ACTA Pharmaceutica Sciencia最新文献_第10页

A novel bioactive compounds of 2-azetidinone derived from pyrazin dicarboxylic acid: synthesis and antmicrobial screening 吡嗪二羧酸衍生的2-叠氮二酮活性化合物的合成及抑菌筛选

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05727

A. Ayyash, H. Q. A. Habeeb

{"title":"A novel bioactive compounds of 2-azetidinone derived from pyrazin dicarboxylic acid: synthesis and antmicrobial screening","authors":"A. Ayyash, H. Q. A. Habeeb","doi":"10.23893/1307-2080.aps.05727","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05727","url":null,"abstract":"A series of novel 2-azetidinons entitled N, N’-bis[3-chloro-2-oxo-4-(substituted pyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide and N,N’-bis[3,3-dichloro-2-oxo-4-(substitutedpyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide have been synthesized from the relating newly Schiff bases by [2+2] cycloaddition reaction in good yields. Starting with pyrazine-2,3-dicarboxylic acid which was converted to the corresponding diester in absolute ethanol and glacial acetic acid as a catalyst. After that, the hydazinolysis of resulted diester with hydrazine hydrate afforded dicarbohydrazide which further treated with different substituted pyridine-2-carbaldehyde to give new Schiff bases. These new Schiff bases were reacted with chloroacetochloride and (or) dichloroacetochloride in presence of trimethylamine in DMF solvent under reflux and stirring to yield new derivatives of titled compounds. The structural assignments were estimated from their spectroscopic analysis such as IR,1H NMR, 13C NMR, and C, H, N elemental analysis. The newly prepared 2-azetidinones have been screened for their antimicrobial activity and some of them revealed excellent antibacterial and antifungal activities.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide 与二氧化硅共加工的甘薯淀粉的材料、压缩和压片性能

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05722

L. Bakre, Damola Osibajo, G. Koiki, Oluyemisi Adebowale Bamiro

引用次数: 6

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri 从紫荆叶提取物中分离出两个具有抗疟活性的同源三萜

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05715

Wande M Oluyemi, B. Samuel, Kahlig Hans-peter, Taramelli Donatella, Krenn Liselotte

引用次数: 0

Dexketoprofen trometamol-loaded eudragitÂ® rl 100 nanoparticle formulation, characterization and release kinetics Dexketoprofen trometamol负载eudragitÂ®rl 100纳米颗粒配方，表征和释放动力学

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05705

A. A. Öztürk, E. Yenilmez, Y. Yazan

引用次数: 19

Estimation of natural radioactivity of some medicinal or herbal plants used in kars, turkey 土耳其卡尔斯一些药用或草本植物天然放射性的估计

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05729

G. B. Cengiz, I. Caglar

引用次数: 6

A study of drug-excipient interaction and drug product stability using dry (powder) film coating in comparison with conventional (aqueous) film coating 用干(粉末状)膜包衣与常规(水)膜包衣比较药物-赋形剂相互作用和药物稳定性

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05719

Derar Omari, Y. Akkam

引用次数: 0

Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization 尿苷衍生物的微生物功效及两步合成及光谱表征

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05704

S. R. Devi, Sanjida Jesmin, M. Rahman, M. A. Manchur, Y. Fujii, Y. Ozeki, S. Kawsar

{"title":"Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization","authors":"S. R. Devi, Sanjida Jesmin, M. Rahman, M. A. Manchur, Y. Fujii, Y. Ozeki, S. Kawsar","doi":"10.23893/1307-2080.APS.05704","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05704","url":null,"abstract":"Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The farreaching effects of pharmacological uridine have long been neglected. Here, we report a novel series of uridine esters were designed and synthesized by direct method with microbial efficacy. The structures of the prepared compounds have been characterized using various physico-chemical methods including C, H elemental analysis, melting point determination, IR and 1H-NMR spectroscopy. The synthesized uridine derivatives were subjected to in-vitro antibacterial screening using agar disc diffusion method on some clinically isolated Gram-positive and Gram-negative bacterial strains. Also, antifungal functionality test was performed against a number of plant pathogenic fungi. The compounds showed varied antibacterial and antifungal activities. In addition, cytotoxic activity showed different rate mortality with different concentrations. In conclusion, it may useful for antibacterial and antifungal active agents after investigating their further analysis to develop safer and more potent drugs in the future.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles 三取代2-哌嗪基噻唑的抗菌评价

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05707

B. Giray, L. Yurttaş, Z. Şahin, B. Berk, Ş. Demirayak

引用次数: 1

Preparation and in vitro characterization of a fluconazole loaded chitosan particulate system 负载氟康唑壳聚糖颗粒体系的制备及体外表征

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05713

Gülsel Yurtdaş Kırımlıoğlu, E. Yenilmez, E. Başaran, Y. Yazan

引用次数: 1

Pharmaceutical properties of marine polyphenols: an overview 海洋多酚的药理性质综述

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05714

V. Sang, Ngo Dai Hung, Kim Se-kwon

{"title":"Pharmaceutical properties of marine polyphenols: an overview","authors":"V. Sang, Ngo Dai Hung, Kim Se-kwon","doi":"10.23893/1307-2080.APS.05714","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05714","url":null,"abstract":"The marine environment represents approximately half of the global biodiversity. It is a rich source of structurally diverse and biologically active metabolites, which are important for the discovery of potential therapeutic agents1, 2. During the last decades, marine organisms have received much attention in screening marine natural products for their biomedical and pharmaceutical potentials3-5. Various marine organisms such as algae, tunicates, sponges, soft ABSTRACT Natural products are non-drug materials that have applied for prevention or treatment of health problem. The use of natural products as pharmaceutical ingredients has got much attention by consumers nowadays. Among them, marine organisms are currently considered as a huge source for the discovery of pharmaceutical agents. During the last decades, numerous novel agents have been achieved from marine organisms and many of them have potential application in pharmaceutical industry. Notably, marine algae are known to be one of the most important producers of variety of chemically active metabolites. Especially, phlorotannins, a polyphenol from brown algae, have been revealed to possess numerous biological activities such as UV-protective, anti-oxidant, anti-viral, anti-allergic, anti-cancer, anti-inflammatory, anti-diabetes, and anti-obesity activities. Therefore, phlorotannins are promising agents for development of pharmaceutical products. This contribution focuses on phlorotannins from brown algae and presents potential application in pharmaceutical field due to its biological activities and health benefit effects.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9