Acta medica Indonesiana最新文献

{"title":"Local Crude House Dust Extracts as a Substitute for Standardized House Dust Mite Extracts in Allergy Diagnostic and Immunotherapy.","authors":"Odhi Anggani, Feri Trihandoko, Almarissa Ajeng Prameshwara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Allergic diseases are a significant global health issue commonly triggered by house dust mite (HDM) allergens. Standardized HDM extracts are currently widely used in allergen immunotherapy (AIT) and diagnostic tests. However, in several tropical regions, such as Indonesia, these standardized extracts were either expensive, difficult to obtain, or did not represent local allergen exposure. Previous studies examined crude house dust extracts (CHDE) derived from locally collected dust as a possible substitute because they reflected the complex allergenic and other composition of the local environment. Therefore, this study aimed to review the potential of Local Crude House Dust Extracts (LCHDE) as a regionally relevant substitute source of allergens for both diagnostic and therapeutic applications. LCHDE reflects real environmental exposure, including region-specific mite, fungal, and bacterial components, which could better represent local allergen profiles. LCHDE offered a promising, cost-effective, and contextually relevant option for allergy diagnosis in developing regions. However, its application in immunotherapy necessitated rigorous allergen profiling, and regional collaboration was crucial to establish a CHDE suitable for clinical use.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"314-322"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Research in Cardiovascular Disease in Indonesia: A Scoping Review.","authors":"Simon Salim, Asri C Adisasmita, Sudarto Ranoatmodjo, Muhammad Yamin, Siti Setiati","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular (CV) disease remains the leading cause of mortality and disability worldwide, particularly in developing countries. Beyond mortality, health-related quality of life (HRQoL) is increasingly recognized as a key outcome and is commonly assessed using patient-reported measures. In Indonesia, cultural and linguistic diversity poses challenges, as most HRQoL instruments have been developed in other contexts. This scoping review aimed to map HRQoL research in Indonesian cardiovascular disease populations by identifying validated instruments, describing study designs and measurement tools, and summarizing HRQoL outcomes.</p><p><strong>Methods: </strong>This review was registered on Figshare (DOI: 10.6084/m9.figshare.29218991) and conducted following the Joanna Briggs Institute methodology and PRISMA-ScR guidelines. Literature searches were performed in PubMed, ScienceDirect, Google Scholar, and included grey literature. Studies reporting HRQoL measurement in Indonesian populations were included.</p><p><strong>Results: </strong>A total of 54 studies were included. Both generic and disease-specific HRQoL instruments were identified. Common generic tools included SF-36, SF-12, WHOQOL-BREF, and PedsQL, while disease-specific instruments included MLHFQ, KCCQ, Seattle Angina Questionnaire, AFSS, ASTA, AFEQT, MacNew, and AQUAREL. Only several instruments have been culturally validated, while others were used without prior validation, and some validated tools remained underutilized. HRQoL was influenced by clinical, psychological, behavioral, and social factors.</p><p><strong>Conclusion: </strong>HRQoL research in Indonesia is growing but remains heterogeneous. This mismatch highlights a critical gap between research capacity and real-world implementation in Indonesia. Greater use of standardized tools and longitudinal designs is needed to strengthen patient-centered cardiovascular care.