中华内科杂志最新文献

{"title":"[Analysis of clinical features of 29 adult patients with eosinophilic gastroenteritis].","authors":"X Y Zhao, M Chen, X X Ren, Y Q Shi","doi":"10.3760/cma.j.cn112138-20240930-00626","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240930-00626","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical features, diagnosis and treatment of adult eosinophilic gastroenteritis (EGE). <b>Methods:</b> A retrospective study was conducted to analyze the clinical manifestations, laboratory examinations, endoscopic manifestations, histopathological characteristics, treatment and prognosis of 29 adult patients with EGE admitted to Xijing Hospital from August 2008 to August 2024. <b>Results:</b> Among the 29 adult EGE cases investigated in this study, 17 cases were male and 12 were female. The mean age was (43±19) years old. The main clinical manifestations included abdominal pain (75.9%), diarrhea (58.6%), and weight loss (44.8%). The median absolute value of white blood cells in peripheral blood of the 29 patients was 7.47(6.66,12.47)×10⁹/L, and the white blood cell count increased in 11 cases (37.9%). The median absolute value of eosinophil was 0.98 (0.21,4.76)×10⁹/L, and the eosinophil counts increased in 18 cases (62.1%). The main endoscopic manifestations were mucosal hyperemia edema, erosion and roughness. The histopathological manifestations were characterized by abnormal infiltration of eosinophils. In addition, the most commonly involved locations were the ileocecal junction and colorectum. The treatment methods included food elimination, anti-secretory, anti-histamine, and corticosteroids. All patients were alleviated after treatment, but some patients relapsed after drug withdrawal. <b>Conclusions:</b> The main clinical manifestations of adult EGE were abdominal pain, diarrhea and weight loss. Some patients had elevated peripheral blood eosinophilia, and the main endoscopic manifestations were mucosal hyperemia and edema, erosion, and roughness. The histopathological manifestations were characterized by abnormal infiltration of eosinophils. Finally, EGE can be relieved by diet and drug therapy, but it is easy to relapse.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"412-416"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Glycine receptor antibody-positive stiff-person syndrome: a case report and literature review].","authors":"J C Xu, Y J Zhao, J Yang","doi":"10.3760/cma.j.cn112138-20240726-00476","DOIUrl":"10.3760/cma.j.cn112138-20240726-00476","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"452-456"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of falsely elevated thyrotropin due to interference from anti-thyrotropin autoantibodies].","authors":"J Jin, Y L Cao, Z Y Shan, X C Teng","doi":"10.3760/cma.j.cn112138-20241228-00866","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241228-00866","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"432-436"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progresses in the diagnosis and treatment of monogenic diseases involving the small intestine].","authors":"C Z Ou, T M Xu, R F Zhang, Y Ma, G C Ruan, J Li, J N Li","doi":"10.3760/cma.j.cn112138-20240428-00268","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240428-00268","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"475-483"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A new vision of co-morbidities of celiac disease and other diseases].","authors":"T Li, Y Feng, T Shi, Z Q Li, J J Lu, M Wang, F Gao","doi":"10.3760/cma.j.cn112138-20241001-00642","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241001-00642","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"468-474"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the diagnosis and treatment of eosinophilic gastroenteritis].","authors":"M Chen, Y Q Shi","doi":"10.3760/cma.j.cn112138-20240919-00589","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240919-00589","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"457-461"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multidisciplinary consensus on the diagnosis and treatment of atypical hemolytic uremic syndrome (2025 version)].","authors":"","doi":"10.3760/cma.j.cn112138-20250219-00095","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250219-00095","url":null,"abstract":"<p><p>Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multi-organ damage, with the kidneys being predominantly affected. aHUS results from dysregulation of the complement alternative pathway, triggered by factors including infection, pregnancy, and surgery, among others. Therefore, complement inhibitors play a crucial role in the treatment of aHUS by blocking abnormal activation of the complement system and improving patients' prognosis. This consensus, developed by the Multidisciplinary Consensus Working Group on Atypical Hemolytic Uremic Syndrome Diagnosis and Treatment, is based on the latest literature and guidelines, discusses the pathogenesis, diagnosis and differential diagnosis, and treatment strategies for aHUS, and provides a guide and reference for the standardized diagnosis and management of aHUS in China.