Delirium due to Anticholinergic Drug Burden in Older Persons

The cumulative effect of medications with anticholinergic activity (known as Anticholinergic Drug Burden, ADB) is associated with incident delirium and onset of adverse outcomes in older persons (e.g., cognitive and functional impairment). In a recent study by Egberts and colleagues, the association between delirium and ADB was demonstrated, mainly when assessed using the Anticholinergic Risk Scale (ARS). Although drugs with anticholinergic properties are often included in lists of potentially inappropriate medications, their prescription is still widespread. More efforts should be made to support deprescribing strategies and limit the prescription of potentially harmful medications.