ACS ES&T engineering最新文献

{"title":"Advancing Bioflocculants for Sustainable Harmful Algal Bloom Control: Mechanisms, Applications, and Resource Valorization","authors":"Yang Yang,&nbsp;Cancan Jiang*,&nbsp;Xu Wang,&nbsp;Yawen Xie,&nbsp;Danhua Wang,&nbsp;Shengjun Xu and Xuliang Zhuang*,&nbsp;","doi":"10.1021/acsestengg.4c0075310.1021/acsestengg.4c00753","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00753https://doi.org/10.1021/acsestengg.4c00753","url":null,"abstract":"<p >Harmful algal blooms (HABs) are a growing global problem that endangers ecosystems and public health and urgently needs to be controlled. The use of microbial bioflocculants for bioflocculation is an emerging technology that rapidly aggregates algal cells through charge neutralization, adsorption bridging, and other mechanisms, all while preventing cell lysis. This method achieves algae removal, effectively mitigating harmful algal blooms and enabling the recovery of potential resources. This Review comprehensively analyzes recent advances in bioflocculant technology, focusing on flocculation mechanisms, influencing factors, and applications in HAB management and algal biomass harvesting. Strategies for enhancing bioflocculant performance, including modification, composite development, and optimization of production using low-cost substrates, are discussed. The valorization of harvested algal biomass through various pathways, such as bioenergy production, fertilizer generation, and high-value compound extraction, is explored, highlighting the potential for a circular bioeconomy approach. Current challenges in bioflocculant development and application are critically examined, including the need for mechanistic understanding, efficiency improvement, and cost reduction. Future research directions emphasize elucidating flocculation mechanisms, developing hyper-productive strains, advancing modification and composite techniques, and innovating algal biomass utilization methods. This Review aims to offer a timely assessment of bioflocculant technology’s current status and future prospects for sustainable HAB management and resource recovery. Its ultimate goal is to directly support ongoing initiatives in environmental protection and advance circular economy development.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"569–583 569–583"},"PeriodicalIF":7.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning Three-Electron Oxygen Reduction Pathway for •OH Production from O2: A Critical Review of Fundamental Principles, Catalyst/Electrode Development, and Application","authors":"Jingkun An,&nbsp;Yuyan Tang,&nbsp;Zhihong Ye,&nbsp;Xin Wang,&nbsp;Yujie Feng and Nan Li*,&nbsp;","doi":"10.1021/acsestengg.4c0079510.1021/acsestengg.4c00795","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00795https://doi.org/10.1021/acsestengg.4c00795","url":null,"abstract":"<p >The oxygen reduction reaction (ORR) has been widely studied and applied in various fields. Traditionally, the ORR could be classified into a two-electron pathway with hydrogen peroxide (H₂O₂) as the product and a four-electron pathway with water (H₂O) as the product. Recently, a three-electron pathway, namely, catalyzing O₂ directly into a hydroxyl radical (•OH), has attracted growing attention. Given the development prospects of this emerging reaction, this review focuses on the fundamental principles, catalytic material developments, and applications of the three-electron ORR-based Fenton (like) process. New insight into two/three/four-electron ORR based on proton/electron flow is illustrated, and the required features as well as electrode design strategy are summarized. Extensive discussions on the development and application of monometallic, polymetallic, and metal-free three-electron ORR electrodes are provided. The catalytic mechanisms involved in reactive oxygen species (ROSs) formation, structure–function relationship, and key active site transformation are presented. Finally, the challenges and future prospects of the three-electron ORR are discussed.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"584–606 584–606"},"PeriodicalIF":7.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Electrochemical Technologies for Water Treatment, Resource Recovery, and Sustainable Energy","authors":"Brian P. Chaplin*,&nbsp;","doi":"10.1021/acsestengg.5c0011110.1021/acsestengg.5c00111","DOIUrl":"https://doi.org/10.1021/acsestengg.5c00111https://doi.org/10.1021/acsestengg.5c00111","url":null,"abstract":"","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"566–568 566–568"},"PeriodicalIF":7.