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"396-411"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progresses on phosphate homeostasis and phosphate toxicity in type 2 diabetes mellitus and its complications].","authors":"Y Z Yu, L L Xu, Y Y Wang, Y Xue, S F Li, Y G Wang, B Z Dong","doi":"10.3760/cma.j.cn112138-20241127-00782","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241127-00782","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"492-496"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of ultrasound as an adjunctive diagnostic tool for eosinophilic fasciitis].","authors":"J S Yang, H Zhang, M Li, F Sun, B Zhou, Q Q Zhao, Y H Wan, J Zhu, J L Zhang","doi":"10.3760/cma.j.cn112138-20240425-00263","DOIUrl":"10.3760/cma.j.cn112138-20240425-00263","url":null,"abstract":"<p><p><b>Objective:</b> This study investigates the utility of ultrasound in diagnosing eosinophilic fasciitis (EF). <b>Methods:</b> A retrospective analysis was conducted on the clinical and ultrasound data of 109 EF patients seen at the center between January 1, 2006, and March 31, 2024. The diagnostic efficacy of ultrasound for EF was evaluated by comparing forearm fascia ultrasound findings among EF patients, systemic sclerosis (SSc) patients, and healthy controls (HC). <b>Results:</b> Among the 109 EF patients (male-to-female ratio 2.2︰1), the median age of onset was 36 (29, 48) years, with a median disease duration of 7 (3, 12) months. The study also included 20 SSc patients [median age 49 (35, 61) years] and 20 HC individuals [median age 48 (29, 54) years]. Ultrasound assessments of forearm fascia in EF patients revealed a median fascial thickness of 1.9 (1.4, 2.4) mm. The median fascial thickness was 0.8 (0.7, 0.9) mm in SSc patients and 0.7 (0.5, 0.9) mm in HC individuals. Fascial thickness in EF patients was greater than in SSc (<i>Z</i>=-11.16,<i>P</i><0.001) and HC groups (<i>Z</i>=-11.87, <i>P</i><0.001). There was a correlation between fascia thickness and C-reactive protein (<i>r</i>=0.148, <i>P</i>=0.004), erythrocyte sedimentation rate (<i>r</i>=0.143, <i>P</i>=0.005), and immunoglobulin G (<i>r</i>=0.120, <i>P</i>=0.020) in EF patients. Receiver operating characteristic (ROC) curve analysis demonstrated a sensitivity of 84.0% and specificity of 95.9% for EF diagnosis, with an area under the curve (AUC) of 0.921 and a cut-off value of 1.005 mm. <b>Conclusion:</b> Ultrasound detection of forearm fascial thickening (>1 mm) aids in diagnosing eosinophilic fasciitis, indicating that ultrasound is a supplementary diagnostic tool for EF.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 4","pages":"333-338"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of cardiovascular and cerebrovascular diseases in patients with primary aldosteronism: a propensity score matching study].","authors":"S Wan, T Chen, H M Tian, Y Ren","doi":"10.3760/cma.j.cn112138-20240923-00599","DOIUrl":"10.3760/cma.j.cn112138-20240923-00599","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the characteristics of cardiovascular and cerebrovascular diseases in patients with primary aldosteronism (PA) and compare them with age-, sex-, and blood pressure-matched patients with essential hypertension (EH). <b>Methods:</b> This cross-sectional study was conducted at the West China Hospital of Sichuan University. Patients with PA and EH between December 2018 and December 2021 were included. Demographic characteristics, stroke events, coronary artery diseases, peripheral vascular diseases, and cardiac structure and function indicators were analyzed. Propensity score matching (PSM) was used to balance non-study data. The <i>t</i>-test, chi-square test, and Wilcoxon signed-rank test were used for data comparison. The cardiovascular and cerebrovascular damage in the patients with unilateral and bilateral PA were also compared. <b>Results:</b> A total of 336 and 369 patients with PA and EH, respectively, were enrolled in this study. One hundred and ninety-eight patients from each group were included after PSM; no significant differences were found in terms of age, gender, and blood pressure. The prevalence of stroke in the PA group was considerably higher than that in the EH group [12.6% (25/198) vs. 5.6% (11/198), <i>P</i>=0.014], due to the significantly greater risk of ischemic stroke [10.0% (20/198) vs. 4.5% (9/198), <i>P</i>=0.029]. The prevalence of hemorrhagic stroke, coronary artery disease, peripheral arterial stenosis, aorta atherosclerosis, and aneurysm in the PA group were also higher than those in the EH group, but there was no statistical significance (all <i>P</i>>0.05). More patients with PA had concurrent left ventricular hypertrophy [22.2% (44/198) vs. 9.1% (18/198)], left atrial enlargement [40.4% (80/198) vs. 30.3% (60/198)], ventricular septal thickening [50.0% (99/198) vs. 36.9% (73/198)], and aortic widening [21.7% (43/198) vs. 13.1% (26/198)] than those with EH (all <i>P</i><0.05). Compared with the bilateral PA group, the unilateral PA group had higher prevalence of left ventricular hypertrophy [28.3% (51/180) vs. 13.4% (11/82), <i>P</i>=0.013]. <b>Conclusions:</b> Compared with well-matched patients with EH, patients with PA have significantly higher risks of cardiovascular and cerebrovascular diseases, which are mainly manifested in increased prevalence of stroke and severe damage to the cardiac structure. Patients with unilateral PA may suffer more severe cardiac damage than those with bilateral PA.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 4","pages":"302-308"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}