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ACTA Pharmaceutica Sciencia最新文献

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Cytotoxic effect of some furanosesquiterpenes from balsamodendron myrrha nees. oleo-gum-resin on brine shrimp (artemia salina) larvae ayesha asif1, 苦瓜中呋喃半萜的细胞毒作用。油胶树脂对盐虾(artemia salina)幼虫的影响
ACTA Pharmaceutica Sciencia Pub Date : 2020-01-01 DOI: 10.23893/1307-2080.aps.05824
A. Asif, M. Saeed
{"title":"Cytotoxic effect of some furanosesquiterpenes from balsamodendron myrrha nees. oleo-gum-resin on brine shrimp (artemia salina) larvae ayesha asif1,","authors":"A. Asif, M. Saeed","doi":"10.23893/1307-2080.aps.05824","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05824","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the diabetic patients" knowledge on diabetes and the role of clinical pharmacist in providing pharmaceutical care to them 糖尿病患者糖尿病知识知晓情况及临床药师在为其提供药学服务中的作用调查
ACTA Pharmaceutica Sciencia Pub Date : 2020-01-01 DOI: 10.23893/1307-2080.aps.05827
N. Taner, M. E. Tatlıpınar, A. Aydın, G. Omurtag
{"title":"Investigation of the diabetic patients\" knowledge on diabetes and the role of clinical pharmacist in providing pharmaceutical care to them","authors":"N. Taner, M. E. Tatlıpınar, A. Aydın, G. Omurtag","doi":"10.23893/1307-2080.aps.05827","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05827","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular drug design and docking study of novel n- substituted celecoxib derivatives as selective cyclooxygenase-2 inhibitors 新型n取代塞来昔布衍生物选择性环氧化酶-2抑制剂的分子药物设计与对接研究
ACTA Pharmaceutica Sciencia Pub Date : 2020-01-01 DOI: 10.23893/1307-2080.aps.05823
M. Ezzat, B. A. Razik
{"title":"Molecular drug design and docking study of novel n- substituted celecoxib derivatives as selective cyclooxygenase-2 inhibitors","authors":"M. Ezzat, B. A. Razik","doi":"10.23893/1307-2080.aps.05823","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05823","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Protective effect of trichilia monadelpha (tm) thonn j.j. de wilde in trinitrobenzene sulfonic acid induced colitis in rats 三硝基苯磺酸致大鼠结肠炎的保护作用
ACTA Pharmaceutica Sciencia Pub Date : 2020-01-01 DOI: 10.23893/1307-2080.aps.05825
O. Abiodun, Fisayo Ogunleye, Elohor Ben-upaka
{"title":"Protective effect of trichilia monadelpha (tm) thonn j.j. de wilde in trinitrobenzene sulfonic acid induced colitis in rats","authors":"O. Abiodun, Fisayo Ogunleye, Elohor Ben-upaka","doi":"10.23893/1307-2080.aps.05825","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05825","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Determination amount of silymarin and pharmaceutical products from milk thistle waste obtained from cold press 冷压水飞蓟废液中水飞蓟素及其制品含量的测定
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05706
Derya Duran, S. Ötleş, E. Karasulu
{"title":"Determination amount of silymarin and pharmaceutical products from milk thistle waste obtained from cold press","authors":"Derya Duran, S. Ötleş, E. Karasulu","doi":"10.23893/1307-2080.aps.05706","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05706","url":null,"abstract":"Silybum marianum (L.) Gaertn (synonym Carduus marianus L.) is known as milk thistle. It belongs to Asteraceae family. It originates from the Mediterranean area. However, it has spread to other countries in Europe, Asia, Australia and both Americas1. The primary content of S. marianum is the presence of a group of flavonolignans known as silymarin in the pericarp and seed coat 2. The rate of flavonolignans is usually between 1.5% and 3.5% of the fruit weight1. Silymarin consists of silybin, isosilybin, silydianin, silychristin, isosilychrystin and isosilybinin1.3. Since among flavonolignan compounds silybin has detoxificationing ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Formulation and evaluation of acetylsalicylic acid suppositories using capra hircus (goat) fat and its binary blends 山羊脂肪及其二元共混物乙酰水杨酸栓剂的研制与评价
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05725
O. Aremu, John Paul Adjuzie, O. Olayemi, J. E. Okoh, K. Ekere, O. Fatokun, M. Emeje
