Development and validation of uplc method for the determination of olopatadine hydrochloride in polymeric nanoparticles

Q3 Pharmacology, Toxicology and Pharmaceutics

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI:10.23893/1307-2080.aps.05701

U. Güven, M. Berkman, Y. Yazan

引用次数: 2

Abstract

The conventional eye drops are the most convenient and patient compliant non-invasive route for topical ophthalmic drug delivery. Nasolachrymal drainage, epithelial membrane barriers and non-productive absorption of these ophthalmic preparations can result in poor ocular bioavailability and systemic absorption leading side effects. The limited duration time requires frequently dosing up to 4 times per day for many treatments 1. The active ingredient can ABSTRACT

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高效液相色谱法测定纳米聚合物中盐酸奥洛他定含量的建立与验证

常规滴眼液是眼部局部给药最方便、最符合患者要求的无创途径。鼻泪道引流、上皮膜屏障和这些眼科制剂的非生产性吸收可导致眼生物利用度差和全身吸收导致副作用。有限的持续时间需要经常给药，每天最多4次。有效成分可提取

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACTA Pharmaceutica Sciencia Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sciencia (Acta Pharm. Sci.), formerly known as Bulletin of Pharmacy and Acta Pharmaceutica Turcica is a peer-reviewed scientific journal publishing current research and reviews covering all fields of pharmaceutical sciences since 1953. The original studies accepted for publication must be unpublished work and should contain data that have not been published elsewhere as a whole or a part. The reviews must provide critical evaluation of the state of knowledge related with the subject. All manuscripts has to be written in clear and concise English. Starting from 2016, the journal will be issued quarterly both in paper and on-line formates also publish special issues for national or international scientific meetings and activities in the coverage field.