Acta Facultatis Medicae Naissensis最新文献_第8页

Dependence of the dental status of young individuals with different body weights on their eating behavior 不同体重青少年牙齿状况对饮食行为的影响

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-35901

M. Skrypnyk, T. Petrushanko, K. Neporada, R. Skrypnyk, V. Petrushanko, I. Skrypnyk

{"title":"Dependence of the dental status of young individuals with different body weights on their eating behavior","authors":"M. Skrypnyk, T. Petrushanko, K. Neporada, R. Skrypnyk, V. Petrushanko, I. Skrypnyk","doi":"10.5937/afmnai39-35901","DOIUrl":"https://doi.org/10.5937/afmnai39-35901","url":null,"abstract":"Introduction. Obesity is a global problem of modern society. According to the WHO, in 2016, more than 1.9 billion adults are overweight and about 650 million adults are obese. Numerous studies indicate the role of overweight, obesity and metabolic status on periodontal health, however, the mechanism of their development is not fully understood. Aim. The aim of the study was to explore the mechanism of periodontal disease development in patients with diverse body mass index and the mechanism of extra weight and obesity onset in these patients. Methods. The study involved 132 Ukrainian males and females, 18 - 22 years old. Body mass index was determined in all patients. Information on life history, illness and family history was collected. The assessment of dental status was conducted by indicating the oral and tongue hygiene indices and periodontal indices. Eating behaviour was assessed using the standardised Dutch eating behaviour questionnaire (DEBG) and the three-factor eating questionnaire (TFEQ R-18). Diet assessment was determined by standardized diet questionnaire. Results. More than 60% of young people with the 1st and 2nd degree obesity had eating disorders, the most prevalent were disturbance of cognitive restraint and emotional eating components of eating behavior. The prevalence of periodontal disease was significantly higher in obese individuals, up to 87% in patients with the 1st and 2nd degree obesity. Conclusion. Eating behavior disturbances play a crucial role in the development of obesity in young adults and onset of gingivitis. The cause of non-plaque-induced gingivitis in patients with the 1st and 2nd degree obesity is a impaired general host response to the pathogenic factors of the oral cavity, caused by excess adipose tissue, which led to the development of chronic systemic mild inflammation. That is why these patients need a specific, integrated periodontal treatment.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus 2型糖尿病患者甘油三酯与高密度脂蛋白胆固醇比值升高

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-33239

S. Bilgin, G. Aktas, Tel Atak, O. Kurtkulagi, G. Kahveci, T. Duman, Havva Akın, Buse Balci, Asli Erturk

{"title":"Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus","authors":"S. Bilgin, G. Aktas, Tel Atak, O. Kurtkulagi, G. Kahveci, T. Duman, Havva Akın, Buse Balci, Asli Erturk","doi":"10.5937/afmnai39-33239","DOIUrl":"https://doi.org/10.5937/afmnai39-33239","url":null,"abstract":"Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Methods: Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Results: Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). Conclusion: We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Evaluation of the clinical and biochemical parameters of hospitalized COVID-19 patients: A retrospective, single-center study from Bosnia and Herzegovina 波斯尼亚和黑塞哥维那住院COVID-19患者临床和生化指标评价:一项回顾性、单中心研究

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-33738

A. Subo, A. Dervišević, Z. Omerbašić, M. Zeid, Selma Spahić, Almir Fajkić, D. Suljević

{"title":"Evaluation of the clinical and biochemical parameters of hospitalized COVID-19 patients: A retrospective, single-center study from Bosnia and Herzegovina","authors":"A. Subo, A. Dervišević, Z. Omerbašić, M. Zeid, Selma Spahić, Almir Fajkić, D. Suljević","doi":"10.5937/afmnai39-33738","DOIUrl":"https://doi.org/10.5937/afmnai39-33738","url":null,"abstract":"Background/Aim. For the first time, we evaluated and presented the socio-demographic characteristics, clinical manifestations and laboratory findings of hospitalized coronavirus disease 2019 (COVID-19) patients from Canton Sarajevo, Bosnia and Herzegovina. Methods. This retrospective, single-centre study included 159 RT-PCR verified COVID-19 patients (92 mild/moderate; 67 severe/critical) consecutively hospitalized at the General Hospital \"Prim. dr Abdulah Nakaš\" in Sarajevo, Bosnia and Herzegovina. Socio-demographic, clinical, and laboratory data on admission were retrospectively obtained from each patient's electronic medical record and patient files by two experienced physicians. Results. 43.4% of the patients belonged to the age range of 46-65 years; 71.1% were men, and 68.6% had comorbidities; hypertension was the most prevalent comorbidity (100%), followed by diabetes (91.7%) and ischemic heart disease (35.8%). The leading clinical symptoms were fever (87.44%), tiredness (77.8%), and body/muscle aches (70.3%). There was significant reduction of blood oxygen saturation (p = 0.005), and significant elevation of D-dimer (p = 0.003), CRP (p = 0.044), and fasting plasma glucose (p = 0.047) in the severe/critical patients group compared to mild/moderate group. Conclusion. Older age, the male gender, confirmed comorbidities, decreased blood oxygen saturation, increased levels of CRP, D-dimer, and fasting plasma glucose, together with symptoms of chest pain/shortness of breath and/or diarrhea occurred more frequently in severe/critical than mild/moderate COVID-19 patients.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological and psychiatric comorbidities in bullous pemphigoid 大疱性类天疱疮的神经和精神合并症

