Acta physiologica Academiae Scientiarum Hungaricae最新文献_第2页

Effect of indomethacin on intrarenal circulation and sodium and water excretion in anaesthetised rats with or without acute volume expansion. 吲哚美辛对有或无急性容量扩张麻醉大鼠肾内循环及钠、水排泄的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

J Bartha, C Hably

{"title":"Effect of indomethacin on intrarenal circulation and sodium and water excretion in anaesthetised rats with or without acute volume expansion.","authors":"J Bartha, C Hably","doi":"","DOIUrl":"","url":null,"abstract":"Effects of the prostaglandin synthesis inhibitor indomethacin (4 mg/kg) were studied on the intrarenal circulation of anaesthetised (pentothal 50 mg/kg i.p.) rats in normovolemia or subjected to acute extracellular volume expansion (intravenous infusion of 0.9% NaCl at a dose of 50 ml/kg) using Sapirstein's 86Rb indicator dilution technique. Circulatory parameters were determined one hour after indomethacin treatment. The following conclusions were drawn: 1. In normovolemic rats the renal, cortical and medullary blood flow remained unaltered. No changes occurred in regional vascular resistances of the kidney or in the distribution pattern of intrarenal blood flow. Water output was moderately reduced while sodium excretion remained unaffected. 2. In rats subjected to acute extracellular volume expansion renal cortical blood flow was slightly augmented, medullary perfusion rate declined; the intrarenal blood flow distribution was shifted towards the cortex. The vascular resistance in the cortex did not change whereas that in the medulla was slightly augmented. Under these conditions indomethacin did not influence salt and water excretion. Our results provide further evidence that unlike in anaesthetised dog, in the anaesthetised rat endogenous prostaglandins probably do not play a decisive role in the control of renal blood flow, intrarenal circulation and salt and water excretion.","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochemical detection of nickel in the myocardium after acute carbon monoxide intoxication. 急性一氧化碳中毒后心肌镍的细胞化学检测。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

I Balogh, G Rubányi, M Oberna, G Pogátsa

引用次数: 0

Partial purification from bovine pulmonary tissue of a protein capable of inhibiting in vivo DNA synthesis in mouse pulmonary cells. 从牛肺组织中部分纯化一种能够抑制小鼠肺细胞体内DNA合成的蛋白质。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

Z Marcsek, J Menyhárt

引用次数: 0

Responses of subclavian baroreceptors of the dog to changes of static pressure. 犬锁骨下压力感受器对静压变化的反应。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

A U Kadiri

引用次数: 0

The mechanism underlying the dantrolene-induced positive inotropic effect in guinea pig atrial myocardium. 丹曲林诱导豚鼠心房心肌正性肌力作用的机制。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

J Mészáros, V Kecskeméti, J Szegi

引用次数: 0

Cardiovascular reactions from hypothalamic self-stimulation in the rat. 大鼠下丘脑自我刺激引起的心血管反应。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

E A Yumatov, E A Kiyatkin

{"title":"Cardiovascular reactions from hypothalamic self-stimulation in the rat.","authors":"E A Yumatov, E A Kiyatkin","doi":"","DOIUrl":"","url":null,"abstract":"Arterial blood pressure (BP) and heart rate (HR) were continuously recorded during lateral hypothalamic self-stimulation with optimal stimulus parameters in rats. Hyper-hypotensive, hypertensive and hypotensive reactions were observed during separate self-stimulation, and the biphasic type considerably prevailed over other types of reactions. During the single cycles of self-stimulation hyper-hypotensive and hypertensive reactions with different heart rate reactions also occurred. In this case the biphasic type was seen in 75% of all reactions, whereas the hypotensive type occurred in 25% of the cases. The main type of BP reaction (92%) during continuous self-stimulation for 60-240 min was a gradual increase of the mean BP level from 15 to 40 mm Hg against initial values (p less than 0.001), that depended on the duration of self-stimulation. Changes of HR were more variable: tachycardia and bradycardia were seen approximately with the same frequency. Comparative analysis of cardiovascular reactions during hypothalamic SS and escape reactions provoked by ventromedial hypothalamus stimulation revealed some peculiarities of autonomic manifestations during positive and negative emotional reactions. The results of this comparison raises the question of a stress-reaction during self-stimulation behaviour.","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18200719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of intracerebroventricularly administered cholecystokinin antisera on active avoidance and conditioned feeding behaviour of rats. 脑室注射胆囊收缩素抗血清对大鼠主动回避和条件进食行为的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

M Fekete, M Balázs, G Telegdy

引用次数: 0

Effect of calcium chloride on gross behavioural changes produced by carbachol and eserine in cats. 氯化钙对氯乙醇和甘油引起的猫总体行为改变的影响。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

D B Beleslin, R Samardzic, S K Krstić, M Strbac

引用次数: 0

Dependence of nickel-induced coronary vasoconstriction on the activity of the electrogenic Na+, K+-pump. 镍诱导的冠状血管收缩对电致钠钾泵活性的依赖性。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

G Rubányi, M Bakos, K Hajdu, T Pataki

引用次数: 0

The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat. 吲哚美辛致大鼠胃溃疡、西咪替丁和前列环素对胃溃疡的保护作用与胃底粘膜cAMP系统的关系。

Acta physiologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

F Morón, T Jávor, M Bata, M Fiegler, G Mózsik

{"title":"The relationships between indomethacine-induced gastric ulcer, ulcer protection by cimetidine and prostacyclin and the cAMP system of the gastric fundic mucosa in the rat.","authors":"F Morón, T Jávor, M Bata, M Fiegler, G Mózsik","doi":"","DOIUrl":"","url":null,"abstract":"Gastric ulcer was provoked by indomethacine (20 mg/kg s.c.) in rats. The ulcer protection by prostacyclin and cimetidine as well as the changes of tissue cAMP level in the gastric fundic mucosa--during ulcer-provocation and ulcer protection--were studied. The animals received prostacyclin (125, 250 and 500 micrograms/kg) and cimetidine (2.5 and 50 mg/kg) together with indomethacine. Evaluation of the results was undertaken 4 hours after the administration of the provoking agent. The number and severity of the ulcers as well as the cAMP level of the gastric fundic mucosa were measured. The following results were obtained: (1) cAMP level of the gastric fundic mucosa remained unaltered at the time of ulcer provocation; (2) cimetidine and prostacyclin reduced the number and severity of the ulcers in a dose-dependent manner; (3) cAMP level of the gastric fundic mucosa was reduced after cimetidine and prostacyclin treatment in a dose-dependent manner, the extent of which however did not show any correlation with the degree of ulcer-preventive action. The experimental results indicate that (1) the development of indomethacine-induced gastric ulcer is independent of the ATP--adenylate cyclase--cAMP system of the gastric fundic mucosa; (2) the ulcer protective action of cimetidine and prostacyclin is independent of tissue cAMP system of the gastric fundic mucosa in this model.","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17370443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0