2019 Computing in Cardiology (CinC)最新文献_第10页

An Algorithm for Early Detection of Sepsis Using Traditional Statistical Regression Modeling 基于传统统计回归模型的脓毒症早期检测算法

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005699

Roshan Pawar, J. Bone, J. Ansermino, M. Görges

{"title":"An Algorithm for Early Detection of Sepsis Using Traditional Statistical Regression Modeling","authors":"Roshan Pawar, J. Bone, J. Ansermino, M. Görges","doi":"10.23919/CinC49843.2019.9005699","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005699","url":null,"abstract":"Sepsis is the final common pathway for many infections, whereby the body’s immune response leads to organ failure, and eventually death. It is associated with high mortality rates and, if survived, significant morbidity. Early detection is imperative to improve outcomes. Yet, there is also a need to avoid a high false alarm rate. The aim of this study was to develop and evaluate a simple algorithm for early sepsis detection.Significant missing data were encountered in the dataset, which were forward-filled or substituted with population means. Clinically relevant variable combinations were added along with transformation features including dichotomization, z-scores, first derivative, and changes from baseline. A logistic regression model was used to identify candidate features and build the overall risk score function for prediction.The final candidate score had areas under the receiver operating characteristic curve of 0.747, 0.760, and 0.783 for the three test data sets. It had accuracies of 0.795, 0.889, 0.815, respectively, and an overall utility score for the full test set of 0.249 using a cutoff of 0.024.Evaluation indicated significant potential for further optimization, including reduction of false-positive predictions. Adding features capturing change over time is expected to provide scope for further investigation.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"1 1","pages":"Page 1-Page 4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89796323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sleep Stage Influence on the Autonomic Modulation of Sleep Apnea Syndrome 睡眠阶段对睡眠呼吸暂停综合征自主神经调节的影响

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005885

M. Calvo, R. Jané

{"title":"Sleep Stage Influence on the Autonomic Modulation of Sleep Apnea Syndrome","authors":"M. Calvo, R. Jané","doi":"10.23919/CinC49843.2019.9005885","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005885","url":null,"abstract":"Hypoxia induced by obstructive sleep apnea (OSA) leads to the deregulation of the autonomic nervous system (ANS), resulting in an abnormally increased sympathetic activity. Since ANS modulation varies throughout the night, notably for each sleep stage, the hypno-gram and heart rate signals of 81 OSA patients were collected during a polysomnography. They were classified as mild-moderate (n=44) or severe (n=37) based on their apnea-hypopnea index (AHI). Spectral heart rate variability (HRV) series were extracted by a time-frequency approach. These series were then averaged for each sleep stage, in order to compare the sympathetic modulation of mild-moderate and severe patients at the following phases: rapid eye movement (REM), S1, S2 and SWS (slow wave sleep). According to normalized power at the low-frequency band (LFnu) values, severe OSA seems to be associated with an increased sympathetic modulation at non-REM sleep. Moreover, a decreased autonomic variability throughout the night may be related to a reduced adaptability of the cardiovascular system, characterizing a more advanced stage of the disease. These results provide further evidence for the role of autonomic alterations induced by hypoxia, suggesting the use of HRV analysis, together with AHI, for the study of OSA severity.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"24 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82561798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Monitoring Remote of Biomedical Signal 生物医学信号远程监测

