Extravascular circulation of plasma proteins.

G Szabó, Z Magyar
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Abstract

The escape of radioiodinated serum albumin (RISA) from the circulation and lymphatic albumin transport was investigated in anaesthetized rabbits. The fraction of RISA escaping each hour from the circulation was 0.0932 +/- 0.0075, lymphatic albumin transport in the thoracic duct was 0.0389 +/- 0.0026 in the hepatic lymph trunk 0.0115 +/- 0.016, in the intestinal trunk 0.0122 +/- 0.0037 and in the renal lymphatics 0.0185 +/- 0.0021. About 78% of the lymph and 91% of albumin transported by the thoracic duct originated from the abdominal and renal lymphatics. The ratio of albumin escape from the circulation versus lymphatic return was 2.36. From the first slopes of the lymphatic RISA activity curves the albumin escape rates were calculated and found to be 1.89 in the liver, 2.32 in the kidney, 0.69 in the intestine and 0.20 g h-1 kg-1 tissue weight in the leg (skin). The lymph vessels returned 17% of the escaped albumin, from the liver about 12% from the intestines and almost all from the kidneys. A very strong correlation (r = 0.996) was found between lymph to plasma albumin concentration ratios and the first slopes of the RISA equilibration curves, proving that protein concentration in the lymph is determined by the rate of protein escape from the capillaries and that the rates obtained from the first slopes of the RISA cpm/g albumin in lymph per RISA cpm/g albumin in plasma equilibration curves are a measure of capillary permeability to protein.

血浆蛋白的血管外循环。
研究了麻醉家兔放射碘化血清白蛋白(RISA)在循环中的逃逸和淋巴白蛋白的转运。RISA每小时从循环中排出的比例为0.0932 +/- 0.0075,胸导管淋巴白蛋白转运率为0.0389 +/- 0.0026,肝淋巴干0.0115 +/- 0.016,肠干0.0122 +/- 0.0037,肾淋巴0.0185 +/- 0.0021。经胸导管输送的约78%的淋巴液和91%的白蛋白来源于腹淋巴和肾淋巴。白蛋白从循环中逸出与淋巴返回的比率为2.36。从淋巴RISA活性曲线的第一个斜率计算白蛋白逃逸率,发现肝脏为1.89,肾脏为2.32,肠道为0.69,腿部(皮肤)为0.20 g h-1 kg-1组织重量。淋巴管返回了17%的白蛋白,从肝脏返回了12%,从肠道返回了12%,几乎全部从肾脏返回。淋巴与血浆白蛋白浓度比与RISA平衡曲线的第一次斜率之间存在很强的相关性(r = 0.996),证明淋巴中的蛋白质浓度是由蛋白质从毛细血管中逃逸的速率决定的,并且从血浆平衡曲线中每RISA cpm/g白蛋白的RISA cpm/g白蛋白的第一次斜率获得的速率是衡量毛细血管对蛋白质渗透率的一个指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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