Acta Histochemica Et Cytochemica最新文献_第7页

ZMYM3 May Promote Cell Proliferation in Small Cell Lung Carcinoma. ZMYM3可能促进小细胞肺癌细胞增殖。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-10-29 Epub Date: 2021-10-02 DOI: 10.1267/ahc.21-00012

Noritaka Kudo, Shinji Kudoh, Akira Matsuo, Yamato Motooka, Takaaki Ito

引用次数: 0

Tissue-specific Physical and Biological Microenvironments Modulate the Behavior of Cervical Squamous Cell Carcinoma. 组织特异性物理和生物微环境调节宫颈鳞状细胞癌的行为。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-10-29 Epub Date: 2021-10-06 DOI: 10.1267/ahc.21-00038

Katsuyuki Hanashima, Takashi Akutagawa, Mihoko Yamamoto-Rikitake, Takehisa Sakumoto, Maki Futamata, Yoshifumi Nakao, Masatoshi Yokoyama, Shuji Toda, Shigehisa Aoki

{"title":"Tissue-specific Physical and Biological Microenvironments Modulate the Behavior of Cervical Squamous Cell Carcinoma.","authors":"Katsuyuki Hanashima, Takashi Akutagawa, Mihoko Yamamoto-Rikitake, Takehisa Sakumoto, Maki Futamata, Yoshifumi Nakao, Masatoshi Yokoyama, Shuji Toda, Shigehisa Aoki","doi":"10.1267/ahc.21-00038","DOIUrl":"https://doi.org/10.1267/ahc.21-00038","url":null,"abstract":"The mechanisms controlling the aggressiveness and survival of cervical SCC cells remain unclear. We investigated how the physical and biological microenvironments regulate the growth, apoptosis and invasiveness of cervical cancer cells. Dynamic flow and air exposure were evaluated as physical microenvironmental factors, and stromal fibroblasts were evaluated as a biological microenvironmental factor. To investigate any regulatory effects of these microenvironmental factors, we established a new culture model which concurrently replicates fluid streaming, air exposure and cancer-stromal interactions. Three cervical cancer cell lines were cultured with or without NIH 3T3 fibroblasts. Air exposure was realized using a double-dish culture system. Dynamic flow was created using a rotary shaker. Dynamic flow and air exposure promoted the proliferative activity and decreased the apoptosis of cervical cancer cells. Fibroblasts regulated the invasive ability, growth and apoptosis of cervical cancer cells. Extracellular signal-regulated kinase and p38 signaling were regulated either synergistically or independently by dynamic flow, air exposure and cellular interactions, depending on the cervical cancer cell type. This study demonstrates that the physical and biological microenvironments interact to regulate the aggressiveness and survival of cervical cancer cells. Our simple culture system is a promising model for developing further treatment strategies for various types of cancer.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/ad/21-00038.PMC8569132.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39612330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cold-induced Conversion of Connective Tissue Skeleton in Brown Adipose Tissues. 棕色脂肪组织结缔组织骨架的冷诱导转化。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-10-29 Epub Date: 2021-10-06 DOI: 10.1267/ahc.21-00030

Masako Yudasaka, Yuko Okamatsu-Ogura, Takeshi Tanaka, Kumiko Saeki, Hiromichi Kataura

{"title":"Cold-induced Conversion of Connective Tissue Skeleton in Brown Adipose Tissues.","authors":"Masako Yudasaka, Yuko Okamatsu-Ogura, Takeshi Tanaka, Kumiko Saeki, Hiromichi Kataura","doi":"10.1267/ahc.21-00030","DOIUrl":"https://doi.org/10.1267/ahc.21-00030","url":null,"abstract":"Thermogenesis via fatty acid-induced uncoupled mitochondrial respiration is the primary function of brown adipose tissue (BAT). In response to changes in ambient temperatures, the weight and specific gravity of BAT change, depending on the quantity of lipid droplets stored in brown adipocytes (BA). Such conditions should result in the reconstruction of connective tissue skeletons, especially of collagen fiber networks, although the mechanisms have not been clarified. This study showed that, within 4 hr of exposing mice to a cold environment, collagen fibers in the extracellular matrix (ECM) of BAT became discontinuous, twisted, emancipated, and curtailed. Surprisingly, the structure of collagen fibers returned to normal after the mice were kept at room temperature for 19 hr, indicating that the alterations in collagen fiber structures are physiological processes association with adaptation to cold environments. These dynamic changes in connective tissue skeletons were not observed in white adipose tissues, suggesting that they are unique to BAT. Interestingly, the vascular permeability of BAT was also augmented by exposure to cold. Collectively, these findings indicate that dynamic changes in ECM collagen fibers provide high flexibility to BAT, enabling the adjustment of tissue structures and the regulation of vascular permeability, resulting in adaptation to changes in ambient temperatures.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/a3/21-00030.PMC8569133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39612328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Endurance Exercise on Basement Membrane in the Soleus Muscle of Aged Rats. 耐力运动对老年大鼠比目鱼肌基底膜的影响。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-10-29 Epub Date: 2021-10-27 DOI: 10.1267/ahc.21-00057