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005724

D. P. D. Silva, W. Watanabe, W. S. Lopes, Henrique Rodrigues, R. R. Silva, J. Salinet, M. Bissaco, D. G. Goroso

{"title":"Monitoring Remote of Biomedical Signal","authors":"D. P. D. Silva, W. Watanabe, W. S. Lopes, Henrique Rodrigues, R. R. Silva, J. Salinet, M. Bissaco, D. G. Goroso","doi":"10.23919/CinC49843.2019.9005724","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005724","url":null,"abstract":"The remote monitoring of the biomedical signal is an important tool for assessing the quality of life, control and prevention of diseases. In this research, we developed and validated a remote monitoring system for prevention and health promotion. The system architecture is composed of 3 main modules: a) interface for recording food intake and monitoring physical activity and heart rate frequency by a mobile application; b) interface for insert anthropometric assessment data of patient; c) web interface where all data is remotely shown through reports with information that can assist in preventive health actions. The study involved 70 children aged between 8 and 12 years. They were monitored for 4 months by the app installed in the children's own smartphones. Significant differences were observed in the frequency domain and nonlinear heart rate variability variables between each anthropometric group. Moreover, within the same group, there were also differences between night-morning and afternoon/evening time. Being the biggest variation in the frequency domain parameters during afternoon/evening time for the obese group.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"22 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82652085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic Pressure Waveforms Reconstruction Using Simplified Kalman Filter 基于简化卡尔曼滤波的主动脉压力波形重建

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005554

Wenyan Liu, Zongpeng Li, Yang Yao, Shuran Zhou, Yuelan Zhang, Lisheng Xu

引用次数: 0

Isosbestic Point in Optical Mapping; Theoretical and Experimental Determination With Di-4-ANBDQPQ Transmembrane Voltage Sensitive Dye 光学映射中的等吸点双-4- anbdqpq跨膜电压敏感染料的理论与实验测定

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005532

I. Uzelac, C. Crowley, F. Fenton

{"title":"Isosbestic Point in Optical Mapping; Theoretical and Experimental Determination With Di-4-ANBDQPQ Transmembrane Voltage Sensitive Dye","authors":"I. Uzelac, C. Crowley, F. Fenton","doi":"10.23919/CinC49843.2019.9005532","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005532","url":null,"abstract":"Optical mapping methods utilize fluorescence dyes to measure dynamic response of cardiac tissue such as changes in transmembrane potential (Vm). For the commonly used Vm sensitive dyes, a dye absorption and emission spectra shift as Vm changes. Signals relevant to Vm are calculated as a relative fluorescence change with respect to the fluorescence baseline. The amplitude of the change depends on the long-pass (LP) filter cut-on wavelength, placed on the sensor side, and the excitation wavelength. An excitation wavelength near the absorption peak, termed the isosbestic point, results in minimal absorption coefficient change as absorption spectra shifts. Consequentially the fluorescence intensity virtually does not change, when fluorescence across the entire emission spectra is measured, irrelevant of Vm changes. In this study we experimentally determined the isosbestic point for a near infrared dye Di-4-ANBDQPQ. We then present a theoretical study examining the dye linear or non-linear response as the fractional fluorescence change of Vm change, due to emission spectra shift and amplitude change, over a range of excitation wavelengths and LP filters. Linear \"optical\" response is important to quantify certain aspects of cardiac dynamics such as the action potential (AP) shape and duration, especially when studying drug effects and dynamical substrates for arrhythmia development.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"13 1","pages":"Page 1-Page 4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75057821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute MI Detection Derived From ECG Parameters Distribution 基于心电参数分布的急性心肌梗死检测

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005742

Alfonso Aranda, Joël M. H. Karel, P. Bonizzi, R. Peeters

引用次数: 0

Quantification of Linear and Nonlinear Cardiorespiratory Interactions Under Autonomic Nervous System Blockade 自主神经系统阻断下线性和非线性心肺相互作用的量化

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005628

C. Varon, Dries Hendrikx, J. Bolea, P. Laguna, R. Bailón

引用次数: 3

Characterization of Blood Flow Changes in Normal and Pathological Aortic Dilation from 4D Flow Magnetic Resonance Imaging 正常和病理性主动脉扩张血流变化的4D磁共振成像表征

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005740

Sophia Houriez--Gombaud-Saintonge, A. Pascaner, G. Soulat, U. Gencer, T. Dietenbeck, D. Craiem, E. Bollache, Y. Chenoune, É. Mousseaux, N. Kachenoura

