Acta medica Okayama最新文献_第6页

Treatment of Tenosynovial Giant Cell Tumor of the Cervical Spine with Postoperative Anti-RANKL Antibody (Denosumab) Administration. 术后抗rankl抗体（Denosumab）治疗颈椎腱鞘巨细胞瘤。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-12-01 DOI: 10.18926/AMO/67877

Yuichi Hirata, Takayuki Nagase, Susumu Sasada, Yoshiyuki Ayada, Hayato Miyake, Chiaki Sugahara, Hidetaka Yamamoto, Yoshinao Oda, Takao Yasuhara, Shota Tanaka

引用次数: 0

Prognostic Efficacy of the Albumin Grade in Patients with Hepatocellular Carcinoma. 肝细胞癌患者白蛋白分级的预后效果

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67662

Yuichi Hirano, Kazuhiro Nouso, Kazuya Kariyama, Atsushi Hiraoka, Shohei Shiota, Akiko Wakuta, Satoshi Yasuda, Hidenori Toyoda, Kunihiko Tsuji, Takeshi Hatanaka, Satoru Kakizaki, Atsushi Naganuma, Toshifumi Tada, Ei Itobayashi, Toru Ishikawa, Noritomo Shimada, Koichi Takaguchi, Akemi Tsutsui, Takuya Nagano, Michitaka Imai, Shinichiro Nakamura, Takashi Kumada

{"title":"Prognostic Efficacy of the Albumin Grade in Patients with Hepatocellular Carcinoma.","authors":"Yuichi Hirano, Kazuhiro Nouso, Kazuya Kariyama, Atsushi Hiraoka, Shohei Shiota, Akiko Wakuta, Satoshi Yasuda, Hidenori Toyoda, Kunihiko Tsuji, Takeshi Hatanaka, Satoru Kakizaki, Atsushi Naganuma, Toshifumi Tada, Ei Itobayashi, Toru Ishikawa, Noritomo Shimada, Koichi Takaguchi, Akemi Tsutsui, Takuya Nagano, Michitaka Imai, Shinichiro Nakamura, Takashi Kumada","doi":"10.18926/AMO/67662","DOIUrl":"10.18926/AMO/67662","url":null,"abstract":"We previously found that \"albumin grade\", formerly called the \"ALBS grade,\" demonstrated significant capability for prognostic stratification in hepatocellular carcinoma (HCC) patients treated with lenvatinib. The purpose of the present study was to compare the performance of the albumin grade with that of the modified albumin-bilirubin (mALBI) grade in predicting overall survival of HCC patients with different BCLC stages and treatment types. We enrolled 7,645 Japanese patients newly diagnosed with HCC using the Akaike information criteria (AIC), likelihood ratio, and C-index in different Barcelona Clinic Liver Cancer (BCLC) stages and treatments. The albumin grade showed similar and slightly better performance than the mALBI grade for BCLC stage 0 and A and especially for patients who underwent curative surgery and ablation. In patients treated with transcatheter arterial chemoembolization, molecular targeted agents, and the best supportive care, the mALBI grade had better performance than the albumin grade. However, the differences of the indices were very small in all scenarios. Overall, the albumin grade was comparable in efficacy to the mALBI grade, showing particular benefit for patients with early-stage HCC.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"377-386"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Radon Inhalation on Murine Brain Proteins: Investigation Using Proteomic and Multivariate Analyses. 吸入氡对小鼠脑蛋白质的影响：利用蛋白质组学和多元分析进行研究

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67663

Shota Naoe, Ayumi Tanaka, Norie Kanzaki, Reiju Takenaka, Akihiro Sakoda, Takaaki Miyaji, Kiyonori Yamaoka, Takahiro Kataoka

{"title":"Effect of Radon Inhalation on Murine Brain Proteins: Investigation Using Proteomic and Multivariate Analyses.","authors":"Shota Naoe, Ayumi Tanaka, Norie Kanzaki, Reiju Takenaka, Akihiro Sakoda, Takaaki Miyaji, Kiyonori Yamaoka, Takahiro Kataoka","doi":"10.18926/AMO/67663","DOIUrl":"10.18926/AMO/67663","url":null,"abstract":"Radon is a known risk factor for lung cancer; however, it can be used beneficially, such as in radon therapy. We have previously reported the enhancement of antioxidant effects associated with trace amounts of oxidative stress as one of the positive biological effects of radon inhalation. However, the biological effects of radon inhalation are incompletely understood, and more detailed and comprehensive studies are required. Although several studies have used proteomics to investigate the effects of radon inhalation on body proteins, none has focused on brain proteins. In this study, we evaluated the expression status of proteins in murine brains using proteomic and multivariate analyses to identify those whose expressions changed following two days of radon inhalation at a concentration of 1,500 Bq/m3. We found associations of radon inhalation with the expressions of seven proteins related to neurotransmission and heat shock. These proteins may be proposed as biomarkers indicative of radon inhalation. Although further studies are required to obtain the detailed biological significance of these protein alterations, this study contributes to the elucidation of the biological effects of radon inhalation as a low-dose radiation.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"387-399"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occult Nesidioblastosis Detected by 111In-Pentetreotide Single-Photon Emission Computed Tomography. 通过 111In-Pentetreotide 单光子发射计算机断层扫描发现的隐匿性网状母细胞增生症

