Acta materia medica最新文献

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The 'New (Nu)-clear' evidence for the tumor-driving role of PI3K. PI3K 推动肿瘤作用的 "新(Nu)-明确 "证据。
Acta materia medica Pub Date : 2022-01-01 Epub Date: 2022-05-16 DOI: 10.15212/amm-2022-0013
Franklin Mayca Pozo, Tony Hunter, Youwei Zhang
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引用次数: 0
Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity. 海洋放线菌的细胞毒性化合物:来源、结构和生物活性。
Acta materia medica Pub Date : 2022-01-01 DOI: 10.15212/amm-2022-0028
Ziyan Qiu, Yinshuang Wu, Kunyan Lan, Shiyi Wang, Huilin Yu, Yufei Wang, Cong Wang, Shugeng Cao
{"title":"Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity.","authors":"Ziyan Qiu,&nbsp;Yinshuang Wu,&nbsp;Kunyan Lan,&nbsp;Shiyi Wang,&nbsp;Huilin Yu,&nbsp;Yufei Wang,&nbsp;Cong Wang,&nbsp;Shugeng Cao","doi":"10.15212/amm-2022-0028","DOIUrl":"https://doi.org/10.15212/amm-2022-0028","url":null,"abstract":"<p><p>Marine actinomycetes produce a substantial number of natural products with cytotoxic activity. The strains of actinomycetes were isolated from different sources like fishes, coral, sponges, seaweeds, mangroves, sediments etc. These cytotoxic compounds can be categorized briefly into four classes: polyketides, non-ribosomal peptides and hybrids, isoprenoids and hybrids, and others, among which majority are polyketides (146). Twenty two out of the 254 compounds showed potent cytotoxicity with IC<sub>50</sub> values at ng/mL or nM level. This review highlights the sources, structures and antitumor activity of 254 natural products isolated from marine actinomycetes, which were new when they were reported from 1989 to 2020.</p>","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802659/pdf/nihms-1850447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10475769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Drug discovery is an eternal challenge for the biomedical sciences 药物发现是生物医学科学的永恒挑战
Acta materia medica Pub Date : 2022-01-01 DOI: 10.15212/amm-2022-1001
L. Hua, Wei Wenyi, Hongxi Xu
{"title":"Drug discovery is an eternal challenge for the biomedical sciences","authors":"L. Hua, Wei Wenyi, Hongxi Xu","doi":"10.15212/amm-2022-1001","DOIUrl":"https://doi.org/10.15212/amm-2022-1001","url":null,"abstract":"aWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China bDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States cSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44489865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
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