山羊脂肪及其二元共混物乙酰水杨酸栓剂的研制与评价

Q3 Pharmacology, Toxicology and Pharmaceutics

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI:10.23893/1307-2080.aps.05725

O. Aremu, John Paul Adjuzie, O. Olayemi, J. E. Okoh, K. Ekere, O. Fatokun, M. Emeje

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引用次数: 1

摘要

研究了山羊脂(GF)及其与棕榈仁油和液体石蜡二元共混物的乙酰水杨酸(ASA)栓剂的配方及性能评价。以可可脂为标准参考栓底。采用熔融法制备含ASA (300 mg)的直肠栓剂，采用标准程序对其外观、抗压强度、重量变化、熔点、液化时间、含量均匀性和体外释放度进行评价。液化或解体时间(分钟)顺序为:ACB(4.40±0.84)AGF >AGL>ACB (p GP > GF > CB(p<0.05)。上述结果表明，GL或GP具有良好的潜力，可作为ASA栓剂制剂中的替代栓剂碱。

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Formulation and evaluation of acetylsalicylic acid suppositories using capra hircus (goat) fat and its binary blends

A study has been made on the formulation and evaluation of Acetylsalicylic acid (ASA) suppositories using Goat fat (GF) and its binary blends with Palm Kernel oil and Liquid Paraffin. Cocoa butter was used as the standard reference suppository base. Rectal suppositories containing ASA (300 mg) in pre-calibrated mould were prepared by fusion method and evaluated for appearance, crushing strength, weight variation, melting point, liquefaction time, content uniformity and in-vitro release using standard procedures. Liquefaction or disintegration time (minutes) followed this order: ACB(4.40±0.84) AGF >AGL>ACB (p<0.05). Results obtained indicated that the bases used generally could be ranked in the order of GL > GP > GF > CB (p<0.05) in terms of favourable physicochemical properties investigated. The foregoing indicates that GL or GP has promising potential and could be a substitute suppository base in the formulation of ASA suppositories.

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来源期刊

ACTA Pharmaceutica Sciencia Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sciencia (Acta Pharm. Sci.), formerly known as Bulletin of Pharmacy and Acta Pharmaceutica Turcica is a peer-reviewed scientific journal publishing current research and reviews covering all fields of pharmaceutical sciences since 1953. The original studies accepted for publication must be unpublished work and should contain data that have not been published elsewhere as a whole or a part. The reviews must provide critical evaluation of the state of knowledge related with the subject. All manuscripts has to be written in clear and concise English. Starting from 2016, the journal will be issued quarterly both in paper and on-line formates also publish special issues for national or international scientific meetings and activities in the coverage field.