中华内科杂志最新文献

{"title":"[Interpretation of the 2025 American Association of Cardiovascular and Pulmonary Rehabilitation scientific statement: optimization strategies for aerobic exercise volume on cardiac rehabilitation outcomes].","authors":"L Y Zhu, Z C Liu, X Yang, X F Zhang","doi":"10.3760/cma.j.cn112138-20250922-00563","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250922-00563","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"407-412"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress of mechanisms and treatment for mental stress-induced myocardial ischemia from a sex difference perspective].","authors":"J Q Jin, M Y Liu, L J Zhang, Y M Li","doi":"10.3760/cma.j.cn112138-20251028-00646","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20251028-00646","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"491-495"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research and application progresses of bronchoscopic lung volume reduction with endobronchial valve in severe chronic obstructive pulmonary disease].","authors":"H M Rong, F Wang","doi":"10.3760/cma.j.cn112138-20251126-00721","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20251126-00721","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"503-507"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and prognostic analysis of acute erythroid leukemia].","authors":"S S Zhao, H Wang, R Wang, C Qiao, X Chen, M Hong, G S He, W Y Shen, L Fan, Y Wang","doi":"10.3760/cma.j.cn112138-20260107-00011","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20260107-00011","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical characteristics and prognosis of acute erythroid leukemia (AEL). <b>Methods:</b> A retrospective case series study was conducted. Clinical data from 23 patients with AEL admitted to the Department of Hematology at the First Affiliated Hospital of Nanjing Medical University from January 2015 to May 2025 were collected. Laboratory features and prognostic outcomes were summarized. Overall survival (OS) was analyzed using the Kaplan-Meier method, and log-rank test was used for comparisons between groups. <b>Results:</b> Among the 23 patients with AEL, 13 were male (56.5%) and 10 were female (43.5%), with a median age of 62 years (range: 13-80 years). Of these patients, 10 (43.5%) had primary AEL, 5 (21.7%) had treatment-related AEL, and 8 (34.8%) had AEL secondary to other myeloid diseases. Among the secondary AEL cases, 5 were associated with myelodysplastic syndrome, 2 with chronic myeloid leukemia, and 1 with aplastic anemia. Regarding TP53 abnormalities, 38.1% (8/21) of patients had TP53 deletions, and among the 16 patients who underwent next-generation sequencing, all had TP53 mutations. The most frequent TP53 mutation sites were R248Q/W/L/P (3/16), H193R/D/L (2/16), and C242 frameshift mutations (2/16). The median OS was 1.23 months (range: 0.27-13.53 months). The median OS was 1.00 month (95%<i>CI</i> 0.77-1.23) in patients with TP53 mutation frequency >40% (<i>n</i>=8), compared with 3.07 months (95%<i>CI</i> 0-6.81) in those with TP53 mutation frequency ≤40% (<i>n</i>=8). The difference in OS between the two groups was statistically significant (<i>χ</i>²=7.65, <i>P</i>=0.006). There was no statistically significant difference in OS between patients receiving intensive chemotherapy and those receiving low-intensity chemotherapy (<i>P</i>=0.161). The median OS was 2.20 months (95%<i>CI</i> 1.06-3.34) in the primary group, 7.20 months (95%<i>CI</i> 0-20.01) in the treatment-related group, and 0.93 months (95%<i>CI</i> 0.66-1.21) in the secondary group. Survival differed significantly among the three etiological groups (<i>χ</i>²=11.53, <i>P</i>=0.003). <b>Conclusion:</b> AEL is a subtype of acute myeloid leukemia with extremely poor prognosis that is highly associated with TP53 gene abnormalities.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"452-458"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report of apparent mineralocorticoid excess syndrome induced by a licorice preparation].","authors":"L R Xie, J T Dou, Z H Lyu, S C Zhang, B Li","doi":"10.3760/cma.j.cn112138-20260113-00029","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20260113-00029","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"483-485"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current research status of early carbapenem-resistant <i>Klebsiella pneumoniae</i> infections after lung transplantation].","authors":"S Q Xue, X S Li, T Qian, M Xiong, Y T Qiao, M T Zhang, L Zhu, J Y Chen, B Wu","doi":"10.3760/cma.j.cn112138-20251106-00672","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20251106-00672","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"496-502"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathologic features and treatment of 13 cases of Castleman's disease].","authors":"X R Li, F M Wang, X L Zhang, B C Liu","doi":"10.3760/cma.j.cn112138-20250909-00533","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250909-00533","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To analyze and summarize the clinical and pathological characteristics, therapeutic strategies, and prognostic outcomes of adult patients with Castleman disease. &lt;b&gt;Methods:&lt;/b&gt; In this single-center case series, clinical data from 13 adult patients treated for confirmed Castleman disease at Zhongda Hospital Affiliated with Southeast University between April 2020 and December 2024 were retrospectively analyzed. Primary observation indicators included demographic characteristics, clinical manifestations, histological classification, and findings from laboratory and imaging examinations. Treatment modalities and prognostic outcomes were also assessed. Fisher's exact test was used for group comparisons. &lt;b&gt;Results:&lt;/b&gt; Among the 13 patients, 7 were male and 6 were female, with a median age at onset of 49 years (range, 22-71 years). Three patients were diagnosed with unicentric Castleman disease (UCD), whereas 10 presented with multicentric Castleman disease (MCD). Most UCD patients were asymptomatic systemically (2/3), while one patient presented with paraneoplastic