4open最新文献

{"title":"Remarks on GRN-type systems","authors":"Eduard Brokan, F. Sadyrbaev","doi":"10.1051/fopen/2020009","DOIUrl":"https://doi.org/10.1051/fopen/2020009","url":null,"abstract":"Systems of ordinary differential equations that appear in gene regulatory networks theory are considered. We are focused on asymptotical behavior of solutions. There are stable critical points as well as attractive periodic solutions in two-dimensional and three-dimensional systems. Instead of considering multiple parameters (10 in a two-dimensional system) we focus on typical behaviors of nullclines. Conclusions about possible attractors are made.","PeriodicalId":6841,"journal":{"name":"4open","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74911444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: Paradox of increasing capacities versus focus on Hippocratic ethics?","authors":"G. Anogeianakis","doi":"10.1051/fopen/2020003","DOIUrl":"https://doi.org/10.1051/fopen/2020003","url":null,"abstract":"A simple statistical review of the results of the increased availability of ICU beds in the EU shows that irrespective of whether a country has a lot of ICU beds or just a few, the death rates due to COVID-19 is still the same (P = 0 34, Fig 1 and Tab 1) An answer to the paradox comes from a group of intensive care physicians from long-suffering Italy [2], who claim that, at present, attention is focused mainly on increasing capacities (e g , the number of ICU beds, respirators and intensive care units, etc ) Conflict of interest The author, George Anogeianakis, certifies that he has no financial conflict of interest (e g , consultancies, stock ownership, equity interest, patent/licensing arrangements, etc ) in connection with this article 1","PeriodicalId":6841,"journal":{"name":"4open","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84993256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: Pandemic surgery guidance","authors":"B. Brücher, G. Nigri, A. Tinelli, J. F. Lapeña, E. Espín-Basany, P. Macrì, E. Matevossian, Sergio Ralon, R. Perkins, R. Lück, R. Kube, J. Costa, Y. Mintz, M. Tez, S. Allert, S. Sökmen, A. Spychała, B. Zilberstein, F. Marusch, M. Kermansaravi, W. Kycler, D. Vicente, M. Scherer, A. Rivkind, N. Elias, G. Wallner, F. Roviello, L. Santos, Raimund JC Araujo, A. Szold, Raúl Oleas, M. Rupnik, J. Salber, I. Jamall, A. Engel","doi":"10.1051/fopen/2020002","DOIUrl":"https://doi.org/10.1051/fopen/2020002","url":null,"abstract":"Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the British Intercollegiate General Surgery Guidance as well as recommendations from the USA, Asia, and Italy. The aim is to take responsibility and to provide guidance for surgery during the COVID-19 crisis in a simplified way addressing the practice of surgery, healthcare staff and patient safety and care. It is the responsibility of scientists and the surgical team to specify what is needed for the protection of patients and the affiliated healthcare team. During crises, such as the COVID-19 pandemic, the responsibility and duty to provide the necessary resources such as filters, Personal Protective Equipment (PPE) consisting of gloves, fluid resistant (Type IIR) surgical face masks (FRSM), filtering face pieces, class 3 (FFP3 masks), face shields and gowns (plastic ponchos), is typically left up to the hospital administration and government. Various scientists and clinicians from disparate specialties provided a Pandemic Surgery Guidance for surgical procedures by distinct surgical disciplines such as numerous cancer surgery disciplines, cardiothoracic surgery, ENT, eye, dermatology, emergency, endocrine surgery, general surgery, gynecology, neurosurgery, orthopedics, pediatric surgery, reconstructive and plastic surgery, surgical critical care, transplantation surgery, trauma surgery and urology, performing different surgeries, as well as laparoscopy, thoracoscopy and endoscopy. Any suggestions and corrections from colleagues will be very welcome as we are all involved and locked in a rapidly evolving process on increasing COVID-19 knowledge.","PeriodicalId":6841,"journal":{"name":"4open","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91030094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-messengers at ultra-high energies with the Pierre Auger Observatory","authors":"J. Souchard","doi":"10.1051/fopen/2020004","DOIUrl":"https://doi.org/10.1051/fopen/2020004","url":null,"abstract":"The Pierre Auger Observatory is an Ultra-High Energy Cosmic Ray (UHECR) detector which has studied cosmic particles with energies above and around 1018 eV for more than 15 years. It has proved to be the most competitive instrument at these energies and has produced a wealth of valuable results, improving our understanding of UHECRs. A complete understanding of these highest energy particles is crucial to understand the extreme astrophysical events in which they are produced and accelerated, as well as their propagation to Earth. In the same range of energies, UHE photons and neutrinos are of paramount importance as, being electrically neutral, they point back to their origin while charged particles are deflected in the galactic and extragalactic magnetic fields. The