Acta Chirurgica Belgica最新文献

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Congenital bronchoesophageal fistula in an adult patient. 一名成年患者的先天性支气管食管瘘。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2024-02-01 Epub Date: 2022-12-22 DOI: 10.1080/00015458.2022.2158575
Kubilay İnan, Nurettin Karaoğlanoğlu
{"title":"Congenital bronchoesophageal fistula in an adult patient.","authors":"Kubilay İnan, Nurettin Karaoğlanoğlu","doi":"10.1080/00015458.2022.2158575","DOIUrl":"10.1080/00015458.2022.2158575","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital bronchoesophageal fistulas are extremely rare. Symptoms may not be detected before treatment or may be seen intermittently until advanced ages. Treatment is surgical closure of the fistula.</p><p><strong>Case presentation: </strong>A 20-year-old female patient with presented complaints of sputum production and cough. A fistula was confirmed between the middle esophagus and the left main bronchus by bronchoscopy. Management is by surgical closure of the fistula <i>via</i> right thoracotomy. The patient had an uneventful recovery.</p><p><strong>Conclusion: </strong>Congenital bronchoesophageal fistula malformation can cause long-term respiratory symptoms associated with the fistula and loss of lung parenchyma if left untreated.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"54-56"},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10414007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric thoracoscopic lung resections: a comprehensive analysis of congenital lesion cases 小儿胸腔镜肺切除术:先天性病变病例综合分析
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-21 DOI: 10.1080/00015458.2023.2297539
Gijsbert Musters, Sjoerd de Beer, Joost van Schuppen, Justin de Jong, Ramon Gorter, Matthijs Oomen
{"title":"Pediatric thoracoscopic lung resections: a comprehensive analysis of congenital lesion cases","authors":"Gijsbert Musters, Sjoerd de Beer, Joost van Schuppen, Justin de Jong, Ramon Gorter, Matthijs Oomen","doi":"10.1080/00015458.2023.2297539","DOIUrl":"https://doi.org/10.1080/00015458.2023.2297539","url":null,"abstract":"Congenital lung lesions in pediatric patients may be managed conservatively or by video assisted thoracoscopic surgery (VATS). This study aimed to determine the complications after VATS for congeni...","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"48 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138826365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The historical course of varicose vein surgery in the Persian medicine. 波斯医学中静脉曲张手术的历史进程。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-01 Epub Date: 2023-09-12 DOI: 10.1080/00015458.2023.2254603
Mohammad Hossein Asadi, Robrecht Van Hee, Azam Khosravi, Reza Shojaee, Saeed Changizi-Ashtiyani, Saeed Amini
{"title":"The historical course of varicose vein surgery in the Persian medicine.","authors":"Mohammad Hossein Asadi, Robrecht Van Hee, Azam Khosravi, Reza Shojaee, Saeed Changizi-Ashtiyani, Saeed Amini","doi":"10.1080/00015458.2023.2254603","DOIUrl":"10.1080/00015458.2023.2254603","url":null,"abstract":"<p><strong>Introduction: </strong>Dawali (varicose veins) is the disease of chronic dilation of veins. The veins of the legs become dilated and blue due to excessive accumulation of blood. This disease and the effort to identify and treat it has a very long history. The condition may have first been described in the Ebers Papyrus more than 3500 years ago. The present study deals with the turning points and progress of varicose vein surgery since ancient times, emphasizing the innovations of the scholars of the Islamic period.</p><p><strong>Methods: </strong>The present study is based on searching library documents and database data such as PubMed, Scopus, Science Direct, and search engines such as Google Scholar. In the end, the Prisma flow chart was drawn.</p><p><strong>Results: </strong>Besides diagnosing different varicose veins (legs, thighs, abdomen, uterus, and testes), the scholars of the Islamic period were well-versed in their prevention, etiology, and treatment. In treating varicose veins, these physicians used methods such as cleansing, phlebotomy, compression, leech therapy, and surgery, and some of them were the founders of new treatments.</p><p><strong>Conclusion: </strong>The surgical treatment of varicose veins in the past was similar to modern surgical therapies. What distinguishes yesterday's varicose vein surgery from today's surgery is a more advanced tool. There is no denying the remarkable progress in using health principles, treatment techniques, and surgical instruments to facilitate surgery and reduce the disease's complications and recurrence. However, the treatment framework and foundation, such as phlebectomy and compression, were all invented and introduced in the distant past.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"589-600"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10265698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum immune biomarker levels combined with hepatitis B virus infection status predict early recurrence of early-stage hepatocellular carcinoma with microvascular invasion after liver resection. 血清免疫生物标志物水平结合乙型肝炎病毒感染状况预测肝切除术后微血管侵袭的早期肝细胞癌早期复发。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-01 Epub Date: 2022-11-11 DOI: 10.1080/00015458.2022.2136051
