Journal of Polymers and the Environment最新文献

{"title":"Carboxymethyl Guar Gum Designed with Hyperbranched Grafts of Poly(2-Methacryloyloxyethyl Trimethylammonium Chloride) for Enhanced Selective Flocculation of Kaolin-Hematite Mixture","authors":"Sonai Dutta,&nbsp;Sayan Basak,&nbsp;Rahul Chatterjee,&nbsp;Morali Biswas,&nbsp;Sanghamitra Sanyal,&nbsp;Abhijit Bandyopadhyay","doi":"10.1007/s10924-025-03525-4","DOIUrl":"10.1007/s10924-025-03525-4","url":null,"abstract":"<div><p>The depletion of high-grade ore reserves necessitates innovative approaches in mineral processing, particularly for recovering valuable minerals from fine tailings. This study examines the use of bio-based hyperbranched polymers synthesized from carboxymethyl guar gum for selective flocculation of minerals, specifically focusing on kaolinite and iron ore mixtures in wastewater. Traditional coagulants present environmental drawbacks, prompting the exploration of biodegradable alternatives. Hyperbranched polymers possess a unique architecture that may enhance their interaction with suspended particles, potentially improving flocculation efficiency. This research investigates the grafting of carboxymethyl guar gum with Poly (2-methacryloyloxyethyl trimethylammonium chloride), which provides a high charge density and a stable cationic character across a range of pH levels. A kaolinite-iron ore model system was employed to evaluate the selectivity and efficiency of the synthesized flocculants under controlled conditions. Results indicate that hyperbranched carboxymethyl guar gum/Poly(2-methacryloyloxyethyl trimethylammonium chloride) exhibits improved flocculation performance and mineral selectivity compared to traditional flocculants. This study highlights the potential of HBPs as effective and environmentally sustainable alternatives for mineral recovery and wastewater treatment applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2229 - 2248"},"PeriodicalIF":4.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Polymeric Membranes Via Additive Manufacturing for Methylene Blue Adsorption","authors":"Allef Gabriel da Silva Fortes,&nbsp;Iago Rodrigues de Abreu,&nbsp;Renato de Sousa Nascimento Júnior,&nbsp;Arthur Antonio Sousa Sampaio,&nbsp;Luigi Veloso Leitão,&nbsp;Ana Luisa Teixeira Reis,&nbsp;Lauriene Gonçalves da Luz Silva,&nbsp;Ana Carolina Lemos de Morais,&nbsp;Tatianny Soares Alves,&nbsp;Renata Barbosa,&nbsp;Rudy Folkersma","doi":"10.1007/s10924-025-03508-5","DOIUrl":"10.1007/s10924-025-03508-5","url":null,"abstract":"<div><p>3D printing has found applications across various sectors, including water treatment, where the incorporation of novel materials enhances sustainability and imparts specific functional properties. This study focused on the production of polymeric filaments for Fused Deposition Modeling (FDM) 3D printing, utilizing a PLA/PBAT blend infused with activated carbon and magnesium oxide, with concentrations up to 6 parts per hundred resin (PHR), for use in water treatment membranes. The distribution, composition, and morphology of the particles were assessed using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). Alterations in physical properties, including water absorption and contact angle, were observed in comparison to the pure commercial blend. An adsorption efficiency exceeding 60% for methylene blue was achieved, as confirmed by SEM analysis of the membranes. Furthermore, the filaments demonstrated suitability for the production of high-quality water treatment membranes, as evidenced by SEM and Optical Microscopy (OM) analysis.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"2029 - 2057"},"PeriodicalIF":4.