{"title":"A method for comparing time series by untangling time-dependent and independent variations in biological processes","authors":"A. J. Thottupattu, J. Sivaswamy","doi":"10.1145/3681795","DOIUrl":"https://doi.org/10.1145/3681795","url":null,"abstract":"Biological processes like growth, aging, and disease progression are generally studied with follow-up scans taken at different time points, i.e., image time series (TS) based analysis. Image time series represents the evolution of anatomy over time, but different anatomies may have different structural characteristics and temporal paths. Therefore, separating the time-dependent path difference and time-independent basic anatomy/shape changes is important when comparing two image time series to understand the causes of the observed differences better. A method to untangle and quantify the path and shape difference between the TS is presented in this paper. The proposed method is evaluated with simulated and adult and fetal neuro templates. Results show that the metric can separate and quantify the path and shape differences between TS.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"45 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faustino Muetunda, Soumaya Sabry, M. Jamil, Sebastião Pais, Gael Dias, João Cordeiro
{"title":"AI-assisted Diagnosing, Monitoring, and Treatment of Mental Disorders: A Survey","authors":"Faustino Muetunda, Soumaya Sabry, M. Jamil, Sebastião Pais, Gael Dias, João Cordeiro","doi":"10.1145/3681794","DOIUrl":"https://doi.org/10.1145/3681794","url":null,"abstract":"Globally, 1 in 7 people has some kind of mental or substance use disorder that affects their thinking, feelings, and behaviour in everyday life. People with mental health disorders can continue their normal lives with proper treatment and support. Mental well-being is vital for physical health. The use of AI in mental health areas has grown exponentially in the last decade. However, mental disorders are still complex to diagnose due to similar and common symptoms for numerous mental illnesses, with a minute difference. Intelligent systems can help us identify mental diseases precisely, which is a critical step in diagnosing. Using these systems efficiently can improve the treatment and rapid recovery of patients. We survey different artificial intelligence systems used in mental healthcare, such as mobile applications, machine learning and deep learning methods, and multimodal systems and draw comparisons from recent developments and related challenges. Also, we discuss types of mental disorders and how these different techniques can support the therapist in diagnosing, monitoring, and treating patients with mental disorders.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"16 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alex Moore, B. Orset, A. Yassaee, Benjamin Irving, Davide Morelli
{"title":"HEalthRecordBERT (HERBERT): leveraging transformers on electronic health records for chronic kidney disease risk stratification","authors":"Alex Moore, B. Orset, A. Yassaee, Benjamin Irving, Davide Morelli","doi":"10.1145/3665899","DOIUrl":"https://doi.org/10.1145/3665899","url":null,"abstract":"Risk stratification is an essential tool in the fight against many diseases, including chronic kidney disease. Recent work has focused on applying techniques from machine learning and leveraging the information contained in a patient’s electronic health record (EHR). Irregular intervals between data entries and the large number of variables tracked in EHR datasets can make them challenging to work with. Many of the difficulties associated with these datasets can be overcome by using large language models, such as bidirectional encoder representations from transformers (BERT). Previous attempts to apply BERT to EHR for risk stratification have shown promise. In this work we propose HERBERT, a novel application of BERT to EHR data. We identify two key areas where BERT models must be modified to adapt them to EHR data, namely: the embedding layer and the pretraining task. We show how changes to these can lead to improved performance, relative to the previous state of the art. We evaluate our model by predicting the transition of chronic kidney disease patients to end stage renal disease. The strong performance of our model justifies our architectural changes and suggests that large language models could play an important role in future renal risk stratification.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"115 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Computation Model to Estimate Interaction Intensity through Non-verbal Behavioral Cues: A Case Study of Intimate Couples under the Impact of Acute Alcohol Consumption","authors":"Zhiwei, Z.Y. Yu, Cory, C.C. Crane, Linlin, L.C. Chen, Maria, M.T. Testa, Zhi, Z.Z. Zheng","doi":"10.1145/3664826","DOIUrl":"https://doi.org/10.1145/3664826","url":null,"abstract":"This work introduced a novel analysis method to estimate interaction intensity, i.e., the level of positivity/negativity of an interaction, for intimate couples (married and heterosexual) under the impact of alcohol, which has great influences on behavioral health. Non-verbal behaviors are critical in interpersonal interactions. However, whether computer vision-detected non-verbal behaviors can effectively estimate interaction intensity of intimate couples is still unexplored. In this work, we proposed novel measurements and investigated their feasibility to estimate interaction intensities through machine learning regression models. Analyses were conducted based on a conflict-resolution conversation video dataset of intimate couples before and after acute alcohol consumption. Results showed the estimation error was at the lowest in the no-alcohol state but significantly increased if the model trained using no-alcohol data was applied to after-alcohol data, indicating that alcohol altered the interaction data in the feature space. While training a model using rich after-alcohol data is ideal to address the performance decrease, data collection in such a risky state is challenging in real life. Thus, we proposed a new State-Induced Domain Adaptation (SIDA) framework, which allows for improving estimation performance using only a small after-alcohol training dataset, pointing to a future direction of addressing data scarcity issues.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":" 1092","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanshan Hu, Manuel Schmidt-Kraepelin, Scott Thiebes, A. Sunyaev
