2019 IEEE International Ultrasonics Symposium (IUS)最新文献

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Finite Element Analysis of SAW Propagation Characteristics in c-plane (0001) and a-plane (11-20) AlScN Thin Films SAW在c面(0001)和a面(11-20)AlScN薄膜中传播特性的有限元分析
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925570
N. Feil, N. Kurz, D. Urban, A. Altayara, B. Christian, A. Ding, A. Žukauskaitė, O. Ambacher
{"title":"Finite Element Analysis of SAW Propagation Characteristics in c-plane (0001) and a-plane (11-20) AlScN Thin Films","authors":"N. Feil, N. Kurz, D. Urban, A. Altayara, B. Christian, A. Ding, A. Žukauskaitė, O. Ambacher","doi":"10.1109/ULTSYM.2019.8925570","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925570","url":null,"abstract":"Al<inf>1−x</inf>Sc<inf>x</inf>N (AlScN) is known for its large elastic and piezoelectric constants and thus is a favorable material for applications in novel radio frequency (RF) components. We investigated a-plane AlScN on r-plane Al<inf>2</inf>O<inf>3</inf> (AlScN(11-20)/Al<inf>2</inf>O<inf>3</inf>(1-102)). The surface acoustic wave (SAW) propagation properties of AlScN(11-20)/Al<inf>2</inf>O<inf>3</inf>(1-102) and AlScN(11-20)/Al<inf>2</inf>O<inf>3</inf>(1-102) were analyzed using finite element method (FEM) simulations and the results were compared. Rayleigh-type and Sezawa-type wave modes were identified and the acoustic parameters such as phase velocity, electromechanical coupling coefficient, and reflectivity were evaluated. An increased effective coupling of 5.5 % was detected for Rayleigh-type waves on AlScN(11-20)/Al<inf>2</inf>O<inf>3</inf>(1-102). The Sezawa-type modes show an even higher coupling up to 6.2 %. Furthermore, we detected increased reflectivity of AlScN(11-20) films compared to c-plane AlScN(0001). Our results reveal the potential of using a-plane AlScN for increasing the electromechanical coupling, which is needed for the upcoming piezo-acoustic filter requirements.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"55 1","pages":"2588-2591"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Development and Fabrication of a 3-French Photoacoustic Catheter for Imaging Mouse Colon 用于小鼠结肠成像的3-French光声导管的研制
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925939
R. P. de Oliveira, Nidhi Singh, C. Roa, Jianhua Yin, Chelsea E. Munding, F. Foster, J. C. Machado, C. Démoré
{"title":"Development and Fabrication of a 3-French Photoacoustic Catheter for Imaging Mouse Colon","authors":"R. P. de Oliveira, Nidhi Singh, C. Roa, Jianhua Yin, Chelsea E. Munding, F. Foster, J. C. Machado, C. Démoré","doi":"10.1109/ULTSYM.2019.8925939","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925939","url":null,"abstract":"Colon cancer is the third most common cancer in the world, if skin cancer is not considered. Despite the high incidence and high mortality rate, most of the outcomes could be prevented by using accurate techniques for early cancer detection to enable early treatment. In this context, it is important to conduct preclinical studies, using animal models of colon diseases, to test new diagnostic approaches including imaging instrumentation. We have previously used a 3-French ultrasound IVUS catheter to image the layered structure in the mouse colon, detect polyps, and visualize their invasion through the colon wall. Now we aim to add photoacoustic (PA) imaging with a miniaturized probe designed for combined micro-ultrasound (micro-US) and (PA) imaging of the mouse colon. For this purpose, a mini US probe was manufactured to fit a previous system used before.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"72 5 Pt 1 1","pages":"1789-1792"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77490301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Capsule Endoscopy Components for in vivo and ex vivo Microultrasound Near-Field Imaging 超声胶囊内窥镜组件用于体内和离体微超声近场成像
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925827
C. Lemke, Hannah Thomson, H. Lay, B. Cox, Y. Qiu, R. Clutton, S. Cochran
{"title":"Ultrasound Capsule Endoscopy Components for in vivo and ex vivo Microultrasound Near-Field Imaging","authors":"C. Lemke, Hannah Thomson, H. Lay, B. Cox, Y. Qiu, R. Clutton, S. Cochran","doi":"10.1109/ULTSYM.2019.8925827","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925827","url":null,"abstract":"Ultrasound capsule endoscopy (USCE) has attracted increased interest recently. In order to image the walls of the gastrointestinal (GI) tract with USCE efficiently, both high-frequency ultrasound (i.e. microultrasound) imaging and good acoustic coupling are needed. Tissue to be scanned is expected close to the transducer surface, but the near-field tissue echoes may be easily lost in the acoustic ring-down. Here, we present experimental ex vivo and in vivo porcine small bowel imaging results from an USCE prototype. The preliminary results show that the near-field image can be recovered after post-processing. Although some limitations in imaging the GI tract are inherent in the use of focused single element transducers, solving the problem of near-field imaging is relevant to all USCE implementations.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"138 1","pages":"1793-1796"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77524283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Development of an Innovative Ultrasonic Reader for the Authentication and Identification of Copper Canisters for Spent Nuclear Fuel 新型废核燃料铜罐超声识别仪的研制
