Acta Chirurgica BelgicaPub Date : 2024-04-01Epub Date: 2023-05-26DOI: 10.1080/00015458.2023.2216377
Mehmet Ali Yeşiltaş, Ali Aycan Kavala, Saygin Turkyilmaz, Yusuf Kuserli, Gülsüm Türkyilmaz, Hasan Toz, Can Özen
{"title":"Surgical treatment of constrictive pericarditis at a single center: 10 years of experience.","authors":"Mehmet Ali Yeşiltaş, Ali Aycan Kavala, Saygin Turkyilmaz, Yusuf Kuserli, Gülsüm Türkyilmaz, Hasan Toz, Can Özen","doi":"10.1080/00015458.2023.2216377","DOIUrl":"10.1080/00015458.2023.2216377","url":null,"abstract":"<p><strong>Background: </strong>Constrictive pericarditis (CP) is a pericardial disease characterized by the pericardium becoming calcified or fibrotic as a result of chronic inflammation, which impairs diastolic filling by compressing the cardiac chambers. Pericardiectomy is a promising surgical option for treating CP. In this study, we reviewed over 10 years of preoperative, perioperative, and short-term postoperative follow-ups of patients who underwent pericardiectomy for constrictive pericarditis at our clinic.</p><p><strong>Methods: </strong>Between January 2012 and May 2022, 44 patients were diagnosed with constrictive pericarditis. Twenty-six patients underwent pericardiectomy for CP. Median sternotomy is the surgical approach of choice because it provides easy access for complete pericardiectomy.</p><p><strong>Results: </strong>The patient median age was 56 (min: 32, max: 71), and 22 out of 26 patients (84.6%) were male. Twenty-one patients (80.8%) complained of dyspnea, which was the most common reason for admission. Twenty-four patients (92.3%) were scheduled for elective surgery. Cardiopulmonary bypass (CPB) was used during the procedure in six patients (23%). The duration of intensive care stay was two days (min: 1, max: 11), and the total hospitalization was six days (min: 4, max: 21). No in-hospital mortality was observed.</p><p><strong>Conclusion: </strong>The median sternotomy approach provides a critical advantage in terms of performing a complete pericardiectomy. Although CP is a chronic condition, early diagnosis and planning of pericardiectomy before irreversible deterioration of cardiac function leads to a notable reduction in mortality and morbidity.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"107-113"},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-04-01Epub Date: 2023-05-09DOI: 10.1080/00015458.2023.2210699
Juliana Pereira-Macedo, Bárbara Freire, Carlos Macedo-Oliveira, João Mendes, Márcia Carvalho, João Rocha-Neves, Sofia Fonseca, Margarida Vinagreiro, Ricardo Lemos, Nair Silva, Francisco Sampaio
{"title":"Hyperfunctioning papillary thyroid carcinoma - a case report and literature review.","authors":"Juliana Pereira-Macedo, Bárbara Freire, Carlos Macedo-Oliveira, João Mendes, Márcia Carvalho, João Rocha-Neves, Sofia Fonseca, Margarida Vinagreiro, Ricardo Lemos, Nair Silva, Francisco Sampaio","doi":"10.1080/00015458.2023.2210699","DOIUrl":"10.1080/00015458.2023.2210699","url":null,"abstract":"<p><strong>Background: </strong>Malignant hyperfunctioning thyroid nodules are rare and more likely to occur in follicular cancer types rather than papillary variants. The authors present a case of a papillary thyroid carcinoma associated with a hyperfunctioning nodule.</p><p><strong>Methods: </strong>A single adult patient submitted to total thyroidectomy with the presence of thyroid carcinoma within hyperfunctioning nodules was selected. Additionally, brief literature was conducted.</p><p><strong>Results: </strong>An asymptomatic 58-year-old male was subjected to routine blood analysis and a TSH level of <0.003 mIU/L was found. Ultrasonography revealed a 21 mm solid, hypoechoic, and heterogenous nodule with microcalcifications in the right lobe. A fine needle aspiration guided by ultrasound resulted in a follicular lesion of undetermined significance. A <sup>99m</sup>Tc thyroid scintigram was followed and identified a right-sided hyperfunctioning nodule. Another cytology was performed and a papillary thyroid carcinoma was derived as a result. The patient underwent a total thyroidectomy. Postoperative histology confirmed the diagnosis and a tumor-free margin with no vascular or capsular invasions.</p><p><strong>Conclusion: </strong>Hyperfunctioning malignant nodules are a rare association, although a careful approach should be led since major clinical implications arise. Selective fine needle aspiration in all suspicious ≥1 cm nodules should be considered.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"147-152"},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9421962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-04-01Epub Date: 2023-03-27DOI: 10.1080/00015458.2023.2190289
