Zongxing Xie, Bing Zhou, Xi Cheng, E. Schoenfeld, Fan Ye
{"title":"Passive and Context-Aware In-Home Vital Signs Monitoring Using Co-Located UWB-Depth Sensor Fusion","authors":"Zongxing Xie, Bing Zhou, Xi Cheng, E. Schoenfeld, Fan Ye","doi":"10.1145/3549941","DOIUrl":"https://doi.org/10.1145/3549941","url":null,"abstract":"Basic vital signs such as heart and respiratory rates (HR and RR) are essential bio-indicators. Their longitudinal in-home collection enables prediction and detection of disease onset and change, providing for earlier health intervention. In this article, we propose a robust, non-touch vital signs monitoring system using a pair of co-located Ultra-Wide Band (UWB) and depth sensors. By extensive manual examination, we identify four typical temporal and spectral signal patterns and their suitable vital sign estimators. We devise a probabilistic weighted framework (PWF) that quantifies evidence of these patterns to update the weighted combination of estimator output to track the vital signs robustly. We also design a “heatmap”-based signal quality detector to exclude the disturbed signal from inadvertent motions. To monitor multiple co-habiting subjects in-home, we build a two-branch long short-term memory (LSTM) neural network to distinguish between individuals and their activities, providing activity context crucial to disambiguating critical from normal vital sign variability. To achieve reliable context annotation, we carefully devise the feature set of the consecutive skeletal poses from the depth data, and develop a probabilistic tracking model to tackle non-line-of-sight (NLOS) cases. Our experimental results demonstrate the robustness and superior performance of the individual modules as well as the end-to-end system for passive and context-aware vital sign monitoring.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 1","pages":"1 - 31"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64053506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aviv Elor, Steve Whittaker, Sri Kurniawan, Sam Michael
{"title":"BioLumin: An Immersive Mixed Reality Experience for Interactive Microscopic Visualization and Biomedical Research Annotation","authors":"Aviv Elor, Steve Whittaker, Sri Kurniawan, Sam Michael","doi":"10.1145/3548777","DOIUrl":"https://doi.org/10.1145/3548777","url":null,"abstract":"Many recent breakthroughs in medical diagnostics and drug discovery arise from deploying machine learning algorithms to large-scale data sets. However, a significant obstacle to such approaches is that they depend on high-quality annotations generated by domain experts. This study develops and evaluates BioLumin, a novel immersive mixed reality environment that enables users to virtually shrink down to the microscopic level for navigation and annotation of 3D reconstructed images. We discuss how domain experts were consulted in the specification of a pipeline to enable automatic reconstruction of biological models for mixed reality environments, driving the design of a 3DUI system to explore whether such a system allows accurate annotation of complex medical data by non-experts. To examine the usability and feasibility of BioLumin, we evaluated our prototype through a multi-stage mixed-method approach. First, three domain experts offered expert reviews, and subsequently, nineteen non-expert users performed representative annotation tasks in a controlled setting. The results indicated that the mixed reality system was learnable and that non-experts could generate high-quality 3D annotations after a short training session. Lastly, we discuss design considerations for future tools like BioLumin in medical and more general scientific contexts.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 1","pages":"1 - 28"},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47033654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SCouT: Synthetic Counterfactuals via Spatiotemporal Transformers for Actionable Healthcare","authors":"Bhishma Dedhia, Roshini Balasubramanian, N. Jha","doi":"10.1145/3617180","DOIUrl":"https://doi.org/10.1145/3617180","url":null,"abstract":"The Synthetic Control method has pioneered a class of powerful data-driven techniques to estimate the counterfactual reality of a unit from donor units. At its core, the technique involves a linear model fitted on the pre-intervention period that combines donor outcomes to yield the counterfactual. However, linearly combining spatial information at each time instance using time-agnostic weights fails to capture important inter-unit and intra-unit temporal contexts and complex nonlinear dynamics of real data. We instead propose an approach to use local spatiotemporal information before the onset of the intervention as a promising way to estimate the counterfactual sequence. To this end, we suggest a Transformer model that leverages particular positional embeddings, a modified decoder attention mask, and a novel pre-training task to perform spatiotemporal sequence-to-sequence modeling. Our experiments on synthetic data demonstrate the efficacy of our method in the typical small donor pool setting and its robustness against noise. We also generate actionable healthcare insights at the population and patient levels by simulating a state-wide public health policy to evaluate its effectiveness, an in silico trial for asthma medications to support randomized controlled trials, and a medical intervention for patients with Friedreich’s ataxia to improve clinical decision-making and promote personalized therapy.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42581687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehak Gupta, Thao-Ly T Phan, H Timothy Bunnell, Rahmatollah Beheshti
