{"title":"A Case of Hemoptysis due to Rupture of Bronchial Varices Requiring Multidisciplinary Treatment.","authors":"Hajime Suzuki, Suguru Hitomi, Kazuki Hasegawa, Jiro Kamiyama, Masashi Gokita, Katsunobu Teshigahara, Shigemasa Taguchi, Kazuya Kiyota","doi":"10.1002/ams2.70128","DOIUrl":"10.1002/ams2.70128","url":null,"abstract":"<p><strong>Background: </strong>This paper describes a rare case of hemoptysis caused by the rupture of a bronchial varix.</p><p><strong>Case presentation: </strong>A 68-year-old man was admitted to the hospital due to recurrent episodes of hemoptysis. Bronchoscopy showed a cord-like lesion in the left main bronchus, and the findings of the subsequent endobronchial ultrasound and bronchial venography on the third hospital day led to a diagnosis of hemoptysis due to a bronchial varix rupture. Through multidisciplinary collaboration, hemostasis was achieved by performing a combination of treatments, including bronchial artery embolization, percutaneous transvenous bronchial venous embolization, and endoscopic variceal sclerotherapy.</p><p><strong>Conclusion: </strong>Successful management of bronchial varix rupture requires early diagnosis and collaborative hemostatic procedures involving multiple medical specialties.</p>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 ","pages":"e70128"},"PeriodicalIF":1.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute Medicine & SurgeryPub Date : 2026-04-16eCollection Date: 2026-01-01DOI: 10.1002/ams2.70129
Hitoshi Kobata, Masayuki Oka
{"title":"Near-Sudden Unexpected Death in Epilepsy Rescued by Bystander Use of an Automated External Defibrillator: A Case of Nonconvulsive Seizure.","authors":"Hitoshi Kobata, Masayuki Oka","doi":"10.1002/ams2.70129","DOIUrl":"10.1002/ams2.70129","url":null,"abstract":"<p><strong>Background: </strong>Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality in people with epilepsy; however, it remains under-recognized by the general public and healthcare providers.</p><p><strong>Case presentation: </strong>A 42-year-old man was transported to the emergency department in a coma after resuscitation with an automated external defibrillator by a caregiver. He had intellectual disability and uncontrolled seizures despite receiving multiple antiseizure medications for > 20 years. Electrocardiography showed no ST change or prolonged QTc interval. Emergency coronary angiography revealed no significant stenosis. The patient returned to the previous state after targeted temperature management at 34°C. Most SUDEP cases present generalized tonic-clonic seizures (GTCS), leading to respiratory arrest and asystole. Although ventricular fibrillation following a nonconvulsive seizure is exceptional, this patient had no cardiac factors and was consistent with SUDEP.</p><p><strong>Conclusion: </strong>All healthcare providers caring for people with epilepsy should be aware of SUDEP to help prevent epilepsy-related deaths.</p>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":"e70129"},"PeriodicalIF":1.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Methemoglobinemia Suspected to Be Induced by Rabeprazole.","authors":"Ryo Kawasaki, Chiaki Toida, Hiroshi Kamijo, Mayo Akita, Masao Hattori, Michitaro Ichikawa, Hiroshi Takayama, Hiroshi Miyama, Kenichi Nitta, Hiroshi Imamura","doi":"10.1002/ams2.70130","DOIUrl":"10.1002/ams2.70130","url":null,"abstract":"<p><strong>Background: </strong>Methemoglobinemia is a rare but potentially life-threatening condition characterized by reduced oxygen delivery owing to hemoglobin oxidation to its ferric form. Although it is commonly associated with agents such as dapsone and lidocaine, to our knowledge, no prior cases of methemoglobinemia associated with proton pump inhibitors (PPIs) have been reported. We report a case of methemoglobinemia suspected to be induced by rabeprazole in an elderly patient.</p><p><strong>Case presentation: </strong>The patient was an 82-year-old woman who developed progressive cyanosis and had elevated methemoglobin (MetHb) levels while on rabeprazole. Her MetHb levels decreased after rabeprazole discontinuation but again increased on drug reintroduction. Other medications and congenital causes were excluded, and the aforementioned temporal relationship suggested an association with rabeprazole.</p><p><strong>Conclusion: </strong>PPIs may be associated with methemoglobinemia, although causality cannot be definitively established based on a single case. The chemical structure of rabeprazole, particularly the presence of an amino group, may contribute to oxidative processes. Clinicians should consider PPIs as a potential contributing factor in unexplained methemoglobinemia and promptly discontinue the suspected agent when appropriate.</p>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":"e70130"},"PeriodicalIF":1.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Characteristics of Patients With Overdose Engaging in Nonmedical Use of Prescription Drugs: A Single-Center Study in Japan","authors":"Nobuki Shioya, Nozomu Inoue, Takahiro Nishitani, Naonori Kawashima, Yuki Tsukamoto, Tomohiro Sato, Yoshihiro Sadamoto, Yuki Naito, Kohji Hazama, Yasuo Shichinohe","doi":"10.1002/ams2.70126","DOIUrl":"10.1002/ams2.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The nonmedical use of prescription drugs (NMUPD) through channels outside the healthcare system has emerged as a significant public health issue; however, its clinical implications in overdose cases remain underexplored in Japan. This study aimed to elucidate the prevalence and characteristics of NMUPD in patients with acute drug overdose.