null,"abstract":"Background: Today, the value of screening for frailty among older adults is undisputed; to this endeavor, care at-home professionals are the “frailty whistleblowers” of choice. Yet, they need quick at-hand tools for routine use. To this aim, this study proposes a frailty index (FI) directly derived from the interRAI-HC MDS. The FI is used to assess frailty in a panel of home service recipients to document the rate of frailty among types of users. \u0000Methods: “fraXity” relies on a case-control design comparing community dwelling older adults receiving home care or assistance to peers who do not receive formal home services. The participants (N = 231) received the interRAI-HC at home from trained nurses. MDS data were used to derive a FI by following published guidelines. Regression modeling was used to assess group differences in the outcomes of interest. \u0000Results: The FI was normally distributed, with a mean of 0.19 (SD 0.10), and a value of 0.46 at the 99th percentile. The effect of age was significant (B = 0.003, 95% CI = (0.001–0.005)). As compared to the control group (FI = 0.14 ± 0.07, m ± SD), the FI was higher among individuals who received assistance (B = 0.04, 95% CI = (0.02–0.07)) and care (B = 0.11, 95% CI = (0.08–0.14)). These differences were adjusted for age. \u0000Conclusions: The results replicate demonstrations of MDS-based FI derivations and support the usefulness of a FI to distinguish different types of home service recipients. The study is a proof of concept supporting the need of a comprehensive assessment of health needs for all individuals who apply for homes services, including those admitted only for assistance. Further work is needed to evaluate the cost-benefit ratio of implementing the proposed methodology in homecare practice. \u0000Trial Registration: ClinicalTrials.gov, NCT03883425, registered on March 20, 2019.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"27 supp1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89851277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Situated Precision Healthcare in the Smart Medical Home: Bringing NASA's Research Strategy down to Earth. 智能医疗家庭中的精准医疗：将NASA的研究战略付诸实践。

Advances in geriatric medicine and research Pub Date : 2020-01-01 Epub Date: 2020-06-29 DOI: 10.20900/agmr20200017

Gary Riccio, Rhoda Au, Richard van Emmerik, Mohammed Eslami

{"title":"Situated Precision Healthcare in the Smart Medical Home: Bringing NASA's Research Strategy down to Earth.","authors":"Gary Riccio, Rhoda Au, Richard van Emmerik, Mohammed Eslami","doi":"10.20900/agmr20200017","DOIUrl":"10.20900/agmr20200017","url":null,"abstract":"This special issue is ambitious in that it calls for strategic transformation in research on Alzheimer's Disease (AD) and related dementias, including innovation in both research design and value delivery, through lifestyle interventions that implicitly relate to a much broader range of comorbidities and diseases of aging. One response to this challenge is to venture beyond the boundaries of research that supports the healthcare industry. Toward this end, we introduce opportunities for research translation and knowledge transfer from NASA to the healthcare industry. Our intent is to show how NASA's approach to research can guide innovation for a smart medical home, most notably for AD and other diseases of aging. The article is organized in four major sections: (a) aggregating fragmented research communities; (b) lifestyle interventions in the medical home; (c) multiscale computational modeling and analysis; and (d) lifespan approach to precision brain health. We provide novel motivations and transformative paths to a diversity of specific lines of research, across communities, that would be difficult to discover in common methods of networking within research communities and even through sophisticated bibliographic methods. We thus reveal how knowledge transfer between the public and private sector can stimulate development of broader scientific communities and achieve a more coherent strategic approach to integration and development of a diversity of capabilities including but not limited to technology.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40417047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans. 美国人按性别、种族和手优势划分的绝对握力百分位数和体重指数标准化。

Advances in geriatric medicine and research Pub Date : 2020-01-01 Epub Date: 2019-12-31 DOI: 10.20900/agmr20200005

Ryan McGrath, Kyle J Hackney, Nicholas A Ratamess, Brenda M Vincent, Brian C Clark, William J Kraemer

{"title":"Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.","authors":"Ryan McGrath, Kyle J Hackney, Nicholas A Ratamess, Brenda M Vincent, Brian C Clark, William J Kraemer","doi":"10.20900/agmr20200005","DOIUrl":"10.20900/agmr20200005","url":null,"abstract":"Background: Gender and ethnicity are factors which influence strength, and hand dominance could be a critical component of handgrip strength (HGS) testing. Providing such HGS percentiles across the lifespan may help to identify weakness-related health concerns. We sought to generate growth charts and curves for HGS by gender and ethnicity in a nationally-representative sample of Americans aged 6-80 years.Methods: Data from 13,617 participants in the 2011-2012 and 2013-2014 waves of the National Health and Nutrition Examination Survey were analyzed. HGS was measured with a handgrip dynamometer. Age, gender, ethnicity, and hand dominance were self-reported. Body Mass Index (BMI) was calculated from height and body mass. Measures of absolute HGS and HGS normalized to BMI were separately included in parametric quantile regression analyses for determining the 10th-90th percentiles across ages by gender and ethnicity. Similar models were also conducted by hand dominance.Results: Differences in absolute HGS and HGS normalized to BMI quantiles across ages existed for each ethnicity regardless of gender. In men, absolute HGS generally increased until about 25 years of age, began to decline around age 30 years, and regressed into older adulthood. In women, absolute HGS appeared to rise starting at age 6 years, peaked between 20 and 30 years of age, but was maintained into mid-life before declining in older adulthood. Similar results were found for HGS normalized to BMI.Conclusions: Our findings provide percentile charts for HGS capacity that could be utilized for comparing individual measures of HGS to those from a United States population-representative sample.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37536081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Why Loneliness Interventions Are Unsuccessful: A Call for Precision Health. 孤独干预为何不成功？呼吁精准健康。