Xiaobo Wang, Yuanquan Zhao, Tao Bai, Jiazhou Ye, Shaolong Lu, Feixiang Wu, Lequn Li, Jie Chen
{"title":"Serum immune biomarker levels combined with hepatitis B virus infection status predict early recurrence of early-stage hepatocellular carcinoma with microvascular invasion after liver resection.","authors":"Xiaobo Wang, Yuanquan Zhao, Tao Bai, Jiazhou Ye, Shaolong Lu, Feixiang Wu, Lequn Li, Jie Chen","doi":"10.1080/00015458.2022.2136051","DOIUrl":"10.1080/00015458.2022.2136051","url":null,"abstract":"<p><strong>Introduction: </strong>The tumor immune response plays a vital role in cancer recurrence in patients with malignancies. We aim to clarify the risk factors for early recurrence and investigate the efficacy of blood-based biomarkers to predict the risk of early recurrence in early-stage hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) after hepatectomy.</p><p><strong>Materials and methods: </strong>A total of 101 cases of HCC with MVI who underwent liver resection were enrolled. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors of early recurrence. We calculated the area under the receiver operating characteristic curve to evaluate the performance of the four biomarkers identified as risk factors for early recurrence.</p><p><strong>Results: </strong>Multiple logistic regression analysis indicated that complement (C)4, cluster of differentiation (CD)4+, immunoglobulin A (IgA), and hepatitis B virus (HBV) DNA of greater than 500 IU/mL were correlated with early recurrence of HCC. The area under the curve was greater for the combination model than for the HBV DNA, CD4+, IgA, or C4 models alone.</p><p><strong>Conclusion: </strong>Preoperative serum CD4+, C4, IgA, and HBV DNA levels were linked with early recurrence of early-stage HCC with MVI and the combination model was of considerable predictive value for the prognosis of HCC with MVI.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"659-665"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative transarterial chemoembolization (TACE) + liver resection versus upfront liver resection for large hepatocellular carcinoma (≥5 cm): a systematic review and meta-analysis. 术前经动脉化疗栓塞(TACE) +肝切除术与术前肝切除术治疗大肝癌(≥5 cm):一项系统回顾和荟萃分析
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-01 Epub Date: 2023-09-08 DOI: 10.1080/00015458.2023.2256539
Kai Siang Chan, Wei Xuan Tay, Feng Yi Cheo, Vishal G Shelat
{"title":"Preoperative transarterial chemoembolization (TACE) + liver resection versus upfront liver resection for large hepatocellular carcinoma (≥5 cm): a systematic review and meta-analysis.","authors":"Kai Siang Chan, Wei Xuan Tay, Feng Yi Cheo, Vishal G Shelat","doi":"10.1080/00015458.2023.2256539","DOIUrl":"10.1080/00015458.2023.2256539","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) accounts for majority of primary liver cancer. Use of preoperative neoadjuvant transarterial chemoembolization (PN-TACE) may result in tumor shrinkage and improve resectability. This study aims to summarize the outcomes of PN-TACE versus upfront liver resection (Up-LR) in large HCC (≥5 cm).</p><p><strong>Methods: </strong>PubMed, Embase, The Cochrane Library, and Scopus were systematically searched till September 2022 for studies comparing PN-TACE versus Up-LR. The primary study outcomes were overall survival (OS), disease-free survival (DFS), and recurrence. Our secondary outcomes were postoperative morbidity and mortality.</p><p><strong>Results: </strong>There were 12 studies with 15 data sets including 3960 patients (PN-TACE <i>n</i> = 2447, Up-LR <i>n</i> = 1513). Majority (89.5%, <i>n</i> = 1250/1397) of patients had Child's A liver cirrhosis. Incidence of Child's B cirrhosis was higher in PN-TACE compared to Up-LR (Odds ratio (OR) 1.69, 95% CI: 1.18, 2.41, <i>p</i> = 0.004). Pooled hazard ratio (HR) for OS showed no significant difference between PN-TACE and Up-LR (HR 0.87, 95% CI: 0.64, 1.18, <i>p</i> = 0.37), but DFS was superior in PN-TACE (HR 0.79, 95% CI: 0.63, 0.99, <i>p</i> = 0.04). Subgroup analysis based on study design failed to show any significant effect in randomized controlled trials (<i>n</i> = 2/15 data sets). However, operating time (mean difference (MD) 31.94 min, 95% CI: 2.42, 61.45, <i>p</i> = 0.03) and blood loss (MD 190.93 ml, 95% CI: 10.22, 317.65, <i>p</i> = 0.04) were higher in PN-TACE. Intrahepatic and extrahepatic recurrence, post-operative morbidity and in-hospital mortality were comparable between PN-TACE and Up-LR.</p><p><strong>Conclusion: </strong>In retrospective studies, PN-TACE resulted in superior DFS compared to Up-LR. However, this may be confounded by selection bias.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"601-617"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10186157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The history of esophageal surgery. 食管手术史。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-01 Epub Date: 2023-09-05 DOI: 10.1080/00015458.2023.2254604
