Acta medica Okayama最新文献_第6页

Inhibition of Air-Exposure Stress-Induced Autolysis in Clostridium perfringens by Zn2. Zn2对空气暴露胁迫诱导的产气荚膜梭菌自溶的抑制作用。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-10-01 DOI: 10.18926/AMO/69435

Nozomu Matsunaga, Seira Egusa, Riyo Aono, Eiji Tamai, Yasuo Hitusmoto, Seiichi Katayama

{"title":"Inhibition of Air-Exposure Stress-Induced Autolysis in Clostridium perfringens by Zn2.","authors":"Nozomu Matsunaga, Seira Egusa, Riyo Aono, Eiji Tamai, Yasuo Hitusmoto, Seiichi Katayama","doi":"10.18926/AMO/69435","DOIUrl":"https://doi.org/10.18926/AMO/69435","url":null,"abstract":"Clostridium perfringens is a pathogenic anaerobe that causes gas gangrene and food poisoning. Although autolysin-mediated reorganization of the bacterial cell wall is crucial for cell division, excessive autolysin activity induced by stressors can lead to cell lysis. In C. perfringens, air exposure is a significant stressor that causes cell lysis, and Acp (N-acetylglucosaminidase) is known to be a major autolysin. To further facilitate C. perfringens research, a technology to prevent air-induced cell lysis must be developed. This study investigated the role of Acp in air-induced autolysis and explored potential inhibitors that would prevent cell lysis during experimental procedures. Morphological analyses confirmed that Acp functions as an autolysin in C. perfringens, as acpdeficient strains exhibited filamentous growth. The mutants exhibited negligible autolysis under air-exposure stress, confirming the involvement of Acp in the autolytic process. We also evaluated the effects of various divalent cations on Acp activity in vitro and identified Zn2+ as a potent inhibitor. Brief treatment with a Zn2+- containing buffer induced dose-dependent cell elongation and autolysis inhibition in C. perfringens. These findings demonstrate that simple Zn2+ treatment before experiments stabilizes C. perfringens cells, reducing autolysis under aerobic conditions and facilitating various biological studies, except morphological analyses.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 5","pages":"345-352"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Scleral Adjustment Method: A Novel Adjustable Suture Technique in Strabismus Surgery. 巩膜调整法的评价：斜视手术中一种新颖的可调节缝合技术。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-10-01 DOI: 10.18926/AMO/69434

Ichiro Hamasaki, Kiyo Shibata

{"title":"Evaluation of Scleral Adjustment Method: A Novel Adjustable Suture Technique in Strabismus Surgery.","authors":"Ichiro Hamasaki, Kiyo Shibata","doi":"10.18926/AMO/69434","DOIUrl":"https://doi.org/10.18926/AMO/69434","url":null,"abstract":"To determine whether passing a pole suture through the sclera at two points provides fixation comparable to that of a sliding noose, we measured the tensile strength of the suture‒sclera interface during simulated traction. In this in vitro study, three suture patterns were evaluated in porcine eyeballs, using 6-0 polyglycolic acid sutures. Patterns A (control), B (second suture pass perpendicular), and C (second suture pass in the same direction) were compared. The tensile strength of each pattern was measured 20 times using a KANON TK300CN, and the results were analyzed using the Kruskal‒Wallis test. Pattern A showed a tensile strength of 2±4 gram-force (gf) (range: 0-12). Pattern B showed 112±38 gf (range: 61-184). Pattern C showed 139±31 gf (range: 97-204). Patterns B and C had significantly higher tensile strengths than Pattern A (p<0.001). Although Pattern C was not significantly different from Pattern B (p=0.363), it exhibited the highest tensile strength. Lifting the suture between the first and second suture passes allows for an adjustable suture length, suggesting that adjustability can be achieved using only the sclera. This scleral adjustment method with a second suture pass offers a durable means of securing extraocular muscles and may represent a valuable addition to adjustable suturing techniques.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 5","pages":"339-343"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status of Extracorporeal Membrane Oxygenation as a Treatment Strategy for Primary Graft Dysfunction after Lung Transplantation. 体外膜氧合治疗肺移植术后原发性移植物功能障碍的现状。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-10-01 DOI: 10.18926/AMO/69433

Kei Matsubara, Kentaroh Miyoshi, Shinichi Toyooka

引用次数: 0

Comparison of Extraocular Muscles in Patients with Exotropia and Healthy Participants Using Anterior Segment Optical Coherence Tomography. 前段光学相干断层扫描对外斜视患者和健康人眼外肌的比较

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-10-01 DOI: 10.18926/AMO/69436

