中华内科杂志最新文献

{"title":"[Thrombotic microangiopathy caused by tyrosine kinase inhibitor in small intestine stromal tumor: a case report].","authors":"Z Q Wang, C N Gao, J Xu, X N Chen","doi":"10.3760/cma.j.cn112138-20241107-00739","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241107-00739","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"441-444"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the clinical characteristics of 59 cases of autoimmune gastritis].","authors":"L Guan, X H Zhang, Y Feng, Y L Li","doi":"10.3760/cma.j.cn112138-20240930-00634","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240930-00634","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical characteristics of patients with autoimmune gastritis (AIG) and compare the associated factors between AIG and type B atrophic gastritis. <b>Methods:</b> A total of 59 patients were diagnosed as showing AIG at the First Affiliated Hospital of China Medical University between January 2021 and August 2024. These patients were age-and sex-matched with 59 patients diagnosed with type B atrophic gastritis at the same center. The basic information and relevant clinical indicators of the two groups of patients were recorded. Univariate and multivariate logistic analyses were used to determine the differential factors between AIG and type B atrophic gastritis. <b>Results:</b> AIG mainly occurred in patients aged 50-70 years and showed a sex ratio of approximately 1∶3. Anti-intrinsic factor antibody (IFA)-positive results were observed in 28.8% of patients showing AIG. The pepsinogen Ⅰand pepsinogen Ⅰ/Ⅱ ratio in the IFA-positive group was significantly lower than that in the IFA-negative group [4.8 (2.8,6.3) vs.13.3 (5.8, 25.2) μg/L, <i>t</i>=-5.24, <i>P</i><0.05; 1.0±0.6 vs. 2.2±1.6, <i>t</i>=-3.72, <i>P</i><0.05]. Among the patients with AIG, 35.2% had anemia, including 1.8% with severe anemia. The relevant indicators showed no statistically significant differences between patients with and without anemia. After univariate and multivariate logistic analyses, we compared gastric function and <i>Helicobacter pylori</i> infection in patients with AIG and type B atrophic gastritis, and the gastrin 17 level was identified an independent differential factor between the two groups (<i>OR</i>=0.913, 95%<i>CI</i> 0.851-0.978, <i>P</i>=0.010). <b>Conclusion:</b> The gastrin 17 level can help distinguish AIG and type B atrophic gastritis, and is valuable for early identification of AIG.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"417-423"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of renal sarcoidosis presenting with acute exacerbation of chronic renal insufficiency].","authors":"X J Tian, Q Jia, L J He, D Wang","doi":"10.3760/cma.j.cn112138-20241202-00792","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241202-00792","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"436-440"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chronic kidney disease-associated pruritus combined with anxiety and depression treated with nalfurafine hydrochloride: a case report].","authors":"L Yin, H Ding, Y Y Xu","doi":"10.3760/cma.j.cn112138-20250116-00042","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250116-00042","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"445-447"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of tumor necrosis factor receptor-associated periodic fever syndrome complicated with immunodeficiency caused by a new TNFRSF1A mutation].","authors":"X Y Yang, Y L Chen, D Z Liu, X P Hong","doi":"10.3760/cma.j.cn112138-20240515-00308","DOIUrl":"10.3760/cma.j.cn112138-20240515-00308","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"448-451"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The comorbidity mechanism of celiac disease and immunoglobulin A nephropathy].","authors":"Y Y Gong, X Y Liu, Y Chen","doi":"10.3760/cma.j.cn112138-20240625-00403","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240625-00403","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"462-467"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Recommendations for the disease-modifying treatments of early Alzheimer's disease].","authors":"","doi":"10.3760/cma.j.cn112138-20241028-00709","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241028-00709","url":null,"abstract":"<p><p>Monoclonal antibodies targeting β-amyloid (Aβ)(represented by Lecanemab) have been approved in the United States, Japan and China for the treatment of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) or mild AD dementia, and AD treatment has moved towards the era of disease modifying therapy (DMT). In view of the lack of use experience with DMT in China, this article presents recommendations for Aβ-based DMT clinical practice based on its clinical evidence, as well as its existing usage experience and research regarding AD. These recommendations include the mechanism of action, patient selection, standardized use, effectiveness, and safety monitoring, intending to help guide the rational use in real-world clinical practice.