Konstantinos Laios, Konstantinos G Apostolou, Alexios Vavlas, Aggelos Ntousopoulos, Dimosthenis Chrysikos, Theodoros Troupis, Marianna Karamanou, Dimitrios Schizas
{"title":"The history of esophageal surgery.","authors":"Konstantinos Laios, Konstantinos G Apostolou, Alexios Vavlas, Aggelos Ntousopoulos, Dimosthenis Chrysikos, Theodoros Troupis, Marianna Karamanou, Dimitrios Schizas","doi":"10.1080/00015458.2023.2254604","DOIUrl":"10.1080/00015458.2023.2254604","url":null,"abstract":"<p><strong>Background: </strong>Esophageal surgery has always been considered extremely demanding, given the surgical experience and skills required, due to the anatomic location of the esophagus as well as the impact of such extensive operations on patients' homeostasis. The intention of the present study is to review all historical time points of esophageal surgery, from its inception to the modern era of minimally invasive esophageal surgery.</p><p><strong>Methods: </strong>The first clear description of esophageal surgery is dated back to 1738, in an attempt to remove a foreign body from the thoracic esophagus. However, the high morbidity and mortality rates of esophageal surgical operations led to the invention and application of less invasive surgical procedures.</p><p><strong>Results: </strong>Esophageal surgery has evolved from extensive surgical operations to minimally invasive esophagectomies, aiming exclusively to reduce perioperative morbidity and mortality, while maintaining surgical effectiveness. Despite the fact that benign esophageal pathologies were the main stimulus for this evolution, minimally invasive esophageal surgery is now applied even in patients with esophageal cancer, with outcomes comparable to those of traditional surgical approaches.</p><p><strong>Conclusion: </strong>It would be interesting to see how all these new surgical techniques may evolve, altering further the current status of esophageal surgery in the future.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"712-723"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10526721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-Guided peripheral nerve blocks for major amputation in critically ill patients with peripheral artery disease. 超声引导外周神经阻滞治疗外周动脉疾病危重患者截肢。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-12-01 Epub Date: 2022-09-07 DOI: 10.1080/00015458.2022.2118985
Haiyang Wang, Zhitong Yan, Menglin Nie, Jian Fu
{"title":"Ultrasound-Guided peripheral nerve blocks for major amputation in critically ill patients with peripheral artery disease.","authors":"Haiyang Wang, Zhitong Yan, Menglin Nie, Jian Fu","doi":"10.1080/00015458.2022.2118985","DOIUrl":"10.1080/00015458.2022.2118985","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the safety and efficacy of major amputation under ultrasound-guided peripheral nerve blocks in critical peripheral artery disease (PAD) patients.</p><p><strong>Methods: </strong>We reviewed the medical records of consecutive patients who underwent major amputation at our center between December 2012 and December 2020. The patients' baseline demographics and comorbidities were collected. The primary outcomes were 30-day and 12-month mortality. The secondary outcomes were intraoperative events, complications and intensive care unit (ICU) admission.</p><p><strong>Results: </strong>Fifteen patients classified as American Society of Anesthesiologist (ASA) III and 13 ASA IV (mean age: 76.07 ± 11.78 years) were included in the study. These patients were critically ill and had many comorbidities, such as coronary artery disease. All amputations were successfully performed under ultrasound-guided PNB without conversion to GA, but intravenous analgesia was given in 7 patients during the operation. The majority of the patients had stable hemodynamics except for 2 patients who had hypoxia, so none of the patients were transferred to the ICU postoperatively. None of the patients suffered from acute cardio-cerebral events. However, 5 patients had wound infections, and 4 of 5 patients had to receive reamputation. None of the patients died within 48 h after amputation. However, the 30-day mortality was 3.57%, and the 12-month mortality was up to 35.71%.</p><p><strong>Conclusion: </strong>This study demonstrates that major amputation could be safely and effectively performed under ultrasound-guided peripheral nerve blocks for critically ill patients, and ultrasound-guided peripheral nerve blocks could be an alternative for patients at high risk of general anesthesia or spinal anesthesia.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"1 1","pages":"625-631"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41676479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benign multicystic peritoneal mesothelioma in a sexagenerian man: an uncommon case presentation 良性多囊腹膜间皮瘤在一个六十多岁的男人:一个罕见的病例介绍
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-11-20 DOI: 10.1080/00015458.2023.2251793