Yuki Chihara, Ichiro Hamasaki, Kiyo Shibata, Shin Morisawa, Reika Kono, Keisuke Kanenaga, Yuki Morizane

{"title":"Comparison of Extraocular Muscles in Patients with Exotropia and Healthy Participants Using Anterior Segment Optical Coherence Tomography.","authors":"Yuki Chihara, Ichiro Hamasaki, Kiyo Shibata, Shin Morisawa, Reika Kono, Keisuke Kanenaga, Yuki Morizane","doi":"10.18926/AMO/69436","DOIUrl":"https://doi.org/10.18926/AMO/69436","url":null,"abstract":"To analyze and characterize the medial and lateral rectus muscles in patients with exotropia using anterior segment optical coherence tomography (AS-OCT). This study included 24 patients with exotropia (48 eyes) and 25 healthy individuals (50 eyes). Anterior segment optical coherence tomography was used to construct the en face images. The anterior chamber angle to the extraocular muscle insertion distance, muscle width, and muscle fiber angle from the muscle insertion sites were compared between the exotropia and the control groups. The correlation between these parameters and age or angle of deviation was evaluated. The mean ages were 13.2±4.1 years for the exotropia group and 17.6±7.2 years for the control group. The lateral rectus angle was significantly more inwardly rotated in the exotropia group than in the control group (1.6±6.3°, -1.4±4.0°, p=0.014). With increasing angle of deviation, the width of the lateral rectus increased (p=0.002). Our results indicate that the lateral rectus angle is significantly more inwardly rotated in patients with exotropia. These findings should contribute to a deeper understanding of the extraocular muscles in patients with this condition.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 5","pages":"353-358"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein-Barr Virus-Associated Early Gastric Carcinoma with Lymphoid Stroma Mimicking a Submucosal Tumor: A Typical Case Diagnosed by Endoscopic Resection and Treated by Local Resection with Sentinel Node Navigation. eb病毒相关性早期胃癌伴淋巴样间质模拟粘膜下肿瘤：经内镜切除诊断并局部切除前哨淋巴结导航治疗的典型病例

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-10-01 DOI: 10.18926/AMO/69442

Hiroshi Isozaki, Sasau Matsumoto, Takehiro Takama, Yuka Isozaki, Shigeki Murakami

{"title":"Epstein-Barr Virus-Associated Early Gastric Carcinoma with Lymphoid Stroma Mimicking a Submucosal Tumor: A Typical Case Diagnosed by Endoscopic Resection and Treated by Local Resection with Sentinel Node Navigation.","authors":"Hiroshi Isozaki, Sasau Matsumoto, Takehiro Takama, Yuka Isozaki, Shigeki Murakami","doi":"10.18926/AMO/69442","DOIUrl":"https://doi.org/10.18926/AMO/69442","url":null,"abstract":"Gastric cancer with lymphoid stroma (GCLS) accounts for 1%-7% of gastric cancers; ~80% are Epstein-Barr virus (EBV)-positive. The rate of lymph node metastasis is relatively low, even when an early GCLS has invaded the submucosa. We report an early GCLS with massive submucosal invasion mimicking a submucosal tumor (SMT), diagnosed by endoscopic submucosal resection (ESD) and treated with local resection and sentinel node navigation surgery (SNNS). The patient was a 40-year-old Japanese man. A protruding lesion on the greater curvature of the middle part of his stomach was detected by X-ray, and an endoscopic examination revealed a 2.5-cm protruding tumor covered with a normal mucosa and small ulcers at the apex. ESD was performed for a diagnosis. The pathological diagnosis was lymphoepithelioma-like gastric cancer (GCLS), pT1b(SM2), Ly0, V0, pHM1, pVM1. EBV infection in the cancer cells was confirmed pathologically by EBV-encoded RNA. The local resection was performed using SNNS. The patient has had no recurrence or post-gastrectomy syndrome 4 years postsurgery. EBV-associated early GCLS resembling an SMT is relatively rare, and clinicians need to be aware of this disease. Local resection using SNNS may be a surgical option for GCLS cases with a low rate of lymphatic metastasis.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 5","pages":"399-404"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral and Global Femoral Offset, but not Anteroposterior Offset, to Improve Postoperative Outcomes Following Total Hip Arthroplasty: Considerations Independent of the Contralateral Side. 股骨和全股偏置，而不是前后位偏置，改善全髋关节置换术后的术后结果：独立于对侧的考虑。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69152

Norio Imai, Yuki Hirano, Daisuke Homma, Yuki Endo, Yoji Horigome, Hayato Suzuki, Hiroyuki Kawashima

