Acta materia medica最新文献_第5页

Functions and therapeutic potentials of exosomes in osteosarcoma. 外泌体在骨肉瘤中的功能和治疗潜力。

Acta materia medica Pub Date : 2022-10-18 DOI: 10.15212/amm-2022-0024

Jiaji Yue, Zhe-Sheng Chen, Xiang-Xi Xu, Shenglong Li

引用次数: 5

Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy 基于铁下垂和光动力联合疗法的癌症治疗新进展

Acta materia medica Pub Date : 2022-10-18 DOI: 10.15212/amm-2022-0025

Zeping Gao, Shunzhe Zheng, K. Kamei, Chutong Tian

{"title":"Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy","authors":"Zeping Gao, Shunzhe Zheng, K. Kamei, Chutong Tian","doi":"10.15212/amm-2022-0025","DOIUrl":"https://doi.org/10.15212/amm-2022-0025","url":null,"abstract":"Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species and aggravate oxidative stress in tumor cells. Combining ferroptosis with PDT cooperatively regulates intracellular redox homeostasis, thus increasing cancer cell susceptibility to oxidative stress and yielding synergistic anticancer effects. In this review, various strategies for combining ferroptosis with PDT are comprehensively summarized and discussed, including mono-PDT and PDT-induced ferroptosis, combining PDT with small-molecule ferroptosis inducers, and combining PDT with metal-ion-induced ferroptosis. Additionally, the possibility of combining ferroptosis and PDT with other anti-tumor therapies is discussed. Finally, the prospects and challenges of combining ferroptosis with PDT in clinical cancer treatment are addressed. With increased understanding of the superiority of combination PDT with ferroptosis for cancer treatment, we hope that drug delivery systems based on this strategy will be further developed to increase anticancer efficiency and achieve successful clinical translation.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46883262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

In vitro characterization and cellular uptake profiles of TAMs-targeted lipid calcium carbonate nanoparticles for cancer immunotherapy 靶向tam的脂质碳酸钙纳米颗粒用于癌症免疫治疗的体外表征和细胞摄取谱

Acta materia medica Pub Date : 2022-10-12 DOI: 10.15212/amm-2022-0030

Xiaoyan Xu, Renjie Li, Runqi Dong, Yan-fang Yang, Hongliang Wang, Jia Hua Cheng, Yuling Liu, Jun Ye

{"title":"In vitro characterization and cellular uptake profiles of TAMs-targeted lipid calcium carbonate nanoparticles for cancer immunotherapy","authors":"Xiaoyan Xu, Renjie Li, Runqi Dong, Yan-fang Yang, Hongliang Wang, Jia Hua Cheng, Yuling Liu, Jun Ye","doi":"10.15212/amm-2022-0030","DOIUrl":"https://doi.org/10.15212/amm-2022-0030","url":null,"abstract":"Tumor-associated macrophages (TAMs) are key contributors to tumor development, accelerated tumor invasion and metastasis, and induction of immunosuppression. Targeted delivery of immunomodulatory agents to promote polarization of TAMs may alleviate the immunosuppressive tumor microenvironment. Calcium carbonate nanoparticles (CCN), which exhibit excellent biocompatibility, pH sensitivity, and easy surface modification, have attracted substantial attention in targeted nano delivery. In this study, CCN were used as a matrix material to develop UNO-peptide-modified lipid CCN for targeted immunomodulation of TAMs by using the mannose receptor overexpressed on the surfaces of TAMs as targets. The preparation of CCN was optimized through single-factor testing with the gas diffusion method with the particle size as the index. The surface modification of CCN with UNO-peptide-modified phospholipids was performed, and its targeting effect on TAMs was investigated. The average particle size of the CCN and UNO-peptide-modified CCN was 144.5 ± 3.8 nm and 167.0 ± 1.3 nm, respectively. UNO-peptide-modified CCN entered TAMs via actively targeted uptake mediated by mannose receptors. Our results demonstrated that the developed UNO-peptide-modified CCN with controlled nano-size and excellent TAMs-targeting properties is a highly promising nanocarrier for targeted delivery of TAM immunomodulatory agents.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41783643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics 以1h - nmr为基础的代谢组学评估人参皂苷CK对氧化应激诱导的神经元损伤的保护作用