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-35922

Arsovska Mirceska, K. Damevska, V. Simeonovski, A. Jović, D. Tiodorovic

{"title":"Neurological and psychiatric comorbidities in bullous pemphigoid","authors":"Arsovska Mirceska, K. Damevska, V. Simeonovski, A. Jović, D. Tiodorovic","doi":"10.5937/afmnai39-35922","DOIUrl":"https://doi.org/10.5937/afmnai39-35922","url":null,"abstract":"Introduction: Bullous pemphigoid (BP) is an autoimmune skin disease that typically presents with severe itching and blistering, with or without eczematous and urticarial lesions. Patients with BP are at an increased risk of comorbid conditions, especially neurologic and psychiatric diseases. Several recent studies have found a link between BP and neurological disorders, especially stroke, dementia, and Parkinson's disease. The aim of our study was to evaluate the prevalence of neurological and psychiatric comorbidities and their treatment in BP patients. Methods: A cross-sectional, observational, descriptive study was conducted based on the analysis of the medical records of 105 patients with confirmed BP. Demographic and clinical data on BP, neurological and psychiatric comorbidities were collected and statistically analyzed for all patients. Results: The median age was 77.8±10.6 years (range, 39-98 years). Among the study group, 71 (67,61%) patients had neurological comorbidity. Comorbidity with the highest frequency was ischemic stroke found in 28 (26,67%) patients, followed by dementia in 27 (25,71%), Alzheimer's in 11 (10,48%) and Parkinson's disease 5 (4,76%) patients. It was noted that there was a statistically significant difference among male and female patients with Alzheimer's disease (p = 0,0046) and psychiatric disorder (p = 0,044). Conclusion: Neurological disorders usually precede the diagnosis of BP, and mortality may be higher in patients with comorbid conditions. Clinicians should be aware of the early signs and symptoms of BP, primarily in patients with primary neurological disorders such as dementia, stroke, or Parkinson's disease.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the hematological picture with antithyroid therapy in Graves' disease 格雷夫斯病抗甲状腺治疗的血液学图像综述

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-36192

Aksanur Gokce, T. Omma, Mustafa Çelikc, I. Taşkaldıran

{"title":"An overview of the hematological picture with antithyroid therapy in Graves' disease","authors":"Aksanur Gokce, T. Omma, Mustafa Çelikc, I. Taşkaldıran","doi":"10.5937/afmnai39-36192","DOIUrl":"https://doi.org/10.5937/afmnai39-36192","url":null,"abstract":"Aim: Graves' disease is an autoimmune thyroid disease that is the most common cause of hyperthyroidism. Peripheral blood cell parameters such as neutrophils, lymphocytes, and platelets play a role in inflammation control. Several studies have proven that neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are indicators of chronic subclinical inflammation in various diseases. In our study, we aimed to review the peripheral blood picture by evaluating these parameters before and after antithyroid treatment in patients with Graves' disease. Patients and methods: A total of 120 patients (93 female, 27 male) between the ages of 18-65 were included. Demographic data, hemogram and biochemical data of the patients were recorded retrospectively at the time of diagnosis and after euthyroidism was achieved with medical treatment. Results: During the treatment, there was an increase in hemoglobin, lymphocytes, neutrophils and red cell distribution width, while a decrease in monocytes was observed. There was no significant difference between white blood cell, platelet and mean platelet volume. In addition, while there was no statistically significant difference between neutrophil-lymphocyte ratio (p = 0.8) and thrombocyt-lymphocyte ratio (p = 0.078) after euthyroid state, a statistically significant difference was found in favor of a decrease in monocyte-lymphocyte ratio (p = 0.006). Conclusion: Changes in hematopoiesis are relatively common in patients with newly diagnosed Graves' disease, and initiation of antithyroid therapy leads to improvement in these parameters. Although neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are accepted as new, non-invasive markers in clinical evaluation, in our study only a significant decrease in monocyte-lymphocyte ratio levels was observed after euthyroidism was achieved with antithyroid treatment.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"71 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eating and swallowing disorders in children with cleft lip and/or palate 唇裂和/或腭裂儿童饮食和吞咽障碍

