苯、甲苯和间二甲苯对大鼠急性作用的比较研究。

K A Paksy, J Moinár, M Náray, G Barcza
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引用次数: 0

摘要

我们测试了溶剂在腹腔注射后对动机状态的影响,以及它们的镇静作用。采用开阔场地(探索活动、运动)、活动轮(跑步活动)、试管试验和倾斜平面(肌肉无力、不协调)试验。这两种药物在低剂量时已被证明在引起肌肉无力和共济失调方面是相似的。苯在这方面是最有效的。然而,这三种溶剂在影响运动活动方面形成强烈对比。而苯,尤其是甲苯对中枢神经系统有刺激作用,而间二甲苯处理后则没有这种作用。根据人类使用这些物质的经验,可以认为,在大鼠中应用的筛选程序可能有助于预测人类的急性不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative study on the acute effects of benzene, toluene and m-xylene in the rat.

Solvents were tested for their influence on motivational state, as well as for their sedative effects, after intraperitoneal administration. The following tests were used: open field (exploratory activity, locomotion), activity wheel (running activity), tube test and tilted plane (muscle weakness, incoordination). The agents proved to be similar in causing muscle weakness and ataxia already at low dose levels. Benzene was the most potent in this respect. The three solvents, however, contrasted strongly in influencing motor activity. While benzene and especially toluene exerted CNS stimulation, no such effect could be detected following m-xylene treatment. On the basis of human experiences with these substances it may be suggested that the screening procedure applied in rats might be useful for predicting acute adverse effects in man.

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