中华整形外科杂志最新文献

{"title":"[Pyrroloquinoline quinone inhibited oxidative stress induced-apoptosis of Schwann cells via mitochondrial apoptotic signaling pathway in vitro].","authors":"Bin He,&nbsp;Haiying Tao,&nbsp;Ailin Wei,&nbsp;Xiaohai Li,&nbsp;Haohuan Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanisms of Pyrroloquinoline quinone (PQQ) against oxidative stress induced apoptosis in Schwann cells (SCs).</p><p><strong>Methods: </strong>SCs were cultured in vitro, identified by S-100 immunofluorence staining. SCs were divided into control group,H2O2 induced group,H2O2 + PQQ treated group.CCK-8 assay was used to detect cell proliferation. Apoptosis was detected by flow cytometry with Annecin V-FITC/PI staining, mitochondrial transmembrane potential was detected by flow cytometry with JC-1 labeled staining, cytochrome C (CytC), Bax and Caspase-9 protein levels was detected by Western blot analysis.</p><p><strong>Results: </strong>In this study, the S-100 positive cells were more than 95％,cell proliferation was decreased in H2O2 induced SCs,apoptotic rate was increased, mitochondrial transmnembrane potential was decreased,CytC, Bax and Caspase-9 protein levels were increased. After PQQ added, cell proliferation was increased, apoptotic rate decreased, mitochondrial transmembrane potential increased, CytC, Bax and Caspase-9 protein levels decreased.</p><p><strong>Conclusions: </strong>PQQ protects SCs from oxidative induced apoptosis by inhibiting mitochondrial signaling pathway.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"33 1","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the pain in extremities caused by intramuscular venous malformation and surgical treatments].","authors":"Xiaonan Guo,&nbsp;Changxian Dong,&nbsp;Dakan Liu,&nbsp;Yubin Gong,&nbsp;Junbo Qiao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the pain caused by intramuscular venous malformation, so as to avoid misdiagnosis.</p><p><strong>Methods: </strong>We retrospectively analyzed 173 patients who received surgical treatments in our department between Jan.2012 to Dec.2014,with the main complaint of local pain and were diagnosed as intramuscular venous malformation. The mechanisms of the local pain, based on the image data, intra-operative findings, pathology reports and the comparison of the Visual Analogue Scale(VAS)data before and after operation were summarized. The surgical interventions included simple excision or excision + adhesiolysis or excision + adhesiolysis + nerve decompression.</p><p><strong>Results: </strong>The reasons of local pain can be divided into 4 categories:①lesion located in the tendon insertions;②lesion involving the local nerve, inducing the thickening and tensing of its epineurium and the increasing of its diameter;③lesion infiltrated to the periosteum;④phlebolith in it. All the 173 patients received surgical treatments and got varying degrees of relieving from local pain.63 patients got a decrease of the VAS by 5 or more, and 95 cases' VAS number decreased by 3-4,the rest 15 patients' VAS cut down by 1-2.</p><p><strong>Conclusions: </strong>Intramuscular venous malformation is an important reason for local pain and should not be neglected. Surgical treatment can be an effective method to remove the lesion and relieve local pain.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":" ","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36366073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Surgical treatment of ingrown toenail and paronychia with lateral toe incision].","authors":"Songhua Cao,&nbsp;Ning Zhang,&nbsp;Yang Wang,&nbsp;Ruilin Cheng,&nbsp;Yong Hu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate and compare the advantages of surgical treatment of ingrown toenail with the traditional Winograd method.</p><p><strong>Methods: </strong>From Aug.2013 to Jun.2015,77 cases (89 toes) with 15-58 years were involved in the study.37 cases (42 toes) were treated with Winograd method and other 40 cases (47 toes) were treated with a method using lateral incision without cutting the nail fold. The time of returning to normal activities, infection rate, recurrence rate, pain VAS score and shape satisfaction VAS score were evaluated to display the aesthetic and functional result of the both methods.</p><p><strong>Results: </strong>All patients were followed up with an average of 8.6 months. The patients treated with the novel method returned to normal activities after (5.3 ± 0.5) d post-surgery, which was much shorter than that (7.3 ± 0.6) d in patients with the Winograd method (P ＜ 0.05).And the infection rate in the lateral incision group was also lower than that in the Winograd method group (P ＜ 0.05).At 3 days post-surgery, the pain VAS score in Winograd method group was higher (P ＜ 0.05),but the difference of pain VAS score disappeared after 1 and 6 months post-surgery (P ＞ 0.05).The shape satisfaction VAS score were 9.2 ± 0.6 in the lateral incision group and 7.1 ± 0.7 in the Winograd group, showing significant difference (P ＜ 0.05).</p><p><strong>Conclusions: </strong>The lateral incision method without incising the nail fold reserves the nail groove and brings faster recovery to normal activities with less pain, lower infection rate and more satisfactory toenail shape.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":" ","pages":"21-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36366074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reconstruction of buccal defect using free anterolateral thigh flaps after radical resection of buccal cancer].","authors":"Ting Zhou,&nbsp;Gouwen Sun,&nbsp;Mingxing Lu,&nbsp;Jianmin Wen,&nbsp;Xin Chen,&nbsp;Jun Cao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the value of different designed anterolateral thigh flaps(ALT) in the reconstruction of buccal defect after radical resection of buccal cancer.