发布求助
文献互助 智能选刊 最新文献

ACTA Pharmaceutica Sciencia最新文献

筛选
英文 中文
Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form 分光光度法测定散装和片剂异烟肼的两种新方法
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05721
O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho
{"title":"Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form","authors":"O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho","doi":"10.23893/1307-2080.APS.05721","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05721","url":null,"abstract":"To develop two new spectrophotometric methods for the analysis of isoniazid in bulk form and tablets. The methods involved condensation of isoniazid with salicylaldehyde and diazo coupling with diazotized p-nitroaniline. Critical factors were optimised; evidence for new product formation, selection of analytical wavelengths, temperature and time and solvent for dilution. Validation was carried out according to ICH guidelines. The new methods were used for isoniazid tablets. Isoniazid formed an imine and azo adduct readily with the two reagents at 30 0C after 5 and 20 mins, and determined at 405 and 420 nm, respectively. Low LODs were obtained for the two methods and recoveries were generally above 98%. The methods were successfully adopted for the assay of isoniazid in tablets and there were no significant differences in the contents when compared with the official titrimetric method of analysis. The methods could find application as in-process method in pharmaceutical industries.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats 白化大鼠抗炎降糖作用的研究
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05726
Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi
{"title":"Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats","authors":"Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi","doi":"10.23893/1307-2080.aps.05726","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05726","url":null,"abstract":"Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A novel bioactive compounds of 2-azetidinone derived from pyrazin dicarboxylic acid: synthesis and antmicrobial screening 吡嗪二羧酸衍生的2-叠氮二酮活性化合物的合成及抑菌筛选
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05727
A. Ayyash, H. Q. A. Habeeb
{"title":"A novel bioactive compounds of 2-azetidinone derived from pyrazin dicarboxylic acid: synthesis and antmicrobial screening","authors":"A. Ayyash, H. Q. A. Habeeb","doi":"10.23893/1307-2080.aps.05727","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05727","url":null,"abstract":"A series of novel 2-azetidinons entitled N, N’-bis[3-chloro-2-oxo-4-(substituted pyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide and N,N’-bis[3,3-dichloro-2-oxo-4-(substitutedpyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide have been synthesized from the relating newly Schiff bases by [2+2] cycloaddition reaction in good yields. Starting with pyrazine-2,3-dicarboxylic acid which was converted to the corresponding diester in absolute ethanol and glacial acetic acid as a catalyst. After that, the hydazinolysis of resulted diester with hydrazine hydrate afforded dicarbohydrazide which further treated with different substituted pyridine-2-carbaldehyde to give new Schiff bases. These new Schiff bases were reacted with chloroacetochloride and (or) dichloroacetochloride in presence of trimethylamine in DMF solvent under reflux and stirring to yield new derivatives of titled compounds. The structural assignments were estimated from their spectroscopic analysis such as IR,1H NMR, 13C NMR, and C, H, N elemental analysis. The newly prepared 2-azetidinones have been screened for their antimicrobial activity and some of them revealed excellent antibacterial and antifungal activities.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide 与二氧化硅共加工的甘薯淀粉的材料、压缩和压片性能
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05722
L. Bakre, Damola Osibajo, G. Koiki, Oluyemisi Adebowale Bamiro
{"title":"Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide","authors":"L. Bakre, Damola Osibajo, G. Koiki, Oluyemisi Adebowale Bamiro","doi":"10.23893/1307-2080.aps.05722","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05722","url":null,"abstract":"This study aims to co-process native Ipomea batatas starch (NPS) with colloidal silicon dioxide and evaluate the properties of the co-processed excipient (CPS). The powder morphology was determined by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-Ray Diffraction (XRD) measurements. The compressional, mechanical and release properties of metronidazole tablet formulations were evaluated. NPS was predominantly oval in shape while CPS had more large truncated ellipsoidal granules. Both NPS and CPS exhibited spectra typical of a Type A XRD pattern, but CPS has a sharp peak with strong intensity at 270 2q which was absent in NPS. Although NPS had a faster onset of plastic deformation, the overall amount of plastic deformation was higher in CPS. Tablets formulated with CPS had faster dissolution than those containing similar concentration of NPS. The co-processing of Ipomea batatas starch with colloidal silicon dioxide resulted in modification of its powder and tableting properties.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri 从紫荆叶提取物中分离出两个具有抗疟活性的同源三萜
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05715
Wande M Oluyemi, B. Samuel, Kahlig Hans-peter, Taramelli Donatella, Krenn Liselotte
{"title":"Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri","authors":"Wande M Oluyemi, B. Samuel, Kahlig Hans-peter, Taramelli Donatella, Krenn Liselotte","doi":"10.23893/1307-2080.APS.05715","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05715","url":null,"abstract":"Combretum genus (Combretaceae) is used locally in the treatment of various diseases including malaria. Current study aimed to investigate the antiplasmodial activities of methanol extract of C. zenkeri in Plasmodium falciparum chloroquine sensitive (D10) and resistant (W2) strains and identify the bioactive principles. Repeated chromatographic separation was carried out on the chloroform fraction to afford the isolation of bioactive compounds which was characterized by application of spectroscopic techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR). Antiplasmodial activities of chloroform fraction (D10; IC50= 12.57±1.57 μg/mL and W2; IC50= 12.14±0.95 μg/mL) showed more activity than the n-butanol fraction (D10; IC50= 61.98±3.25 μg/mL and W2; IC50= 61.26±8.64 μg/mL). Phytochemical investigation of the extract afforded isolation of two triterpenes with antimalarial activities. This paper identified for the first time the antimalarial principles in C. zenkeri as ursolic and oleanolic acids; which justified the local use of the plant in the treatment of malaria.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexketoprofen trometamol-loaded eudragit® rl 100 nanoparticle formulation, characterization and release kinetics Dexketoprofen trometamol负载eudragit®rl 100纳米颗粒配方，表征和释放动力学
