Analyst最新文献

{"title":"Self-Adaptive Nanophotonic Metasurfaces Enabling Digital Twins: Toward Continuous Personalized Healthcare in Aging and Disability","authors":"Bakr Ahmed Taha,Ali J. Addie,Khalid Hassan Ibnouf,Majid S. Jabir,Omar Talal Mahmood,R. Apsari,Norhana Arsad","doi":"10.1039/d6an00888g","DOIUrl":"https://doi.org/10.1039/d6an00888g","url":null,"abstract":"Continuous physiological monitoring is a prerequisite in medicine that enables early disease detection, long-term health monitoring, and individualized therapeutic interventions. Although wearable optical biosensors have evolved significantly, their long-term clinical deployment remains limited by mechanical degradation, signal drift, biofouling, energy constraints, and poor integration with intelligent healthcare infrastructure. These issues are especially acute in the aged and disabled, when constant, dependable, and tailored monitoring is critical for proactive disease treatment. As a result, next-generation sensing technologies must progress beyond passive data collection toward self-adaptive systems capable of maintaining analytical accuracy while supporting patient-specific clinical interpretation and clinician-supervised decision-making. This perspective presents an overview of self-adaptive nanophotonic metasurfaces as the sensing foundation for Living Digital Twins (LDTs) in personalized healthcare. To create an intelligent sensing ecosystem, the proposed framework combines flexible plasmonic, localized surface plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), artificial intelligence, internet of nano things (IoNT) connectivity, and individualized digital twin analytics. The proposed framework combines continuous multimodal biomarker sensing with patient-specific physiological modelling to support longitudinal updating of digital representations. Edge intelligence enables low-latency signal processing, while adaptive analytics may improve sensing stability, calibration, and patient-specific interpretation. The integration of adaptive nanophotonic sensing with digital twins therefore represents a prospective approach for supporting early identification of physiological deterioration, individualized risk assessment, and clinician-supervised treatment planning in aging and disabled populations.","PeriodicalId":63,"journal":{"name":"Analyst","volume":"76 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148980640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly imprinted electrochemiluminescence sensor based on a Co/Zn-MOF@POMs composite for sensitive and selective detection of fumonisin B1.","authors":"Zhenghong Zhao, Jinling Pu, Shuzhen Xu, Yue Xu, Zihao Huang, Lianming Zhang, Xiaoping Wei, Jianping Li","doi":"10.1039/d6an00387g","DOIUrl":"10.1039/d6an00387g","url":null,"abstract":"<p><p>Fumonisin B1 (FB1), a highly toxic secondary metabolite produced by <i>Fusarium</i> fungi, poses a significant threat to global food safety; therefore, sensitive, selective, and reliable analytical methods are urgently needed. In this work, we report a novel molecularly imprinted electrochemiluminescence (ECL) sensor for the quantitative determination of FB1. A Co/Zn bimetallic metal-organic framework@polyoxometalate (Co/Zn-MOF@POMs) nanocomposite was synthesized <i>via</i> a one-pot strategy and used to modify a glassy carbon electrode. The incorporated polyoxometalates (POMs) markedly improved the interfacial electron-transfer kinetics of the Co/Zn-MOF scaffold, resulting in substantial amplification of the ECL signal generated by ZnAgInS quantum dots (QDs). Subsequently, a molecularly imprinted polymer (MIP) layer was electropolymerized on the modified electrode using <i>o</i>-phenylenediamine as the functional monomer and 1,2,3-propanetricarboxylic acid as a structural dummy template designed to mimic key topological and functional features of FB1. Upon FB1 rebinding, the exposed amine groups on the captured FB1 molecules underwent a condensation reaction with carboxyl-functionalized ZnAgInS QDs, enabling site-specific immobilization of the luminophores close to the recognition cavities. Under optimized conditions, the sensor exhibited a linear ECL response to FB1 over a concentration range of 6.0 × 10^-14 to 1.0 × 10^-10 mol L^-1 (<i>R</i>² = 0.9987), with a detection limit of 3.3 × 10^-15 mol L^-1 (S/N = 3). This approach offers a robust and reproducible platform for trace-level FB1 monitoring in real-world food and agricultural samples.