Acta materia medica Pub Date : 2022-10-07 DOI: 10.15212/amm-2022-0009

Na Li, Yanhong Zhang, Jing-wei Lv, Dazhong Sun, Jianan Lin, Qihang Pang, Hui Li, Zhanhong Cao, Yaxin Liu, Zhuguo Li, Xingyu Fang, Dianyu Li, Haonan Bai, Yuanyuan An, Jun Jiang, Rui Zhang, Qing Yang

{"title":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics","authors":"Na Li, Yanhong Zhang, Jing-wei Lv, Dazhong Sun, Jianan Lin, Qihang Pang, Hui Li, Zhanhong Cao, Yaxin Liu, Zhuguo Li, Xingyu Fang, Dianyu Li, Haonan Bai, Yuanyuan An, Jun Jiang, Rui Zhang, Qing Yang","doi":"10.15212/amm-2022-0009","DOIUrl":"https://doi.org/10.15212/amm-2022-0009","url":null,"abstract":"Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer’s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this study, the protective effects of ginsenoside CK against oxidative stress damage induced by hydrogen peroxide in HT22 cells were investigated with 1H nuclear magnetic resonance (1H-NMR)-based metabolomics. The optimal CK concentration for decreasing oxidative stress damage in nerves was determined with MTT assays. CK (8 μM) significantly increased the HT22 cell survival rate after the model was established. Cell lysates were subjected to 1H-NMR metabolomics, western blotting, and ATP assays for verification. Metabolic perturbation occurred in HT22 cells in the model group but not the control group. Twenty biomarkers were identified and used to analyze metabolic pathways. CK reversed metabolic changes in HT22 cells by altering taurine, glutamate, glycine, and glutathione metabolism. Subsequently, CK increased ATP content and the expression of components of the PI3K/AKT signaling pathway in HT22 cells. These findings demonstrated that CK prevents oxidative stress damage and protects nerves by regulating energy-metabolism pathways, such as those of taurine, glutamate, and other amino acids, thus providing a rationale for the use of CK in Alzheimer’s disease treatment.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43068130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer STAT3直接抑制剂6-乙氧基二氢血根碱对癌症具有抗癌活性

Acta materia medica Pub Date : 2022-10-06 DOI: 10.15212/amm-2022-0027

Xue-wen Liu, Xin Jin, Hongling Ou, Chen Qian, Hui Wu, C. Zuo, Yuliang Ren, Miaoxin Fu, Te Zhang, Liang Zhang, Y. Si, Ying Liu

{"title":"The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer","authors":"Xue-wen Liu, Xin Jin, Hongling Ou, Chen Qian, Hui Wu, C. Zuo, Yuliang Ren, Miaoxin Fu, Te Zhang, Liang Zhang, Y. Si, Ying Liu","doi":"10.15212/amm-2022-0027","DOIUrl":"https://doi.org/10.15212/amm-2022-0027","url":null,"abstract":"Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged as a potential therapeutic strategy for many cancer types. In this study, the effect of 6-ethoxydihydrosanguinarine (6-EDS), a secondary transformation product formed from dihydrosanguinarine, isolated from Macleaya (Papaveraceae), was evaluated in gastric cancer (GC). We demonstrated that 6-EDS inhibited the survival, migration, and invasiveness of GC cells in vitro. Moreover, 6-EDS inhibited STAT3 phosphorylation and transcriptional activity, thus suppressing the mRNA expression of downstream target genes associated with the malignant survival, migration, and invasiveness of GC cells. Molecular docking indicated that 6-EDS directly bound the SH2 domain of STAT3. Molecular dynamics simulations suggested that 6-EDS inhibited the binding of phosphorylated and non-phosphorylated STAT3 to target DNA. Cellular thermal-shift assays and microscale thermophoresis further confirmed the direct binding of 6-EDS to STAT3. Site-directed mutagenesis indicated that the S611 residue in the SH2 domain of STAT3 is critical for 6-EDS binding. In vivo, 6-EDS decreased tumor growth in xenografted nude mice by blocking STAT3 signaling. These findings indicated that 6-EDS, a direct STAT3 inhibitor, may be a potent anticancer candidate for GC therapy.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43597903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis 转运蛋白调控的分子机制及其在肝内胆汁淤积中的损害