flux of extragalactic photons, neutrinos, and cosmic rays are believed to be highly linked, by their origin and their interactions. Each messenger provides different information about the potential sources, and having detection means for all four messengers, including gravitational waves, allows us to shed light on energetic sources of astroparticles. The Pierre Auger Observatory benefits from a large exposure and a good angular resolution, and is efficient in detecting UHE photons and neutrinos. These performances make possible follow-up searches for events detected by gravitational waves, such as the binary mergers observed by the LIGO/Virgo detectors, or any other energetic sources of particles.","PeriodicalId":6841,"journal":{"name":"4open","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87963160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A copula based representation for tailings dam failures","authors":"Laura Maria Canno Ferreira Fais, V. González-López, D. S. Rodrigues, Rafael Rodrigues de Moraes","doi":"10.1051/fopen/2020011","DOIUrl":"https://doi.org/10.1051/fopen/2020011","url":null,"abstract":"In this article, we model the dependence between dam factor and D max, where dam factor is an indicator of risk of a tailings dam failure, which involves the height H of the tailings dam, the volume of material housed by the tailings dam VT and the volume dispensed by the tailings dam, VF, when the dam breaks. And, Dmax is the maximum distance traveled by the material released by the tailings dam, after the collapse. With the dependence found via copula models and Bayesian estimation, given a range of dam factor, we estimate the probability of the released material to exceed a certain threshold. Since the dam factor involves the released volume VF (unknown before the dam break), we present a naive way to estimate it using VT and H. In this way, it is possible to estimate the dam factor of a tailings dam and with such a value to identify the probability of the tailings dam to show a Dmax that exceeds a certain threshold.","PeriodicalId":6841,"journal":{"name":"4open","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81058379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More on algebraic properties of the discrete Fourier transform raising and lowering operators","authors":"M. Atakishiyeva, N. Atakishiyev, J. Loreto-Hernández","doi":"10.1063/1.5114023","DOIUrl":"https://doi.org/10.1063/1.5114023","url":null,"abstract":"In the present work, we discuss some additional findings concerning algebraic properties of the N-dimensional discrete Fourier transform (DFT) raising and lowering difference operators, recently introduced in [Atakishiyeva MK, Atakishiyev NM (2015), J Phys: Conf Ser 597, 012012; Atakishiyeva MK, Atakishiyev NM (2016), Adv Dyn Syst Appl 11, 81–92]. In particular, we argue that the most authentic symmetrical form of discretization of the integral Fourier transform may be constructed as the discrete Fourier transforms based on the odd points N only, while in the discrete Fourier transforms on the even points N this symmetry is spontaneously broken. This heretofore undetected distinction between odd and even dimensions is shown to be intimately related with the newly revealed algebraic properties of the above-mentioned DFT raising and lowering difference operators and, of course, is very consistent with the well-known formula for the multiplicities of the eigenvalues, associated with the N-dimensional DFT. In addition, we propose a general approach to deriving the eigenvectors of the discrete number operators N(N), that avoids the above-mentioned pitfalls in the structure of each even-dimensional case N = 2L.","PeriodicalId":6841,"journal":{"name":"4open","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82137520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eigenvalues of matrices related to the octonions","authors":"R. Serôdio, P. Beites, J. Vitória","doi":"10.1051/FOPEN/2019014","DOIUrl":"https://doi.org/10.1051/FOPEN/2019014","url":null,"abstract":"A pseudo real matrix representation of an octonion, which is based on two real matrix representations of a quaternion, is considered. We study how some operations defined on the octonions change the set of eigenvalues of the matrix obtained if these operations are performed after or before the matrix representation. The established results could be of particular interest to researchers working on estimation algorithms involving such operations.","PeriodicalId":6841,"journal":{"name":"4open","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88077995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stochastic profile of Epstein-Barr virus in nasopharyngeal carcinoma settings","authors":"M. Cordeiro, J. E. García, V. González-López, Sergio L. M. londono","doi":"10.1051/FOPEN/2019020","DOIUrl":"https://doi.org/10.1051/FOPEN/2019020","url":null,"abstract":"We build a profile of the Epstein-Barr virus (EBV) by means of genomic sequences obtained from patients with nasopharyngeal carcinoma (NPC). We consider a set of sequences coming from the NCBI free source and we assume that this set is a collection of independent samples of stochastic processes