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulating Co and Pd Nanoparticles as Spatially Separated Dual Active Sites for Heterogeneous Persulfate Activation: Synergistic Catalysis and Switching of the Primary Reaction Pathway","authors":"Jaemin Choi,&nbsp;Dahye Min,&nbsp;Kali Rigby,&nbsp;Eun-Tae Yun,&nbsp;Jaesung Kim,&nbsp;Yae-Eun Kim,&nbsp;Yong-Yoon Ahn,&nbsp;Yunho Lee,&nbsp;Changha Lee,&nbsp;Eun-Ju Kim,&nbsp;Pedro J. J. Alvarez,&nbsp;Jae-Hong Kim and Jaesang Lee*,&nbsp;","doi":"10.1021/acsestengg.4c0066610.1021/acsestengg.4c00666","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00666https://doi.org/10.1021/acsestengg.4c00666","url":null,"abstract":"<p >This study demonstrates that the carbon encapsulation of Pd and Co as spatially isolated redox-active sites can synergistically enhance the activation of peroxymonosulfate (PMS) and peroxydisulfate (PDS) and enable persulfate precursor-sensitive degradation routes. The superiority of bimetal–carbon composites (i.e., Pd/Co@NC) was confirmed based on a higher efficiency of Pd/Co@NC with varying Pd/Co ratios for persulfate activation than the sum of efficiencies of single metal-component catalysts applied at corresponding dosages. Treatment performances of Pd/Co@NC with different metal compositions aligned with the dependence of electrical conductivity and binding affinity of Pd/Co@NC on the relative metal content. Reflecting differential reactivity of monometallic components toward persulfate, the primary degradation pathway was switched, depending on the persulfate type. Pd/Co@NC caused radical-induced oxidation upon PMS addition while initiating nonradical PDS activation through electron-transfer mediation, based on retarding effects of radical scavengers, reactivity toward multiple organics, Koutecký–Levich plots, electron paramagnetic spectral features, and product distribution. The fabrication strategy to enable the separate carbon encapsulation of two metallic sites with different catalytic reactivity created metal–carbon composites that retained the advantages of radical and nonradical persulfate activation under realistic treatment conditions; i.e., treatability of a wide spectrum of organics and minimal interference of background compounds in complex water matrices.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"756–771 756–771"},"PeriodicalIF":7.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Osmosis in an Advanced Water Treatment Train Produces a Simple, Consistent Microbial Community","authors":"Rose S. Kantor*,&nbsp;Lauren C. Kennedy,&nbsp;Scott E. Miller,&nbsp;Jorien Favere and Kara L. Nelson*,&nbsp;","doi":"10.1021/acsestengg.4c0066510.1021/acsestengg.4c00665","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00665https://doi.org/10.1021/acsestengg.4c00665","url":null,"abstract":"<p >Potable water reuse has become a key component of water sustainability planning in arid regions. Many advanced water purification facilities use reverse osmosis (RO) as part of treatment, including as a barrier for microorganisms; however, regrowth after RO treatment has been observed. Questions remain about the identity, source, and survival mechanisms of microorganisms in RO permeate, but the extremely low biomass of this water is a limitation for common microbiological methods. Here, we performed high-throughput sequencing on samples collected throughout a potable reuse train, including samples collected by filtering large volumes of RO permeate and biomass collected from RO membranes during an autopsy. We observed a stable, consistent microbial community across three months and in two parallel RO trains. RO permeate samples contained Burkholderiaceae at high relative abundance, including one <i>Aquabacterium</i> sp. that accounted for 29% of the community, on average. Like most other RO permeate microorganisms, this sequence was not seen in upstream samples and we suggest that biofilm growing on unit process infrastructure, rather than active treatment breakthrough, was the primary source. A metagenome-assembled genome corresponding to <i>Aquabacterium</i> sp. from RO permeate was found to lack most sugar-utilization pathways and to be able to consume low molecular weight organic molecules, potentially those that pass through RO.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"772–781 772–781"},"PeriodicalIF":7.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsestengg.4c00665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad Influence of Quorum Sensing in Environmental Biotechnology: From Mechanisms to Applications","authors":"Shunan Zhao,&nbsp;Yunong Dai,&nbsp;Ruikang Wang,&nbsp;Qianli Guo,&nbsp;Ge Song,&nbsp;Liuying Song,&nbsp;Jiyong Bian,&nbsp;Kai Zhao*,&nbsp;Ruiping Liu and Yu-You Li,&nbsp;","doi":"10.1021/acsestengg.4c0065710.1021/acsestengg.4c00657","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00657https://doi.org/10.1021/acsestengg.4c00657","url":null,"abstract":"<p >Quorum sensing (QS), a pivotal cell-to-cell communication mechanism in microbial communities, plays a significant role in regulating microbial behaviors such as biofilm formation and sludge granulation, which are critical for the efficiency of wastewater treatment systems. This review provides thorough insight into the QS pathway modulation, focusing on the utilization of signaling molecules, particularly N-acyl homoserine lactones (AHLs), to augment microbial aggregation and extracellular polymeric substance synthesis within wastewater biotreatment