{"title":"ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer","authors":"Federica Foglietta, Loredana Serpe, Roberto Canaparo","doi":"10.1186/s11671-023-03939-w","DOIUrl":"10.1186/s11671-023-03939-w","url":null,"abstract":"<div><p>Reactive species refers to a group of chemicals, mainly reactive oxygen species (ROS) and reactive nitrogen species (RNS), that are naturally formed by cells as a byproduct of cell metabolism and regulated by various internal and external factors. Due to their highly chemical reactivity, ROS play a crucial role in physiological and pathological processes which is why studies on ROS regulation for disease treatment show attracted increasing interest. Notably, ROS are now studied as a powerful therapeutic weapon in ROS-regulating therapies such as ROS-based cytotoxic therapies mediated by ROS-increasing agents for cancer treatment. Thanks to the significant progress in nanotechnology, innovative nanoplatforms with ROS-regulating activities have been developed to look for effective ROS-related nanomedicines. In this review, studies on ROS-based cytotoxic therapies against cancer as photodynamic therapy (PDT), sonodynamic therapy (SDT), radiation therapy (RT) and chemodynamic therapy (CDT) are discussed, with a focus on the stimuli-responsive ROS-generating nanoplatforms developed for breaking the current therapeutic limits of ROS-based cytotoxic therapies. Finally, we suppose that our review on this developing field will be valuable for promoting the progress of ROS-based cytotoxic therapies not only in basic research but overall, in translational research and clinical application.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-023-03939-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138573765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cosmic radiation shielding property of boron reinforced continuous fiber nanocomposites produced by electrospinning","authors":"Mücahid Özcan, Cengiz Kaya, Figen Kaya","doi":"10.1186/s11671-023-03940-3","DOIUrl":"10.1186/s11671-023-03940-3","url":null,"abstract":"<div><p>Electrospinning, a cutting-edge production technique, is used to create boron-reinforced continuous fiber nanocomposites that shield space missions from cosmic radiation, a significant hazard. By incorporating boron, which is known for its exceptional neutron shielding properties, into the polymer matrix, a composite material that is flexible, lightweight, and highly resistant to radiation is produced. The results indicate that continuous fiber nanocomposites reinforced with boron, boric acid, or both have a high shielding efficiency against cosmic radiation. The adaptability and low weight of the manufactured nanocomposites make them ideal for space applications. While boric acid combines with PVA at the molecular level and alters the molecular chain structure of PVA, it is believed that elemental boron is only incorporated as particulates into the PVA polymer. It is known that both boric acid and elemental boron doped nanocomposites provide samples with a thickness of 10 microns with 13.56% neutron shielding and superior photon blocking ability.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-023-03940-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olumakinde Charles Omiyale, Mariama Musa, Adewunmi Ifeoluwa Otuyalo, Tolulope Judah Gbayisomore, Damilola Zainab Onikeku, Solomon Damilare George, Possible Okikiola Popoola, Olabimpe Oluwatoyin Olofin, Kelechi Franklin Umunnam, Patricia Okwuchi Nneji, Musa Adnan, Taiwo Temitope Ogunjobi
{"title":"A review on selenium and gold nanoparticles combined photodynamic and photothermal prostate cancer tumors ablation","authors":"Olumakinde Charles Omiyale, Mariama Musa, Adewunmi Ifeoluwa Otuyalo, Tolulope Judah Gbayisomore, Damilola Zainab Onikeku, Solomon Damilare George, Possible Okikiola Popoola, Olabimpe Oluwatoyin Olofin, Kelechi Franklin Umunnam, Patricia Okwuchi Nneji, Musa Adnan, Taiwo Temitope Ogunjobi","doi":"10.1186/s11671-023-03936-z","DOIUrl":"10.1186/s11671-023-03936-z","url":null,"abstract":"<div><p>The acceptance of nanoparticle technology in the quest for cancer treatment is due to its many potentials and possibilities of filling in the gaps in the limitations of the current treatment modalities. Insights into the possibilities of getting even more from this technology, as well as the synergistic