Sylvain Liet, Mathilde Logeay, Emmanuel Besnier, Jean Selim, Gregory Wood, Jean-Jacques Tuech, Julien Coget, Vincent Compère, Emilie Occhiali, Benjamin Popoff, Thomas Clavier
{"title":"Effect of opioid-free anesthesia on post-operative period in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched study.","authors":"Sylvain Liet, Mathilde Logeay, Emmanuel Besnier, Jean Selim, Gregory Wood, Jean-Jacques Tuech, Julien Coget, Vincent Compère, Emilie Occhiali, Benjamin Popoff, Thomas Clavier","doi":"10.1080/00015458.2023.2190289","DOIUrl":"10.1080/00015458.2023.2190289","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pain after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is important. It appears essential to reduce postoperative pain and morphine consumption.</p><p><strong>Methods: </strong>Retrospective study in a university hospital comparing patient benefiting from CRS-HIPEC under opioid-free anesthesia (OFA; dexmedetomidine) to those anesthetized with opioid anesthesia (OA; remifentanil) using a propensity score matching method. The main objective was the impact of OFA on postoperative morphine consumption in the first 24 h after surgery.</p><p><strong>Results: </strong>102 patients were included, matching on the propensity score allowed selecting 34 unique pairs analyzed. Morphine consumption was lower in the OFA group than in the OA group (3.0 [0.00-11.0] mg/24 h <i>vs</i>. 13.0 [2.5-25.0] mg/24 h; <i>p</i> = 0.02). In multivariable analysis, OFA was associated with a reduction of 7.2 [0.5-13.9] mg of postoperative morphine (<i>p</i> = 0.04). The rate of renal failure with a KDIGO-score > 1 was lower in the OFA group than in the OA group (12% <i>vs</i>. 38%; <i>p</i> = 0.01). There was no difference between groups concerning length of surgery/anesthesia, norepinephrine infusion, volume of fluid therapy, post-operative complications, rehospitalization or ICU readmission within 90 days, mortality, and postoperative rehabilitation.</p><p><strong>Conclusion: </strong>Our results suggest that OFA for CRS-HIPEC patients appears safe and is associated with less postoperative morphine use and acute kidney injury.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"81-90"},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9229116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"'Carried away by a moonlight shadow' -<i>In memoriam</i> Prof. em. Dr. med. Paul L.O. Broos 1945-2023.","authors":"Carl De Crée","doi":"10.1080/00015458.2024.2320983","DOIUrl":"10.1080/00015458.2024.2320983","url":null,"abstract":"","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"1-5"},"PeriodicalIF":0.8,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139745805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-02-01Epub Date: 2023-01-03DOI: 10.1080/00015458.2022.2163957
Marco Parillo, Caterina Bernetti, Carlo Altomare, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi
{"title":"Extrahepatic abscess and dropped gallstones: a case report and a narrative review of an unusual delayed complication of laparoscopic cholecystectomy.","authors":"Marco Parillo, Caterina Bernetti, Carlo Altomare, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi","doi":"10.1080/00015458.2022.2163957","DOIUrl":"10.1080/00015458.2022.2163957","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic cholecystectomy is the most common minimally invasive abdominal surgery procedure performed in Western countries; it offers several advantages over laparotomy but still carries some risks, such as intraoperative spillage of bile and gallstones. Diagnosis of dropped gallstones could be challenging, it is frequently delayed, and this can lead to further complications such as abscesses formation.</p><p><strong>Methods: </strong>We report the history of a 51-year-old male with persistent dull abdominal pain in association to appetite loss, vomiting episodes and changes in regular bowel habits, a past medical history of laparoscopic cholecystectomy for biliary lithiasis (1.5 years earlier) and minimum elevation of inflammatory markers and gamma-GT values.