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"222-252"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When More Becomes Harm: The Art of Managing Multimorbidity and Multicomplexity in Older Adults.","authors":"Siti Setiati","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multimorbidity and multicomplexity are increasingly becoming the norm in geriatric clinical practice, with a recent Indonesian multicentre study revealing that 80.7% of older outpatients present with multiple coexisting conditions. This editorial discusses the limitations of conventional single-disease guidelines when applied to complex older adults, where simultaneous treatments often lead to polypharmacy, cumulative anticholinergic burdens, and potential adverse outcomes. Highlighting findings from a recent study in Acta Medica Indonesiana, which found polypharmacy in 43.9% of Indonesian geriatric outpatients but a low rate of high anticholinergic burden (1.8%), the editorial underscores the concept of \"appropriate polypharmacy\" under close clinical monitoring. To effectively navigate multicomplexity defined by the intricate interactions between pathophysiology, treatment effects, functional status, and social context, clinicians must look beyond rigid numerical targets and adopt patient-centered frameworks such as the Geriatrics 5Ms. Central to this approach is the art of judicious deprescribing, utilizing validated criteria like the AGS Beers or STOPP/START to optimize care and minimize harm. Ultimately, modern geriatric care requires a fundamental shift from merely extending lifespan to enhancing health span, focusing on \"What Matters Most\" to the patient. Integrating these competencies into medical education is vital to prepare future frontline clinicians for the realities of aging populations.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"133-137"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Performance of the Clinical Frailty Scale for Predicting 30-Day Mortality in Hospitalised Indonesian Older Adults.","authors":"Ressy Hastopraja, Dina Aprillia Ariestine, Ariantho Sidasuha Purba","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Frailty is common among hospitalized elderly patients, with prevalence rates ranging from 27% to 80%. Frail individuals have a higher risk of mortality than non-frail individuals do. The Clinical Frailty Scale (CFS), developed by the Canadian Study of Health and Aging (CSHA), is a widely used tool for assessing frailty and clinical outcomes in older adults. This study aimed to evaluate the prognostic performance of the CFS in predicting 30-day mortality among elderly inpatients.</p><p><strong>Methods: </strong>This prospective cohort study included patients aged ≥ 60 years admitted to the Haji Adam Malik Central General Hospital in Medan, Indonesia. Discrimination and calibration of the CFS were evaluated using the ROC curve and Hosmer-Lemeshow tests, while logistic regression identified factors independently associated with mortality. Discrimination and calibration of the CFS were evaluated using the ROC curve and Hosmer-Lemeshow tests, while logistic regression identified factors independently associated with mortality.</p><p><strong>Results: </strong>Among 120 patients, the 30-day mortality rate was 43.3%. The Hosmer-Lemeshow test indicated good calibration (p = 0.661), and ROC curve analysis showed good discrimination (AUC = 83.2%, 95% CI 76%-90.4%). Multivariate analysis identified the C-reactive protein level, CFS score, and nutritional status as independent predictors of 30-day mortality.</p><p><strong>Conclusion: </strong>Clinical Frailty Scale (CFS) demonstrates good prognostic performance for predicting 30-day mortality among elderly inpatients, with elevated CRP, higher CFS scores, and malnutrition serving as independent predictors of death.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"203-211"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Listening to Quran Recitation on the Quality of Life of Systemic Lupus Erythematosus Patients: A Quasi-Experimental Study.","authors":"Karina Wijayanti, Alvina Widhani, Sukamto Koesnoe, Rudi Putranto, Anshari Saifuddin Hasibuan, Eka Ginanjar, Teguh Harjono Karjadi, Chyntia Olivia Maurine Jasirwan, Pringgodigdo Nugroho","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Quality of life (QoL) is not sufficiently considered in current systemic lupus erythematosus (SLE) treatment targets, even though it's significantly impaired. Studies have shown that higher religiousness is associated with a higher QoL. This study aimed to determine the effect of listening to Quran recitations on the QoL of SLE patients.