中华内科杂志最新文献

{"title":"[Recommendations for the disease-modifying treatments of early Alzheimer's disease].","authors":"","doi":"10.3760/cma.j.cn112138-20241028-00709","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241028-00709","url":null,"abstract":"<p><p>Monoclonal antibodies targeting β-amyloid (Aβ)(represented by Lecanemab) have been approved in the United States, Japan and China for the treatment of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) or mild AD dementia, and AD treatment has moved towards the era of disease modifying therapy (DMT). In view of the lack of use experience with DMT in China, this article presents recommendations for Aβ-based DMT clinical practice based on its clinical evidence, as well as its existing usage experience and research regarding AD. These recommendations include the mechanism of action, patient selection, standardized use, effectiveness, and safety monitoring, intending to help guide the rational use in real-world clinical practice.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"385-395"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hot topic: indications for molecular testing in ultrasound-guided biopsy of thyroid nodules and cervical lymph nodes].","authors":"H L Li, J J Ma, T T Zhou, S H Zhang, J Zhai, B Zhang","doi":"10.3760/cma.j.cn112138-20250102-00002","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250102-00002","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"377-384"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of tumor necrosis factor receptor-associated periodic fever syndrome complicated with immunodeficiency caused by a new TNFRSF1A mutation].","authors":"X Y Yang, Y L Chen, D Z Liu, X P Hong","doi":"10.3760/cma.j.cn112138-20240515-00308","DOIUrl":"10.3760/cma.j.cn112138-20240515-00308","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"448-451"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between depression and death in the maintenance hemodialysis population: a cohort study].","authors":"X X Xu, L L Wang, H Tian, L Li, H Zheng, X Y Gu, C S Dai, L Jiang","doi":"10.3760/cma.j.cn112138-20241115-00760","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241115-00760","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To identify factors associated with depressive symptoms in maintenance hemodialysis patients and to examine the relationship between these symptoms and mortality. &lt;b&gt;Methods:&lt;/b&gt; Between January and December 2019, patients who received maintenance hemodialysis in the Blood Purification Center of the Second Affiliated Hospital of Nanjing Medical University were enrolled in a prospective cohort study. Depressive symptoms were assessed using the internationally validated patient health questionnaire-8 (PHQ-8). Sleep quality and anxiety were measured with the Pittsburgh sleep quality index (PSQI) and the generalized anxiety disorder-7 (GAD-7) scale, respectively. Follow-up continued until December 31, 2022, with all-cause mortality as the primary outcome. Ordinal logistic regression was used to identify independent predictors of depression severity. Cox proportional hazards models evaluated the association between depressive symptoms and mortality. &lt;b&gt;Results:&lt;/b&gt; A total of 532 maintenance hemodialysis (MHD) patients completed the study. Among them, 177 (33.3%) exhibited depressive symptoms. Compared with patients without depression, those with mild or moderate-to-severe depression were older [median age: 58 (50, 66) vs. 60 (55, 65) vs. 55 (46, 64)], more likely to smoke [35.9% (51/142) vs. 40.0% (14/35) vs.26.2% (93/355)], had poorer sleep quality [PSQI: 9 (6, 13) vs. 12 (9, 17) vs. 5 (3, 9)], and higher anxiety levels [GAD-7: 1 (0, 3) vs. 3 (1, 6) vs. 0 (0, 1)], the differences among the three groups were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). Ordinal logistic regression identified smoking status, history of diabetes or cardiovascular disease, hemoglobin level, PSQI score, and GAD-7 score as independent predictors of depression severity (&lt;i&gt;OR&lt;/i&gt;=1.60, 1.80, 1.81, 0.98, 3.67, 8.67; all &lt;i&gt;P&lt;/i&gt;&lt;0.05). After a median follow-up of 40 (35, 44) months, 109 patients died, including 66 (60.6%) from cardio-cerebrovascular causes and 24 (22.0%) from infections. Kaplan-Meier analysis revealed significantly lower cumulative survival in the depression group compared to the non-depression group (&lt;i&gt;P&lt;/i&gt;&lt;0.001). Cox regression analysis demonstrated that depressive symptoms remained independently associated with all-cause mortality after adjusting for confounders (&lt;i&gt;HR&lt;/i&gt;=1.06, 95%&lt;i&gt;CI&lt;/i&gt; 1.00-1.13, &lt;i&gt;P&lt;/i&gt;=0.048), with an even stronger association observed for patients with PHQ-8 scores≥2.9 (&lt;i&gt;HR&lt;/i&gt;=1.10, 