Advances in geriatric medicine and research最新文献

Weakness Status is Differentially Associated with Time to Diabetes in Americans 虚弱状态与美国人患糖尿病时间的不同关系

Advances in geriatric medicine and research Pub Date : 2024-07-24 DOI: 10.20900/agmr20240004

K.-P. Knoll, Yeong Rhee, Natasha Fillmore, Donald A. Jurivich, Justin J Lang, Brenda M. McGrath, Grant R Tomkinson, Ryan McGrath

引用次数: 0

Memory Loss and Missteps: Investigating Fall Risks in Alzheimer's and Dementia Patients. 记忆丧失与失足：调查阿尔茨海默氏症和痴呆症患者的跌倒风险。

Advances in geriatric medicine and research Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.20900/agmr20240005

Asmaa Namoos, Nicholas Thomson, Sarah Bradley, Amanda Rudderman, Michel Aboutanos

{"title":"Memory Loss and Missteps: Investigating Fall Risks in Alzheimer's and Dementia Patients.","authors":"Asmaa Namoos, Nicholas Thomson, Sarah Bradley, Amanda Rudderman, Michel Aboutanos","doi":"10.20900/agmr20240005","DOIUrl":"10.20900/agmr20240005","url":null,"abstract":"Background: Degenerative diseases such as Alzheimer's disease and dementia are significant health concerns among older adults in the United States, contributing substantially to the high incidence of falls in this population. This study aims to investigate the incidence and prevalence of falls among older adults diagnosed with Alzheimer's disease and dementia and explore the association between these conditions and the occurrence of traumatic brain injuries (TBIs).Methods: A retrospective cohort study was conducted using data from 17,000 older adults aged 65 and above, arrived at the hospital with fall related injuries, obtained from the TriNetX network at Virginia Commonwealth University Health System (VCUHS) between January 1, 2019, and December 31, 2023. Data included demographic information, diagnosis codes (ICD-10), and details on falls, Alzheimer's disease, dementia, and TBIs. Descriptive statistics and logistic regression analyses were performed using TriNetX analytical tools.Results: Older adults with Alzheimer's disease (incidence proportion: 3.11%, prevalence: 4.81%) and dementia (incidence proportion: 12.46%, prevalence: 17.06%) had a significantly higher incidence of falls compared to those without these conditions. Females showed a slightly higher incidence of falls than males. Logistic regression analysis indicated that patients with Alzheimer's disease had a reduced risk of TBIs (OR = 0.765, 95% CI: 0.588-0.996, p = 0.047), while those with unspecified dementia had an increased risk (OR = 1.161, 95% CI: 1.002-1.346, p = 0.047).Conclusions: Our study reveals a higher risk of falls and traumatic brain injuries (TBIs) in older adults with dementia compared to those with Alzheimer's disease. These findings underscore the need for targeted fall prevention strategies and educational programs for caregivers.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis-Based Comparison of Annual Fall Risk between Older Adults with Alzheimer's Disease and Mild Cognitive Impairment. 基于元分析的阿尔茨海默病和轻度认知障碍老年人年跌倒风险比较。

Advances in geriatric medicine and research Pub Date : 2024-01-01 Epub Date: 2024-03-20 DOI: 10.20900/agmr20240002

Caroline Simpkins, Sara Mahmoudzadeh Khalili, Feng Yang

{"title":"Meta-Analysis-Based Comparison of Annual Fall Risk between Older Adults with Alzheimer's Disease and Mild Cognitive Impairment.","authors":"Caroline Simpkins, Sara Mahmoudzadeh Khalili, Feng Yang","doi":"10.20900/agmr20240002","DOIUrl":"10.20900/agmr20240002","url":null,"abstract":"Background: Falls are a primary cause of injuries and hospitalization in older adults. It has been reported that cognitive impairments and dementia can increase fall risk in the older population; however, it remains unknown if fall risk differs among subgroups of dementia. This meta-analysis summarized previous studies reporting the annual fall risk of people with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and compared the fall risk between these two groups of people with dementia.Methods: Thirty-five studies enrolling 7844 older adults with AD or MCI were included. The annual fall prevalence and average number of falls of the included studies were meta-analyzed and compared by random-effects models with inverse variance weights.Results: The annual fall prevalence in people with AD (43.55%) was significantly higher than MCI (35.26%, p < 0.001). A χ2 test indicated that the pooled fall prevalence is significantly higher in people with AD than MCI χ2 = 158.403, p < 0.001). Additionally, the yearly average number of falls in AD was higher than in MCI (1.30 vs 0.77 falls/person).Conclusions: The results showed that older people with AD experience a higher annual fall prevalence with a larger number of falls than older adults with MCI. The results suggested that the fall risk measurements should be reported separately between people with AD and MCI. The findings could provide preliminary guidance for the identification of individuals with dementia who experience a high fall risk.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Falls and Alzheimer Disease. 跌倒与阿尔茨海默病