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-30733

J. Todorović, Mirna Zelić, Lana Jerkić

{"title":"Eating and swallowing disorders in children with cleft lip and/or palate","authors":"J. Todorović, Mirna Zelić, Lana Jerkić","doi":"10.5937/afmnai39-30733","DOIUrl":"https://doi.org/10.5937/afmnai39-30733","url":null,"abstract":"Introduction. Cleft lip and palate are complex congenital anomalies of the orofacial system of children. Feeding and swallowing problems occur with varying degrees in children with cleft lip and/or palate. Aim. The aim of this paper was to review the literature and available evidence regarding the types of eating and swallowing disorders that can be identified in children with cleft lip and/or palate, as well as a description and types of compensatory strategies and interventions to alleviate difficulties. Methods. Insight into the relevant literature was performed by specialized search engines on the internet and insight into the electronic database. Results. The extent of the cleft is related to the severity of eating and swallowing disorders, so the most common problems are decreased oral sensitivity, cough, choking, nasal regurgitation, difficulty in sucking, laryngotracheal aspiration due to inadequate airway protection during swallowing, which may result in pneumonia and lung damage. Feeding and swallowing difficulty is also a source of stress for parents. Conclusion. Choking, coughing, nasal regurgitation, laryngotracheal aspiration, excessive air intake can lead to dehydration, malnutrition, but also the need for alternative feeding methods Therefore, it is of great importance to identify the problems of feeding and swallowing in a timely manner, along with modifications of the feeding method.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary and lifestyle habits of patients with type 2 diabetes in Subotica 苏博蒂察2型糖尿病患者的饮食和生活习惯

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-34287

Hajnalka Požar, D. Simin, Čaba Požar

{"title":"Dietary and lifestyle habits of patients with type 2 diabetes in Subotica","authors":"Hajnalka Požar, D. Simin, Čaba Požar","doi":"10.5937/afmnai39-34287","DOIUrl":"https://doi.org/10.5937/afmnai39-34287","url":null,"abstract":"Introduction: The activities of the health care service in the control of diabetes and the improvement of glucoregulation of patients are primarily focused on lifestyle modification. The goal of this study was to review the recommendations in the field of adequate nutrition and lifestyle and to assess the health behavior of patients with type 2 diabetes in Subotica. Methodology: The research was conducted in the form of a cross-sectional study in February 2017 at the Diabetes Counseling Center of the Health Center in Subotica, Serbia. The study included 114 patients with type 2 diabetes. The research instrument consisted of a customized survey questionnaire. Results: Only a third of the patients actually consumed at least five meals a day, that was suggested as part of the treatment. Three-quarters of patients always prepared their own meals, but 41% of them never read the declarations about the ingredients of the food they consumed. Twenty percent of patients did not know how to assemble a healthy plate and what low-carbohydrate foods were. Two-thirds of patients used dietary supplements. A relatively small number, one-quarter of patients, consumed alcoholic beverages and 22 patients were active smokers. More than half of the patients exercised lightly, although 68% of them were dissatisfied with their body weight. Conclusion: We identified some deficiencies in the health behavior and lifestyle of people with diabetes. There is a recommendation to repeat the information on proper nutrition and the importance of physical activity in achieving ideal health and optimal glucoregulation during the educational work with patients.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Textural and sensory characterization of carbomeric gels with panthenol 泛醇碳聚物凝胶的结构和感官特性

