Acta materia medica最新文献_第4页

Aging and cancer hallmarks as therapeutic targets 衰老和癌症标志作为治疗靶点

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0018

Jingchao Wang, Jonathan Wei, H. Inuzuka

{"title":"Aging and cancer hallmarks as therapeutic targets","authors":"Jingchao Wang, Jonathan Wei, H. Inuzuka","doi":"10.15212/amm-2023-0018","DOIUrl":"https://doi.org/10.15212/amm-2023-0018","url":null,"abstract":"The prevalence of age-related diseases has been progressively increasing worldwide. The pathogenesis of these disorders, including cancer, is closely associated with an age-dependent decline in cellular functions. There are multiple layers of crosstalk between aging processes and oncogenesis. Therefore, a better understanding of the interplay between aging and cancer will facilitate the development of novel therapeutic intervention strategies for malignancies at advanced ages. Recent review articles have concisely summarized and updated aging and cancer hallmark features and adequately discussed the interplays at both the cellular and molecular levels. Because aging and cancer share several key mechanisms that define the hallmarks, targeting shared features, such as cellular senescence, may be beneficial for cancer prevention and treatments. Notably, senolysis, an innovative therapeutic intervention for selectively removing senescent cells, holds great promise for developing new therapeutic approaches for cancers and other age-related diseases, such as viral infections and cardiovascular diseases. Herein we briefly summarize the recently updated knowledge on aging and cancer hallmarks, as well as the advances in senolysis for age-related conditions.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67303897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Corrigendum to: Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2 更正:水飞蓟宾通过靶向Skp2对非小细胞肺癌具有治疗效果

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-1001

Shi-Bing Zhang, Ming Hong, Xiao-Yang Sun, Da Huang, Dan-Hua He, Yu-Fei Chen, Yong Yuan, Yong-Qiang Liu

引用次数: 1

Biological functions and therapeutic potential of acylation by histone acetyltransferases 组蛋白乙酰转移酶酰基化的生物学功能和治疗潜力

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0010

Nan Li, Clark Hamor, Y. An, Licheng Zhu, Yusheng Gong, Y. Toh, Yusong R. Guo

引用次数: 1

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0016

W. Mao, Z. Ding, Keyi Wang, Ming Chen

{"title":"Cuproptosis-related MTF1 inhibits kidney renal clear cell carcinoma progression by suppressing proliferation and regulating immune cell infiltration","authors":"W. Mao, Z. Ding, Keyi Wang, Ming Chen","doi":"10.15212/amm-2023-0016","DOIUrl":"https://doi.org/10.15212/amm-2023-0016","url":null,"abstract":"Cuproptosis is a newly identified specific form of programmed cell death. Our study aimed to identify cuproptosis-related genes (CRGs) in patients with kidney renal clear cell carcinoma (KIRC) from the The Cancer Genome Atlas database and to evaluate CRG biological functions. Using lasso regression, we identified four KIRC prognosis-associated CRGs and constructed an associated prognostic risk signature. Kaplan-Meier curves showed that patients with high-risk scores had significantly lower survival times than patients with low-risk scores. Multivariate Cox analysis identified MTF1 and FDX1 as two independent overall survival CRGs. Moreover, qRT-PCR showed that MTF1 and FDX1 expression was downregulated in KIRC and knockdown of MTF1 and FDX1 significantly promoted KIRC cell proliferation and migration ability. In addition, the MTF1 level was positively correlated with immune cell infiltration and knockdown of MTF1 promoted tumor growth in vivo. We developed a signature of prognostic risk-associated CRGs that accurately predicted the prognostic status of KIRC patients. MTF1 and FDX1 were shown to be key CRGs. MTF1 acts as a tumor suppressor, and may be involved in the progression of KIRC by inhibiting proliferation and regulating immune cell infiltration.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67303822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An intrinsic connection between COVID-19 and aging COVID-19与衰老之间存在内在联系