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel and Highly Efficient Antibacterial PLA Composites Prepared with Liquidambar Orientalis Oil and Ag@g-C3N4 Nanocomposite","authors":"Zehra Durmus,&nbsp;Roberto Köferstein,&nbsp;Arzu Özgen,&nbsp;Titus Lindenberg,&nbsp;A. Wouter Maijenburg,&nbsp;Ali Durmus","doi":"10.1007/s10924-025-03520-9","DOIUrl":"10.1007/s10924-025-03520-9","url":null,"abstract":"<div><p>Flexible PLA-based antibacterial composite films were prepared using a natural oil, <i>Liquidambar orientalis</i>, as bio-based plasticizer, and 2D graphitic carbon nitride (g-C₃N₄) decorated with Ag nanoparticles with a particle size of 10–30 nm as antibacterial agent (Ag@g-C₃N₄). This structurally designed antibacterial nanocomposite was synthesized with the preparation of g-C₃N₄ by high-temperature annealing followed by the reduction of silver salt onto g-C₃N₄. The Ag@g-C₃N₄ nanocomposite exhibited a surface area value of 18 g/m². PLA/Ag@g-C₃N₄ composite films were prepared with solution casting method by introducing 30 phr of <i>L. orientalis</i> oil and various amounts (1, 2 and 4 phr) of Ag@g-C₃N₄. It was found that 30 phr of <i>L. orientalis</i> oil successfully plasticized the PLA and reduced its glass transition temperature from 60 °C to 43 °C and its melting temperature more than 10 °C by reducing the strong interactions and hydrogen bonds between PLA chains. <i>L. orientalis</i> oil also acted as a dispersion agent for the Ag@g-C₃N₄ nanocomposite particles and significantly improved their antibacterial activity. Antibacterial tests performed using Gram-positive bacteria (<i>Staphylococcus aureus ATCC 25923</i>) and Gram-negative bacteria (<i>Escherichia coli ATCC 25922</i> and <i>Acinetobacter baumannii ATCC BAA 747</i>) indicated that introducing a small amount of 2D Ag@g-C₃N₄ nanocomposite particles into PLA yielded superior antibacterial activity.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2249 - 2266"},"PeriodicalIF":4.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03520-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polylactic Acid/Calcium Silicate Composite Scaffold Fabricated by Selective Laser Sintering with Coordinated Regulation of Bioactivity Induction, Degradation, and Mechanical Enhancement","authors":"Dongying Li,&nbsp;Yanrong Zhou,&nbsp;Peng Chen,&nbsp;Changfeng Li,&nbsp;Jianfei Zhang,&nbsp;Zonghan Li,&nbsp;Zixiong Zhou,&nbsp;Mengqi Li,&nbsp;Yong Xu","doi":"10.1007/s10924-025-03531-6","DOIUrl":"10.1007/s10924-025-03531-6","url":null,"abstract":"<div><p>Developing a biomimetic porous composite scaffold with mechanical properties tailored to meet the requirements of bone defect repair, enhanced bioactivity, and controlled biodegradability is of great significance for effective bone regeneration. In this work, calcium silicate (CS, CaSiO₃) was introduced into polylactic acid (PLA) as an addition. A scaffold model was then constructed using triply periodic minimal surfaces (TPMS), and a PLA/CS composite scaffold was fabricated using selective laser sintering (SLS) technology. Among them, when the CS content was 5wt%, the compressive strength and modulus of the composite scaffold were 4.8 MPa and 52.1 MPa, respectively, which were 104.2% and 43.9% higher than those of the PLA scaffold. The mechanical strengthening can be attributed to the particle reinforcement effect caused by the inherent high stiffness of CS. Additionally, the incorporation of CS accelerates the degradation of the scaffold while enhancing its bioactivity. The composite scaffold also demonstrated favorable cell compatibility in in vitro tests, supporting its potential for biological integration. In summary, the PLA/CS composite scaffold with coordinated regulation of multiple properties is expected to become a potential choice for bone defect repair. </p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1778 - 1791"},"PeriodicalIF":4.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Degradation and Optimization of Waste Polyisocyanurate by La-Ni Perovskite Catalysts","authors":"Xiaohua Gu,&nbsp;Shangwen Zhu,&nbsp;Anyu Fan,&nbsp;QingLong Zhao,&nbsp;Qingyong Su","doi":"10.1007/s10924-025-03528-1","DOIUrl":"10.1007/s10924-025-03528-1","url":null,"abstract":"<div><p>Polyisocyanurate (PIR) foams cannot be processed quickly and efficiently due to their thermophysical properties. To address this challenge, this work investigates the alcoholysis degradation process of waste PIR foams, aiming at the high-value utilization of resources. With respect to the chemical recovery method of polyurethane, the effects of catalyst type, dosage, and ratio on the effect of