</p><p><strong>Methods: </strong>From March 2009 to May 2016,142 cases were diagnosed as buccal cancer in the Department of Oral and Maxillofacial Surgery of Nanjing University. All patient underwent radical resection, followed by reconstruction with different anterolateral thigh flaps. The clinical date were retrospectively analyzed. .</p><p><strong>Results: </strong>Among 142 cases, the muscuiocutaneous ALT flaps were used in 60 cases, the fasciocutaneous ALT flaps in 60,and the thin ALT flaps in 22.The size of the flaps ranged from 4 cm ×5 cm to 14 cm × 10 cm. Operative exploration during the perioperative period were performed in 4 patients, including 2 flaps with thrombotic events and 2 flaps with venous thrombosis. Among them,2 flaps survived completely and 2 flaps were failure. The mean follow-up period was 37 months (range:3 to 85 months).</p><p><strong>Conclusions: </strong>The different designed anterolateral thigh flap for the buccal defects resulting from tumour excision is an ideal choice for reconstruction of buccal defects</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":" ","pages":"30-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36366075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical study of five combined operation for anus reconstruction].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study the effect of five combined operation for anus reconstruction after Miles operation in patients with lower colorectal cancer.</p><p><strong>Methods: </strong>60 patients with lower colorectal cancers received Miles operation, followed by five combined operation for anus reconstruction (internal and external anal sphincter, rectal flap, rectal angle, anus perineal reconstruction).</p><p><strong>Results: </strong>5-6 days after operation, all cases had desire to excretion.2-3 weeks lateral, all cases desired to control excretion and excreted 1 or 2 times per-day. Internal rectum testing showed the static pressure in anus, the constrictive pressure, and the static pressure in rectum were all normal. The survival rate of patients over 5 years was beyond 88％.</p><p><strong>Conclusions: </strong>It suggests that five combined operation for anus reconstruction after Miles operation could avoid man-made anus on abdomen. It can improve the patients' life quality, long-term survival rate. And it's also economical method for patients.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"429-31"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36363538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hair removal with IPL on expansion flap via subcutaneous route in a swine model].","authors":"Yongqiang Feng,&nbsp;Lyuping Huang,&nbsp;Haiyue Jiang,&nbsp;Yuanyuan Guan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect and safety of hair removal via subcutaneous route with IPL in expanded flap.</p><p><strong>Methods: </strong>A total of 14 experimental zones were established in two healthy Guizhou mini-pigs with dark hair and white skin.All these skin zones were allocated in seven groups: group 1-6 underwent skin soft tissue expansion(stage I: implantation of expander, stage Ⅱ: removal of expander).The subcutaneous tissue in group 1 received IPL irradiation of common level during stage Ⅰ and Ⅱ of skin expansion, group 2 received irradiation of high level during stage Ⅰ, group 4 received irradiation of common level during stage Ⅱ, group 5 received irradiation of high level during stage Ⅱ, group 6 received irradiation of low level during stage Ⅰ and Ⅱ as well as flap trim during stage Ⅱ, group 3 received no irradiation, and the skin in group 7 received irradiation of common level through epidermal route during stage Ⅰ and Ⅱ. Treatments were conducted using a contact tip with IPL(λ =650-950 nm) radiant exposures of different fluencies (common level 18 J/cm2,high level 22 J/cm2,and low level 15 J/cm2) with single pulsed duration of 50 ms. The temperature of tissue surface was determined by infrared thermograph. The microcirculation of expansion flap was determined with PeriFlux System. Digital images were taken for the calculation of hair density count by software Image J.</p><p><strong>Results: </strong>The temperature of tissue surface received IPL irradiation decreased soon within 2 minutes. The microcirculation of skin expansion flap in group 1,2,3,6 were all restrained, which began to restore within 4 hour post operation. The hair density in group 1 was the lowest with hair removal rate of 79.17％ ± 2.81％,which was higher than the others significantly(P ＜ 0.05).The hair removal rate in group 6 was 72.95％ ± 13.10％.The hair removal rates in group 4 and 5 were lower than 40％.The hair removal rates in group 7 was 67.38％ ± 7.10％.</p><p><strong>Conclusions: </strong>IPL irradiation via subcutaneous route may restrain microcirculation of expansion flap transiently, which was reversible. The hair removal rates can reach above 80％ over 6 months post treatment. It indicates that IPL irradiation via subcutaneous route might be a safe and effective hair removal methods, which may be more effective when it is initiated before the implantation of skin expander.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"446-52"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36363539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Long-term effect of botulinum toxin type A injection on hypertrophic acne scar].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate both the short-and long-term effect of botulinum toxin type A (BTXA) injection on hypertrophic ache scar.</p><p><strong>Methods: </strong>A total of 26 patients with acne scar received BTXA injection of within 100 units. The effect was evaluated using the ECCA grading scale before treatment and during clinic re-visit, which based on history of acne scar and number of scar area.The short-and long-term effect was recorded. The average follow-up period was 39.23 months. All results were evaluated by SPSS 21.0.ANOVA was used to evaluate average value and standard deviation of ECCA grading scale. Kaplan-Meier survival curve was used to evaluate relapse-free period, and Pearson test was used to detect relevant factors of relapse-free period.