</p><p><strong>Methods: </strong>A quasi-experimental study with a pretest-posttest study design was conducted at Cipto Mangunkusumo Hospital, Jakarta. Participants were females aged 18 years or older with SLE, Muslim, and not experiencing hearing loss. Those who didn't regularly listen to the Quran were assigned to the control group. The intervention group consisted of patients who had previously listened to the Quran on a more regular basis, as well as those who had not. The intervention group listened to a Quran (QS. Ar-Rahman) for a minimum duration of 15 minutes, twice daily, for 40 days. A comparison of the effects of listening to the Quran within the group was conducted using a paired T-test, with a Wilcoxon test applied when necessary. p-values of less than 0.05 were considered statistically significant.</p><p><strong>Results: </strong>A total of 65 participants were included in the study, with 32 in the intervention group and 33 in the control group. The results indicated a significant increase in QoL in the intervention group (p=0.023). Additionally, there was a reduction in anxiety levels within the intervention group (p=0.030).</p><p><strong>Conclusion: </strong>Listening to Quran recitation can enhance QoL, while also decreasing anxiety in patients with SLE.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"253-263"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Irregular Beat: An Unexpected Case of Raynaud's Phenomenon in a Patient with Atrial Fibrillation.","authors":"Ni Putu Widyanti Suastiari, Rahmania Rahmania, Riawati Utama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Raynaud's phenomenon is characterized by episodic vasospasm of the extremities, often triggered by cold or stress. It is a hallmark of systemic sclerosis (SSc) and is frequently associated with pulmonary arterial hypertension (PAH). PAH may cause right atrial dilatation, predisposing to atrial fibrillation (AF). While Raynaud's and PAH are well-documented, their coexistence with AF is rarely reported. A 71-year-old male presented with rapid AF and pulmonary oedema. On admission, vital signs were stable, but he developed symmetrical discoloration of the fingers, palms, and feet after cold exposure in the ICU, accompanied by numbness and pain. Laboratory tests revealed prolonged PT, high ESR (65/121 mm/hr), and positive ANA (44.8 IU/mL). ECG showed rapid AF with left ventricular hypertrophy. Chest X-ray demonstrated pulmonary artery dilatation and cardiomegaly. Echocardiography revealed moderate tricuspid regurgitation and severe PAH. This case illustrates a rare combination of Raynaud's phenomenon, PAH, and AF, likely secondary to autoimmune vascular dysfunction. PAH-induced atrial dilatation may trigger AF, while endothelial dysfunction may worsen Raynaud's symptoms. A positive ANA suggests underlying SSc or SLE. Early recognition and multidisciplinary management targeting pulmonary pressure, arrhythmia control, and vasospasm are crucial to prevent complications. Long-term outcome was not assessed due to loss to follow-up.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"277-280"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition from Quadrivalent to Trivalent Influenza Vaccination Compared with Continued Quadrivalent Vaccination for Preventing Severe Influenza Outcomes in Populations in Indonesia: Implications from the 2025-2026 Epidemiological Landscape.","authors":"Sukamto Koesnoe, Cissy Kartasasmita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seasonal influenza remains a global public health challenge, with an estimated 1 billion infections and 290,000-650,000 respiratory deaths each year. The 2024-2025 season recorded a high disease burden in the United States, with tens of millions of symptomatic cases and hundreds of thousands of hospitalizations, as well as the highest hospitalization rates in the FluSurv-NET surveillance era. Entering the 2025-2026 season, a shift in dominance toward influenza A(H3N2) has been observed in various regions, including the emergence of subclade K (J.2.4.1), which has spread globally and become the dominant variant in several regions. In Indonesia, surveillance data indicate an increase in influenza activity in late 2025, followed by a decline in early 2026, with the positivity rate peaking during this period before returning to low activity levels. Subclade K has been detected across multiple provinces with wide geographic distribution, and most cases present with mild to moderate clinical manifestations. Serological studies have shown reduced antigenic reactivity between the vaccine and circulating viruses; however, real-world vaccine effectiveness data indicate that protection against severe disease remains preserved, with higher effectiveness observed in children compared to adults. The World Health Organization has recommended transitioning from quadrivalent to trivalent vaccines since 2023, following the absence of the B/Yamagata lineage in global circulation since 2020. This study presents an updated overview of global and national influenza epidemiology and its implications for vaccination policy, providing a scientific basis to support consideration of transitioning to trivalent vaccines in Indonesia.