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05705
A. A. Öztürk, E. Yenilmez, Y. Yazan
{"title":"Dexketoprofen trometamol-loaded eudragit® rl 100 nanoparticle formulation, characterization and release kinetics","authors":"A. A. Öztürk, E. Yenilmez, Y. Yazan","doi":"10.23893/1307-2080.APS.05705","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05705","url":null,"abstract":"The particle size of the formulations was measured in the range of 475.5-798.7 nm. The droplet size distribution of the formulations was observed in the range of 0.349-0.395. These results showed that nanosized and monodispersed formulations were prepared. The drug content was found to be in the range of 35-38%. DT-loaded particles exhibited nanostructured and spherical shape. In vitro release studies showed extended release of DT. Release was found to fit Korsmeyer-Peppas kinetic model using DDSolver software program.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
A study of drug-excipient interaction and drug product stability using dry (powder) film coating in comparison with conventional (aqueous) film coating 用干(粉末状)膜包衣与常规(水)膜包衣比较药物-赋形剂相互作用和药物稳定性
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05719
Derar Omari, Y. Akkam
{"title":"A study of drug-excipient interaction and drug product stability using dry (powder) film coating in comparison with conventional (aqueous) film coating","authors":"Derar Omari, Y. Akkam","doi":"10.23893/1307-2080.aps.05719","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05719","url":null,"abstract":"Solid pharmaceutical dosage forms like tablets, capsules, granules, pellets etc. are coated for many purposes such as protection from moisture, light or oxygen; masking of odor or taste; acid resistance in gastric fluids; and to modify drug release from these dosage forms as controlled or delayed action. Traditionally, coating is carried out using either organic solution or aqueous solution or dispersion of certain polymers sprayed, after mixing with other substances ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of natural radioactivity of some medicinal or herbal plants used in kars, turkey 土耳其卡尔斯一些药用或草本植物天然放射性的估计
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.aps.05729
G. B. Cengiz, I. Caglar
{"title":"Estimation of natural radioactivity of some medicinal or herbal plants used in kars, turkey","authors":"G. B. Cengiz, I. Caglar","doi":"10.23893/1307-2080.aps.05729","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05729","url":null,"abstract":"In Natural radioactive materials may be existing in the environmental substances that have uses in pharmacy and medicine as health supplements. In this study, natural radionuclides such as 226Ra, 232Th, and 40K were measured in seven medicinal or herbal plants collected from the local market in Kars, Turkey were analysed. All samples were analysed by means of gamma-ray spectrometer using NaI(Tl) detector. The radioactivity concentrations were found to vary in the range of 16.39±2.2 to 32.76 ±3.5 Bqkg-1 for 226Ra, 19.74±3.7 to 85.01±5.6 Bqkg-1 for 232Th, and from 795.82±9.8 to 1056.28±14.4 Bqkg-1 for 40K. Rosehip showed the lowest activity concentrations of 226Ra, 232Th and 40K, while rumex patientia showed the highest activity concentration of 40K. In this research study, we aimed to determine the activity concentrations of radionuclides in medicinal plants and provide useful information to carry out a dose assessment to be exposed to people using medicinal plants for healing various diseases.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization 尿苷衍生物的微生物功效及两步合成及光谱表征
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05704
S. R. Devi, Sanjida Jesmin, M. Rahman, M. A. Manchur, Y. Fujii, Y. Ozeki, S. Kawsar
{"title":"Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization","authors":"S. R. Devi, Sanjida Jesmin, M. Rahman, M. A. Manchur, Y. Fujii, Y. Ozeki, S. Kawsar","doi":"10.23893/1307-2080.APS.05704","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05704","url":null,"abstract":"Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The farreaching effects of pharmacological uridine have long been neglected. Here, we report a novel series of uridine esters were designed and synthesized by direct method with microbial efficacy. The structures of the prepared compounds have been characterized using various physico-chemical methods including C, H elemental analysis, melting point determination, IR and 1H-NMR spectroscopy. The synthesized uridine derivatives were subjected to in-vitro antibacterial screening using agar disc diffusion method on some clinically isolated Gram-positive and Gram-negative bacterial strains. Also, antifungal functionality test was performed against a number of plant pathogenic fungi. The compounds showed varied antibacterial and antifungal activities. In addition, cytotoxic activity showed different rate mortality with different concentrations. In conclusion, it may useful for antibacterial and antifungal active agents after investigating their further analysis to develop safer and more potent drugs in the future.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles 三取代2-哌嗪基噻唑的抗菌评价
ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI: 10.23893/1307-2080.APS.05707
B. Giray, L. Yurttaş, Z. Şahin, B. Berk, Ş. Demirayak
{"title":"Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles","authors":"B. Giray, L. Yurttaş, Z. Şahin, B. Berk, Ş. Demirayak","doi":"10.23893/1307-2080.APS.05707","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05707","url":null,"abstract":"Bacterial resistance to the treatment of infectious diseases is the main problem. Many classes of antibiotics are facing resistance and have initiated new efforts to develop new derivatives and discover new chemical classes.1 Gram positive and gram-negative bacteria such as Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa etc. are responsible for many diverse infections which even can cause of death.2","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书