Acta physiologica Academiae Scientiarum Hungaricae最新文献_第5页

Extravascular circulation of plasma proteins. 血浆蛋白的血管外循环。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

G Szabó, Z Magyar

{"title":"Extravascular circulation of plasma proteins.","authors":"G Szabó, Z Magyar","doi":"","DOIUrl":"","url":null,"abstract":"The escape of radioiodinated serum albumin (RISA) from the circulation and lymphatic albumin transport was investigated in anaesthetized rabbits. The fraction of RISA escaping each hour from the circulation was 0.0932 +/- 0.0075, lymphatic albumin transport in the thoracic duct was 0.0389 +/- 0.0026 in the hepatic lymph trunk 0.0115 +/- 0.016, in the intestinal trunk 0.0122 +/- 0.0037 and in the renal lymphatics 0.0185 +/- 0.0021. About 78% of the lymph and 91% of albumin transported by the thoracic duct originated from the abdominal and renal lymphatics. The ratio of albumin escape from the circulation versus lymphatic return was 2.36. From the first slopes of the lymphatic RISA activity curves the albumin escape rates were calculated and found to be 1.89 in the liver, 2.32 in the kidney, 0.69 in the intestine and 0.20 g h-1 kg-1 tissue weight in the leg (skin). The lymph vessels returned 17% of the escaped albumin, from the liver about 12% from the intestines and almost all from the kidneys. A very strong correlation (r = 0.996) was found between lymph to plasma albumin concentration ratios and the first slopes of the RISA equilibration curves, proving that protein concentration in the lymph is determined by the rate of protein escape from the capillaries and that the rates obtained from the first slopes of the RISA cpm/g albumin in lymph per RISA cpm/g albumin in plasma equilibration curves are a measure of capillary permeability to protein.","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18197368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and isolation of three acetylcholinesterase inactivating fractions in the venom of Dendroaspis angusticeps. 石斛毒液中三个乙酰胆碱酯酶失活部位的鉴定与分离。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

J Wangai, K Thairu, B S Bharaj, B V Telang

引用次数: 0

Effects of drugs on the production of stress ulcer in the rat. 药物对应激性溃疡大鼠产生的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

L Nagy, G Mózsik, M Fiegler, E Gerber, T Past, C Ruzsa, Z Vezekényi, T Jávor

引用次数: 0

Effect of indomethacin on renal function during different levels of surgical stress. 不同手术应激水平下吲哚美辛对肾功能的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

G Kövér, K Szemerédi, H Tost

{"title":"Effect of indomethacin on renal function during different levels of surgical stress.","authors":"G Kövér, K Szemerédi, H Tost","doi":"","DOIUrl":"","url":null,"abstract":"To determine whether renal prostaglandins participate in the regulation of renal blood flow, sodium and water excretion during \"stress situation\", renal function was investigated in two groups of anaesthetized dogs, subjected to minor and to more severe surgical stress under control conditions, and following the administration of 4 mg/kg indomethacin i.v. In the control studies, the renal haemodynamic parameters (CPAH, Cinulin), urine output and sodium excretion were not different in those animals in which the surgical traumatization was more severe from data obtained in similarly anaesthetized dogs. Extracellular volume expansion induced with i.v. infusion of Ringer solution enhanced sodium and water excretion in both groups, however, the increase of sodium excretion was less in the dogs subjected to more severe stress. During indomethacin infusion glomerular filtration did not change in either groups; CPAH decreased by 20-25% in the anaesthetized animals and 35-40% in dogs in which the surgical stress was more severe. In this group the total renal blood flow was reduced by 40% simultaneously with the haemodynamic changes; sodium and water excretion fell in both groups. After indomethacin infusion the diuretic response of the kidneys to extracellular volume expansion was markedly reduced in the anaesthetized dogs, the diuretic and natriuretic effects being almost completely inhibited in the animals subjected to more severe stress. These data suggest that in the anaesthetized dog endogenous prostaglandins may serve to maintain renal blood flow but not the glomerular filtration rate. Inhibition of prostaglandin synthesis during more severe stress results in increased renal vascular resistance and reduced renal blood flow. Accordingly, the data provide evidence that renal prostaglandins counteract in the kidney the vasoconstrictor mechanisms activated during more severe surgical traumatization. The data do not support the direct physiological role of prostaglandins in regulating tubular function.","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18172159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacologic assessment of the functional state in stenosed coronary circulation of the dog. 犬冠状动脉循环狭窄功能状态的药理学评价。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

V Kékesi, A Juhász-Nagy

引用次数: 0

Effect of isoproterenol on renal function. 异丙肾上腺素对肾功能的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

T Zahajszky, G Fejes-Tóth, J Filep

引用次数: 0

Comparative study on the acute effects of benzene, toluene and m-xylene in the rat. 苯、甲苯和间二甲苯对大鼠急性作用的比较研究。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

K A Paksy, J Moinár, M Náray, G Barcza