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925590
C. Clementi, F. Littmann, L. Capineri
{"title":"Development of an Innovative Ultrasonic Reader for the Authentication and Identification of Copper Canisters for Spent Nuclear Fuel","authors":"C. Clementi, F. Littmann, L. Capineri","doi":"10.1109/ULTSYM.2019.8925590","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925590","url":null,"abstract":"The final disposal of nuclear spent fuel in long-term geological repositories introduces the need to develop new technologies to keep the Continuity of Knowledge of nuclear spent fuel. In the recent past, an innovative approach based on ultrasound has been proposed by authors and several studies have been accomplished to validate the method. This work aims to describe the development of a new ultrasonic reading system which can be considered as an optimized version of previous prototypes. This paper describes the development of a new reader prototype designed to provide a remote control of the scanning and speed up the acquisition time, without losing accuracy. The novel version includes a stepper motor to move the transducer and the Seal Fingerprint Acquisition Device (SFAD), that is used to control the motor, transmit/receive signals to/from the probe through a SPI bus and send data wirelessly to a control station.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"119 1","pages":"1601-1604"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77585639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Towards a CMOS Integrated Optically Controlled AlN Transducer CMOS集成光控AlN换能器的研制
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926050
Yutong Liu, J. Kuo, M. Abdelmejeed, A. Lal
{"title":"Towards a CMOS Integrated Optically Controlled AlN Transducer","authors":"Yutong Liu, J. Kuo, M. Abdelmejeed, A. Lal","doi":"10.1109/ULTSYM.2019.8926050","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8926050","url":null,"abstract":"A framework for an ultrafast Sonic Fourier transform (SFT) physical computer leveraging the property that the Fourier transform of an image is its far-field pattern has been presented recently by our group. To represent different input images requires actuating a 2D array of transducers with controllable magnitude and phase. In this work, we demonstrate a CMOS-based optically controlled excitation approach for AlN transducers. This approach provides an optical pixel based amplitude modulation of electrically generated ultrasonic waves, providing a direct interface between an optical camera-like imager and ultrasonic waves, allowing for instantaneous control of the drive amplitude of all array transducers at the same time. The monolithic integration of this CMOS-based control circuitry and the AlN transducer array would enable the proposed SFT to instantly respond to the light from the environment or from an image mask, achieving real-time image recognition in the Fourier domain. In this work, we demonstrate the proposed single pixel architecture using an AlN transducer wire-bonded to the CMOS pixel circuitry comprised of a p+/n-well photodiode, a transimpedance amplifier, and a voltage controlled variable gain amplifier. We demonstrate the tuning of the pixel drive amplitude from 5 – 47.9mV by varying incident optical intensity from 0 – 250mW/mm2, resulting in receive amplitudes of 0.5 – 2.4 mV on an adjacent receive transducer located 200 um from the transmit pixel.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"51 1","pages":"1996-1999"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80169572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Non-Contact laser ultrasound (N-CLUS) system for medical imaging and elastography 用于医学成像和弹性成像的非接触式激光超声(N-CLUS)系统
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925569
R. Haupt, Xiang Zhang, J. Fincke, J. Richardson, J. Hughes, B. Anthony, A. Samir