{"title":"Mapping Distributed Ledger Technology Characteristics to Use Cases in Healthcare: A Structured Literature Review","authors":"Shanshan Hu, Manuel Schmidt-Kraepelin, Scott Thiebes, A. Sunyaev","doi":"10.1145/3653076","DOIUrl":"https://doi.org/10.1145/3653076","url":null,"abstract":"Following the success of the Bitcoin blockchain, distributed ledger technology (DLT) has received extensive attention in health informatics research. Yet, the healthcare industry is highly complex with many different stakeholders, information systems, regulations, and challenges. Thus, DLT may be used in various settings and for different purposes. First surveys have started to synthesize our knowledge of the different use cases, in which healthcare may benefit from DLT implementations. However, an in-depth understanding of whether and how these use cases differ concerning their requirements of DLT characteristics (i.e., technical or administrative design features) is still lacking. In this work, we conducted a structured review of 185 studies on DLT-based applications in healthcare. The results reveal six pertinent use cases, each with its own combination of different purposes that DLT is used for. Furthermore, our study shows that each of these use cases has a unique set of requirements with regard to the most important DLT characteristics. In doing so, we seek to guide practitioners in the development of highly effective DLT-based applications in various healthcare settings and pave the way for future research to investigate the understudied areas of DLT-based applications in healthcare.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":" November","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"iScan: Detection of Colorectal Cancer From CT Scan Images Using Deep Learning","authors":"Sagnik Ghosal, Debanjan Das, Jay Kumar Rai, Akanksha Singh Pandaw, Sakshi Verma","doi":"10.1145/3676282","DOIUrl":"https://doi.org/10.1145/3676282","url":null,"abstract":"\u0000 Colorectal cancer, a highly lethal form of cancer, can be treated effectively if detected early. However, the current diagnosis process involves a time-consuming and manual review of CT scans to identify cancerous regions and behavior, leading to resource consumption, subjectivity, and dependency on manual assessment. We propose a 3-phase deep neural system for automated colorectal cancer detection using CT scan images to address these challenges. It includes a SegNet network to identify tumor locations, an InceptionResNet V2 network to classify tumors as benign or malignant, and an analysis of tumor area cum perimeter to predict the cancer stage. The proposed model offers a fully automated solution by combining these functionalities under a single umbrella. In real-life CT scans from 37 patients, the proposed model achieved 95.8\u0000 \u0000 (%)\u0000 \u0000 ROI segmentation accuracy, a dice coefficient of 0.6214, 69.75\u0000 \u0000 (%)\u0000 \u0000 IoU score, and 95.83\u0000 \u0000 (%)\u0000 \u0000 tumor classification accuracy. The unique approach using Radial Length (RL) and Circularity (C) parameters predicted the T-stage with close to 85\u0000 \u0000 (%)\u0000 \u0000 accuracy. Based on these outcomes, the proposed system establishes itself as a reliable and suitable alternative to traditional cancer diagnosis techniques by leveraging the power of automation, deep learning, and innovative parameter analysis.\u0000","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"8 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siyang Song, Yi-Xiang Luo, Tugba Tumer, Michel Valstar, Hatice Gunes
{"title":"Loss Relaxation Strategy for Noisy Facial Video-based Automatic Depression Recognition","authors":"Siyang Song, Yi-Xiang Luo, Tugba Tumer, Michel Valstar, Hatice Gunes","doi":"10.1145/3648696","DOIUrl":"https://doi.org/10.1145/3648696","url":null,"abstract":"Automatic depression analysis has been widely investigated on face videos that have been carefully collected and annotated in lab conditions. However, videos collected under real-world conditions may suffer from various types of noises due to challenging data acquisition conditions and lack of annotators. Although deep learning (DL) models frequently show excellent depression analysis performances on datasets collected in controlled lab conditions, such noise may degrade their generalization abilities for real-world depression analysis tasks. In this paper, we uncovered that noisy facial data and annotations consistently change the distribution of training losses for facial depression DL models, i.e., noisy data-label pairs cause larger loss values compared to clean data-label pairs. Since different loss functions could be applied depending on the employed model and task, we propose a generic loss function relaxation strategy that can jointly reduce the negative impact of various noisy data and annotation problems occurring in both classification and regression loss functions, for face video-based depression analysis, where the parameters of the proposed strategy can be automatically adapted during depression model training. The experimental results on 25 different artificially created noisy depression conditions (i.e., five noise types with five different noise levels) show that our loss relaxation strategy can clearly enhance both classification and regression loss functions, enabling the generation of superior face video-based depression analysis models under almost all noisy conditions. Our approach is robust to its main variable settings, and can adaptively and automatically obtain its parameters during training.