properties of photothermal therapy (PTT) and photodynamic therapy (PDT)—the use of reactive oxygen species (ROS)—can also be exploited in the ablation of prostate cancer tumors. Therefore, the combination of gold and selenium photoactive nanoparticles as platforms for drug delivery via PTT/PDT in prostate cancer therapy, with a specific emphasis on the 'micro-carrier' based approach, was discussed and explored in this review under relevant subtopics ranging from understanding the complex chemistry and biology of the pharmacologically active Se/Au-containing agents to giving a thorough knowledge of these therapeutic agents' potential as a targeted and successful treatment strategy for prostate cancer by investigating the complex mechanisms behind their delivery, activation, and synergistic effects. Furthermore, this article presents a comprehensive overview of the current research environment, problems encountered, and future perspectives in the continuous war against prostate cancer.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-023-03936-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138557044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metasurface-driven polarization-division multiplexing of PCSEL for optical communications","authors":"Wen-Chien Miao, Chia-Hsun Chang, Fu-He Hsiao, Yun-Han Chang, Jhih-Hao Huang, Huan-Teng Su, Chang-Yi Lin, Chun-Liang Lin, Chi-Wai Chow, Yu-Heng Hong, Yao-Wei Huang, Hao-Chung Kuo","doi":"10.1186/s11671-023-03935-0","DOIUrl":"10.1186/s11671-023-03935-0","url":null,"abstract":"<div><p>Free-space optical communications hold promising advantages, including a large bandwidth, access to license-free spectrum, high data rates, quick and simple deployment, low power consumption, and relaxed quality requirements. Nevertheless, key technical challenges remain, such as a higher transmission efficiency, a lower transmission loss, and a smaller form factor of optical systems. Here, we demonstrate the viability of circular-polarization-multiplexed multi-channel optical communication using metasurfaces alongside a photonic-crystal surface-emitting laser (PCSEL) light source at wavelength of 940 nm. Through the light manipulation with metasurface, we split the linearly polarized incidence into left and right circular polarizations with desired diffraction angles. Such orthogonal polarization states provide a paradigm of polarization division multiplexing technique for light communication. The PCSEL light source maintains a low divergence angle of about 0.373 degrees after passing through an ultra-thin metasurface without further bulky collimator or light guide, making end-to-end (E2E) and device-to-device (D2D) communications available in a compact form. Both light source and modulated polarized light exhibit a − 3 dB bandwidth over 500 MHz, with successful 1 Gbit/s transmission demonstrated in eye diagrams. Our results affirm that metasurface effectively boosts transmission capacity without compromising the light source's inherent properties. Future metasurface designs could expand channel capacity, and its integration with PCSEL monolithically holds promise for reducing interface losses, thereby enhancing efficiency.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-023-03935-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138553768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geyse A. C. Ribeiro, Scarllett L. S. de Lima, Karolinne E. R. Santos, Jhonatam P. Mendonça, Pedro Macena, Emanuel C. Pessanha, Thallis C. Cordeiro, Jules Gardener, Guilhermo Solórzano, Jéssica E. S. Fonsaca, Sergio H. Domingues, Clenilton C. dos Santos, André H. B. Dourado, Auro A. Tanaka, Anderson G. M. da Silva, Marco A. S. Garcia
{"title":"Zn‐doped MnOx nanowires displaying plentiful crystalline defects and tunable small cross-sections for an optimized volcano-type performance towards supercapacitors","authors":"Geyse A. C. Ribeiro, Scarllett L. S. de Lima, Karolinne E. R. Santos, Jhonatam P. Mendonça, Pedro Macena, Emanuel C. Pessanha, Thallis C. Cordeiro, Jules Gardener, Guilhermo Solórzano, Jéssica E. S. Fonsaca, Sergio H. Domingues, Clenilton C. dos Santos, André H. B. Dourado, Auro A. Tanaka, Anderson G. M. da Silva, Marco A. S. Garcia","doi":"10.1186/s11671-023-03933-2","DOIUrl":"10.1186/s11671-023-03933-2","url":null,"abstract":"<div><p>MnO<sub>x</sub>-based nanomaterials are promising large-scale electrochemical energy storage devices due to their high specific capacity, low toxicity, and low cost. However, their slow diffusion kinetics is still challenging, restricting practical applications. Here, a one-pot and straightforward method was reported to produce Zn-doped MnO<sub>x</sub> nanowires with abundant defects and tunable small cross-sections, exhibiting an outstanding specific capacitance. More specifically, based on a facile hydrothermal strategy, zinc sites could be uniformly dispersed in the α-MnO<sub>x</sub> nanowires structure as a function of composition (0.3, 2.1, 4.3, and 7.6 wt.