Acta materia medica Pub Date : 2022-10-06 DOI: 10.15212/amm-2022-0029

Xiping Li, Y. Zu, Guodong Li, Dong Xiang, Chengliang Zhang, Dong Liu

引用次数: 1

Advances in therapeutic nanodrug delivery systems for infectious lung diseases: a review 传染性肺部疾病纳米药物治疗系统的研究进展

Acta materia medica Pub Date : 2022-08-30 DOI: 10.15212/amm-2022-0019

Gang Sheng, Na Tian, Huijuan Duan, Zhaogang Sun, Hong-qian Chu

引用次数: 8

Establishment of a protein thermal shift chip (PTSC) for COVID-19 and exploration of the future of protein chips in pharmacology 新型冠状病毒蛋白热移芯片(PTSC)的建立及蛋白芯片在药理学领域的未来探索

Acta materia medica Pub Date : 2022-08-03 DOI: 10.15212/amm-2022-0016

Peng Chen, Zhao Cui, Caifeng Li, Shiwen Deng, Han Yang

引用次数: 0

Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2 水飞蓟宾通过靶向Skp2对非小细胞肺癌具有治疗作用

Acta materia medica Pub Date : 2022-08-03 DOI: 10.15212/amm-2022-0011

Shi-Bing Zhang, M. Hong, Xiao-Yang Sun, Da-xiong Huang, Dan-hua He, Yu-Fei Chen, Yong Yuan, Yongqiang Liu

{"title":"Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2","authors":"Shi-Bing Zhang, M. Hong, Xiao-Yang Sun, Da-xiong Huang, Dan-hua He, Yu-Fei Chen, Yong Yuan, Yongqiang Liu","doi":"10.15212/amm-2022-0011","DOIUrl":"https://doi.org/10.15212/amm-2022-0011","url":null,"abstract":"Silybin (SB), a natural flavonoid isolated from Silybum marianum, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the anticancer targets of SB and the underlying mechanism were unclear. Herein, we found that SB significantly inhibited the proliferation of non-small cell lung cancer without causing cytotoxicity toward normal Beas-2B bronchial epithelial cells. Mechanistically, SB binds the F-box protein Skp2 and disrupts Skp1-Skp2 interaction, thereby decreasing Skp2 protein levels, inducing accumulation of Skp2 substrates, and leading to G1-phase cell-cycle arrest and the suppression of cell migration. In lung orthotopic xenografts, SB also significantly decreased Skp2 expression and increased p27/Kip1 protein levels. SB administration inhibited tumor growth and metastasis in lung tissue, thus prolonging survival time in mice without causing obvious toxicity. Thus, SB is a potential Skp2-targeting agent that warrants further clinical investigation.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67303275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

MDM2-BCL-X_L PROTACs enable degradation of BCL-X_L and stabilization of p53. MDM2-BCL-XL PROTACs能够降解BCL-XL并稳定p53。

Acta materia medica Pub Date : 2022-07-21 DOI: 10.15212/amm-2022-0022

Mengyang Chang, Feng Gao, Jing Chen, Giri Gnawali, Wei Wang

引用次数: 4