</p><p><strong>Results: </strong>Ultrasound examination showed perihepatic stones and magnetic resonance imaging revealed the presence of multiple perihepatic abscesses, findings compatible with fibrotic-inflammatory phenomena from 'dropped gallstones'. A re-laparoscopy was then performed with an abscess collection containing multiple gallstones; a liver wedge resection was also required due to strong adhesions. At follow up, the patient had improved both on clinical and biochemical perspective.</p><p><strong>Conclusion: </strong>Dropped gallstones are an underreported cause of morbidity and diagnostic dilemmas in subjects who underwent to laparoscopic cholecystectomy, in relation to infectious complications that can occur even several months or years after surgery. Imaging represents a valuable aid in the correct non-invasive diagnostic process, but proper awareness of this insidious condition is necessary. Surgeons and radiologists should always consider this eventuality in the differential diagnosis of a patient presenting with abdominal abscesses and history of cholecystectomy.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"57-61"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10470618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-02-01Epub Date: 2023-03-13DOI: 10.1080/00015458.2023.2184939
Büşra Burcu, Nadir Adnan Hacım, Ozan Caliskan, Serdar Demirgan, Talar Vartanoglu Aktokmakyan, Serhat Meric, Tomris Duymaz, Onder Karabay, Ali Solmaz
{"title":"Impact of body weight-based dosing of palonosetron and ondansetron on postoperative nausea and vomiting following laparoscopic sleeve gastrectomy: a randomized, double-blind study.","authors":"Büşra Burcu, Nadir Adnan Hacım, Ozan Caliskan, Serdar Demirgan, Talar Vartanoglu Aktokmakyan, Serhat Meric, Tomris Duymaz, Onder Karabay, Ali Solmaz","doi":"10.1080/00015458.2023.2184939","DOIUrl":"10.1080/00015458.2023.2184939","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) is a frequent adverse effect following laparoscopic sleeve gastrectomy. Palonosetron with a standard dosing (75 μg) schedule has been questioned due to its low efficiency in obese patients. This study aimed to investigate the effectiveness and safety of the body weight-based dosing of palonosetron in managing PONV following laparoscopic sleeve gastrectomy.</p><p><strong>Methods: </strong>A single-center, prospective, double-blinded randomized study was conducted between August 2021 and December 2021. Patients who underwent laparoscopic sleeve gastrectomy were prospectively recruited in the study. One hundred patients were randomly divided into palonosetron (Group P) and ondansetron (Group O). The demographic and clinical variables were recorded. The primary outcome of the study was the incidence of PONV between the two groups during the hospitalization. The secondary outcomes were the number of rescue anti-emetic and analgesic medications and the Functional Living Index-Emesis scores.</p><p><strong>Results: </strong>There were 50 patients in each group (Group P and Group O). There were significant differences in the scores of POVN, nausea, and vomiting favoring Group P. In Group P, the rate of patients using rescue anti-emetics was significantly lower. The incidence of complete response and proportion of patients with higher Functional Living Index-Emesis scores were significantly higher in patients using palonosetron.</p><p><strong>Conclusions: </strong>The use of palonosetron significantly reduced the incidence of PONV following laparoscopic sleeve gastrectomy. There was a significant improvement in the scores of Functional Living Index-Emesis in patients using palonosetron.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"41-49"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-02-01Epub Date: 2022-11-12DOI: 10.1080/00015458.2022.2145725
Diomidis Antoniadis, Alexander Giakoustidis, Daniel Paramythiotis, Antonios Michalopoulos, Zisis N Mandanas, Vasileios N Papadopoulos
