中华内科杂志最新文献

{"title":"[Progress of type 2 diabetes in the past decade].","authors":"Y P Wang, Y M Mu","doi":"10.3760/cma.j.cn112138-20240904-00552","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240904-00552","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1137-1143"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guidelines for the diagnosis and management of multiple myeloma: 2024 updates].","authors":"J Lu","doi":"10.3760/cma.j.cn112138-20241008-00662","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241008-00662","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1160-1162"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Glucokinase activators: the first step in regulating intracellular glucose metabolism].","authors":"Y Hu, Y J Li, Y M Mu","doi":"10.3760/cma.j.cn112138-20240713-00448","DOIUrl":"10.3760/cma.j.cn112138-20240713-00448","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1170-1174"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of risk stratification in guidelines for the diagnosis and management of multiple myeloma in China (2024 revision)].","authors":"S N Chen, L G Qiu","doi":"10.3760/cma.j.cn112138-20241008-00665","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241008-00665","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1175-1178"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress in IgG₄-related disease over the recent decade].","authors":"Y X Nie, W Zhang","doi":"10.3760/cma.j.cn112138-20240924-00602","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240924-00602","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1144-1148"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on multidisciplinary clinical management for chronic kidney disease].","authors":"","doi":"10.3760/cma.j.cn112138-20240910-00566","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240910-00566","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) has been a major public health challenge threatening human health worldwide. When patients with CKD eventually progress to end-stage kidney disease, it imposes a substantial burden on individuals and society. Currently, the diagnosis rate of CKD in China remains low, with an unfavorable status regarding diagnosis and treatment. Therefore, it is urgent to establish a comprehensive prevention and treatment system of CKD, that enhances the multidisciplinary clinical management pathway for CKD patients while improving physicians' co-screening and co-management capabilities across various disciplines for high-risk individuals. Based on current evidence and clinical experience, we formulate the expert consensus on multidisciplinary clinical management approach for CKD, which aims to achieve early detection, early treatment, delay the progression of kidney failure, reduce the risk of cardiovascular, cerebrovascular diseases as well as death in CKD patients, while improving the prognosis of CKD patients and alleviating the burden of CKD disease with a multidisciplinary co-screening co-management model for CKD.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1216-1227"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the value of enhanced magnetic resonance imaging in the International Prophylaxis Study Group (IPSG) score of the synovium in hemophilic arthropathy].","authors":"Y X Zhang, S F Wei, F F Zhang, P C Lei, Y H Ge","doi":"10.3760/cma.j.cn112138-20240512-00299","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240512-00299","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the value of enhanced magnetic resonance imaging (MRI) on the assessment of synovial hyperplasia and International Prophylaxis Study Group (IPSG) score of hemophilic arthropathy (HA). <b>Methods:</b> This was a retrospective case series study. Briefly, 54 joints of 46 male patients with hemophilia type A and diagnosed with HA in Henan Provincial People's Hospital from August 2016 to September 2017 were selected. Plain and enhanced MRI were performed at the same time. The IPSG score of synovial hyperplasia and the total joint before and after enhancement were calculated, and the enhancement rate of the synovium and muscles at the same level were also calculated. The differences in synovial hyperplasia and joint total IPSG scores before and after enhancement were compared by paired rank sum test. The correlation between enhancement joint total IPSG score, synovial IPSG score, synovial enhancement rate, total joint bleeding number, course of disease, and Hemophilia Joint Health Score (HJHS) score were analyzed by Spearman's correlation analysis. <b>Results:</b> Enhanced MRI could more clearly show synovial hyperplasia and ensure better accuracy of joint total IPSG score (<i>Z</i>=-2.24, <i>P</i>=0.025). The enhancement extent of synovial hyperplasia was higher than that of the same level muscle. There was no correlation between synovial enhancement rate and total number of joint bleeding, course of disease, and HJHS score. After enhancement, the joint total IPSG score was highly positively correlated with the total number of joint bleeding and the disease course (<i>r</i>=0.96, 0.84, <i>P</i><0.001) and moderately positively correlated with the HJHS score (<i>r</i>=0.58, <i>P</i><0.001). The enhanced synovial IPSG score showed a low positive correlation with the total number of joint bleeding and the disease course (<i>r</i>=0.37, 0.36, <i>P</i>=0.006, 0.008), but no correlation with HJHS score. <b>Conclusion:</b> Enhanced MRI can provide accurate imaging of synovial hyperplasia of HA and make joint IPSG score more accurate.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1246-1251"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[An overlooked risk factor for pan-vascular disease: hyperinsulinemia].","authors":"Y Qian, Q Fu, T Yang","doi":"10.3760/cma.j.cn112138-20240716-00455","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240716-00455","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1163-1169"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Macrophage activation syndrome secondary to systemic sclerosis and systemic lupus erythematosus overlap syndrome: a case report].","authors":"D Ma, Q Wu, J R Cheng, Q R Wu, X Li, Y H Peng","doi":"10.3760/cma.j.cn112138-20240902-00550","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240902-00550","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1257-1260"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and prognostic analysis of prolonged cytopenia after CAR-T cell therapy in LBCL patients].","authors":"H Y Zhu, D Q Zhao, Z Zhuang, J Ruan, C Chen, W Zhang, D B Zhou, Y Zhang","doi":"10.3760/cma.j.cn112138-20240713-00450","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240713-00450","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical features and prognosis of prolonged cytopenia (PC) in patients with large B-cell lymphoma (LBCL) undergoing anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy. <b>Methods:</b> A retrospective case series study was conducted on LBCL patients who received CAR-T cell therapy with a survival time of over one month at the Hematology Department of Peking Union Medical College Hospital from March 2019 to December 2023. Statistical analyses were performed on hematologic changes at 1, 3, 6, and 12 months post-CAR-T infusion, as well as on the progression-free survival (PFS) and post-treatment adverse events, including infections. Patients were categorized into the PC and non-PC groups based on the occurrence of cytopenia at 90 days post-infusion. Differences between groups were compared, and univariate logistic regression analysis was used to identify risk factors. <b>Results:</b> The median age of 27 LBCL patients receiving CAR-T cell therapy was 58 years (range 27-69 years), with 18 males. Among the 27 LBCL patients who received CAR-T cell therapy, PC was observed in 19 patients (70.4%), with instances of neutropenia (48.1%, 13 cases), anemia (37.0%, 10 cases), and thrombocytopenia (22.2%, 6 cases). Univariate logistic regression analysis revealed that prior chemotherapy sensitivity (<i>OR</i>=18.00, 95%<i>CI</i> 1.56-207.45, <i>P</i>=0.020) and bone marrow suppression (<i>OR</i>=18.00, 95%<i>CI</i> 1.38-235.69, <i>P</i>=0.028) were associated with PC. The median follow-up time was 13.5 months. The PC group exhibited a higher risk of infection within 3 months (9/19 vs. 1/8) and a shorter mean PFS (19.3 months vs. 24.4 months), although the difference was not statistically significant (both <i>P</i>>0.05). <b>Conclusions:</b> PC is common following CAR-T cell therapy and is associated with an increased risk of infection and poorer prognosis. Prior treatment sensitivity and bone marrow suppression may serve as indicators of PC.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"63 12","pages":"1238-1245"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}