Yuji Kanazawa, Mamoru Nagano, Satoshi Koinuma, Shinichi Sugiyo, Yasufumi Shigeyoshi

引用次数: 4

Dexmedetomidine and Phosphocreatine Post-treatment Provides Protection against Focal Cerebral Ischemia-reperfusion Injury in Rats. 右美托咪定和磷酸肌酸对大鼠局灶性脑缺血再灌注损伤的保护作用。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-08-25 DOI: 10.1267/ahc.21-00040

Xiaofen Sun, Fang Kang, Yuxian Shen, Yujun Shen, Juan Li

{"title":"Dexmedetomidine and Phosphocreatine Post-treatment Provides Protection against Focal Cerebral Ischemia-reperfusion Injury in Rats.","authors":"Xiaofen Sun, Fang Kang, Yuxian Shen, Yujun Shen, Juan Li","doi":"10.1267/ahc.21-00040","DOIUrl":"https://doi.org/10.1267/ahc.21-00040","url":null,"abstract":"In this study we investigated the neuroprotective efficacy of dexmedetomidine (Dex) and phosphocreatine (PCr) alone or in combination in a rat model of focal cerebral ischemia-reperfusion injury (I/R). I/R was induced by intraluminal middle cerebral artery occlusion (MCAO) and reperfusion. Male Sprague-Dawley rats were randomly allocated to the Sham group and I/R group, and the I/R group was further divided into three subgroups: Dex (9 μg.kg-1 Dex), PCr (180 mg.kg-1 PCr) and Dex + PCr (9 μg.kg-1 Dex + 180 mg.kg-1 PCr). All treatments were given intravenously at the onset of reperfusion. After 24 hr of reperfusion, the neurological deficit score (NDS) was determined and a magnetic resonance imaging (MRI) scan was performed. Serum concentrations of malonaldehyde (MDA) and 4-hydroxynonenal (4-HNE) were measured and cerebral infarct volume was estimated by triphenyl tetrazolium chloride (TTC) staining. Blood brain barrier, neuronal and mitochondrial damage was assessed by optical and electron microscopy. Neuronal injury was further assessed using double cleaved caspase-3 and NeuN immunofluorescent staining. Compared with group I/R, Dex and PCr significantly reduced the neurological deficit score (P < 0.01), infarct volume (P < 0.01), and brain blood barrier, neuronal and mitochondrial damage. The level of oxidative stress (P < 0.001) and neuronal injury (P < 0.001) also decreased and surviving neurons increased (P < 0.001). Compared with Dex or PCr alone, the combination treatment had overall greater effects (P < 0.05). These results indicate that posttreatment with Dex or PCr decreases focal cerebral I/R injury and that these agents in combination have greater protective effects than each alone.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Decreased Gastric Gland Mucin-specific O-glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours. 减少胃腺黏液特异性o -聚糖参与卵巢原发性黏液性肿瘤的进展。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-08-25 Epub Date: 2021-07-07 DOI: 10.1267/ahc.21-00032