alcoholysis were investigated. The results showed that the performance of the resulting recycled PIR tubular shells was superior to that of commercially available products when an alcoholysis agent with a butylene glycol to diethylene glycol ratio of 43:57 was used. The mixture was reacted at 180 °C for 2 h, and a combination of 0.100% LaNiO₃ and 0.200% NaOH catalysts was used. The lowest viscosity of degradation product obtained under this scheme was 2201.6 mPa·s, and the thermal conductivity of the regenerated PIR foam was 0.025 W/(m·K) with a compression strength of 239 kPa. This study provides an efficient and feasible process route for the resource utilization of used PIR foams.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2207 - 2228"},"PeriodicalIF":4.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UiO-66 Metal-organic Framework (MOF) as an Osteogenic Stimulant in the Poly-3-hydroxybutyrate-zein/UiO-66 Electrospun Composite Scaffold for Bone Tissue Engineering Applications","authors":"Saeid Ghasemi,&nbsp;Mahdie Esmaeili,&nbsp;Mohammad Dinari,&nbsp;Arezou Dabiri,&nbsp;Saeed Karbasi","doi":"10.1007/s10924-025-03521-8","DOIUrl":"10.1007/s10924-025-03521-8","url":null,"abstract":"<div><p>Metal-organic frameworks have recently become popular in biomedical applications due to their high surface areas, porosity, suitable mechanical properties, controlled degradability, and selective compositions. Among them, UiO-66 is particularly noteworthy for its exceptional stability, biodegradability, low toxicity, and osteogenic properties. Herein, UiO-66 was synthesized via a solvothermal method and characterized employing FTIR, XRD, FESEM, and TEM analyses. Subsequently, poly-3-hydroxybutyrate-zein/UiO-66 electrospun composite scaffolds were fabricated. Regarding the SEM, mechanical analyses, and water contact angle results, the scaffold containing 2 wt% UiO-66 exhibited the optimum characteristic. EDS and TEM examinations confirmed UiO-66’s presence and distribution, TGA validated its claimed amount in the scaffold, and FTIR revealed the possible interactions between ingredients. Incorporating 2 wt% UiO-66 reduced the fiber diameter and water contact angle by about 54 nm and 20°, respectively, while increasing surface roughness and crystallinity. UiO-66 significantly enhanced ultimate tensile stress and Young’s modulus by approximately 90% and 101%, respectively. It also boosted the biomineralization of the scaffold and hastened the degradation rate. Eventually, adding UiO-66 led to noticeable increases in viability, proliferation, attachment, ALP activity, and ECM mineralization, as well as upregulation of COLΙ, RUNX2, and OCN genes of MG-63 cells seeded on the scaffolds. In conclusion, incorporating UiO-66 not only reinforced the composite scaffold but also stimulated osteogenesis, making it an advantageous candidate for bone tissue engineering applications.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"2001 - 2028"},"PeriodicalIF":4.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Inflammation Suppressing Effects of Prednisolone Encapsulated Alginate/Agarose Co-Polymeric Hydrogel System","authors":"Shivanshu Nautiyal,&nbsp;Muruganandam Mohaneswari Yokesh,&nbsp;Suresh Aravind,&nbsp;Nambolan Varsha,&nbsp;Dinakar Swastha,&nbsp;Kavassery Balasubramanian Samyuktha,&nbsp;Akshad Balde,&nbsp;Soottawat Benjakul,&nbsp;Rasool Abdul Nazeer","doi":"10.1007/s10924-025-03524-5","DOIUrl":"10.1007/s10924-025-03524-5","url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) encompasses a group of chronic inflammatory disorders of the gastrointestinal tract, including Crohn’s disease and Ulcerative colitis. Conventional treatments for IBD often involve systemic administration of corticosteroids, such as Prednisolone (Pred), which can lead to undesirable side effects. Delivery systems are preferred for the administration of drugs, as they enhance the bioavailability of the drug while reducing the dosage and targeting the affected tissue. This leads to effective treatment with minimal side effects. Hydrogels are considered to be one of the effective drug delivery systems as they facilitate site-specific