system. The strategic addition of exogenous AHLs has been demonstrated to significantly accelerate the granulation process in aerobic and anaerobic sludge, leading to the development of more stable and compact granules with enhanced settling velocity and nutrient removal efficiency. Furthermore, the QS pathway significantly impacts microbial community structure and function, with diverse signaling molecules forming a complex regulatory network that can be leveraged to improve the performance of biotechnological processes. In addition to enhancing the advantageous attributes of biofilms, researchers have also immersed themselves in the exploration of quorum quenching (QQ) strategies. These strategies are adeptly applied to disrupt QS pathways, thereby effectively managing membrane fouling within membrane bioreactors (MBRs). By employing QQ enzymes, synthetic analogs, and QQ bacterial strains, researchers present effective approaches to mitigate biofilm-related issues without adversely affecting the microbial treatment processes. The innovative use of immobilized QQ enzymes and the integration of QQ strains into the MBRs have shown promising results in reducing fouling and maintaining operational stability. This review highlights the dual potential of QS manipulation for both enhancing desirable microbial process and controlling detrimental ones. By providing a deeper understanding of the underlying mechanisms and practical applications for QS/QQ pathway, scholars would be expected to develop more efficient and sustainable environmental biotechnology solutions for wastewater treatment and beyond.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 2","pages":"284–302 284–302"},"PeriodicalIF":7.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Osmosis in an Advanced Water Treatment Train Produces a Simple, Consistent Microbial Community.","authors":"Rose S Kantor, Lauren C Kennedy, Scott E Miller, Jorien Favere, Kara L Nelson","doi":"10.1021/acsestengg.4c00665","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00665","url":null,"abstract":"<p><p>Potable water reuse has become a key component of water sustainability planning in arid regions. Many advanced water purification facilities use reverse osmosis (RO) as part of treatment, including as a barrier for microorganisms; however, regrowth after RO treatment has been observed. Questions remain about the identity, source, and survival mechanisms of microorganisms in RO permeate, but the extremely low biomass of this water is a limitation for common microbiological methods. Here, we performed high-throughput sequencing on samples collected throughout a potable reuse train, including samples collected by filtering large volumes of RO permeate and biomass collected from RO membranes during an autopsy. We observed a stable, consistent microbial community across three months and in two parallel RO trains. RO permeate samples contained Burkholderiaceae at high relative abundance, including one <i>Aquabacterium</i> sp. that accounted for 29% of the community, on average. Like most other RO permeate microorganisms, this sequence was not seen in upstream samples and we suggest that biofilm growing on unit process infrastructure, rather than active treatment breakthrough, was the primary source. A metagenome-assembled genome corresponding to <i>Aquabacterium</i> sp. from RO permeate was found to lack most sugar-utilization pathways and to be able to consume low molecular weight organic molecules, potentially those that pass through RO.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"772-781"},"PeriodicalIF":7.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Catalysis Approaches for Methane Utilization","authors":"Jedy Prameswari,&nbsp; and ,&nbsp;Yu-Chuan Lin*,&nbsp;","doi":"10.1021/acsestengg.4c0070010.1021/acsestengg.4c00700","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00700https://doi.org/10.1021/acsestengg.4c00700","url":null,"abstract":"<p >Methane, a potent greenhouse gas (GHG), has exhibited a persistent escalation in emissions from the energy sector. The imperative to mitigate these emissions has become paramount, and one promising avenue is the catalytic conversion of methane into diverse chemicals. This review focuses on the exploration of methane conversion into valuable compounds, including syngas, olefins, and methanol. As advancements in catalysis technology and studies have unfolded, numerous additional insights into the catalytic conversion of methane into novel and significant compounds have surfaced. This review provides an in-depth analysis, focusing predominantly on the latest advancements and cutting-edge innovations in catalytic methane conversion methodologies encompassing methane to acetonitrile and hydrogen cyanide conversion, selective methane conversion to formaldehyde, pyrolysis of methane into solid carbon and hydrogen, and the application of plasma-aided technology. Additionally, it endeavors to elucidate critical parameters and advantages and addresses the intricate array of limitations and future prospects such as theoretical calculations and artificial intelligence (AI)-aided catalyst design.