Ayumi Ohya, Hisanori Matoba, Yasunari Fujinaga, Jun Nakayama

{"title":"Decreased Gastric Gland Mucin-specific O-glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours.","authors":"Ayumi Ohya, Hisanori Matoba, Yasunari Fujinaga, Jun Nakayama","doi":"10.1267/ahc.21-00032","DOIUrl":"https://doi.org/10.1267/ahc.21-00032","url":null,"abstract":"Ovarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 areas of malignant mucinous tumours (malignant) to investigate the expression patterns of αGlcNAc, mucin 2 (MUC2), mucin 5AC (MUC5AC), and MUC6 during the progression of OPMT from benign to malignant. MUC5AC expression was observed in all areas. The frequencies of MUC6- and αGlcNAc-positive areas were decreased with tumour progression. In particular, the decrease in αGlcNAc-positive areas was remarkable. Furthermore, αGlcNAc expression was lower than MUC6 expression at all grades (benign, p < 0.0001; borderline, p = 0.0014; malignant, p = 0.0039). Conversely, there was no difference in the expression frequency or level of MUC2 among the three grades. These results suggest that decreased expression of αGlcNAc relative to MUC6 occurs early in tumour development and marks the initiation of OPMT progression.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/9c/21-00032.PMC8424251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39410616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Forkhead Box I1 in Breast Carcinoma as a Potent Prognostic Factor. 叉头盒I1在乳腺癌中是一个有效的预后因素。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-08-25 Epub Date: 2021-07-31 DOI: 10.1267/ahc.21-00034

Yoshiaki Onodera, Kiyoshi Takagi, Yoshimi Neoi, Ai Sato, Mio Yamaguchi, Yasuhiro Miki, Akiko Ebata, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki

{"title":"Forkhead Box I1 in Breast Carcinoma as a Potent Prognostic Factor.","authors":"Yoshiaki Onodera, Kiyoshi Takagi, Yoshimi Neoi, Ai Sato, Mio Yamaguchi, Yasuhiro Miki, Akiko Ebata, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki","doi":"10.1267/ahc.21-00034","DOIUrl":"https://doi.org/10.1267/ahc.21-00034","url":null,"abstract":"Forkhead box (FOX) proteins are family of transcriptional factors and regulate cell growth and differentiation as well as embryogenesis and longevity. Previous studies have demonstrated that several FOX members regulate growth or metastasis of breast carcinoma, but clinical significance of total FOX members remains unclear. We first examined associations between expression of 40 FOX genes and TNM status of 19 breast carcinoma using microarray data. Subsequently, we immunolocalized FOXI1 in 140 breast carcinomas and evaluated its clinicopathological significance. In the microarray analysis, we newly identified that gene expression of FOXI1 was most pronouncedly linked to metastasis of the breast carcinoma among the FOX members examined. However, clinicopathological significance of FOXI1 has not been examined in the breast carcinoma. FOXI1 immunoreactivity was positive in 44 out of 140 (31%) of breast carcinomas, and it was significantly associated with stage, lymph node metastasis and distant metastasis. The FOXI1 status was significantly associated with worse prognosis of the breast cancer patients, and it turned out to be an independent prognostic factor for both distant disease-free survival and breast cancer-specific survival. These findings suggest that FOXI1 plays important roles in the metastasis of breast carcinoma and immunohistochemical FOXI1 status is a potent prognostic factor.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/4e/21-00034.PMC8424250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39410617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT. 代谢重编程通过TERT的表观遗传调控驱动垂体肿瘤生长。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-06-29 Epub Date: 2021-06-23 DOI: 10.1267/ahc.21-00007

Hiromi Onizuka, Kenta Masui, Kosaku Amano, Takakazu Kawamata, Tomoko Yamamoto, Yoji Nagashima, Noriyuki Shibata

{"title":"Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT.","authors":"Hiromi Onizuka, Kenta Masui, Kosaku Amano, Takakazu Kawamata, Tomoko Yamamoto, Yoji Nagashima, Noriyuki Shibata","doi":"10.1267/ahc.21-00007","DOIUrl":"https://doi.org/10.1267/ahc.21-00007","url":null,"abstract":"Pituitary adenomas are common, benign brain tumors. Some tumors show aggressive phenotypes including early recurrence, local invasion and distant metastasis, but the underlying mechanism to drive the progression of pituitary tumors has remained to be clarified. Aerobic glycolysis known as the Warburg effect is one of the emerging hallmarks of cancer, which has an impact on the tumor biology partly through epigenetic regulation of the tumor-promoting genes. Here, we demonstrate metabolic reprogramming in pituitary tumors contributes to tumor cell growth with epigenetic changes such as histone acetylation. Notably, a shift in histone acetylation increases the expression of telomerase reverse transcriptase (TERT) oncogene, which drives metabolism-dependent cell proliferation in pituitary tumors. These indicate that epigenetic changes could be the specific biomarker for predicting the behavior of pituitary tumors and exploitable as a novel target for the aggressive types of the pituitary tumors.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/f7/ahc-054-87.PMC8275863.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39195137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Immunohistochemical Study of Mitochondrial Ferritin in the Midbrain of Patients with Progressive Supranuclear Palsy. 进行性核上性麻痹患者中脑线粒体铁蛋白的免疫组化研究。