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"281-287"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Treatment Outcomes and Safety of Elobixibat for Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Maggie Liberty, Taufik Sungkar, Peggy Liberty","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Currently available laxatives usage in chronic constipation (CC) has been reported to cause various adverse events, notably melanosis coli and colonic neuromuscular disorder. Elobixibat, an ileal bile acid transporter inhibitor, appears to be a promising option for chronic constipation to counteract this challenge. This study aims to evaluate the treatment outcome and safety of elobixibat for chronic constipation.</p><p><strong>Methods: </strong>This systematic review and meta-analysis were performed on 3 search engines: PubMed/MEDLINE, ScienceDirect, and Cochrane Database of Systematic Reviews. Randomized controlled trials (RCTs) comparing elobixibat 10 mg with placebo in patients with functional chronic constipation were included. The quality of studies was assessed using the Cochrane risk of bias 2.0 tool. Statistical analyses were conducted using RevMan 5.4.1 software.</p><p><strong>Results: </strong>A total of six RCTs that met the inclusion criteria were included in this study. Results demonstrated that elobixibat markedly improved bowel movement with a significant change in spontaneous bowel movement (SBM) (MD 2.91, 95% CI 2.81 to 3.01, p<0.00001) and complete spontaneous bowel movement (MD 0.61, 95% CI 0.38 to 0.83, p<0.00001). The percentage of patients experiencing first SBM in 24 hours was significantly higher in the elobixibat group compared to the placebo group (RR 1.49, 95% CI 1.21 to 1.84, p=0.0002). Stool consistency was improved significantly in the elobixibat group (MD 1.40, 95% CI 1.09 to 1.71, p<0.00001). Moreover, the elobixibat group reported favourable safety with no serious adverse events.</p><p><strong>Conclusion: </strong>Elobixibat shows promising therapeutic efficacy in the treatment of functional chronic constipation. Elobixibat is safe and well-tolerated with minimal adverse events.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"193-202"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-Demographic Characteristics, Income, and Lifestyle of Internists Across Indonesia: A National Cross-Sectional Survey.","authors":"Lugyanti Sukrisman, Evy Yunihastuti, Sally Aman Nasution, Eka Ginanjar, Simon Salim, Andhika Rachman, Ceva Wicaksono Pitoyo, Rudy Hidayat, Adityo Susilo, Hayatun Nufus, Hermawan Susanto, Darmadi Darmadi, Hery Djagat Purnomo, Andi Makbul Aman, Anggoro Budi Hartopo, Selfie Selfie, Ervita Ritonga, Gede Wira Mahadita, Radiyati Umi Partan, Azzaki Abubakar, Nur Samsu, Wachid Putranto, Reinaldo Alexander, Dani Rosdiana, Cecilia Hendratta, Akmal Mufriady Hanif, Astried Indrasari, Erwanto Budi Winulyo, Lukman Pura, Djallalluddin Djallalluddin, Giri Satriya, Andi M H Panjaitan, Elfiani Elfiani, Budiman Gunawan, Annisa Puspitasari Nachrowi, Kurniakin W S Girsang, Erwin A Pangkahila, Joko Anggoro, Dayang Nurbayati, Fahmi R Darkuthni, Petrus Irianto, Komariatun Komariatun, Annelin Kurniati, Haeril Aswar, Nelyan H Mokoginta, Leily D Pawa, Edwin Ambar, Riswan Riswan, Samuel Pratama, Imam Adli, Nurul Inayah Rahmani, Amalia Zahra Afifah, Muhammad Ilham Fajar, Monika Herliana, Zahra Nuril Anwar, Mariska Andrea Siswanto","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Internal medicine specialists have always been one of the pillars that support the health of Indonesian people. Currently, there is no available survey regarding the socio-demography, lifestyle, and income of any medical specialist in Indonesia. This study aims to report this gap in knowledge amongst internists across Indonesia.