95%&lt;i&gt;CI&lt;/i&gt; 1.03-1.16, &lt;i&gt;P&lt;/i&gt;=0.005). However, the associations between depression and cardio-cerebrovascular mortality (&lt;i&gt;P&lt;/i&gt;=0.111) or infection-related mortality (&lt;i&gt;P&lt;/i&gt;=0.509) were not statistically significant. &lt;b&gt;Conclusions:&lt;/b&gt; Depressive symptoms are prevalent among maintenance hemodialysis patients and are independently associated with increased all-cause mortality. Smoking, comorbid diabetes or cardiovascular disease, low hemoglobin level, poor sleep quality, and anxiety are risk factors contributing","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"424-431"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progresses of autoantibodies in interstitial lung disease associated with connective tissue diseases].","authors":"B X Jia, J H Xu, Y L Chen, X P Hong, D Z Liu","doi":"10.3760/cma.j.cn112138-20241013-00678","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241013-00678","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"484-491"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of clinical features of 29 adult patients with eosinophilic gastroenteritis].","authors":"X Y Zhao, M Chen, X X Ren, Y Q Shi","doi":"10.3760/cma.j.cn112138-20240930-00626","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240930-00626","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical features, diagnosis and treatment of adult eosinophilic gastroenteritis (EGE). <b>Methods:</b> A retrospective study was conducted to analyze the clinical manifestations, laboratory examinations, endoscopic manifestations, histopathological characteristics, treatment and prognosis of 29 adult patients with EGE admitted to Xijing Hospital from August 2008 to August 2024. <b>Results:</b> Among the 29 adult EGE cases investigated in this study, 17 cases were male and 12 were female. The mean age was (43±19) years old. The main clinical manifestations included abdominal pain (75.9%), diarrhea (58.6%), and weight loss (44.8%). The median absolute value of white blood cells in peripheral blood of the 29 patients was 7.47(6.66,12.47)×10⁹/L, and the white blood cell count increased in 11 cases (37.9%). The median absolute value of eosinophil was 0.98 (0.21,4.76)×10⁹/L, and the eosinophil counts increased in 18 cases (62.1%). The main endoscopic manifestations were mucosal hyperemia edema, erosion and roughness. The histopathological manifestations were characterized by abnormal infiltration of eosinophils. In addition, the most commonly involved locations were the ileocecal junction and colorectum. The treatment methods included food elimination, anti-secretory, anti-histamine, and corticosteroids. All patients were alleviated after treatment, but some patients relapsed after drug withdrawal. <b>Conclusions:</b> The main clinical manifestations of adult EGE were abdominal pain, diarrhea and weight loss. Some patients had elevated peripheral blood eosinophilia, and the main endoscopic manifestations were mucosal hyperemia and edema, erosion, and roughness. The histopathological manifestations were characterized by abnormal infiltration of eosinophils. Finally, EGE can be relieved by diet and drug therapy, but it is easy to relapse.</p>","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"412-416"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Glycine receptor antibody-positive stiff-person syndrome: a case report and literature review].","authors":"J C Xu, Y J Zhao, J Yang","doi":"10.3760/cma.j.cn112138-20240726-00476","DOIUrl":"10.3760/cma.j.cn112138-20240726-00476","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"452-456"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of falsely elevated thyrotropin due to interference from anti-thyrotropin autoantibodies].","authors":"J Jin, Y L Cao, Z Y Shan, X C Teng","doi":"10.3760/cma.j.cn112138-20241228-00866","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241228-00866","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"432-436"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progresses in the diagnosis and treatment of monogenic diseases involving the small intestine].","authors":"C Z Ou, T M Xu, R F Zhang, Y Ma, G C Ruan, J Li, J N Li","doi":"10.3760/cma.j.cn112138-20240428-00268","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240428-00268","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"475-483"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A new vision of co-morbidities of celiac disease and other diseases].","authors":"T Li, Y Feng, T Shi, Z Q Li, J J Lu, M Wang, F Gao","doi":"10.3760/cma.j.cn112138-20241001-00642","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241001-00642","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 5","pages":"468-474"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}