% Zn). Such a process avoided the formation of different crystalline phases during the synthesis. The reproducible method afforded uniform nanowires, in which the size of cross-sections decreased with the increase of Zn composition. Surprisingly, we found a volcano-type relationship between the storage performance and the Zn loading. In this case, we demonstrated that the highest performance material could be achieved by incorporating 2.1 wt.% Zn, exhibiting a remarkable specific capacitance of 1082.2 F.g<sup>−1</sup> at a charge/discharge current density of 1.0 A g<sup>−1</sup> in a 2.0 mol L<sup>−1</sup> KOH electrolyte. The optimized material also afforded improved results for hybrid supercapacitors. Thus, the results presented herein shed new insights into preparing defective and controlled nanomaterials by a simple one-step method for energy storage applications.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rishabh Srivastava, Himanshu Chaudhary, Anuj Kumar, Felipe M. de Souza, Sanjay R. Mishra, Felio Perez, Ram K. Gupta
{"title":"Optimum iron-pyrophosphate electronic coupling to improve electrochemical water splitting and charge storage","authors":"Rishabh Srivastava, Himanshu Chaudhary, Anuj Kumar, Felipe M. de Souza, Sanjay R. Mishra, Felio Perez, Ram K. Gupta","doi":"10.1186/s11671-023-03937-y","DOIUrl":"10.1186/s11671-023-03937-y","url":null,"abstract":"<div><p>Tuning the electronic properties of transition metals using pyrophosphate (P<sub>2</sub>O<sub>7</sub>) ligand moieties can be a promising approach to improving the electrochemical performance of water electrolyzers and supercapacitors, although such a material’s configuration is rarely exposed. Herein, we grow NiP<sub>2</sub>O<sub>7</sub>, CoP<sub>2</sub>O<sub>7</sub>, and FeP<sub>2</sub>O<sub>7</sub> nanoparticles on conductive Ni-foam using a hydrothermal procedure. The results indicated that, among all the prepared samples, FeP<sub>2</sub>O<sub>7</sub> exhibited outstanding oxygen evolution reaction and hydrogen evolution reaction with the least overpotential of 220 and 241 mV to draw a current density of 10 mA/cm<sup>2</sup>. Theoretical studies indicate that the optimal electronic coupling of the Fe site with pyrophosphate enhances the overall electronic properties of FeP<sub>2</sub>O<sub>7</sub>, thereby enhancing its electrochemical performance in water splitting. Further investigation of these materials found that NiP<sub>2</sub>O<sub>7</sub> had the highest specific capacitance and remarkable cycle stability due to its high crystallinity as compared to FeP<sub>2</sub>O<sub>7</sub>, having a higher percentage composition of Ni on the Ni-foam, which allows more Ni to convert into its oxidation states and come back to its original oxidation state during supercapacitor testing. This work shows how to use pyrophosphate moieties to fabricate non-noble metal-based electrode materials to achieve good performance in electrocatalytic splitting water and supercapacitors.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Subha, R. AnuKiruthika, Harsha Sreeraj, K. S. Tamilselvi