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0030

Jingchao Wang, Jonathan Wei, Fabin Dang, Hiroyuki Inuzuka

{"title":"An intrinsic connection between COVID-19 and aging","authors":"Jingchao Wang, Jonathan Wei, Fabin Dang, Hiroyuki Inuzuka","doi":"10.15212/amm-2023-0030","DOIUrl":"https://doi.org/10.15212/amm-2023-0030","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a rapidly spreading outbreak of coronavirus disease 2019 (the COVID-19 pandemic). COVID-19 has severely affected healthcare systems worldwide, as well as the global economy, and has significantly increased morbidity and mortality rates. The majority of COVID-19-related deaths occurred in older individuals, primarily among those with concomitant diseases, including metabolic, respiratory, and cardiovascular diseases. Aging hallmarks, such as cellular senescence, chronic inflammation, and genomic instability, partially explain the increased disease severity at the molecular level with advancing age. Other multifactorial considerations, including healthcare facilities, socioeconomic status, and dissemination of epidemic information, may help control morbidity in the elderly population. While the World Health Organization declared an end to the emergency status of COVID-19 in May 2023, physical and emotional impairments may persist after recovery from the virus. Precautions should therefore be taken to prevent future pandemics, and suitable emphasis should be placed on addressing persistent COVID-19 and preventing future pandemics.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine 单纯疱疹潜伏病毒1型活化增加神经退行性疾病的易感性:中药干预

Acta materia medica Pub Date : 2022-12-30 DOI: 10.15212/amm-2022-0043

Jie Sun, Chang-Yu Yan, Jie Niu, M. Pan, Zhuo Luo, Wen-Jun Duan, Wen Li, Yan-ping Wu, Wan-Yang Sun, Feng Huang, Fan-na Liu, Haizhi Liu, H. Kurihara, Yi-Fang Li, Rong-Rong He

{"title":"Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine","authors":"Jie Sun, Chang-Yu Yan, Jie Niu, M. Pan, Zhuo Luo, Wen-Jun Duan, Wen Li, Yan-ping Wu, Wan-Yang Sun, Feng Huang, Fan-na Liu, Haizhi Liu, H. Kurihara, Yi-Fang Li, Rong-Rong He","doi":"10.15212/amm-2022-0043","DOIUrl":"https://doi.org/10.15212/amm-2022-0043","url":null,"abstract":"Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to increase susceptibility to various diseases, including neurodegenerative diseases (NDs). Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, establishes latent infections in the trigeminal ganglia for the lifetime of the host. Upon reactivation, the latent HSV-1 enters the lytic cycle, which not only causes a substantial production of reactive oxygen species (ROS) in the neurons, but also induces glial cells to produce inflammatory mediators, eventually resulting in neuronal damage and occurrence of NDs. Remarkably, both physical and psychological stress are common stimuli leading to latent HSV-1 reactivation. Acyclovir is a classic antiviral drug for the treatment of HSV-1 infection and recurrence, but acyclovir cannot reverse neuronal damage caused by HSV-1 reactivation. Recent studies have shown that traditional Chinese medicine (TCM) has advantages in the treatment of NDs. In addition, TCM is thought to prevent latent HSV-1 reactivation and NDs, which may involve regulation of the neuro-endocrine-immune network, treatment of emotional disorders, and modulation of oxidative stress. Understanding the mechanism underlying stress-induced reactivation of latent HSV-1 and the potential consequences of NDs is needed. TCM may be a promising alternative therapy for related diseases.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46251198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mass spectrometry imaging advances and application in pharmaceutical research 质谱成像技术及其在药物研究中的应用

Acta materia medica Pub Date : 2022-12-23 DOI: 10.15212/amm-2022-0046

Xiaowei Song, Chao Li, Yifan Meng

{"title":"Mass spectrometry imaging advances and application in pharmaceutical research","authors":"Xiaowei Song, Chao Li, Yifan Meng","doi":"10.15212/amm-2022-0046","DOIUrl":"https://doi.org/10.15212/amm-2022-0046","url":null,"abstract":"Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation. MSI can specifically resolve distributions of a parent drug and its metabolic products across dosed specimens without loss of spatial information, thus facilitating the direct observation of a drug’s pharmacokinetic processes, such as absorption, distribution, metabolism, and excretion. MSI can simultaneously visualize hundreds of phenotype molecules, including proteins, glycans, metabolites, and lipids, which have unique distribution patterns and biofunctions across different physiologic regions. This featured specificity in the chemical and physical spaces empowers MSI as an ideal analytical technique in exploring a drug’s pharmacodynamic properties, including in vitro/in vivo efficacy, safety, potential toxicity, and possible molecular mechanism. The application of MSI in pharmaceutical research has also been expanded from the conventional dosed tissue analysis to the front end of the preclinical drug R&D pipeline, such as investigating the structure-activity relationship, high-throughput in vitro screening, and ex vivo studies on single cells, organoids, or tumor spheroids. This review summarizes MSI application in pharmaceutical research accompanied by its technical and methodologic advances serving this central demand.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44696734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system 癌症治疗:从中药到脂质体输送系统