Advances in geriatric medicine and research Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI: 10.20900/agmr.20240001

Abigail L Kehrer-Dunlap, Audrey A Keleman, Rebecca M Bollinger, Susan L Stark

{"title":"Falls and Alzheimer Disease.","authors":"Abigail L Kehrer-Dunlap, Audrey A Keleman, Rebecca M Bollinger, Susan L Stark","doi":"10.20900/agmr.20240001","DOIUrl":"10.20900/agmr.20240001","url":null,"abstract":"Falls are the leading cause of injury, disability, and injury-related mortality in the older adult population. Older adults with Alzheimer disease (AD) are over twice as likely to experience a fall compared to cognitively normal older adults. Intrinsic and extrinsic fall risk factors may influence falls during symptomatic AD; intrinsic factors include changes in cognition and impaired functional mobility, and extrinsic factors include polypharmacy and environmental fall hazards. Despite many known fall risk factors, the high prevalence of falls, and the presence of effective fall prevention interventions for older adults without cognitive impairment, effective fall prevention interventions for older adults with AD to date are limited and inconclusive. Falls may precede AD-related cognitive impairment during the preclinical phase of AD, though a narrow understanding of fall risk factors and fall prevention interventions for older adults with preclinical AD limits clinical treatment of falls among cognitively normal older adults with preclinical AD. This mini review explores fall risk factors in symptomatic AD, evidence for effective fall prevention interventions in symptomatic AD, and preclinical AD as an avenue for future falls research, including recommendations for future research directions to improve our understanding of falls and fall risk during preclinical AD. Early detection and tailored interventions to address these functional changes are needed to reduce the risk of falls for those at risk for developing AD. Concerted efforts should be dedicated to understanding falls to inform precision fall prevention strategies for this population.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia as a Preoperative Risk Stratification Tool among Older Adults with Inflammatory Bowel Disease. 将 "肌肉疏松症 "作为炎症性肠病老年患者术前风险分层工具。

Advances in geriatric medicine and research Pub Date : 2024-01-01 Epub Date: 2024-05-30 DOI: 10.20900/agmr20240003

Ria Minawala, Adam S Faye

引用次数: 0

Role of Estrogen Receptor α in Aging and Chronic Disease. 雌激素受体α在衰老和慢性疾病中的作用。

Advances in geriatric medicine and research Pub Date : 2023-01-01 DOI: 10.20900/agmr20230005

José V V Isola, Sunghwan Ko, Sarah R Ocañas, Michael B Stout

{"title":"Role of Estrogen Receptor α in Aging and Chronic Disease.","authors":"José V V Isola, Sunghwan Ko, Sarah R Ocañas, Michael B Stout","doi":"10.20900/agmr20230005","DOIUrl":"https://doi.org/10.20900/agmr20230005","url":null,"abstract":"Estrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It also mediates cellular responses to estrogens in multiple nonreproductive organ systems, many of which regulate systemic metabolic homeostasis and inflammatory processes in mammals. The loss of estrogens and/or ERα agonism during aging is associated with the emergence of several comorbid conditions, particularly in females undergoing the menopausal transition. Emerging data also suggests that male mammals likely benefit from ERα agonism if done in a way that circumvents feminizing characteristics. This has led us, and others, to speculate that tissue-specific ERα agonism may hold therapeutic potential for curtailing aging and chronic disease burden in males and females that are at high-risk of cancer and/or cardiovascular events with traditional estrogen replacement therapies. In this mini-review, we emphasize the role of ERα in the brain and liver, summarizing recent evidence that indicates these two organs systems mediate the beneficial effects of estrogens on metabolism and inflammation during aging. We also discuss how 17α-estradiol administration elicits health benefits in an ERα-dependent manner, which provides proof-of-concept that ERα may be a druggable target for attenuating aging and age-related disease burden.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing Falls in Older Women with Urinary Incontinence. 减少患有尿失禁的老年妇女跌倒。