{"title":"Obesity Prediction with EHR Data: A deep learning approach with interpretable elements.","authors":"Mehak Gupta, Thao-Ly T Phan, H Timothy Bunnell, Rahmatollah Beheshti","doi":"10.1145/3506719","DOIUrl":"https://doi.org/10.1145/3506719","url":null,"abstract":"<p><p>Childhood obesity is a major public health challenge. Early prediction and identification of the children at an elevated risk of developing childhood obesity may help in engaging earlier and more effective interventions to prevent and manage obesity. Most existing predictive tools for childhood obesity primarily rely on traditional regression-type methods using only a few hand-picked features and without exploiting longitudinal patterns of children's data. Deep learning methods allow the use of high-dimensional longitudinal datasets. In this paper, we present a deep learning model designed for predicting future obesity patterns from generally available items on children's medical history. To do this, we use a large unaugmented electronic health records dataset from a large pediatric health system in the US. We adopt a general LSTM network architecture and train our proposed model using both static and dynamic EHR data. To add interpretability, we have additionally included an attention layer to calculate the attention scores for the timestamps and rank features of each timestamp. Our model is used to predict obesity for ages between 3-20 years using the data from 1-3 years in advance. We compare the performance of our LSTM model with a series of existing studies in the literature and show it outperforms their performance in most age ranges.</p>","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221869/pdf/nihms-1811884.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40402980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diane J Cook, Miranda Strickland, Maureen Schmitter-Edgecombe
{"title":"Detecting Smartwatch-based Behavior Change in Response to a Multi-domain Brain Health Intervention.","authors":"Diane J Cook, Miranda Strickland, Maureen Schmitter-Edgecombe","doi":"10.1145/3508020","DOIUrl":"10.1145/3508020","url":null,"abstract":"<p><p>In this study, we introduce and validate a computational method to detect lifestyle change that occurs in response to a multi-domain healthy brain aging intervention. To detect behavior change, digital behavior markers (DM) are extracted from smartwatch sensor data and a Permutation-based Change Detection (PCD) algorithm quantifies the change in marker-based behavior from a pre-intervention, one-week baseline. To validate the method, we verify that changes are successfully detected from synthetic data with known pattern differences. Next, we employ this method to detect overall behavior change for n=28 BHI subjects and n=17 age-matched control subjects. For these individuals, we observe a monotonic increase in behavior change from the baseline week with a slope of 0.7460 for the intervention group and a slope of 0.0230 for the control group. Finally, we utilize a random forest algorithm to perform leave-one-subject-out prediction of intervention versus control subjects based on digital marker delta values. The random forest predicts whether the subject is in the intervention or control group with an accuracy of 0.87. This work has implications for capturing objective, continuous data to inform our understanding of intervention adoption and impact.</p>","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268550/pdf/nihms-1768502.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40582785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. B. Morshed, S. S. Kulkarni, Koustuv Saha, Richard Li, L. G. Roper, L. Nachman, Hong Lu, Lucia Mirabella, Sanjeev Srivastava, K. de Barbaro, M. de Choudhury, T. Plötz, G. Abowd
{"title":"Food, Mood, Context: Examining College Students’ Eating Context and Mental Well-being","authors":"M. B. Morshed, S. S. Kulkarni, Koustuv Saha, Richard Li, L. G. Roper, L. Nachman, Hong Lu, Lucia Mirabella, Sanjeev Srivastava, K. de Barbaro, M. de Choudhury, T. Plötz, G. Abowd","doi":"10.1145/3533390","DOIUrl":"https://doi.org/10.1145/3533390","url":null,"abstract":"Deviant eating behavior such as skipping meals and consuming unhealthy meals has a significant association with mental well-being in college students. However, there is more to what an individual eats. While eating patterns form a critical component of their mental well-being, insights and assessments related to the interplay of eating patterns and mental well-being remain under-explored in theory and practice. To bridge this gap, we use an existing real-time eating detection system that captures context during meals to examine how college students’ eating context associates with their mental well-being, particularly their affect, anxiety, depression, and stress. Our findings suggest that students’ irregularity or skipping meals negatively correlates with their mental well-being, whereas eating with family and friends positively correlates with improved mental well-being. We discuss the implications of our study in designing dietary intervention technologies and guiding student-centric well-being technologies.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 1","pages":"1 - 26"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43058553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Federated Learning for Healthcare Domain - Pipeline, Applications and Challenges","authors":"Madhura Joshi, Ankit Pal, Malaikannan Sankarasubbu","doi":"10.1145/3533708","DOIUrl":"https://doi.org/10.1145/3533708","url":null,"abstract":"Federated learning is the process of developing machine learning models over datasets distributed across data centers such as hospitals, clinical research labs, and mobile devices while preventing data leakage. This survey examines previous research and studies on federated learning in the healthcare sector across a range of use cases and applications. Our survey shows what challenges, methods, and applications a practitioner should be aware of in the topic of federated learning. This paper aims to lay out existing research and list the possibilities of federated learning for healthcare industries.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 1","pages":"1 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47382331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rishiraj Adhikary, Dhruvi Lodhavia, Chris Francis, Rohit Patil, Tanmay Srivastava, Prerna Khanna, Nipun Batra, Joseph Breda, J. Peplinski, Shwetak N. Patel