drug delivery. In this study, we aimed to optimize and develop a localized hydrogel-based drug delivery system using agarose (Agr) and alginate (Alg) respectively for targeted drug therapy in IBD. Pred, a potent corticosteroid with anti-inflammatory properties, was incorporated into the optimized hydrogel matrix at various concentrations. The hydrogel exhibited good swelling ability (12–14 g/g) and mucoadhesivity (43.54 ± 2.52%) at lower Agr concentration compared to Alg hydrogel as control. The 1% (w/v) agarose/2% (w/v) alginate hydrogel (A₁AH) was able to encapsulate approximately 97.31 ± 1.77% of Pred and possessed the ability to deliver the drug in a prolonged manner over a sustained time period. The Pred-encapsulated hydrogel (P-A₁AH) system displayed no in vitro cytotoxic effects on HCT116 cell lines and was able to effectively suppress inflammatory mediators like reactive oxygen species (ROS), nitric oxide (NO) and revealed effective wound healing effects. The developed mucoadhesive hydrogel system can be exploited for the delivery of various drugs to target intestinal inflammation for prolonged effects.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2193 - 2206"},"PeriodicalIF":4.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Bio-based Monomer Derived from Camelina Oil and Itaconic Acid for the Synthesis of Film-forming Latexes","authors":"Martin Kolář,&nbsp;Jan Honzíček,&nbsp;Štěpán Podzimek,&nbsp;Martin Hájek,&nbsp;Vladimír Lukeš,&nbsp;Erik Klein,&nbsp;David Kocián,&nbsp;Jana Machotová","doi":"10.1007/s10924-025-03515-6","DOIUrl":"10.1007/s10924-025-03515-6","url":null,"abstract":"<div><p>The need for the production of synthetic polymers from renewable and sustainable resources also affects the area of emulsion polymerization. The bio-based monomer (BBM) was synthesized from camelina oil (CO) and itaconic acid through transesterification and epoxidation of CO, followed by itaconation, resulting in a blend of methyl esters of CO-originated fatty acids functionalized with reactive methyl itaconate groups. Various amounts of BBM (0−30 wt% of BBM in the total monomer mixture) were copolymerized with standard petroleum-based acrylic monomers (specifically methyl methacrylate, butyl acrylate, and methacrylic acid) using the emulsion polymerization technique to obtain film-forming latexes. Infrared and Raman spectroscopies evidenced the successful incorporation of BBM into the structure of latex polymers. The ultra-high molar mass nanogel fraction was detected by asymmetric flow-field flow fractionation coupled with a multiangle light scattering (AF4-MALS) for the BBM comprising copolymers; the higher the BBM content, the more extensive the nanogel fraction. Cross-linking of latex polymers induced by BBM testified to the reactivity of itaconated functions in emulsion polymerization and provided additional evidence of the copolymerization ability of BBM. The incorporation of BBM also resulted in pendulum hardness and glass transition temperature enhancement (about 11% and 9 °C, respectively, in the case of 30 wt% of BBM content in contrast to 0 wt% of BBM content in the copolymer). Coatings with excellent transparency and gloss were obtained from all latexes regardless of the BBM content used. Slightly increased water repellency (about 7 ° increased water contact angle value) and significantly improved water whitening resistance of the coatings (about 80% decreased water whitening after 1-day long water exposure) were found for coatings comprising 30 wt% of BBM in the copolymer, where the water whitening phenomenon was highly dependent on the BBM content.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1829 - 1846"},"PeriodicalIF":4.