{"title":"Mental health well-being and functional adjustment in colorectal cancer patients: a prospective cohort study.","authors":"Diomidis Antoniadis, Alexander Giakoustidis, Daniel Paramythiotis, Antonios Michalopoulos, Zisis N Mandanas, Vasileios N Papadopoulos","doi":"10.1080/00015458.2022.2145725","DOIUrl":"10.1080/00015458.2022.2145725","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer significantly affects the quality of life of patients, while at the same time contributing to the development of symptoms of psychopathology. The aim of this prospective study, is to investigate the role of the disease in the quality of life of patients with colon cancer and in the appearance of symptoms of anxiety and depression, as well as the connection of the above characteristics during the recovery process, given the distress symptoms experienced by the patients.</p><p><strong>Methods: </strong>In the present study, HADS, FACT - C, well as the DT are use, in a sample of 118 patients of an average age of 70.5 ± 8.5 years, which were submitted to partial or total colectomy surgery.</p><p><strong>Results: </strong>Moderate levels of anxiety (<i>M</i> = 8.25, SD = 3.87) and low levels of depression (<i>M</i> = 6.90, SD = 2.97) and distress (<i>M</i> = 5.84, SD = 2.60) emerged preoperatively, while the improvement was significant of patients' quality of life level 6 months after surgery. At the same time, a significant negative effect of the patients' distress level preoperatively on their quality of life, during the recovery process was observed.</p><p><strong>Conclusion: </strong>Preoperative anxiety is not considered to be an element that affects the functionality and the psychological and physical adaptation to the disease of patients with colon cancer. On the contrary, the feelings of distress they experience can be a predictive factor of their quality of life after the partial or total colectomy surgery.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"1 1","pages":"20-27"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46544366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-02-01Epub Date: 2023-01-16DOI: 10.1080/00015458.2023.2168073
Jonathan Nuyts, Charlotte Vanhoenacker, Jana Vellemans, Michael Aertsen, Marc Miserez
{"title":"Gallbladder torsion: a rare cause of acute abdomen in a 12-month old child.","authors":"Jonathan Nuyts, Charlotte Vanhoenacker, Jana Vellemans, Michael Aertsen, Marc Miserez","doi":"10.1080/00015458.2023.2168073","DOIUrl":"10.1080/00015458.2023.2168073","url":null,"abstract":"<p><p><b>Background:</b> Gallbladder torsion is a rare cause of an acute abdomen, predominantly occurring in elderly women and less frequently diagnosed in the pediatric population. The diagnosis is difficult and rarely made preoperatively. However, suspicion needs to be raised in children with acute onset of abdominal pain. Ultrasound can demonstrate different signs putting forward the diagnosis but findings are often non-specific, therefore clinical suspicion should prompt a laparoscopic exploration.<b>Case presentation:</b> We report a case of a 12-month old girl consulting with progressive abdominal discomfort and vomiting. Ultrasound revealed an enlarged gallbladder with thickening of the wall but without demonstrable color Doppler flow and a more horizontal orientation outside its normal anatomic fossa. Gallbladder torsion was suspected. Emergency laparoscopic exploration confirmed the diagnosis and a laparoscopic cholecystectomy was performed. The postoperative course was uneventful.<b>Conclusions:</b> Gallbladder torsion, although rare, should be included in the differential diagnosis of an acute abdomen in children. Early recognition is necessary for a favorable outcome. The diagnosis might be supported by ultrasound but remains difficult, which is why laparoscopic exploration should be considered when the diagnosis remains unclear.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"62-65"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Educational interventions to integrate surgical staff within medical units during the COVID-19 pandemic: EDUCOVID survey.","authors":"Raffaele Brustia, Giuliana Amaddeo, Rami Rhaiem, Eric Levesque, Antoine Monsel, Vanessa Baaroun, Mylène Dimmock, Marc-Antoine Rousseau, Oriane Wagner-Ballon, Francoise Botterel, Pascal Andujar, Daniele Sommacale","doi":"10.1080/00015458.2022.2145720","DOIUrl":"10.1080/00015458.2022.2145720","url":null,"abstract":"<p><strong>Background: </strong>The SARS-CoV-2 (COVID-19) pandemic required a rapid surge of healthcare capacity to face a growing number of critically ill patients. For this reason, a support reserve of physicians, including surgeons, were required to be reassigned to offer support.