Coralie Lete, Tobias Schick, Mazen Takieddine, Eric Guerin, Patrizia Loi, Julie Navez
{"title":"Benign multicystic peritoneal mesothelioma in a sexagenerian man: an uncommon case presentation","authors":"Coralie Lete, Tobias Schick, Mazen Takieddine, Eric Guerin, Patrizia Loi, Julie Navez","doi":"10.1080/00015458.2023.2251793","DOIUrl":"https://doi.org/10.1080/00015458.2023.2251793","url":null,"abstract":"Multicystic mesothelial cyst is a rare, and usually benign, tumor which is rarely diagnosed preoperatively due to the poor specificity of its symptomatology.We report the case of a 63-year-old man ...","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"228 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138542231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute abdomen: a rare presentation of group a streptococcal infection. 急腹症:罕见的a组链球菌感染。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-08-01 DOI: 10.1080/00015458.2022.2040108
Jelle Lubach, Marie Vannijvel, Hendrik Stragier, Yves Debaveye, Albert Wolthuis
{"title":"Acute abdomen: a rare presentation of group a streptococcal infection.","authors":"Jelle Lubach,&nbsp;Marie Vannijvel,&nbsp;Hendrik Stragier,&nbsp;Yves Debaveye,&nbsp;Albert Wolthuis","doi":"10.1080/00015458.2022.2040108","DOIUrl":"https://doi.org/10.1080/00015458.2022.2040108","url":null,"abstract":"<p><p>In this case report we describe a 38-year old female patient admitted to the emergency department with acute abdomen and sepsis. Broad-spectrum antibiotics were started. Abdominal imaging was inconclusive, exploratory laparoscopy showed four-quadrant peritonitis. No provoking factor could be withheld. Due to clinical deterioration the patient was transferred to the intensive care unit. Blood cultures showed the presence of group A streptococcus, and clindamycin was associated. She recovered, and could be discharged after several days. Peritonitis caused by group A <i>Streptococcus pyogenes</i> is rare in healthy individuals, and occurs mostly in middle-aged women. There is no consensus regarding surgical treatment but surgical exploration is often necessary to exclude secondary peritonitis. Treatment with broad-spectrum antibiotics and supportive measurements remain the cornerstone in patient management. Association of clindamycin has been shown to reduce mortality. There is inconclusive evidence to support Intravenous polyspecific immunoglobulin G (IVIG) therapy in streptococcal toxic shock syndrome.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"123 4","pages":"440-443"},"PeriodicalIF":0.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alveolar soft tissue sarcoma: a report of 50 cases at a single institution. 肺泡软组织肉瘤:附50例报告。
IF 0.8 4区 医学
Acta Chirurgica Belgica Pub Date : 2023-08-01 DOI: 10.1080/00015458.2022.2049060
Pengyuan Zhao, Huixiang Li, Huayan Ren
{"title":"Alveolar soft tissue sarcoma: a report of 50 cases at a single institution.","authors":"Pengyuan Zhao,&nbsp;Huixiang Li,&nbsp;Huayan Ren","doi":"10.1080/00015458.2022.2049060","DOIUrl":"https://doi.org/10.1080/00015458.2022.2049060","url":null,"abstract":"<p><strong>Background: </strong>Alveolar soft-part sarcoma (ASPS) is a rare soft tissue sarcoma subtype, occurring mainly in young people, with poor prognosis.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of localized or metastatic ASPS patients admitted to the First Affiliated Hospital of Zhengzhou University (China) from 2012 to 2020, focusing on treatment and prognosis.</p><p><strong>Results: </strong>The median age at diagnosis was 24 years (range: 1.4-78 years). Women (<i>n</i> = 29, 58%), especially those aged <30 years, dominated this series. The most common metastasis site was lung. Thirty-one (62%) patients developed lung metastasis (localized: <i>n</i> = 9 [18%]; metastatic: <i>n</i> = 22 [44%]). Only a tumor maximum diameter ≥ 5 cm was associated with a high lung metastasis rate (<i>p</i> = 0.039). The mean follow-up time was 37.5 months (1-108 months), and the 5-year overall survival (OS) rate was 84.7%. Univariate analysis indicated that distant metastasis observed at the initial visit and incomplete resection of the primary tumor were associated with poor OS. For localized cases, neither surgery plus radiotherapy (<i>p</i> = 0.486) nor surgery plus chemotherapy (<i>p</i> = 0.536) improved progression-free survival compared to surgery alone. Among the metastatic cases, the disease control rate (PR + SD) was higher for targeted therapy (60%) and combined immunosuppressive therapy (100%) than for conventional cytotoxic chemotherapy (26%).</p><p><strong>Conclusions: </strong>Postoperative adjuvant radiotherapy and chemotherapy do not provide good local control for patients with localized disease. Although there is no standard treatment strategy for patients with advanced or metastatic disease, they can benefit from targeted therapy and/or immunosuppressive therapy.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":"123 4","pages":"375-383"},"PeriodicalIF":0.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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