{"title":"SpiroMask: Measuring Lung Function Using Consumer-Grade Masks","authors":"Rishiraj Adhikary, Dhruvi Lodhavia, Chris Francis, Rohit Patil, Tanmay Srivastava, Prerna Khanna, Nipun Batra, Joseph Breda, J. Peplinski, Shwetak N. Patel","doi":"10.1145/3570167","DOIUrl":"https://doi.org/10.1145/3570167","url":null,"abstract":"According to the World Health Organisation (WHO), 235 million people suffer from respiratory illnesses which causes four million deaths annually. Regular lung health monitoring can lead to prognoses about deteriorating lung health conditions. This article presents our system SpiroMask that retrofits a microphone in consumer-grade masks (N95 and cloth masks) for continuous lung health monitoring. We evaluate our approach on 48 participants (including 14 with lung health issues) and find that we can estimate parameters such as lung volume and respiration rate within the approved error range by the American Thoracic Society (ATS). Further, we show that our approach is robust to sensor placement inside the mask.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"4 1","pages":"1 - 34"},"PeriodicalIF":0.0,"publicationDate":"2022-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46158090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kahyun Lee, Mehmet Kayaalp, Sam Henry, Özlem Uzuner
{"title":"A Context-Enhanced De-identification System.","authors":"Kahyun Lee, Mehmet Kayaalp, Sam Henry, Özlem Uzuner","doi":"10.1145/3470980","DOIUrl":"https://doi.org/10.1145/3470980","url":null,"abstract":"<p><p>Many modern entity recognition systems, including the current state-of-the-art de-identification systems, are based on bidirectional long short-term memory (biLSTM) units augmented by a conditional random field (CRF) sequence optimizer. These systems process the input sentence by sentence. This approach prevents the systems from capturing dependencies over sentence boundaries and makes accurate sentence boundary detection a prerequisite. Since sentence boundary detection can be problematic especially in clinical reports, where dependencies and co-references across sentence boundaries are abundant, these systems have clear limitations. In this study, we built a new system on the framework of one of the current state-of-the-art de-identification systems, NeuroNER, to overcome these limitations. This new system incorporates context embeddings through forward and backward <i>n</i> -grams without using sentence boundaries. Our context-enhanced de-identification (CEDI) system captures dependencies over sentence boundaries and bypasses the sentence boundary detection problem altogether. We enhanced this system with deep affix features and an attention mechanism to capture the pertinent parts of the input. The CEDI system outperforms NeuroNER on the 2006 i2b2 de-identification challenge dataset, the 2014 i2b2 shared task de-identification dataset, and the 2016 CEGS N-GRID de-identification dataset (<i>p</i> < 0.01). All datasets comprise narrative clinical reports in English but contain different note types varying from discharge summaries to psychiatric notes. Enhancing CEDI with deep affix features and the attention mechanism further increased performance.</p>","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525195/pdf/nihms-1725224.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39540705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Rohani, M. Faurholt-Jepsen, L. Kessing, J. Bardram
{"title":"Benefits of Using Activity Recommender Technology for Self-management of Depressive Symptoms","authors":"D. Rohani, M. Faurholt-Jepsen, L. Kessing, J. Bardram","doi":"10.1145/3462212","DOIUrl":"https://doi.org/10.1145/3462212","url":null,"abstract":"Behavioral Activation (BA)therapy has shown to be effective in treating depression. Recommending healthy activities is a core principle in Behavioral Activation (BA), which is typically done by the therapist. However, most BA smartphone applications do not recommend specific activities. This article reports quantitative results from an 8-week feasibility study of a previously presented smartphone-based BA recommender system. The system supports the planning and enacting of pleasurable activities and promotes activation of diverse activity types. Enrollment included 43 clinically depressed patients who installed the system on their phone and initiated activity scheduling. Twenty-nine patients used the system daily for more than a week.These patients presented a significant reduction in depressive symptoms during the study period. They displayed a more personalized usage approach and created recurring health goals comprising of their own customized activities. Furthermore, they took inspiration within various types of activities, thereby displaying more activity diversity. This study suggests that enacting a diverse mixture of activities that promote good sleep, personal hygiene, exercise, social contact, and leisure time can be essential in managing depressive symptoms. A smartphone-based activity recommender system can help patients achieve this.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"2 1","pages":"1 - 21"},"PeriodicalIF":0.0,"publicationDate":"2021-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47017235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}