</p><p><strong>Objective: </strong>To realize a survey on the educational programs deployed (face-to-face or e-learning focusing on infective area, basic gestures, COVID clinical management and intensive care medicine), and their impact on behavior change (Kirkpatrick 3) of the target population of surgeons, measured on a five modalities Likert scale.</p><p><strong>Design: </strong>Cross-sectional online e-survey (NCT04732858) within surgeons from the Assistance Publique - Hôpitaux de Paris network, metropolitan area of Paris, France.</p><p><strong>Results: </strong>Cross-sectional e-Survey: among 382 surgeons invited, 37 (9.7%) participated. The effectiveness of the educational interventions on behavior changes was rated within the highest region of the Likert scale by 15% (<i>n</i> = 3) and 22% (<i>n</i> = 6) for 'e-learning' and 'face-to-face' delivery modes, respectively.</p><p><strong>Conclusions: </strong>Despite the low response rate, this survey suggests an overall low impact on behaviour change among responders affiliated to a surgical discipline.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"12-19"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Chirurgica BelgicaPub Date : 2024-02-01Epub Date: 2024-01-24DOI: 10.1080/00015458.2023.2291295
Ruxandra Coropciuc, Catalina Moreno-Rabié, Wouter De Vos, Elke Van de Casteele, Luc Marks, Vincent Lenaerts, Evy Coppejans, Olivier Lenssen, Renaat Coopman, Jan Walschap, Nasser Nadjmi, Reinhilde Jacobs, Constantinus Politis, Tim Van den Wyngaert
{"title":"Navigating the complexities and controversies of medication-related osteonecrosis of the jaw (MRONJ): a critical update and consensus statement.","authors":"Ruxandra Coropciuc, Catalina Moreno-Rabié, Wouter De Vos, Elke Van de Casteele, Luc Marks, Vincent Lenaerts, Evy Coppejans, Olivier Lenssen, Renaat Coopman, Jan Walschap, Nasser Nadjmi, Reinhilde Jacobs, Constantinus Politis, Tim Van den Wyngaert","doi":"10.1080/00015458.2023.2291295","DOIUrl":"10.1080/00015458.2023.2291295","url":null,"abstract":"<p><strong>Objectives: </strong>To provide a critical update identifying the knowledge gaps and controversies in medication-related osteonecrosis of the jaw (MRONJ) within the Belgian healthcare context and outline opportunities for improvement and research in these areas.</p><p><strong>Methods: </strong>A literature review was performed to identify guidelines from international clinical societies in oncology or oral and maxillofacial surgery on diagnosing, preventing, and treating MRONJ. The recommendations were critically assessed in light of recent developments in the field and confronted with the clinical experience of experts.</p><p><strong>Results: </strong>Despite progress in the diagnostic criteria of MRONJ, the continued need for an 8-week timeout period should be reconsidered. Furthermore, 3D imaging techniques should be introduced to improve diagnosis and staging. The staging system remains ambiguous regarding Stage 0 MRONJ, and ongoing confusion exists regarding the term non-exposed MRONJ. The prevention of MRONJ should be tailored, considering the individual patient's risk of MRONJ, frailty, and life expectancy. More research seems needed into the efficacy and safety of drug holidays, considering the risks of rebound remodeling on fractures. With renewed interest in surgical and adjunct management techniques, adequately designed clinical studies are needed to help translate trial outcomes into universally applicable treatment guidelines taking into account individual patient characteristics.</p><p><strong>Conclusions: </strong>Important knowledge gaps remain and hamper the development of clinical guidelines. Several controversies were identified where consensus is lacking, and further harmonization between stakeholders is necessary. Finally, the need for randomized controlled comparative clinical trials in MRONJ resonates harder than ever to identify the best treatment for individual patients.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"1-11"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}