{"title":"Formulation and evaluation of acetylsalicylic acid suppositories using capra hircus (goat) fat and its binary blends","authors":"O. Aremu, John Paul Adjuzie, O. Olayemi, J. E. Okoh, K. Ekere, O. Fatokun, M. Emeje","doi":"10.23893/1307-2080.aps.05725","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05725","url":null,"abstract":"A study has been made on the formulation and evaluation of Acetylsalicylic acid (ASA) suppositories using Goat fat (GF) and its binary blends with Palm Kernel oil and Liquid Paraffin. Cocoa butter was used as the standard reference suppository base. Rectal suppositories containing ASA (300 mg) in pre-calibrated mould were prepared by fusion method and evaluated for appearance, crushing strength, weight variation, melting point, liquefaction time, content uniformity and in-vitro release using standard procedures. Liquefaction or disintegration time (minutes) followed this order: ACB(4.40±0.84) <AGL(6.20±0.83) <AGP(7.14±0.84) < AGF(11.45±2.20) while cumulative drug release (%) is AGP> AGF >AGL>ACB (p<0.05). Results obtained indicated that the bases used generally could be ranked in the order of GL > GP > GF > CB (p<0.05) in terms of favourable physicochemical properties investigated. The foregoing indicates that GL or GP has promising potential and could be a substitute suppository base in the formulation of ASA suppositories.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Flax seed mucilage-chitosan polyelectrolyte complex nanoparticles: optimization, characterization and evaluation 亚麻籽黏液-壳聚糖聚电解质复合纳米颗粒:优化、表征和评价
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05716
M. Bhatia, Sunidhi Lohan
{"title":"Flax seed mucilage-chitosan polyelectrolyte complex nanoparticles: optimization, characterization and evaluation","authors":"M. Bhatia, Sunidhi Lohan","doi":"10.23893/1307-2080.aps.05716","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05716","url":null,"abstract":"Flax (Linum usitatissimum), also known as common flax or linseed consists of the dried fully ripe seeds of the genus Linum belonging to family Linaceae 1. Chemically, it contains d-galacturonic acid, l-rhamnose, l-galactose, and dxylose. It is gluten free and also rich in omega-3, omega-6, α-linolenic acid, lignans, high quality proteins and fibers. The flax seed mucilage has been widely ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Development and validation of uplc method for the determination of olopatadine hydrochloride in polymeric nanoparticles 高效液相色谱法测定纳米聚合物中盐酸奥洛他定含量的建立与验证
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05701
U. Güven, M. Berkman, Y. Yazan
{"title":"Development and validation of uplc method for the determination of olopatadine hydrochloride in polymeric nanoparticles","authors":"U. Güven, M. Berkman, Y. Yazan","doi":"10.23893/1307-2080.aps.05701","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05701","url":null,"abstract":"The conventional eye drops are the most convenient and patient compliant non-invasive route for topical ophthalmic drug delivery. Nasolachrymal drainage, epithelial membrane barriers and non-productive absorption of these ophthalmic preparations can result in poor ocular bioavailability and systemic absorption leading side effects. The limited duration time requires frequently dosing up to 4 times per day for many treatments 1. The active ingredient can ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form 分光光度法测定散装和片剂异烟肼的两种新方法
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05721
O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho
{"title":"Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form","authors":"O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho","doi":"10.23893/1307-2080.APS.05721","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05721","url":null,"abstract":"To develop two new spectrophotometric methods for the analysis of isoniazid in bulk form and tablets. The methods involved condensation of isoniazid with salicylaldehyde and diazo coupling with diazotized p-nitroaniline. Critical factors were optimised; evidence for new product formation, selection of analytical wavelengths, temperature and time and solvent for dilution. Validation was carried out according to ICH guidelines. The new methods were used for isoniazid tablets. Isoniazid formed an imine and azo adduct readily with the two reagents at 30 0C after 5 and 20 mins, and determined at 405 and 420 nm, respectively. Low LODs were obtained for the two methods and recoveries were generally above 98%. The methods were successfully adopted for the assay of isoniazid in tablets and there were no significant differences in the contents when compared with the official titrimetric method of analysis. The methods could find application as in-process method in pharmaceutical industries.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats 白化大鼠抗炎降糖作用的研究
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05726
Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi
{"title":"Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats","authors":"Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi","doi":"10.23893/1307-2080.aps.05726","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05726","url":null,"abstract":"Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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