Acta medica Okayama最新文献_第7页

Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study. S-1/奥沙利铂和贝伐单抗治疗晚期结直肠癌患者的多机构 2 期研究的长期随访数据：HiSCO-02研究

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66670

Manabu Shimomura, Katsunori Shinozaki, Takuya Yano, Shintaro Akabane, Hideki Ohdan

{"title":"Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study.","authors":"Manabu Shimomura, Katsunori Shinozaki, Takuya Yano, Shintaro Akabane, Hideki Ohdan","doi":"10.18926/AMO/66670","DOIUrl":"10.18926/AMO/66670","url":null,"abstract":"Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"47-52"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostate Biopsy May Not Be Indicated Early after Bacillus Calmette Guérin Treatment. 前列腺活检可能并非卡介苗杆菌治疗后的早期适应症。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66665

Naoki Akagi, Akihiro Kanematsu, Koji Shigesaka, Kimihiro Shimatani, Shingo Yamamoto

{"title":"Prostate Biopsy May Not Be Indicated Early after Bacillus Calmette Guérin Treatment.","authors":"Naoki Akagi, Akihiro Kanematsu, Koji Shigesaka, Kimihiro Shimatani, Shingo Yamamoto","doi":"10.18926/AMO/66665","DOIUrl":"10.18926/AMO/66665","url":null,"abstract":"Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients' PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"9-13"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139988992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study. 甲氨蝶呤相关淋巴组织增生性疾病患者停用甲氨蝶呤后坏死病灶的消退：一项回顾性 CT 研究。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66668

Takahiro Kitayama, Takashi Tanaka, Yuichiro Kanie, Yohei Marukawa, Katsuhide Kojima, Takehiro Tanaka, Soshi Takao, Takao Hiraki

{"title":"Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study.","authors":"Takahiro Kitayama, Takashi Tanaka, Yuichiro Kanie, Yohei Marukawa, Katsuhide Kojima, Takehiro Tanaka, Soshi Takao, Takao Hiraki","doi":"10.18926/AMO/66668","DOIUrl":"10.18926/AMO/66668","url":null,"abstract":"This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"29-36"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139988994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Combined Use of Transabdominal Ultrasonography and Fecal Immunochemical Test Examinations in Ulcerative Colitis. 溃疡性结肠炎患者联合使用经腹超声波检查和粪便免疫化学试验检查的效用

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66674

Masahiro Takahara, Sakiko Hiraoka, Masayasu Ohmori, Keiko Takeuchi, Kensuke Takei, Yuki Aoyama, Eriko Yasutomi, Shoko Igawa, Toshihiro Inokuchi, Junki Toyosawa, Yasushi Yamasaki, Hideaki Kinugasa, Keita Harada, Hideki Onishi, Hiroyuki Okada

引用次数: 0

Quantitative Assessment of the Heat Transfer Capacity of Ice Bags and their Cooling Effects on the Skin Surface and Core Temperature. 定量评估冰袋的传热能力及其对皮肤表面和核心温度的降温效果。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66671

Yukiko Ichikawa, Tetsuya Ogino

{"title":"Quantitative Assessment of the Heat Transfer Capacity of Ice Bags and their Cooling Effects on the Skin Surface and Core Temperature.","authors":"Yukiko Ichikawa, Tetsuya Ogino","doi":"10.18926/AMO/66671","DOIUrl":"10.18926/AMO/66671","url":null,"abstract":"Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"53-61"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139988993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat. 一例使用马来酸曲美布汀治疗有效的特发性消化性溃疡。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66675

Keisuke Miyake, Tomohiro Tanikawa, Ken Haruma, Mayuko Kawada, Katsunori Ishii, Noriyo Urata, Ken Nishino, Mitsuhiko Suehiro, Miwa Kawanaka, Noriaki Manabe, Hirofumi Kawamoto

引用次数: 0

Is Proximal Triangular Fixation Better than the Conventional Method in Adult Spinal Deformity Surgery? 在成人脊柱畸形手术中，近端三角固定法是否优于传统方法？

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66669

Masato Tanaka, Umesh Meena, Takuya Taoka, Yoshihiro Fujiwara, Daiichiro Yokomizo, Santosh Kumar Bashyal, Naveen Sake, Shinya Arataki

{"title":"Is Proximal Triangular Fixation Better than the Conventional Method in Adult Spinal Deformity Surgery?","authors":"Masato Tanaka, Umesh Meena, Takuya Taoka, Yoshihiro Fujiwara, Daiichiro Yokomizo, Santosh Kumar Bashyal, Naveen Sake, Shinya Arataki","doi":"10.18926/AMO/66669","DOIUrl":"10.18926/AMO/66669","url":null,"abstract":"In adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 years). Clinical and radiographic outcomes were assessed using visual analogue scale (VAS) values for back pain and the Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and postoperatively. Surgical times and intraoperative blood loss of the two groups were not significantly different (493 vs 490 min, 1,260 vs 1,173 mL). Clinical outcomes such as VAS and ODI were comparable in the two groups. Proximal junctional kyphosis in group T was slightly lower than that of group C (28.5% vs 47.5%, p=0.491). However, based on radiology, proximal screw pullout occurred significantly less frequently in the triangular fixation group than the conventional group (0.0% vs 22.5%, p=0.049). Clinical outcomes in the two groups were not significantly different.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"37-46"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Continuous Low-Dose Lenvatinib for the Treating of the Patients with Unresectable Thyroid Carcinoma. 持续低剂量伦伐替尼治疗无法切除的甲状腺癌患者的意义

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66672

Daizo Murakami, Kohei Nishimoto, Soshi Takao, Satoru Miyamaru, Tomoka Kadowaki, Haruki Saito, Hiroki Takeda, Momoko Ise, Koichi Suyama, Yorihisa Orita

{"title":"Significance of Continuous Low-Dose Lenvatinib for the Treating of the Patients with Unresectable Thyroid Carcinoma.","authors":"Daizo Murakami, Kohei Nishimoto, Soshi Takao, Satoru Miyamaru, Tomoka Kadowaki, Haruki Saito, Hiroki Takeda, Momoko Ise, Koichi Suyama, Yorihisa Orita","doi":"10.18926/AMO/66672","DOIUrl":"10.18926/AMO/66672","url":null,"abstract":"The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 1","pages":"63-70"},"PeriodicalIF":0.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139988996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Macrophages in Liver Fibrosis. 巨噬细胞在肝纤维化中的作用

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66664

Cuiming Sun, Akihiro Matsukawa

引用次数: 0

Ectopic Breast Cancer Arising within an Axillary Lymph Node. 发生在腋窝淋巴结内的异位乳腺癌

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2024-02-01 DOI: 10.18926/AMO/66676

Kei Toshima, Tadahiko Shien, Midori Filiz Nishimura, Yoko Suzuki, Shogo Nakamoto, Maya Uno, Ryo Yoshioka, Takahiro Tsukioki, Yuko Takahashi, Takayuki Iwamoto, Tsuguo Iwatani, Hiroyuki Yanai

引用次数: 0