{"title":"Plant exosomes: nano conveyors of pathogen resistance","authors":"D. Subha, R. AnuKiruthika, Harsha Sreeraj, K. S. Tamilselvi","doi":"10.1186/s11671-023-03931-4","DOIUrl":"10.1186/s11671-023-03931-4","url":null,"abstract":"<div><p>The entry of a pathogen into a plant host is a complex process involving multiple steps. Survival techniques from the pathogen and the defense mechanisms of the plant lead to a plethora of molecular interactions during the operation. Plant extracellular vesicles, especially the exosomes in the size range of 50–150 nm play a crucial role in plant defense. They act as signalosomes capable of transporting bioactive lipids, proteins, RNA and metabolites between the host and the pathogen. Recent research works have revealed that anti-microbial compounds, stress response proteins and small RNA are among the contents of these extracellular vesicles. The current review article analyses the cruciality of the cross-talk between the host and the pathogen organized through trafficking of small RNA via exosomes towards RNA induced gene silencing in the pathogenic organisms. Recent studies have shown that extracellular vesicles released by both plants and the pathogens, play a crucial role in cross-kingdom communication, thereby regulating the host response and contributing to plant immunity. An in-depth understanding of the mechanism by which the EVs mediate this inter-species and cross-kingdom regulation is currently needed to develop sustainable plant-protection strategies. The review highlights on the latest advances in understanding the role of EVs in establishing host–pathogen relationship, modulating plant immunity and approaches for how these findings can be developed into innovative strategies for crop protection.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode","authors":"Hao-Fang Peng, Chih-Kang Chang, Rohit Gupta, Jian-Jang Huang","doi":"10.1186/s11671-023-03930-5","DOIUrl":"10.1186/s11671-023-03930-5","url":null,"abstract":"<div><p>The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138447458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tyler Johnson, Keliang Wang, Qi Hua Fan, Andre Lee
{"title":"Plasma modification of graphene nanoplatelets surfaces","authors":"Tyler Johnson, Keliang Wang, Qi Hua Fan, Andre Lee","doi":"10.1186/s11671-023-03929-y","DOIUrl":"10.1186/s11671-023-03929-y","url":null,"abstract":"<div><p>Atmospheric plasma processing, which combines the efficacy of chemical processes and the safety of physical processes, has been used to modify the surface characteristics of graphite-based materials. In this work, two distinct plasma source gases, C<sub>4</sub>F<sub>8</sub> and O<sub>2</sub>, with the addition of a rotary reactor were used. The effectiveness of modifying the basal plane of intercalated graphite nanoplatelets (GnP) was investigated with various analytical techniques and the visual observation of the dispersion of these plasma-treated GnP in solvents was also reported. It is shown that this low-temperature plasma processing technique can be used to successfully modify the GnP surface without significantly changing the intrinsic structure of the GnP, which is desirable in many applications. With the C<sub>4</sub>F<sub>8</sub> plasma treatment, the immersion characteristics in solvents can be tuned and the functional groups present on the surface can be tailored to produce desired bonding environments. This surface chemistry tunability will provide the needed functionalities in creating graphene-containing composite materials.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Core atoms escape from the shell: reverse segregation of Pb–Al core–shell nanoclusters via nanoscale melting","authors":"Wenkai Wu, Theodoros Pavloudis, Richard E. Palmer","doi":"10.1186/s11671-023-03924-3","DOIUrl":"10.1186/s11671-023-03924-3","url":null,"abstract":"<div><p>Melting is a phase transition that profoundly affects the fabrication and diverse applications of metal nanoclusters. Core–shell clusters offer distinctive properties and thus opportunities compared with other classes of nano-alloys. Molecular dynamics simulations have been employed to investigate the melting behaviour of Pb–Al core–shell clusters containing a fixed Pb<sub>147</sub> core and varying shell thickness. Our results show that the core and shell melt separately. Surprisingly, core melting always drives the core Pb atoms to break out the shell and coat the nanoclusters in a reversed segregation process at the nanoscale. The melting point of the core increases with the shell thickness to exceed that of the bare core cluster, but the thinnest shell always supresses the core melting point. These results can be a reference for the future fabrication, manipulation, and exploitation of the core–shell nanoalloys chosen. The system chosen is ideally suited for experimental observations.</p></div>","PeriodicalId":715,"journal":{"name":"Nanoscale Research Letters","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}