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"385-395"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hot topic: indications for molecular testing in ultrasound-guided biopsy of thyroid nodules and cervical lymph nodes].","authors":"H L Li, J J Ma, T T Zhou, S H Zhang, J Zhai, B Zhang","doi":"10.3760/cma.j.cn112138-20250102-00002","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250102-00002","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"377-384"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between depression and death in the maintenance hemodialysis population: a cohort study].","authors":"X X Xu, L L Wang, H Tian, L Li, H Zheng, X Y Gu, C S Dai, L Jiang","doi":"10.3760/cma.j.cn112138-20241115-00760","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241115-00760","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To identify factors associated with depressive symptoms in maintenance hemodialysis patients and to examine the relationship between these symptoms and mortality. &lt;b&gt;Methods:&lt;/b&gt; Between January and December 2019, patients who received maintenance hemodialysis in the Blood Purification Center of the Second Affiliated Hospital of Nanjing Medical University were enrolled in a prospective cohort study. Depressive symptoms were assessed using the internationally validated patient health questionnaire-8 (PHQ-8). Sleep quality and anxiety were measured with the Pittsburgh sleep quality index (PSQI) and the generalized anxiety disorder-7 (GAD-7) scale, respectively. Follow-up continued until December 31, 2022, with all-cause mortality as the primary outcome. Ordinal logistic regression was used to identify independent predictors of depression severity. Cox proportional hazards models evaluated the association between depressive symptoms and mortality. &lt;b&gt;Results:&lt;/b&gt; A total of 532 maintenance hemodialysis (MHD) patients completed the study. Among them, 177 (33.3%) exhibited depressive symptoms. Compared with patients without depression, those with mild or moderate-to-severe depression were older [median age: 58 (50, 66) vs. 60 (55, 65) vs. 55 (46, 64)], more likely to smoke [35.9% (51/142) vs. 40.0% (14/35) vs.26.2% (93/355)], had poorer sleep quality [PSQI: 9 (6, 13) vs. 12 (9, 17) vs. 5 (3, 9)], and higher anxiety levels [GAD-7: 1 (0, 3) vs. 3 (1, 6) vs. 0 (0, 1)], the differences among the three groups were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). Ordinal logistic regression identified smoking status, history of diabetes or cardiovascular disease, hemoglobin level, PSQI score, and GAD-7 score as independent predictors of depression severity (&lt;i&gt;OR&lt;/i&gt;=1.60, 1.80, 1.81, 0.98, 3.67, 8.67; all &lt;i&gt;P&lt;/i&gt;&lt;0.05). After a median follow-up of 40 (35, 44) months, 109 patients died, including 66 (60.6%) from cardio-cerebrovascular causes and 24 (22.0%) from infections. Kaplan-Meier analysis revealed significantly lower cumulative survival in the depression group compared to the non-depression group (&lt;i&gt;P&lt;/i&gt;&lt;0.001). Cox regression analysis demonstrated that depressive symptoms remained independently associated with all-cause mortality after adjusting for confounders (&lt;i&gt;HR&lt;/i&gt;=1.06, 95%&lt;i&gt;CI&lt;/i&gt; 1.00-1.13, &lt;i&gt;P&lt;/i&gt;=0.048), with an even stronger association observed for patients with PHQ-8 scores≥2.9 (&lt;i&gt;HR&lt;/i&gt;=1.10, 95%&lt;i&gt;CI&lt;/i&gt; 1.03-1.16, &lt;i&gt;P&lt;/i&gt;=0.005). However, the associations between depression and cardio-cerebrovascular mortality (&lt;i&gt;P&lt;/i&gt;=0.111) or infection-related mortality (&lt;i&gt;P&lt;/i&gt;=0.509) were not statistically significant. &lt;b&gt;Conclusions:&lt;/b&gt; Depressive symptoms are prevalent among maintenance hemodialysis patients and are independently associated with increased all-cause mortality. Smoking, comorbid diabetes or cardiovascular disease, low hemoglobin level, poor sleep quality, and anxiety are risk factors contributing","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"424-431"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progresses of autoantibodies in interstitial lung disease associated with connective tissue diseases].","authors":"B X Jia, J H Xu, Y L Chen, X P Hong, D Z Liu","doi":"10.3760/cma.j.cn112138-20241013-00678","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241013-00678","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"484-491"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}