pemphigoid (PNP). All MCD patients exhibited generalized lymphadenopathy at multiple sites; seven had serous cavity effusions, and three demonstrated renal involvement. Diagnosis was confirmed via lymph node or mass biopsy, with pathological classification revealing seven cases of hyaline vascular type, five cases of plasma cell type, and one case of mixed type. No statistically significant differences were observed in pathological subtypes or immunohistochemical staining results between MCD and UCD patients (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Laboratory findings showed that only the median levels of C-reactive protein and the median percentage of reticulocytes in MCD patients were above the normal reference range, while the median or mean levels of all other detectable indicators were within normal limits in both MCD and UCD patients. Treatment was tailored to clinical subtype, surgical feasibility, and disease characteristics. Five patients with localized disease and no systemic symptoms (2 UCD, 3 MCD) underwent surgery alone; two with localized disease and comorbidities (1 UCD with PNP, 1 human herpesvirus 8-positive MCD) received surgery plus pharmacotherapy; four MCD patients with multicentric lymphadenopathy and multiorgan involvement received pharmacotherapy alone; and two MCD patients with superficial lesions and no systemic symptoms were managed by observation alone. All patients improved and were discharged. At a median follow-up of 12 months (range, 6-17 months), all remained alive with no recurrence. &lt;b&gt;Conclusions:&lt;/b&gt; Adult UCD was predominantly asymptomatic systemically or localized, whereas MCD was associated with generalized lymphadenopathy and multisystem involvement. Treatment for UCD primarily involved surgical resection, while MCD required comprehensive pharmacotherapy. Prognosis was favorable for UCD, and MCD patients also achieved remission following treat","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"465-472"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The 518th case: multiple intracranial lesions, fever, rash].","authors":"Q Liu, P P Shi, X Chen, Y L Su, X L Xing, Z X Wang, W Zhang, Y Yuan","doi":"10.3760/cma.j.cn112138-20251229-00799","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20251229-00799","url":null,"abstract":"<p><p>This article reports the case of a 58-year-old male patient who presented with a generalized rash, intermittent fever, and a concomitant perianal abscess, as well as mycoplasma pneumoniae psittacosis. The initial symptom was episodic slurred speech, which progressively developed into symptoms such as delayed responses and left-sided limb weakness. Cranial magnetic resonance imaging revealed gradually progressive intracranial lesions characterized primarily by asymmetric white matter damage, with no enhancement upon contrast administration. Serum HIV antibody testing was positive. Next-generation sequencing of pathogens in the cerebrospinal fluid detected DNA from hepatitis B virus, John Cunningham (JC) virus, and Epstein-Barr virus. The patient was ultimately diagnosed with AIDS combined with progressive multifocal leukoencephalopathy. This case highlights that for lesions predominantly involving the white matter with an asymmetric bilateral distribution, the possibility of progressive leukoencephalopathy should be considered, and HIV antibody screening is warranted.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"513-518"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert guidance and consensus for standardization of lipid profile testing report in China].","authors":"L Zhang, Z Y Chen, D Q Peng, Y L Guo, H X Xu, W Gan, Z W Wang, Z Wang, S X Luo, N Q Wu, H L Cong, G F Wu, M Hu, G S Ma, H Q Song, S D Zhou, H Chen, Z H Zhou, H Yan, J P Li, C S Ma","doi":"10.3760/cma.j.cn112138-20260210-00085","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20260210-00085","url":null,"abstract":"<p><p>Domestic and international guidelines focusing on ASCVD risk stratification and precision treatment of dyslipidemia emphasize the formulation of individualized LDL-C targets based on risk stratification. However, in current clinical practice in China, most lipid profile testing reports adopt a single presentation format, with the indicated reference ranges only applicable to the general healthy population, which fails to meet the needs of stratified treatment for patients with varying risk levels.To promote the precise diagnosis and assessment of dyslipidemia, and improve the treatment rate and long-term compliance rate of dyslipidemia, the Expert Group of Expert guidance and consensus for standardization of lipid profile testing report in China has organized multidisciplinary experts to formulate and issue Expert guidance and consensus for standardization of lipid profile testing report in China. This document provides guidance for the clinical reform of lipid profile testing reports. Through the reform and standardization of lipid profile testing reports, it aims to raise the awareness and attention of cardiologists, non-cardiovascular specialists, and patients with dyslipidemia, improve the awareness and diagnosis rates of dyslipidemia among different populations, and facilitate the implementation of individualized risk assessment and precision treatment regimens. It will also help establish a more scientific and efficient system for lipid management, enhance the efficiency of medical resource utilization, reduce the risk of CVD and the associated burden on medical insurance expenditures, and yield greater public health and economic benefits.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"418-429"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report of small cell lung cancer with acute pancreatitisand and intestinal pseudo-obstruction as initial manifestations].","authors":"H Li, Z Y Wu, B Wang, T C Song, W J Wang, S H Shao, D C Li, B Cao","doi":"10.3760/cma.j.cn112138-20260123-00048","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20260123-00048","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"65 5","pages":"478-482"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}