{"title":"Non-Contact laser ultrasound (N-CLUS) system for medical imaging and elastography","authors":"R. Haupt, Xiang Zhang, J. Fincke, J. Richardson, J. Hughes, B. Anthony, A. Samir","doi":"10.1109/ULTSYM.2019.8925569","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925569","url":null,"abstract":"MIT Lincoln Laboratory, the Medical Device Realization Center (MEDRC) at MIT, and the Massachusetts General Hospital (MGH) are collaboratively developing a novel optical system that acquires ultrasound images within the human body without physical contact to the patient. The system is termed, non-contact laser ultrasound (N-CLUS) and yields anatomical images in tissue and bone and can also measure elastographic properties, in-vivo, all from an operational standoff of a few inches to several meters as desired. N-CLUS employs a pulsed laser that converts optical energy into ultrasonic waves at the skin surface via photoacoustic mechanisms, while, a laser Doppler vibrometer measures reflected-emerging ultrasonic waves from tissue at depth at the skin surface. The key of the N-CLUS approach is driven by shallow optical absorptivity that creates an acoustic source that enables ultrasound propagation deeper into the tissue.We discuss the motivation of the non-contact laser concept, its development path involving signal generation, skin and eye safe laser measurement, and system design perspectives. Elastogrphic measurements are then demonstrated with determination of bone elastic moduli for beef rib within tissue. N-CLUS images from soft tissue specimens are also compared with commercial ultrasound, showing that the noncontact optical approach may have potential as a viable method in medical ultrasound.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"34 1","pages":"1921-1925"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79026787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Fast Ultrasound to Ultrasound Auto-Registration for Interventional Cardiology 介入心脏病学快速超声到超声自动登记
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925750
A. Pham, Erik Andreas Rye Berg, F. Veronesi, S. Fiorentini, A. Fatemi, B. Grenne, O. Gérard, G. Kiss
{"title":"Fast Ultrasound to Ultrasound Auto-Registration for Interventional Cardiology","authors":"A. Pham, Erik Andreas Rye Berg, F. Veronesi, S. Fiorentini, A. Fatemi, B. Grenne, O. Gérard, G. Kiss","doi":"10.1109/ULTSYM.2019.8925750","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925750","url":null,"abstract":"Many interventional procedures rely on 3D trans-esophageal echocardiography (TEE) imaging to guide the interventionist during instrument/device manipulation inside the heart. Manual registration of ultrasound to ultrasound or other modalities is commercially available. However, auto-registration is highly desirable, to avoid manual re-labelling and to estimate probe motion for motion compensation during surgery. There are a number of published auto-registration methods, but they are not suitable for interventional setups as they are not fast enough. In this work we present a close to real-time 3D ultrasound volume to 3D ultrasound volume auto-registration method that is implemented on the GPU. The auto-registration method performed on the clinical data was successful and good visual alignment was observed in 5 out of 7 cases. Decomposing a volume into its polynomial coefficients took 73ms and was performed once for each pyramid level. One iteration took on an average of 53ms. The proposed registration method is fast enough to allow real-time usage on the ultrasound scanner. When the method converges to a good result it is close to the expert’s manual registration with discrepancies of 0.48 ± 2.1mm for translation in the X direction, -0.8 ± 2.0mm for translation in the Y direction, 0.86 ± 1.8mm for translation in the Z direction, -1.82 ± 1.54◦ for rotation about the X axis, 1.47 ± 2.77◦ for rotation about the Y axis, and -0.63 ± 0.76◦ for rotation about the Z axis.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"45 1","pages":"16-19"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79298513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Over 12% of Coupling Coefficient Demonstrated by 3GHz Sc0.12Al0.88N Based Laterally Coupled Alternating Thickness (LCAT) Mode Resonators 基于3GHz Sc0.12Al0.88N的横向耦合交变厚度(LCAT)模式谐振器证明耦合系数超过12%
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926087
Nan Wang, Yao Zhu, Bangtao Chen, Ying Zhang
{"title":"Over 12% of Coupling Coefficient Demonstrated by 3GHz Sc0.12Al0.88N Based Laterally Coupled Alternating Thickness (LCAT) Mode Resonators","authors":"Nan Wang, Yao Zhu, Bangtao Chen, Ying Zhang","doi":"10.1109/ULTSYM.2019.8926087","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8926087","url":null,"abstract":"In this work, we report a laterally coupled alternating thickness (LCAT) mode resonators operating at 3GHz with an effective electromechanical coupling coefficient (k<sup>2</sup><inf>eff</inf>) of 12.1%, using 12% scandium-doped aluminum nitride (Sc<inf>0.12</inf>Al<inf>0.88</inf>N) as the piezoelectric layer. The top and bottom electrodes are formed by patterning two groups of interdigitated electrodes (IDEs) on the top and bottom surface of the