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 2","pages":"325–343 325–343"},"PeriodicalIF":7.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsestengg.4c00700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Droplet Digital PCR Facilitates the Revelation of Metabolic Interactions Among Key Microorganisms in the Integrated Simultaneous Desulfurization and Denitrification Process","authors":"Qian Liu,&nbsp;Qi Zhou,&nbsp;Jie Chen,&nbsp;Shuang Gao,&nbsp;Suyun Sun,&nbsp;Yu Tao,&nbsp;Xiaodong Xin,&nbsp;Wei Li,&nbsp;Sihao Lv,&nbsp;Ai-jie Wang and Cong Huang*,&nbsp;","doi":"10.1021/acsestengg.4c0070110.1021/acsestengg.4c00701","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00701https://doi.org/10.1021/acsestengg.4c00701","url":null,"abstract":"<p >The integrated simultaneous desulfurization and denitrification (ISDD) process offers a viable solution for coremoval of sulfate and nitrate while recovering elemental sulfur. However, the metabolic interactions among the functional microorganisms involved in the bioconversion of carbon, nitrogen, and sulfur in this process remain poorly understood. In this study, a quantitative framework was established to measure the absolute abundances of individual bacterial and archaeal taxa by integrating the precision of droplet digital PCR with the high-throughput 16S rRNA gene amplicon sequencing. Quantitative measurements of absolute abundances identified the dominant species as COD/sulfate ratio varied from 1 to 3 and then back to 1. As the COD/sulfate ratio increased from 1 to 3, sulfate removal efficiency improved from 57.67% to 94.69%, accompanied by increased hydrogen and methane production. <i>Desulfobulbus</i> exhibited a competitive advantage in facilitating metabolite transfer and enhancing methane production efficiency. Furthermore, higher influent COD upregulated <i>apr</i>, <i>omcS</i>, and <i>nirK</i> genes, while downregulating the <i>sqr</i> gene. Five pairs of electron-shuttling systems among <i>Methanobacterium</i>, <i>Methanosaeta</i>, <i>Anaerolineaceae</i>, <i>Desulfobulbus</i> and <i>Sulfurovum</i> were explained through structural equation modeling (SEM). These findings offer valuable insights into microbial interactions that could enhance ISDD system performance.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"816–827 816–827"},"PeriodicalIF":7.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Impact of Halogen Ions on the Oxidative Dynamics and Halogenated Byproduct Transformation in the Ferrate(VI)-Periodate Combined System","authors":"Xin-Jia Chen,&nbsp;Chang-Wei Bai,&nbsp;Pi-Jun Duan,&nbsp;Zhi-Quan Zhang and Fei Chen*,&nbsp;","doi":"10.1021/acsestengg.4c0062910.1021/acsestengg.4c00629","DOIUrl":"https://doi.org/10.1021/acsestengg.4c00629https://doi.org/10.1021/acsestengg.4c00629","url":null,"abstract":"<p >Ferrate (Fe(VI)) and periodate (PI) are powerful oxidizing agents that have emerged as significant contributors to advanced wastewater treatment methods. Their synergistic interaction has been recognized for its enhanced oxidative capabilities. However, the presence of organic and inorganic ions, particularly halide ions such as chloride (Cl^–), bromide (Br^–), and iodide (I^–), can significantly influence oxidation kinetics and the transformation of organic pollutants. This study systematically investigated the oxidation mechanisms of the Fe(VI)–PI system and its performance in the presence of these halide ions. Dynamic experiments showed that halide ions markedly affected the activity of the Fe(VI)–PI system. Specifically, in the presence of Cl^–, the degradation efficiency of sulfamethoxazole (SMX) increased by 4.8% at pH 7.0 and 22.2% at pH 8.0. Similarly, Br^– enhanced the degradation efficiency by 12.5% at pH 7.0 and 26.2% at pH 8.0. In contrast, I^– completely inhibited the degradation process, likely due to their interaction with the oxidant. Additional removal experiments, detection tests, and electron spin resonance (ESR) analyses revealed that introducing halide ions significantly altered the composition of reactive species. Cl^– and Br^– promoted the formation of ^•OH and facilitated the reduction of Fe(VI) to Fe(IV)/Fe(V) species. This effect was strongly dependent on pH, which in turn influenced the degradation pathway. Product analysis and toxicity assessments further indicated that halide ions might lead to the formation of halogenated byproducts in the Fe(VI)–PI system, with pH playing a crucial role in regulating this process. This study provides a deeper understanding of the influence of halide ions on oxidation reactions and highlights their role in controlling the degradation of micropollutants and the formation of disinfection byproducts in water treatment.</p>","PeriodicalId":7008,"journal":{"name":"ACS ES&T engineering","volume":"5 3","pages":"666–677 666–677"},"PeriodicalIF":7.4,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}