{"title":"Characterization of Blood Flow Changes in Normal and Pathological Aortic Dilation from 4D Flow Magnetic Resonance Imaging","authors":"Sophia Houriez--Gombaud-Saintonge, A. Pascaner, G. Soulat, U. Gencer, T. Dietenbeck, D. Craiem, E. Bollache, Y. Chenoune, É. Mousseaux, N. Kachenoura","doi":"10.23919/CinC49843.2019.9005740","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005740","url":null,"abstract":"Aim: Maximal diameter (Dmax), which is commonly used to diagnose thoracic aortic aneurysm (TAA) was previously shown to be normal in 20-30% of patients who ultimately develop dissection. Besides, inner aortic flow is associated with its wall dynamics. Thus, our aim was to quantify aortic flow changes using 4D flow MRI in the setting of ascending aorta (AA) dilation.Methods: We studied 20 patients with TAA and tricuspid aortic valve (TAA) and 56 healthy controls (30 subjects, 36±9y ≤50 years named YC, 26 subjects, 65±9y >50 years named OC). All underwent 4D flow MRI. After aortic segmentation, regional volume of backward flow (VBF) was extracted in addition to in-cross-section velocity standard deviation (SD) as well as maximal velocity jet angle (Angle) and eccentricity (Ecc). Receiver operating characteristic (ROC) analysis was performed to assess ability of flow indices to characterize dilation.Results: While AA Dmax changed by 1.4 folds between TAA and OC, VBF changed by 6.5 folds, and Ecc, Angle and SD changed by 1.3 to 1.9 folds between the two groups. Moreover VBF varied consistently with age and was able to detect AA dilation with an accuracy of 0.98.Conclusion: 4D flow MRI indices of local aortic flow disorganization, specifically backward flow, were able to accurately characterize dilation.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"75 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80794178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Geometry in Atrial Fibrillation Markers Obtained With Electrocardiographic Imaging 心电图成像对房颤标志物的几何影响

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005905

R. Molero, A. Climent, I. Hernández-Romero, A. Liberos, F. Fernández‐Avilés, F. Atienza, M. Guillem, M. Rodrigo

{"title":"Effects of Geometry in Atrial Fibrillation Markers Obtained With Electrocardiographic Imaging","authors":"R. Molero, A. Climent, I. Hernández-Romero, A. Liberos, F. Fernández‐Avilés, F. Atienza, M. Guillem, M. Rodrigo","doi":"10.23919/CinC49843.2019.9005905","DOIUrl":"https://doi.org/10.23919/CinC49843.2019.9005905","url":null,"abstract":"Electrocardiographic imaging (ECGI) can characterise cardiac pathologies such as atrial fibrillation (AF) through specific markers based on frequency or phase analysis. In this study, the effect of the geometry of patients’ torso and atria in the ECGI resolution is studied.A realistic 3D atrial geometry was located on 30 patient torsos and ECGI signals were calculated for 30 different AF simulations in each torso. Dominant frequency (DF) and reentrant activity analysis were calculated for each scenario. Anatomical and geometrical measurements of each torso (30-80% of variability between patients) and atria were calculated and compared with the errors in the ECGI estimation versus the departing EGM maps.Results show evidences that big chest dimensions worsen the non-invasive calculation of AF markers (p<0.05). Also, higher number of visible electrodes from each atrial region improves ECGI characterization measured as lower DF deviations (0.64±0.26 Hz vs 0.72±0.27 Hz, p<0.05) and higher reentrant activity coincidence (10.1±12.2% vs 3.4±3.4%, p<0.05).Torso and atrial geometry affect the quality of the non-invasive reconstruction of AF markers such as DF or reentrant activity. Knowing the geometrical parameters that worsen non-invasive AF maps may help to measure each detected AF driver reliability.","PeriodicalId":6697,"journal":{"name":"2019 Computing in Cardiology (CinC)","volume":"56 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80867241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Mathematical Models for the Mouse Atrial Fast Sodium Channel 小鼠心房快速钠通道的新数学模型

2019 Computing in Cardiology (CinC) Pub Date : 2019-09-01 DOI: 10.23919/CinC49843.2019.9005857

Shanzhuo Zhang, Wei Wang, Kuanquan Wang, Henggui Zhang

引用次数: 0