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this observational study, we retrospectively studied patients with overdose who were admitted to a tertiary emergency department in Japan between April 2017 and March 2024. Patients were categorized into the NMUPD group (obtained drugs via nonmedical routes, such as family, acquaintances, the Internet, and unauthorized workplace access) and prescribed group. Demographic, clinical, and overdose-related variables were compared between the groups. Statistical analyses included the chi-square and Mann–Whitney <i>U</i> tests, with multiple imputation for missing data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 416 patients with overdose, 7.9% met the NMUPD criteria. The primary sources of NMUPD were family members, followed by friends/acquaintances, Internet purchases, and unauthorized pharmacy access. The NMUPD group showed significantly higher rates of alcohol coingestion (<i>p</i> = 0.029) and absence of psychiatric diagnoses (<i>p</i> = 0.009). Benzodiazepines predominated in both groups, with frequent use of non-benzodiazepine and antidepressants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study revealed that NMUPD occurs even within Japan's tightly regulated healthcare system, primarily via informal sources such as patients' families and friends. NMUPD was linked to alcohol coingestion and limited psychiatric follow-ups. NMUPD involved several commonly prescribed psychotropic drug classes rather than a single class.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prehospital Variability of Pediatric Emergency Acuity Assessment Criteria in Japan: A Nationwide Analysis of Fire Department Protocols","authors":"Sakura Minami, Chiaki Toida, Naoki Yogo, Noriyuki Kaku, Takeru Abe, Takashi Moriya","doi":"10.1002/ams2.70124","DOIUrl":"10.1002/ams2.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>In pediatric emergency care, acuity assessment is required based on age-specific physiological characteristics. However, in Japan, prehospital pediatric acuity d protocols vary regionally in the assessment tools and vital sign criteria used. This study aimed to clarify the differences in assessment tools and vital sign criteria currently used for pediatric acuity determination in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used data from a nationwide survey conducted in August 2024 by the Pediatric Emergency Committee, Japanese Society for Emergency Medicine, which targeted emergency medical services supervisors at all 720 fire departments across Japan regarding the presence and content of pediatric acuity determination protocols. Collected protocols were compared and analyzed for differences in assessment tools, vital sign thresholds, and age categorizations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses were obtained from 561 departments (77.9%). After consolidation of duplicate prefecture-level protocols, 32 unique pediatric acuity determination protocols were included in the final analysis. Only one protocol fully adhered to the Fire and Disaster Management Agency (FDMA) framework, whereas most protocols were based on the Foundation for Ambulance Service Development (FASD) criteria. The upper and lower limits of vital signs varied, with apparent differences in younger age groups. Age categorizations ranged from three broad divisions to detailed subdivisions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Japan's prehospital pediatric acuity determination shows substantial regional variability, reflected in the identification of multiple distinct protocols and limited real-world adherence to FDMA-based criteria. Nationwide standardization and implementation of FDMA-based criteria should be prioritized before developing new systems, followed by validation in real-world practice to ensure feasibility, equity, and clinical effectiveness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting Reduced Left Ventricular Ejection Fraction in Patients With ST-Elevation Myocardial Infarction: Role of the Quick Forrester Classification","authors":"Yosuke Matsumoto, Shoji Kawakami, Hidenobu Koga, Eigo Nawata, Yoshihiro Ota, Hikaru Sasamoto, Masato Takei, Chikako Tamura, Kenichi Kitahara, Tetsuhisa Yamada, Jun-Ichiro Nishi","doi":"10.1002/ams2.70120","DOIUrl":"10.1002/ams2.70120","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cardiogenic shock, heart failure, and reduced left ventricular ejection fraction (LVEF) are major determinants of poor prognosis in patients with ST-elevation myocardial infarction (STEMI). Rapid identification of high-risk patients and subsequent provision of multidisciplinary care are critical. However, traditional risk scores mainly rely on infarct size, age, and hemodynamics, which may offer limited discriminatory ability at the time of hospital arrival. We developed a quick Forrester classification (QFC) using the respiratory rate (RR) and serum lactate levels upon hospital arrival and investigated its association with a reduced LVEF of patients with STEMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included consecutive patients with STEMI from 2018 to 2023. Patients were divided into four QFC classes: Class-1 (RR < 20 per minute and lactate < 2.0 mmol/L), Class-2 (RR ≥ 20 per minute and lactate < 2.0 mmol/L), Class-3 (RR < 20 per minute and lactate ≥ 2.0 mmol/L), and Class-4 (RR ≥ 20 per minute and lactate ≥ 2.0 mmol/L). The primary endpoint was the LVEF < 45% measured by transthoracic echocardiography before discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 569 patients with STEMI (Class-1: 118; Class-2: 146; Class-3: 92; Class-4: 213), the QFC Class-4 demonstrated the highest proportions of reduced LVEF (26%) and mechanical circulatory support use (13%). In multivariable logistic analysis, Class-4 was independently associated with reduced LVEF compared with Class-1 (odds ratio 2.47).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The QFC, based solely on RR and lactate levels, was significantly associated with reduced LVEF in STEMI. This simple bedside tool may support rapid identification of high-risk patients on arrival and complement existing risk stratification strategies to facilitate timely multidisciplinary management. <b>Clinical Trial Registration:</b> Aso Iizuka Hospital/approval ID: 21068.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"13 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}