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03515-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer Synergy: Enhancing PA6/PLA Properties with POE-g-MA and Bioactive Glass for Advanced Biomedical Solutions","authors":"Mohammad Javad Azizli,&nbsp;Soheila Lashgari,&nbsp;Katayoon Rezaeeparto,&nbsp;Somayeh Parham,&nbsp;Azam Ghadami,&nbsp;Lobat Tayebi,&nbsp;Ehsan Vafa,&nbsp;Mohammadreza Asadizadegan","doi":"10.1007/s10924-025-03505-8","DOIUrl":"10.1007/s10924-025-03505-8","url":null,"abstract":"<div><p>This study examined the effects of adding Polyethylene-octene elastomer modified with maleic anhydride (POE-g-MA) as a compatibilizing agent, along with bioactive glass particles (BG), to a blend of polyamide 6 (PA6) and poly (lactic acid) (PLA). The research focused on analyzing the morphology, rheological behavior, thermomechanical characteristics and shape memory capabilities of the resulting composite materials. Utilizing Field Emission Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM), it was found that the inclusion of the compatibilizer and BG significantly improved dispersion and phase interactions within the matrix, which was linked to enhanced interfacial adhesion. The addition of BG also contributed to greater thermal stability, as indicated by a rise in the activation energy (Ea) required for thermal degradation of the samples. Contact angle and degradation analysis indicate good biocompatibility and biostability of composites. Mechanical tests demonstrated notable improvements in Charpy impact strength and tensile strength for the “P80/L20/C5/BG10” sample, showing increases of over 120% and 56%, respectively, compared to the PA6/PLA blend without additives. Rheological studies revealed that the inclusion of both the compatibilizer and BG modified the viscoelastic characteristics of the samples, with zero shear rate viscosity and relaxation time increasing as BG content rose, in line with the Carreau-Yasuda model. Additionally, the combined effects of the compatibilizer and BG significantly enhanced the polymer’s ability to retain its shape, resulting in enhanced recovery factor (Rf) and recovery rate (Rr). This research highlights the potential of using POE-g-MA and BG to improve the performance attributes of PA6/PLA composites for advanced applications, demonstrating significant improvements in morphology, thermal stability, mechanical strength, rheological behavior, shape memory capabilities, and biomedical uses.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1947 - 1971"},"PeriodicalIF":4.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03505-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interactions Between Polyhydroxyalkanoates and Cells Involved in the Process of Tissue Damage Repair","authors":"Galina A. Ryltseva,&nbsp;Alexey E. Dudaev,&nbsp;Sergei Y. Lipaikin,&nbsp;Fares D. E. Ghorabe,&nbsp;Natalia G. Menzyanova,&nbsp;Sviatlana A. Ulasevich,&nbsp;Ekaterina V. Skorb,&nbsp;Tatiana G. Volova,&nbsp;Ekaterina I. Shishatskaya","doi":"10.1007/s10924-025-03513-8","DOIUrl":"10.1007/s10924-025-03513-8","url":null,"abstract":"<div><p>The control of the surface topography of biomaterials is a key factor for the management of post-implantation recovery processes. The study of the influence of the nanorelief of polyhydroxyalkanoate (PHA) films on the functional state of cells involved in tissue healing process is important for the development of biocompatible materials for tissue engineering. In this work, polymer films based on polyhydroxyalkanoates of various compositions with different surface relief were analyzed. The effect of the nanorelief of PHA films on the morphology, adhesion and proliferation of cells involved in regenerative processes in tissue damage (erythrocytes, macrophages, fibroblasts) was evaluated. According to the obtained results, it was found that all films samples based on polyhydroxyalkanoates of various compositions have high biocompatibility and do not cause any pronounced negative cellular reactions. However, differences in cell morphology, adhesion, and proliferation were noted between film samples. In the case of P3HB films, a slight activation of local inflammatory reactions was noted. Thus, P3HB matrix is less preferable for use in restoration of soft tissues. On the other hand, films based on P3HB3HV demonstrated high biocompatibility, which allows to conclude that this copolymer matrix is promising for use in tissue engineering.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1984 - 2000"},"PeriodicalIF":4.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}