{"title":"Femoral and Global Femoral Offset, but not Anteroposterior Offset, to Improve Postoperative Outcomes Following Total Hip Arthroplasty: Considerations Independent of the Contralateral Side.","authors":"Norio Imai, Yuki Hirano, Daisuke Homma, Yuki Endo, Yoji Horigome, Hayato Suzuki, Hiroyuki Kawashima","doi":"10.18926/AMO/69152","DOIUrl":"https://doi.org/10.18926/AMO/69152","url":null,"abstract":"The global femoral offset (the sum of the acetabular and femoral offsets) influences outcomes after total hip arthroplasty (THA). The optimal offset using plain radiographs has been reported, but internal and external rotations of the hip affect the offset value, producing unclear results when the nonsurgical side is not intact. We investigated the relationship between a functional hip score, i.e., the Harris Hip Score (HHS) and its effect on the post-THA anteroposterior and lateral offsets, and we sought to identify the optimal offset value. The cases of 158 patients with hemilateral hip osteoarthritis who underwent THA at a single center were retrospectively analyzed in this cross-sectional study. Three-dimensional pelvic and femoral models generated from computed tomography were used to examine several parameters, and the results revealed a significant binomial correlation among the modified HHS and femoral and global femoral offsets, with maximum values of 21.3 mm and 40 mm/100 cm body height, respectively. Pelvic and femoral parameters were measured and evaluated via alignment with a specific coordinate system. Our findings indicate that preoperative planning using these parameters may improve postoperative hip function, even when the nonoperative side is unsuitable for use as a reference, as in bilateral hip osteoarthritis cases.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"269-278"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Survival Following Extended Cholecystectomy for Synchronous Gallbladder and Regional Lymph Node Metastasis of Lung Adenocarcinoma, with Subsequent Pulmonary Lobectomy. 同时性胆囊和区域淋巴结转移的肺腺癌延长胆囊切除术后的长期生存率，随后的肺叶切除术。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69153

Mao Yoshikawa, Hiroyuki Tao

引用次数: 0

Mimicking Contralateral Pneumothorax during Thoracoscopic Bullectomy Associated with Intraoperative Hyperinflation of a Large Bulla in an Obese Patient. 1例肥胖患者胸腔镜大球切除术中对侧气胸伴术中大球过度膨胀。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69159

Kei Matsubara, Yuho Maki, Yutaka Hirano, Toshiya Fujiwara

引用次数: 0

Parieto-Occipital Disconnection for Drug-Resistant Parieto-Occipital Lobe Epilepsy: A Case Report and Surgical Technique. 耐药顶枕叶癫痫的顶枕分离：1例报告及手术技术。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69155

Shun Tanimoto, Tatsuya Sasaki, Koji Kawai, Tomoya Saijo, Kyohei Kin, Susumu Sasada, Shota Tanaka

{"title":"Parieto-Occipital Disconnection for Drug-Resistant Parieto-Occipital Lobe Epilepsy: A Case Report and Surgical Technique.","authors":"Shun Tanimoto, Tatsuya Sasaki, Koji Kawai, Tomoya Saijo, Kyohei Kin, Susumu Sasada, Shota Tanaka","doi":"10.18926/AMO/69155","DOIUrl":"https://doi.org/10.18926/AMO/69155","url":null,"abstract":"We report a case of drug-resistant parieto-occipital lobe epilepsy successfully treated with parieto-occipital disconnection (POD). An 18-year-old left-handed female, who had undergone surgery for an acute subdural hematoma at 10 months of age, developed drug-resistant epilepsy at age 15. Despite antiepileptic drug treatment, her seizures remained uncontrolled, and at age 18 she was referred to our hospital for evaluation. Magnetic resonance imaging (MRI) revealed atrophy in the left occipital and parietal lobes. Ictal electroencephalography (EEG) confirmed occipital onset of seizures without temporal lobe involvement. She had pre-existing homonymous hemianopsia. POD surgery was performed, carefully preserving the temporal lobe structures. Postoperatively, she experienced transient right-sided paresis, which fully resolved, and achieved complete seizure control at 3 years without memory loss. This case demonstrates that POD, a rare surgical approach, is a viable option for parieto-occipital lobe epilepsy, effectively controlling seizures while minimizing functional impairment in the absence of temporal lobe involvement.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"287-292"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior Uveitis Secondary to an Infected Postoperative Maxillary Cyst. 术后上颌囊肿感染继发于前葡萄膜炎。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69154

Yuta Imamura, Yusuke Shiode, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Hiroya Kindo, Tetsuro Morita, Aya Murai, Mizuo Ando, Yuki Morizane

引用次数: 0