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"12 s2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Interpretable Trend Analysis Neural Networks for Longitudinal Data Analysis","authors":"Zhenjie Yao, Yixin Chen, Jinwei Wang, Junjuan Li, Shuohua Chen, Shouling Wu, Yanhui Tu, Ming-Hui Zhao, Luxia Zhang","doi":"10.1145/3648105","DOIUrl":"https://doi.org/10.1145/3648105","url":null,"abstract":"Cohort study is one of the most commonly used study methods in medical and public health researches, which result in longitudinal data. Conventional statistical models and machine learning methods are not capable of modeling the evolution trend of the variables in longitudinal data. In this paper, we propose a Trend Analysis Neural Networks (TANN), which models the evolution trend of the variables by adaptive feature learning. TANN was tested on dataset of Kaiuan research. The task was to predict occurrence of cardiovascular events within 2 and 5 years, with 3 repeated medical examinations during 2008 and 2013. For 2-year prediction, The AUC of the TANN is 0.7378, which is a significant improvement than that of conventional methods, while that of TRNS, RNN, DNN, GBDT, RF, and LR are 0.7222, 0.7034, 0.7054, 0.7136, 0.7160 and 0.7024, respectively. For 5-year prediction, TANN also shows improvement. The experimental results show that the proposed TANN achieves better prediction performance on cardiovascular events prediction than conventional models. Furthermore, by analyzing the weights of TANN, we could find out important trends of the indicators, which are ignored by conventional machine learning models. The trend discovery mechanism interprets the model well. TANN is an appropriate balance between high performance and interpretability.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"WalkingWizard - A truly wearable EEG headset for everyday use","authors":"Teck Lun Goh, L. Peh","doi":"10.1145/3648106","DOIUrl":"https://doi.org/10.1145/3648106","url":null,"abstract":"\u0000 Electroencephalography (EEG) provides an opportunity to gain insights to electrocortical activity without the need for invasive technology. While increasingly used in various application areas, EEG headsets tend to be suited only to a laboratory environment due to the long preparation time to don the headset and the need for users to remain stationary. We present our design of a dry, dual-electrodes flexible PCB assembly that realizes accurate sensing in face of practical motion artifacts. Using it, we present WalkingWizard, our prototype dry-electrode EEG baseball cap that can be used under motion in everyday scenarios. We first evaluated its hardware performance by comparing its electrode-scalp impedance and ability to capture alpha rhythm against both wet EEG, and commercially available dry EEG headsets. We then tested WalkingWizard using SSVEP experiments, achieving high classification accuracy of 87% for walking speeds up to 5.0km/hr, beating state-of-the-art. Expanding on WalkingWizard, we integrated all necessary electronic components into a flexible PCB assembly - realizing\u0000 WalkingWizard Integrated\u0000 , in a truly wearable form-factor. Utilizing WalkingWizard Integrated, we demonstrated several applications as proof-of-concept: Classification of SSVEP in VR environment while walking, Real-time acquisition of emotional state of users while moving around the neighbourhood, and Understanding the effect of guided meditation for relaxation.\u0000","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"118 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"WalkingWizard - A truly wearable EEG headset for everyday use","authors":"Teck Lun Goh, L. Peh","doi":"10.1145/3648106","DOIUrl":"https://doi.org/10.1145/3648106","url":null,"abstract":"\u0000 Electroencephalography (EEG) provides an opportunity to gain insights to electrocortical activity without the need for invasive technology. While increasingly used in various application areas, EEG headsets tend to be suited only to a laboratory environment due to the long preparation time to don the headset and the need for users to remain stationary. We present our design of a dry, dual-electrodes flexible PCB assembly that realizes accurate sensing in face of practical motion artifacts. Using it, we present WalkingWizard, our prototype dry-electrode EEG baseball cap that can be used under motion in everyday scenarios. We first evaluated its hardware performance by comparing its electrode-scalp impedance and ability to capture alpha rhythm against both wet EEG, and commercially available dry EEG headsets. We then tested WalkingWizard using SSVEP experiments, achieving high classification accuracy of 87% for walking speeds up to 5.0km/hr, beating state-of-the-art. Expanding on WalkingWizard, we integrated all necessary electronic components into a flexible PCB assembly - realizing\u0000 WalkingWizard Integrated\u0000 , in a truly wearable form-factor. Utilizing WalkingWizard Integrated, we demonstrated several applications as proof-of-concept: Classification of SSVEP in VR environment while walking, Real-time acquisition of emotional state of users while moving around the neighbourhood, and Understanding the effect of guided meditation for relaxation.\u0000","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"61 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139836174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}