</p><p><p>Results The BTXA injection showed significant positive long-term effect on inflammatory or hypertrophic acne scar. The average ECCA grading scale was 103.460 ±36.872 before treatment,79.620 ±37.146 at 6 months after treatment,63.160 ±24.049 at 12 months after treatment,47.500 ±4.629 at 18 months after treatment, and 50.000 ± 0.000 at 24 months after treatment,showing significant differences between any of two groups (P ＜ 0.01).Average relapse free period was 28.354 ± 1.775 months. Relapse-free period was related to ECCA grading scale pre treatment and injection times (P ＜ 0.01); meanwhile, dose of BTXA and length of disease all had statistical significance (P ＜ 0.05); however, age and gender had no statistical significance (P ＞ 0.05).</p><p><strong>Conclusions: </strong>The BTXA injection can relieve inflammation and improve scar texture in patients with hypertrophic acne scar in both the short-and long-term follow-up.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"432-7"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36362987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Noninvasive monitoring of changes in the structure and function of masseter muscles after the injection of botulinum toxin type A].","authors":"Zuo Guo,&nbsp;Xuehong Diao,&nbsp;Wen Xia,&nbsp;Tianyi Liu,&nbsp;Yue Chen,&nbsp;Jiezuo Zheng,&nbsp;Zuoqun Zhou,&nbsp;Ping Yang,&nbsp;Jingjing Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect and maintaining period of botulinum toxin A on the masseter muscles through noninvasive monitoring of changes in the structure and function of masseter muscle.</p><p><strong>Methods: </strong>We randomly selected 20 female patients with benign masseter hypertrophy,22-43 years old, who were treated with injection of botulinum toxin A. High-frequency ultrasound was adopted to measure thickness and hardness of muscles.Surface electromyography (sEMG) was used to observe the changes of muscle force. All patients were followed up before and 1,4,12 and 24 weeks after the injection of botulinum toxin type A. Subjective evaluation of the efficacy was performed by questionnaire survey.</p><p><strong>Results: </strong>The thickness and hardness of muscle decreased 1 week after injection which attained the lowest level at 12 weeks. The thickness and hardness reduced by 18％-39％ and 20％-32％ respectively at relaxed state of masseter muscles, the muscle force reduced by 78％ during muscle contraction. The muscle recovered to previous state 24 weeks after injection. The subjective evaluation by doctor and patients was consistent with the results by the high frequency ultrasound and EMG detection results.</p><p><strong>Conclusions: </strong>High frequency ultrasound and surface electromyography are effective and noninvasive means for objective evaluation of masseter muscles after the injection of botulinum toxin type A.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"437-40"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36362988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correction of whistle deformity in bilateral cleft lip with lower lip bipedicle orbicularis oris musculomucosal island flap].","authors":"Zhe Li,&nbsp;Fan Wang,&nbsp;Linqi Liu,&nbsp;Wei Lyu,&nbsp;Shirong Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore a new method to correct the whistle deformity in bilateral cleft lip.</p><p><strong>Methods: </strong>A lower lip bipedicle orbicularis oris musculomucosal island flap was designed to repair the upper vermilion defect.The pedicle of this flap was deepidermidalized and then embedded into the upper lip. The dry lip in the central was reserved to reconstruct the vermilion tubercle.</p><p><strong>Results: </strong>From Aug.2013 to Aug.2015,10 cases were treated successfully with primary healing. With the follow-up period of 5-17 months, the appearance of upper lip was greatly improved with a balanced proportion and full lip tubercle.</p><p><strong>Conclusions: </strong>This lower lip bipedicle orbicularis oris musculomucosal island flap is an ideal method for the correction of whistle deformity in bilateral cleft lip.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"401-4"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36359475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lateral homodigital flap combined with pedicled cross finger flap for repairing degloving injury of fingertip].","authors":"Yunpeng Zhang,&nbsp;Yingyu Zhang,&nbsp;Shunhong Gao,&nbsp;Zhiliang Yu,&nbsp;Wenlong Zhang,&nbsp;Fan Ping","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic effect of lateral homodigital flap combined with pedicled cross finger flap for repairing degloving injury of fingertip.</p><p><strong>Methods: </strong>From February 2012 to July 2015,14 cases with degloving injury of fingertip were treated with lateral homodigital flap combined with vascular pedicled cross finger flap.21 days after operation, the pedicle was cut off, followed by functional exercise.</p><p><strong>Results: </strong>All of the 14 patients were followed up for 3 to 9 months. The texture and appearance of all the flaps were satisfactory.Sense and function of finger recovered well. Two-point discrimination distance ranged from 10 to 13 mm (mean,11.5 mm).</p><p><strong>Conclusions: </strong>Degloving injury of fingertip can be treated by lateral homodigital flap combined with pedicled cross finger flap with satisfactory results.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 6","pages":"422-5"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36363536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}