Dexketoprofen trometamol负载eudragitÂ®rl 100纳米颗粒配方，表征和释放动力学

Q3 Pharmacology, Toxicology and Pharmaceutics

ACTA Pharmaceutica Sciencia Pub Date : 2019-01-01 DOI:10.23893/1307-2080.APS.05705

A. A. Öztürk, E. Yenilmez, Y. Yazan

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引用次数: 19

摘要

测定了配方的粒径范围为475.5 ~ 798.7 nm。结果表明，该配方的滴度分布范围为0.349 ~ 0.395。结果表明，制备出了纳米级单分散配方。药物含量在35-38%之间。dt负载的颗粒呈现纳米结构和球形。体外释放研究显示DT有延长释放。利用DDSolver软件发现Release符合Korsmeyer-Peppas动力学模型。

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Dexketoprofen trometamol-loaded eudragitÂ® rl 100 nanoparticle formulation, characterization and release kinetics

The particle size of the formulations was measured in the range of 475.5-798.7 nm. The droplet size distribution of the formulations was observed in the range of 0.349-0.395. These results showed that nanosized and monodispersed formulations were prepared. The drug content was found to be in the range of 35-38%. DT-loaded particles exhibited nanostructured and spherical shape. In vitro release studies showed extended release of DT. Release was found to fit Korsmeyer-Peppas kinetic model using DDSolver software program.

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来源期刊

ACTA Pharmaceutica Sciencia Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sciencia (Acta Pharm. Sci.), formerly known as Bulletin of Pharmacy and Acta Pharmaceutica Turcica is a peer-reviewed scientific journal publishing current research and reviews covering all fields of pharmaceutical sciences since 1953. The original studies accepted for publication must be unpublished work and should contain data that have not been published elsewhere as a whole or a part. The reviews must provide critical evaluation of the state of knowledge related with the subject. All manuscripts has to be written in clear and concise English. Starting from 2016, the journal will be issued quarterly both in paper and on-line formates also publish special issues for national or international scientific meetings and activities in the coverage field.