Sc<inf>0.12</inf>Al<inf>0.88</inf>N layer, respectively, both made of molybdenum (Mo). The thickness of the top electrode layer, Sc<inf>0.12</inf>Al<inf>0.88</inf>N layer, and the bottom electrode layer is 0.1μm, 0.7μm, and 0.2μm, respectively. The designed resonator is fabricated by in-house 200mm piezoelectric platform, with the Sc<inf>0.12</inf>Al<inf>0.88</inf>N deposited by physical vapour deposition (PVD). Electrical measurement results show that the series resonant frequency (f<inf>s</inf>) and the parallel resonant frequency (f<inf>p</inf>) are 2.96 GHz and 3.10 GHz, respectively, and the corresponding impedance at f<inf>s</inf> (R<inf>s</inf>) and impedance at f<inf>p</inf> (Rp) are 3.19 Ω and 546 Ω, respectively. Besides the high k<sup>2</sup><inf>eff</inf> of 12.1%, no spurious resonant modes are observed within a wide 1.2GHz frequency spectrum, demonstrating great potential of the reported Sc<inf>0.12</inf>Al<inf>0.88</inf>N based LCAT mode resonator in 5G duplexing solution on a single chip.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"18 1","pages":"1971-1973"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81846268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
PMUT-Enabled Underwater Acoustic Source Localization System 启用pmut的水声声源定位系统
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926312
Bernard Herrera, Flavius V. Pop, C. Cassella, M. Rinaldi
{"title":"PMUT-Enabled Underwater Acoustic Source Localization System","authors":"Bernard Herrera, Flavius V. Pop, C. Cassella, M. Rinaldi","doi":"10.1109/ULTSYM.2019.8926312","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8926312","url":null,"abstract":"The present work presents the novel application of Piezoelectric Micromachined Ultrasonic Transducer (PMUT) arrays in an Underwater Acoustic Source Localization System. Based on the difference in the time of arrival of ultrasonic bursts originating from an acoustic beacon, the system is capable of determining the direction to the source with no theoretical limitation on the angular range. A cross correlation technique is used to estimate the time of arrival difference between the received signals. Experiments are performed with the prototype submerged in liquid in a tank for arbitrary positions of a beacon, showing large potential for application of the system in a miniaturized, integrated platform for underwater source localization.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"27 1","pages":"1103-1106"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84329165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Intravascular Sonothrombolysis, in vitro, Using a Small Aperture, Forward-Viewing, Sub-Megahertz Transducer to Enhance tPA Treatment 体外血管内超声溶栓,使用小孔径,前视,亚兆赫传感器增强tPA治疗
2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926028
Leela D. Goel, Huaiyu Wu, Howuk Kim, Bohua Zhang, Jinwook Kim, P. Dayton, Zhen Xu, Xiaoning Jiang
{"title":"Intravascular Sonothrombolysis, in vitro, Using a Small Aperture, Forward-Viewing, Sub-Megahertz Transducer to Enhance tPA Treatment","authors":"Leela D. Goel, Huaiyu Wu, Howuk Kim, Bohua Zhang, Jinwook Kim, P. Dayton, Zhen Xu, Xiaoning Jiang","doi":"10.1109/ULTSYM.2019.8926028","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8926028","url":null,"abstract":"Catheter-based thrombolytic treatments with tissue plasminogen activator (tPA) have long treatment times (>15 hrs) and high risk of intracranial hemorrhage. Sonothrombolysis may improve patient outcomes while reducing the dose of tPA needed for treatment. We recently demonstrated a custom, forward-viewing intravascular (FVI) transducer with microbubbles (MBs) for in vitro sonothrombolysis. For clinical translation, we want to utilize this transducer to enhance tPA treatment. Therefore, the purpose of this study was to examine the thrombolytic outcomes of a forward-looking, IV transducer with tPA in vitro. Blood clots were treated for 30 minutes with either phosphate buffer saline (PBS), ultrasound (US) alone, tPA alone (1µg/ml), tPA + US, or MB + US (108 MB/ml). The percent clot lysis for the control group was 29 ± 4%, tPA alone was 29 ± 9%, and US alone was 25 ± 4%, with no statistically significant differences amongst these conditions. The percent clot lysis was 58 ± 10%, 59 ± 3% and 63 ± 5% for tPA + US and MB + US conditions respectively and both had statistically significantly more clot lysis than the control, US alone, or tPA alone groups. We have demonstrated that a forward-viewing intravascular transducer can be used to enhance tPA mediated sonothrombolysis and is comparable to microbubble mediated sonothrombolysis.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"426 1","pages":"2034-2036"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84949529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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