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-06-29 Epub Date: 2021-06-23 DOI: 10.1267/ahc.21-00019

Zulzikry Hafiz Abu Bakar, Tomoko Kato, Daijiro Yanagisawa, Jean-Pierre Bellier, Ken-Ichi Mukaisho, Ikuo Tooyama

{"title":"Immunohistochemical Study of Mitochondrial Ferritin in the Midbrain of Patients with Progressive Supranuclear Palsy.","authors":"Zulzikry Hafiz Abu Bakar, Tomoko Kato, Daijiro Yanagisawa, Jean-Pierre Bellier, Ken-Ichi Mukaisho, Ikuo Tooyama","doi":"10.1267/ahc.21-00019","DOIUrl":"https://doi.org/10.1267/ahc.21-00019","url":null,"abstract":"Mitochondrial ferritin (FtMt) is a novel ferritin that is localized in the mitochondria. FtMt expression is low in the liver and spleen, and high in the heart, testis, and brain. We previously detected FtMt in dopaminergic neurons in the substantia nigra pars compacta (SNc) in human and monkey midbrains. We investigated the localization and expression of FtMt in the midbrain of patients with progressive supranuclear palsy (PSP) and controls using a monoclonal antibody (C65-2) against human FtMt. FtMt immunoreactivity was weakly detected in neuromelanin-containing neurons in the SNc and ventral tegmental area (VTA) of control cases compared with PSP, which exhibited a remarkable increase in FtMt immunoreactivity. Preincubation of C65-2 with the immunizing FtMt peptide significantly reduced the staining, indicating the specificity of C65-2. Several puncta were observed outside the neurons of PSP, in contrast with the control cases. Double immunofluorescence histochemistry for FtMt and tyrosine hydroxylase (TH), glial fibrillary acidic protein, and Iba1 showed localization of FtMt in dopaminergic neurons, microglia, and astrocytes in PSP. Furthermore, FtMt immunoreactivity was detected in a few TH-negative neurons. In the SNc and VTA, FtMt immunoreactivity colocalized with phosphorylated tau immunoreactivity. Our results indicate that FtMt is involved in the pathology of PSP. Clarifying the involvement of FtMt in PSP is of great interest.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/ed/ahc-054-97.PMC8275861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39195138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Review of miR-326 and Female Related Diseases. miR-326与女性相关疾病研究进展

IF 2.4 4区生物学

Acta Histochemica Et Cytochemica Pub Date : 2021-06-29 Epub Date: 2021-04-22 DOI: 10.1267/ahc.20-00027

Li-Na Lin, Qing-Mei Zhang, Ying-Ying Ge, Bin Luo, Xiao-Xun Xie

{"title":"A Review of miR-326 and Female Related Diseases.","authors":"Li-Na Lin, Qing-Mei Zhang, Ying-Ying Ge, Bin Luo, Xiao-Xun Xie","doi":"10.1267/ahc.20-00027","DOIUrl":"https://doi.org/10.1267/ahc.20-00027","url":null,"abstract":"MicroRNA (miRNA), a non-coding single-stranded RNA molecule with 20-23 nucleotides encoded by endogenous genes, plays an essential role in maintaining normal cell function and regulating cell proliferation, differentiation, apoptosis, autophagy, and cell metabolism. The imbalance between miRNA and genes can cause a series of diseases, including malignancies. miRNA-326 (miR-326) is extensively known for its core regulation of various biological processes. This review presents an overview of the highlights of miR-326 in female-related diseases. To understand the impact of miR-326 on female disorders, we search all published studies about miR-326 having a high incidence in female conditions, including cervical cancer, endometrial cancer, breast cancer, intrauterine adhesion, and multiple autoimmune diseases. We aim to learn about the mutual regulation mechanism between miR-326 and related genes and signaling pathways, as well as to elaborate on the value of miR-326 as a potential biomarker and therapeutic target of female diseases. Our results provide reliable evidence and new strategies for treating female tumors and autoimmune diseases.","PeriodicalId":6888,"journal":{"name":"Acta Histochemica Et Cytochemica","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/bd/ahc-054-79.PMC8275862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39196704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6