related by an equivalence relation. Given a collection {(Xjt)t∈ℤ}pj=1 of p independent discrete time Markov processes with finite alphabet A and state space S, we state that the elements (i, s) and (j, r) in {1, 2,…, p} × S are equivalent if and only if they share the same transition probability for all the elements in the alphabet. The equivalence allows to reduce the number of parameters to be estimated in the model avoiding to delete states of S to achieve that reduction. Through the equivalence relationship, we build the global profile for all the EBV in NPC sequences, this model allows us to represent the underlying and common stochastic law of the set of sequences. The equivalence classes define an optimal partition of {1, 2,…, p} × S, and it is in relation to this partition that we define the profile of the set of genomic sequences.","PeriodicalId":6841,"journal":{"name":"4open","volume":"1998 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88230624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A copula-based consistency analysis of education indicators","authors":"C. Cunha, Mariela Fernández, J. E. García, V. González-López, N. Romano","doi":"10.1051/FOPEN/2019013","DOIUrl":"https://doi.org/10.1051/FOPEN/2019013","url":null,"abstract":"In this paper we investigate the consistency of quality indicators of the Brazilian public educational system. According to the newspaper Estado de São Paulo – Brazil, of January 18, 2017, only 7.3% of students in the third year of high school have an adequate level of mathematics, this shows the relevance of the evaluation and assessment of the Brazilian educational system. In this paper we explore the dependence between two indicators: (i) mean value between the proportions (in two subjects: Portuguese and Mathematics) of students under the basic level (SARESP classification) and (ii) rate of fails, during the years 2013, 2014 and 2015. (i) and (ii) are bases to define the educational quality of public schools for the population of young people, between 14 and 17 years old. This inspection is carried out through the Bayesian estimation of the parameters of the Asymmetric Cubic Sections (ACS) copula. We show that the dependence profile, year after year, behaves in a very unstable way, although during those years there were no substantial changes which justify such instability. Through the copula we compute conditional probabilities of tail events. We verify that an inversion occurred in the concordance/discordance between (i) and (ii). We compute the probability of (i) assuming high values, conditioned to a threshold in (ii). In 2013, as the threshold in (ii) increases the probability increases (concordance), in 2014 the threshold in (ii) is almost irrelevant to the probability and in 2015, as the threshold in (ii) increases the probability decreases (discordance). The inspection of the tail dependence allows to expose some kind of manipulation, in view of for instance, the maintenance of a global index índice de desenvolvimento da educação de São Paulo (IDESP) used to classify the educational institutions.","PeriodicalId":6841,"journal":{"name":"4open","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90005737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"German nursing shortage in hospitals – Homemade by Profititis?","authors":"B. Brücher, D. Deufert","doi":"10.1051/FOPEN/2019007","DOIUrl":"https://doi.org/10.1051/FOPEN/2019007","url":null,"abstract":"The shortage of nursing staff in Germany compromises public healthcare in deference to profits explaining why this is on the daily political and media agenda. In Germany, over a 22 year period, significant savings were achieved by decreases in: (1) hospital beds by −29.3% saving 119 000 beds, (2) patient care and treatment days by −23% saving 43.1 million patient days, and (3) length of hospital stay in days by −39% saving 4.7 days. This occurred together with the parallel increase of treated patient cases by +26.5% with an additional burden of 4.1 million patients. Since 2010, as birth rates increase again treatment cases will also increase. In parallel, the percentage of total nurses has decreased (−2.1%) as well as that of registered nurses in hospitals between 1999 (325 539) and 2009 (324 337) have decreased (−0.4%), in conjunction with nurses employed in preventive and rehabilitation facilities (+15.1%) and/or in outpatient care facilities (+41.1%) and/or nursing homes (+24.8%) and/or nurses working in retirement homes (+77.9%). This “profititis” endangers both patient care and detracts from people joining the nursing profession. It might even be a short-sighted tightrope act which, in the end, might counteract the marketing strategy of “patient safety” by risking quality of patient care. Maybe healthcare politics would be well-advised to re-think the fact that as the population gets older and as birth rates and immigration increases, these factors could result in increased patient caseloads in hospitals which need to be addressed now so as to avert a future crisis.","PeriodicalId":6841,"journal":{"name":"4open","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86515953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}