吲哚美辛对有或无急性容量扩张麻醉大鼠肾内循环及钠、水排泄的影响。

J Bartha, C Hably
{"title":"吲哚美辛对有或无急性容量扩张麻醉大鼠肾内循环及钠、水排泄的影响。","authors":"J Bartha,&nbsp;C Hably","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Effects of the prostaglandin synthesis inhibitor indomethacin (4 mg/kg) were studied on the intrarenal circulation of anaesthetised (pentothal 50 mg/kg i.p.) rats in normovolemia or subjected to acute extracellular volume expansion (intravenous infusion of 0.9% NaCl at a dose of 50 ml/kg) using Sapirstein's 86Rb indicator dilution technique. Circulatory parameters were determined one hour after indomethacin treatment. The following conclusions were drawn: 1. In normovolemic rats the renal, cortical and medullary blood flow remained unaltered. No changes occurred in regional vascular resistances of the kidney or in the distribution pattern of intrarenal blood flow. Water output was moderately reduced while sodium excretion remained unaffected. 2. In rats subjected to acute extracellular volume expansion renal cortical blood flow was slightly augmented, medullary perfusion rate declined; the intrarenal blood flow distribution was shifted towards the cortex. The vascular resistance in the cortex did not change whereas that in the medulla was slightly augmented. Under these conditions indomethacin did not influence salt and water excretion. Our results provide further evidence that unlike in anaesthetised dog, in the anaesthetised rat endogenous prostaglandins probably do not play a decisive role in the control of renal blood flow, intrarenal circulation and salt and water excretion.</p>","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of indomethacin on intrarenal circulation and sodium and water excretion in anaesthetised rats with or without acute volume expansion.\",\"authors\":\"J Bartha,&nbsp;C Hably\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Effects of the prostaglandin synthesis inhibitor indomethacin (4 mg/kg) were studied on the intrarenal circulation of anaesthetised (pentothal 50 mg/kg i.p.) rats in normovolemia or subjected to acute extracellular volume expansion (intravenous infusion of 0.9% NaCl at a dose of 50 ml/kg) using Sapirstein's 86Rb indicator dilution technique. Circulatory parameters were determined one hour after indomethacin treatment. The following conclusions were drawn: 1. In normovolemic rats the renal, cortical and medullary blood flow remained unaltered. No changes occurred in regional vascular resistances of the kidney or in the distribution pattern of intrarenal blood flow. Water output was moderately reduced while sodium excretion remained unaffected. 2. In rats subjected to acute extracellular volume expansion renal cortical blood flow was slightly augmented, medullary perfusion rate declined; the intrarenal blood flow distribution was shifted towards the cortex. The vascular resistance in the cortex did not change whereas that in the medulla was slightly augmented. Under these conditions indomethacin did not influence salt and water excretion. Our results provide further evidence that unlike in anaesthetised dog, in the anaesthetised rat endogenous prostaglandins probably do not play a decisive role in the control of renal blood flow, intrarenal circulation and salt and water excretion.</p>\",\"PeriodicalId\":7049,\"journal\":{\"name\":\"Acta physiologica Academiae Scientiarum Hungaricae\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

采用Sapirstein's 86Rb指标稀释技术,研究前列腺素合成抑制剂吲哚美辛(4 mg/kg)对正常血容量或急性细胞外体积扩张(静脉输注0.9% NaCl,剂量为50 ml/kg)大鼠肾内循环的影响。吲哚美辛治疗1小时后测定循环参数。得出以下结论:1。等容大鼠的肾脏、皮质和髓质血流保持不变。肾脏局部血管阻力和肾内血流分布模式均未发生改变。水输出适度减少,而钠排泄不受影响。2. 急性细胞外容量扩张大鼠肾皮质血流轻度增强,髓质灌注率下降;肾内血流分布向皮质转移。皮层的血管阻力没有变化,而髓质的血管阻力略有增强。在此条件下,吲哚美辛不影响盐和水的排泄。我们的研究结果进一步证明,与麻醉犬不同,在麻醉大鼠中,内源性前列腺素可能在控制肾血流量、肾内循环和盐和水排泄中不起决定性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of indomethacin on intrarenal circulation and sodium and water excretion in anaesthetised rats with or without acute volume expansion.

Effects of the prostaglandin synthesis inhibitor indomethacin (4 mg/kg) were studied on the intrarenal circulation of anaesthetised (pentothal 50 mg/kg i.p.) rats in normovolemia or subjected to acute extracellular volume expansion (intravenous infusion of 0.9% NaCl at a dose of 50 ml/kg) using Sapirstein's 86Rb indicator dilution technique. Circulatory parameters were determined one hour after indomethacin treatment. The following conclusions were drawn: 1. In normovolemic rats the renal, cortical and medullary blood flow remained unaltered. No changes occurred in regional vascular resistances of the kidney or in the distribution pattern of intrarenal blood flow. Water output was moderately reduced while sodium excretion remained unaffected. 2. In rats subjected to acute extracellular volume expansion renal cortical blood flow was slightly augmented, medullary perfusion rate declined; the intrarenal blood flow distribution was shifted towards the cortex. The vascular resistance in the cortex did not change whereas that in the medulla was slightly augmented. Under these conditions indomethacin did not influence salt and water excretion. Our results provide further evidence that unlike in anaesthetised dog, in the anaesthetised rat endogenous prostaglandins probably do not play a decisive role in the control of renal blood flow, intrarenal circulation and salt and water excretion.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信