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-31063

M. Martinović, Nenad Stojanović, I. Nešić

{"title":"Textural and sensory characterization of carbomeric gels with panthenol","authors":"M. Martinović, Nenad Stojanović, I. Nešić","doi":"10.5937/afmnai39-31063","DOIUrl":"https://doi.org/10.5937/afmnai39-31063","url":null,"abstract":"Introduction. The aim of this study was to evaluate the influence of the carbomer concentration (used as the gelling agent, in the range 0.5 - 2.0%) on textural and sensory characteristics of gels with 3% panthenol using sensory analysis as subjective and texture analysis as an objective assessment method. An active substance in the gels was panthenol, which also acted as a neutralizing agent of the carbomer. Participants and methods. Twenty female panelists, aged between 20 and 36, participated in the sensory study and had to fulfill a questionnaire regarding product attributes before, during and after application on the skin. Texture analysis was performed on CT3 Texture Analyzer, after each week for a month, and the following parameters were calculated: hardness cycle 1, hardness cycle 2, cohesiveness, adhesiveness, resilience and springiness. Results. The results showed that gels were stable over time and the structure of the gels was preserved regardless of compression. An increase in hardness and resilience was followed by an increase in the concentration of carbomer, while adhesiveness, cohesiveness and springiness did not differ much among different gels. The same trend was noticed when gels were compared during time. Sensory analysis confirmed findings of texture analysis and showed that with the increment of carbomer concentration, stickiness and density also enhanced, while absorption rate and spreadability decreased. Gel with 1% carbomer was chosen by the majority of panelists as favorite and as a gel they would regularly use. Conclusion. The methods of textural and sensory analysis represent valuable approaches in drug/cosmetic product design because they offer insight in the compliance of patients/consumers.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The influence of selected thickeners on the textural properties of oil-in-water emulsions 选择增稠剂对水包油乳剂结构性能的影响

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-31064

Aleksandra Stolić-Jovanović, M. Martinović, I. Nešić

{"title":"The influence of selected thickeners on the textural properties of oil-in-water emulsions","authors":"Aleksandra Stolić-Jovanović, M. Martinović, I. Nešić","doi":"10.5937/afmnai39-31064","DOIUrl":"https://doi.org/10.5937/afmnai39-31064","url":null,"abstract":"Introduction. Texture profile analysis, as the most popular method of texture analysis today, is used for relating the mechanical characteristics of the samples to their sensory characteristics. Thickeners have an important influence on the mechanical properties of semi-solid products, and thus on the physical stability of creams. Choosing the right one often requires more skill than knowledge. Aims. The aim of this study was to evaluate the influence of thickeners-natural (xanthan gum) as well as naturally modified polymers (hydroxyethylcellulose, c) at the concentration of 1% w/w on the textural properties of oil-in-water emulsions. Results and Discussion. The following parameters of the tested emulsions were determined: adhesiveness, cohesiveness, and hardness. All tested creams reached higher adhesiveness values at the end of the study compared to the originally measured values. However, the presence of thickeners did not increase the stickiness of the formulations since the adhesiveness of the tested samples did not differ much compared to the control sample. Almost similar values of cohesiveness were measured for all samples compared to the initial values. The values of hardness showed that the deformation after two compression cycles did not disrupt the structure and that all preparations were of similar spreadability. Conclusion. The results obtained by texture analysis could be used in the formulation of a cosmetic product with predefined sensory characteristics. Also, they could help in finding an adequate combination and concentration of thickeners for their application in the formulation. Further research should be directed towards the application of more different thickeners and different ranges of their concentrations in the formulation.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vitro assessment of the lipid peroxidation of N,N'-disubstituted benzimidazole-2-thiones: Hydrazides vs esters N,N'-二取代苯并咪唑-2-硫酮脂质过氧化的体外评价:肼类与酯类

IF 0.2

Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI: 10.5937/afmnai39-36399

J. Lazarević, J. Zvezdanović, N. Anastassova, A. Mavrova, D. Yancheva, A. Šmelcerović

{"title":"In vitro assessment of the lipid peroxidation of N,N'-disubstituted benzimidazole-2-thiones: Hydrazides vs esters","authors":"J. Lazarević, J. Zvezdanović, N. Anastassova, A. Mavrova, D. Yancheva, A. Šmelcerović","doi":"10.5937/afmnai39-36399","DOIUrl":"https://doi.org/10.5937/afmnai39-36399","url":null,"abstract":"Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. Material and methods: In the present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) and hydrazide (5 - 7) side chains were investigated for in vitro antioxidant activity using lipid peroxidation method. Results: Among the assayed compounds, three hydrazides, 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-1,3dihydro-2H-benzimidazole-2-thione (5), 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-methyl-1,3-dihydro-2H benzimidazole-2-thione (6) and 1,3-bis[3-(hydrazinooxy)-3-oxopropyl]-5-benzoyl-1,3-dihydro-2H benzimidazole-2-thione (7) showed good antioxidant properties (IC50 ˂ 100 mM), with the best lipid peroxidation inhibition values (IC50) shown for compound 5 (64 ± 10 mM) and compound 6 (73 ± 29 mM). Conclusion: Indicated hydrazide structures may constitute a sort of molecular basis, a promising starting point for the development of compounds for the prevention and treatment of diseases resulting from oxidative damage.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0