</p><p><strong>Methods: </strong>This study was a nationwide cross-sectional study and was conducted via online questionnaires by The Indonesian Society of Internal Medicine Specialists (INASIM) between December 2023 and March 2024. Participants from the existing 39 INASIM branches were selected using cluster random sampling, with a target of 20% of registered internists per branch. Of 1,568 internists invited, 1,082 (69.0%) completed the questionnaire and were included.</p><p><strong>Results: </strong>A total of 1,082 internists participated in this study, mostly male (57.7%), aged 35-49 years (57.7%), non-academic staff (64.3%), practicing as general internists (76.3%) in 3 locations (70.9%). Distribution discrepancy was observed with 58.0% of general internists and 71.5% of subspecialists practicing in urban areas only. Income analyses showed significant positive correlations with age, working years, working hours, and number of practices. Male internists had higher income than their counterparts, indicating a gender-related income gap. The location of practice did not affect income significantly. Amongst internists, there were approximately 11.1% with a history of smoking, 55.9% with daily coffee consumption, 62.9% with sleep deprivation, and more time spent being sedentary.</p><p><strong>Conclusion: </strong>This study identified distribution discrepancy, a gender-related income gap, and unhealthy lifestyle patterns among Indonesian internists, which are issues that warrant targeted policy responses. Nevertheless, these findings may support future policies on equitable workforce distribution, appropriate incentive systems, and physician wellness programs in Indonesia.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"174-192"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticholinergic Burden, Falls, and the Concept of Appropriate Polypharmacy in Indonesian Geriatric Clinics: A Multicentre Observational Study.","authors":"Siti Setiati, Muhammad Khifzhon Azwar, Rensa Rensa, Nina Kemala Sari, Kuntjoro Harimurti, Ika Fitriana, Noto Dwimartutie, Rahmi Istanti, I Gusti Putu Suka Aryana, Sri Sunarti, Agus Sudarso, Dina Aprillia Ariestine, Lazuardhi Dwipa, Novira Widajanti, Nur Riviati, Roza Mulyana, Yudo Murti Mupangati, Fatichati Budiningsih","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>A high anticholinergic burden (ACB) scale score (≥3) and polypharmacy have been viewed negatively due to possible adverse events. As Indonesian multicentre data in this field are lacking, this study aimed to provide regional data related to ACB, polypharmacy, and falls, and to analyse factors potentially linked to falls.</p><p><strong>Methods: </strong>Data from community-dwelling older adults aged ≥60 years were collected in 12 geriatric care centres through history taking and medical records. Bivariate and multivariate analyses were conducted to evaluate the association between covariates and falls.</p><p><strong>Results: </strong>Polypharmacy and high ACB (score ≥3) were observed in 43.9% and 1.8% of 626 older adults, respectively. The five most prescribed drug classes were calcium-channel blockers, angiotensin receptor blockers, statins, beta blockers, and proton pump inhibitors. The three most prescribed drugs with possible anticholinergic activity were furosemide, isosorbide dinitrate, and cetirizine. The prevalence of past-year falls was 16.8%. Falls were associated with age ≥80 years (odds ratio [OR] 2.44, 95% confidence interval [CI] 1.31-4.53), female sex (OR 2.08, 95% CI 1.30-3.31), transient ischaemic attack and cerebrovascular accident (OR 1.97, 95% CI 0.94-4.10), multimorbidity (≥3 co-morbidities) (OR 1.80, 95% CI 1.07-3.03), depression (OR 1.79, 95% CI 1.00-3.23), and polypharmacy (OR 0.65, 95% CI 0.40-1.05).</p><p><strong>Conclusion: </strong>The prevalence of a high ACB score and falls were 1.8% and 16.8%, respectively. Approximately one in two older adults had polypharmacy. We observed a non-significant inverse relationship between polypharmacy and falls. This may possibly suggest appropriate polypharmacy and closer monitoring applied in geriatric settings, which requires further investigation.</p>","PeriodicalId":6889,"journal":{"name":"Acta medica Indonesiana","volume":"58 2","pages":"154-163"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}