Advances in geriatric medicine and research Pub Date : 2020-01-01 Epub Date: 2020-06-17 DOI: 10.20900/agmr20200016

Samia C Akhter-Khan, Rhoda Au

{"title":"Why Loneliness Interventions Are Unsuccessful: A Call for Precision Health.","authors":"Samia C Akhter-Khan, Rhoda Au","doi":"10.20900/agmr20200016","DOIUrl":"10.20900/agmr20200016","url":null,"abstract":"Background: Loneliness has drawn increasing attention over the past few decades due to rising recognition of its close connection with serious health issues, like dementia. Yet, researchers are failing to find solutions to alleviate the globally experienced burden of loneliness.Purpose: This review aims to shed light on possible reasons for why interventions have been ineffective. We suggest new directions for research on loneliness as it relates to precision health, emerging technologies, digital phenotyping, and machine learning.Results: Current loneliness interventions are unsuccessful due to (i) their inconsideration of loneliness as a heterogeneous construct and (ii) not being targeted at individuals' needs and contexts. We propose a model for how loneliness interventions can move towards finding the right solution for the right person at the right time. Taking a precision health approach, we explore how transdisciplinary research can contribute to creating a more holistic picture of loneliness and shift interventions from treatment to prevention.Conclusions: We urge the field to rethink metrics to account for diverse intra-individual experiences and trajectories of loneliness. Big data sharing and evolving technologies that emphasize human connection raise hope for realizing our model of precision health applied to loneliness. There is an urgent need for precise, integrated, and theory-driven interventions that focus on individuals' needs and the subjective burden of loneliness in the ageing context.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Centenarians as Models of Resistance and Resilience to Alzheimer's Disease and Related Dementias. 百岁老人对阿尔茨海默病和相关痴呆的抵抗力和复原力模型。

Advances in geriatric medicine and research Pub Date : 2020-01-01 DOI: 10.20900/agmr20200018

Stacy L Andersen

{"title":"Centenarians as Models of Resistance and Resilience to Alzheimer's Disease and Related Dementias.","authors":"Stacy L Andersen","doi":"10.20900/agmr20200018","DOIUrl":"https://doi.org/10.20900/agmr20200018","url":null,"abstract":"The majority of research to understand the pathogenesis of and contributors to Alzheimer's disease (AD) pathology, dementia, and disease progression has focused on studying individuals who have the disease or are at increased risk of having the disease. Yet there may be much to learn from individuals who have a paradoxical decreased risk of AD suggesting underlying protective factors. Centenarians demonstrate exceptional longevity that for a subset of the cohort is associated with an increased health span characterized by the delay or escape of age-related diseases including dementia. Here, I give evidence of the association of exceptional longevity with resistance and resilience to AD and describe how cohorts of centenarians and their offspring may serve as models of neuroprotection from AD. Discoveries of novel genetic, environmental, and behavioral factors that are associated with a decreased risk of AD may inform the development of interventions to slow or prevent AD in the general population. Centenarian cohorts may also be instrumental in serving as controls to individuals with AD to identify additional risk factors.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Can Patient Frailty Be Estimated from Inpatient Records? A Prospective Cohort Study 从住院病历中可以估计病人的虚弱程度吗?一项前瞻性队列研究

Advances in geriatric medicine and research Pub Date : 2019-12-26 DOI: 10.20900/agmr20200004

C. Marincowitz, V. Turner, V. Allgar, Jodie Bellwood, Alice Wheeler, M. Hale, Harriet Callaghan, A. Clegg, T. Sheldon

{"title":"Can Patient Frailty Be Estimated from Inpatient Records? A Prospective Cohort Study","authors":"C. Marincowitz, V. Turner, V. Allgar, Jodie Bellwood, Alice Wheeler, M. Hale, Harriet Callaghan, A. Clegg, T. Sheldon","doi":"10.20900/agmr20200004","DOIUrl":"https://doi.org/10.20900/agmr20200004","url":null,"abstract":"Background: Frailty is a common condition in older people affecting around 1.8 million people in the UK and is independently associated with adverse outcomes. Frailty is commonly measured with the Clinical Frailty Scale (CFS) which involves a face to face assessment. There is evidence the CFS can be assigned retrospectively from information in patient records, but no research has assessed whether scores can be assigned using routine inpatient records. We aimed to assess whether a CFS could be accurately assigned using hospital inpatient records in a UK setting. \u0000Methods: Forty newly admitted patients aged 65 and over were prospectively recruited at Bradford Royal Infirmary. A CFS score was assigned to each patient using a face to face assessment. A CFS score was independently assigned to each patient solely using information in the inpatient records. A quadratically weighted Cohen’s Kappa was used to estimate inter-rater reliability (IRR) between the assessments. \u0000Results: A Kappa of 0.84 was estimated for the IRR between the scores derived from a face to face assessment and those based solely on inpatient records, indicating good agreement. The Kappa score fell to 0.7 when a 4 category collapsed version of the CFS was used. The IRR appeared unaffected by the number of times a patient had been admitted recently. \u0000Conclusion: The CSF may accurately be determined from data routinely recorded in inpatient records. Retrospectively derived scores can, therefore, be used in analysis of patient outcomes of older people in research and service improvement.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"201 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74532941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10