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67667

Shinya Sakamoto, Motoyasu Tabuchi, Rika Yoshimatsu, Ai Hishida, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi

{"title":"Occult Nesidioblastosis Detected by 111In-Pentetreotide Single-Photon Emission Computed Tomography.","authors":"Shinya Sakamoto, Motoyasu Tabuchi, Rika Yoshimatsu, Ai Hishida, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi","doi":"10.18926/AMO/67667","DOIUrl":"https://doi.org/10.18926/AMO/67667","url":null,"abstract":"Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia, is usually observed in children and infants, although more recently adult-onset nesidioblastosis has also been described. We present a case of nesidioblastosis in a 78-year-old man that was detected by 111In-pentetreotide single photon emission computed tomography (SPECT/CT). The patient was transferred to our hospital's emergency department in a hypoglycemic coma. Dynamic enhanced CT could detect no lesion in the pancreas, but an 111In-pentetreotide SPECT/CT scan performed after a similar episode four weeks later showed increased focal uptake at the head of the pancreas. The results of a selective arterial calcium injection test were negative. After careful consideration and discussion among colleagues, surgical intervention was selected, and a pancreaticoduodenectomy was performed. On histology, there were elevated numbers of Langerhans islets in the pancreatic head, and the islets themselves appeared enlarged. Hypertrophic β-cells comprised the majority, but α-cells, δ-cells and pancreatic polypeptide were also detected in the islets. Based on the histopathological results and repeated hyperinsulinemic hypoglycemic crises, the patient was finally diagnosed with adult-onset nesidioblastosis. He had no hypoglycemic symptoms during outpatient follow-up examination. Since 111In-pentetreotide SPECT/CT may be able to detect nesidioblastosis, clinicians should consider this relatively new-modality examination when encountering such cases.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"423-428"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Report of Bickerstaff Brainstem Encephalitis Induced by Atezolizumab for Metastatic Breast Cancer. 阿特珠单抗治疗转移性乳腺癌诱发比克斯塔夫脑干脑炎的首次报道

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67665

Kyoko Shimoyama, Atsushi Nakajima, Yoshimitsu Minari

引用次数: 0

Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital. 冈山大学医院产碳青霉烯酶肠杆菌属分离菌的表型和遗传特征。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67657

Kazuyoshi Gotoh, Makoto Miyoshi, I Putu Bayu Mayura, Shuma Tsuji, Koji Iio, Shinnosuke Fukushima, Osamu Matsushita, Hideharu Hagiya

{"title":"Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital.","authors":"Kazuyoshi Gotoh, Makoto Miyoshi, I Putu Bayu Mayura, Shuma Tsuji, Koji Iio, Shinnosuke Fukushima, Osamu Matsushita, Hideharu Hagiya","doi":"10.18926/AMO/67657","DOIUrl":"10.18926/AMO/67657","url":null,"abstract":"Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"371-376"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focal Cerebral Hypoperfusion Detected by Arterial Spin-Labeled Magnetic Resonance Imaging in Patients with Migraine Presenting with Neurological Symptoms Concomitant with or without Headache. 通过动脉自旋标记磁共振成像检测伴有或不伴有头痛的偏头痛患者的神经症状的局部脑灌注不足。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67666

Kenichi Kashihara, Minoru Irisawa, Wataru Takao

引用次数: 0

Pediatric Severe Febrile Thrombocytopenia Syndrome: A Case Report and Literature Review. 小儿严重发热性血小板减少综合征：病例报告和文献综述。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67664

Yusuke Toyota, Kazuhiro Uda, Komei Shirabe, Tadashi Moriwake

引用次数: 0

Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis. 影响青少年特发性脊柱侧凸动态姿势控制能力的因素。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67655

Ryoko Yamawaki, Yoshiaki Oda, Shuhei Yamane, Koji Uotani, Haruo Misawa, Yoshimi Katayama, Masanori Hamada, Toshifumi Ozaki

引用次数: 0

Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan. 小于胎龄状态与川崎病风险：日本全国出生队列。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67656

Satoe Takanaga, Naomi Matsumoto, Tomoka Kadowaki, Soshi Takao, Takashi Yorifuji

{"title":"Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan.","authors":"Satoe Takanaga, Naomi Matsumoto, Tomoka Kadowaki, Soshi Takao, Takashi Yorifuji","doi":"10.18926/AMO/67656","DOIUrl":"https://doi.org/10.18926/AMO/67656","url":null,"abstract":"Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"363-370"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0