Advances in geriatric medicine and research Pub Date : 2023-01-01 Epub Date: 2024-01-25 DOI: 10.20900/agmr20230011

Simone Reaves, Lily A Arya, Diane K Newman, Jean Wyman, Heather Klusaritz, Wendy Walsh, Rebecca T Brown, Uduak U Andy

引用次数: 0

Shoulder Dysfunction and Mobility Limitation in Aging. 老年人的肩部功能障碍和活动受限。

Advances in geriatric medicine and research Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI: 10.20900/agmr20230008

Derik L Davis

引用次数: 0

Trends in Passive IoT Biomarker Monitoring and Machine Learning for Cardiovascular Disease Management in the U.S. Elderly Population. 被动物联网生物标志物监测和机器学习在美国老年人群心血管疾病管理中的趋势。

Advances in geriatric medicine and research Pub Date : 2023-01-01 DOI: 10.20900/agmr20230002

Brian F Bender, Jasmine A Berry

{"title":"Trends in Passive IoT Biomarker Monitoring and Machine Learning for Cardiovascular Disease Management in the U.S. Elderly Population.","authors":"Brian F Bender, Jasmine A Berry","doi":"10.20900/agmr20230002","DOIUrl":"https://doi.org/10.20900/agmr20230002","url":null,"abstract":"It is predicted that the growth in the U.S. elderly population alongside continued growth in chronic disease prevalence will further strain an already overburdened healthcare system and could compromise the delivery of equitable care. Current trends in technology are demonstrating successful application of artificial intelligence (AI) and machine learning (ML) to biomarkers of cardiovascular disease (CVD) using longitudinal data collected passively from internet-of-things (IoT) platforms deployed among the elderly population. These systems are growing in sophistication and deployed across evermore use-cases, presenting new opportunities and challenges for innovators and caregivers alike. IoT sensor development that incorporates greater levels of passivity will increase the likelihood of continued growth in device adoption among the geriatric population for longitudinal health data collection which will benefit a variety of CVD applications. This growth in IoT sensor development and longitudinal data acquisition is paralleled by the growth in ML approaches that continue to provide promising avenues for better geriatric care through higher personalization, more real-time feedback, and prognostic insights that may help prevent downstream complications and relieve strain on the healthcare system overall. However, findings that identify differences in longitudinal biomarker interpretations between elderly populations and relatively younger populations highlights the necessity that ML approaches that use data from newly developed passive IoT systems should collect more data on this target population and more clinical trials will help elucidate the extent of benefits and risks from these data driven approaches to remote care.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9636827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion, Aging, and Decision Making: A State of the Art Mini-Review. 情绪、衰老和决策:一项最新研究综述。

Advances in geriatric medicine and research Pub Date : 2023-01-01 DOI: 10.20900/agmr20230003

Joseph A Mikels, David B Taullahu

{"title":"Emotion, Aging, and Decision Making: A State of the Art Mini-Review.","authors":"Joseph A Mikels, David B Taullahu","doi":"10.20900/agmr20230003","DOIUrl":"https://doi.org/10.20900/agmr20230003","url":null,"abstract":"Over the past few decades, interest has begun to surge in understanding the role of emotion in decision making, and more recently in studies across the adult life span. Relevant to age-related changes in decision making, theoretical perspectives in judgment and decision making draw critical distinctions between deliberative versus intuitive/affective processes, as well as integral versus incidental affect. Empirical findings demonstrate the central role of affect in various decision-related domains such as framing and risk taking. To situate this review within an adult life-span context, we focus on theoretical perspectives in adult development regarding emotion and motivation. As a result of age differences in deliberative and emotional processes, taking a life-span perspective is critical to advance a comprehensive and grounded understanding of the role of affect in decision making. Age-related shifts in information processing from negative toward positive material also have consequential implications. By taking a life-span perspective, not only will decision theorists and researchers benefit, but so too will practitioners who encounter individuals of various ages as they make consequential decisions.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9881106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1