Acta materia medica Pub Date : 2022-12-14 DOI: 10.15212/amm-2022-0035

Minhan Fu, Xueying Han, Bin Chen, Lingna Guo, Lei Zhong, Po Hu, Yang Pan, Min Qiu, P. Cao, J. Chen

{"title":"Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system","authors":"Minhan Fu, Xueying Han, Bin Chen, Lingna Guo, Lei Zhong, Po Hu, Yang Pan, Min Qiu, P. Cao, J. Chen","doi":"10.15212/amm-2022-0035","DOIUrl":"https://doi.org/10.15212/amm-2022-0035","url":null,"abstract":"Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable method to treat various diseases with a broad range of biological activity; however, traditional preparations, like decoctions, are often associated with low bioavailability, thus resulting in limited efficacy against cancer. The drawbacks of active TCH components, including instability, poor permeability, high hydrophilicity or hydrophobicity, undesirable pharmacokinetic profiles, and off-target toxicity, also exist. Most TCH medicines are thus limited to a clinical alternative for the treatment of chronic diseases. A liposomal delivery system is the most common class of FDA-approved nanomedicines, which has improved pharmacokinetics, enhanced targetability, and reduced side effects. Therefore, we anticipate that liposomal delivery technology will help concentrate drugs inside tumors, and fully release the therapeutic potential and reduce the side effects of TCH medicines. The review provides a brief overview of several representative TCH components and related liposome delivery strategies for enhanced cancer therapy. Current challenges associated with liposomal targeting of TCH medicines are also discussed for interested researchers.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43828538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing 近红外荧光H2S供体生物硫醇触发的H2S释放促进皮肤伤口愈合

Acta materia medica Pub Date : 2022-11-16 DOI: 10.15212/amm-2022-0032

Xinyue Zhao, Mengbin Ding, Lulu Ning, Fang Yuan, Jingchao Li, Yuan Guo, Y. Mu, Jianjian Zhang

{"title":"Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing","authors":"Xinyue Zhao, Mengbin Ding, Lulu Ning, Fang Yuan, Jingchao Li, Yuan Guo, Y. Mu, Jianjian Zhang","doi":"10.15212/amm-2022-0032","DOIUrl":"https://doi.org/10.15212/amm-2022-0032","url":null,"abstract":"Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2S donors, methods for high-precision detection and imaging of released H2S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent H2S donor, PRO-ST, was developed for real-time visualization of H2S release. PRO-ST consists of a dicyanoisophorone-based NIR fluorescence moiety (TCOO), a biothiol-trigger moiety (4-isothiocyanate benzyl alcohol), and a sulfur-source group (thiophosgene). PRO-ST exhibits high NIR fluorescence enhancement (45-fold), outstanding H2S release efficiency (73%), controllable H2S release (60 min), and excellent cell compatibility. These distinctive features enable PRO-ST to be applied in visualizing H2S release in cells, zebrafish, and mice. Moreover, PRO-ST exhibits excellent performance in visualizing real-time anti-inflammation and wound healing enhancement in biological systems, as confirmed by in situ visualization of H2S release. Thus, PRO-ST provides a versatile and effective method to detect and visualize H2S release, elucidate the mechanisms underlying wound healing, or optimize interventional therapy.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44565418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Structurally diverse polydopamine-based nanomedicines for cancer therapy 用于癌症治疗的结构多样的聚多巴胺基纳米药物

Acta materia medica Pub Date : 2022-10-18 DOI: 10.15212/amm-2022-0023

Yu-Wen Zheng, Tao Cao, Xueying Han, Peng Cao, Qichen Zhan

引用次数: 4