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5344-5353"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of dried blood spot quality control materials in newborn screening for inborn errors of metabolism.","authors":"Xiaoyi Yi, Yiqi Yang","doi":"10.1039/d6an00761a","DOIUrl":"10.1039/d6an00761a","url":null,"abstract":"<p><p>The application of tandem mass spectrometry (MS/MS) for detecting inborn errors of metabolism (IEM) is an important achievement in newborn screening (NBS). A single blood spot provides information on about 60 metabolites and related ratios that enable the screening of approximately 50 different diseases. A major limitation of newborn screening for IEM is the lack of matrix-matched dried blood spot (DBS) quality control (QC) materials in clinical laboratories. Herein, we developed DBS QC materials for IEM and investigated their recovery, homogeneity, and stability. Four concentration levels of DBS materials were prepared by spiking 9 amino acids, 6 acylcarnitines, and succinylacetone into a hemoglobin solution, which was dialyzed prior to preparing DBS. Hemoglobin solutions containing the predetermined quantities of metabolites were spotted, dried, and packaged. Isotope-dilution mass spectrometry was employed to estimate the endogenous contents and validate the final concentrations of alanine (Ala), proline (Pro), valine (Val), leucine (Leu), ornithine (Orn), methionine (Met), phenylalanine (Phe), arginine (Arg), citrulline (Cit), carnitine (C0), acetylcarnitine (C2), glutarylcarnitine (C5DC), octanoylcarnitine (C8), decanoylcarnitine (C10), dodecanoylcarnitine (C12), and succinylacetone (SA). The recovery, homogeneity, and post-preparation short-term stability of the DBS materials were also evaluated using an MS/MS assay. The recovery for amino acids was 81.4%-121.7%, with the exception of 68.2% for Arg. The recovery for acylcarnitines and succinylacetone was 60.0%-97.9%. The homogeneity, evaluated as between-spot coefficient of variation (CV) for the multilevel DBS materials, was 4.4%-16.6% for amino acids and 3.3%-19.8% for acylcarnitines and succinylacetone. Furthermore, DBS materials stored at 4 °C showed minimal deviation over the 28-day evaluation period for all metabolites. Multilevel DBS QC materials based on a hemoglobin matrix for newborn screening of IEM were developed for the first time. These QC materials can be used to monitor the daily analytical performance and improve the technical proficiency in clinical laboratories.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5498-5509"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A gold-palladium bimetallic nanozyme-based colorimetric sensor for nitrite assay.","authors":"Xinyuan Xu, Chenlu Shi, Xiaolin Qu, Yue Pan, Jinjiang Cui, Peng Miao","doi":"10.1039/d6an00892e","DOIUrl":"10.1039/d6an00892e","url":null,"abstract":"<p><p>Bimetallic nanozymes leverage electronic and geometric synergy to overcome single-metal limitations, which may enhance the stability and catalytic efficiency for sensing. We herein synthesize a gold-palladium (Au-Pd) bimetallic nanozyme <i>via</i> a one-step co-reduction method. It exhibits excellent peroxidase-like activity with high substrate affinity and catalytic efficiency. We further construct a colorimetric system for nitrite assay. The AuPd₃ nanozyme catalyzes the oxidation of colorless TMB to blue oxidized TMB (oxTMB) in the presence of H₂O₂. The introduced nitrite could react with oxTMB <i>via</i> diazotization to form yellow products. The recorded absorbance ratio (<i>A</i>₆₅₂/<i>A</i>₄₅₀) thus enables quantitative nitrite detection. This method shows a good linear range from 5 to 500 μM with the limit of detection as low as 0.23 μM. It features simple operation, high sensitivity and favorable accuracy, offering reliable technical support for food safety and environmental monitoring.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5236-5243"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cascaded CHA-CRISPR/Cas12a photoelectrochemical platform enabled by S-scheme Bi₂WO₆/BiOBr for piR-823 detection.","authors":"Xiawen Lin, Peng Ye, Yangyang Ding, Yue Cao, Yuanyuan Wang, Jian He, Yang Zhou","doi":"10.1039/d6an00974c","DOIUrl":"10.1039/d6an00974c","url":null,"abstract":"<p><p>Exosomal piR-823 is a promising specific biomarker for colorectal cancer, yet its ultrasensitive detection remains challenging due to its extremely low abundance and high sequence complexity. Herein, we developed a cascaded CHA-CRISPR/Cas12a photoelectrochemical (PEC) sensing platform enabled by an S-scheme Bi₂WO₆/BiOBr heterojunction for the reliable detection of piR-823. The flower-like spherical Bi₂WO₆/BiOBr heterojunction exhibits enhanced visible-light absorption and efficient charge transfer arising from the S-scheme structure, which establishes a strong photoactive basis for the PEC platform. By integrating catalytic hairpin assembly with CRISPR/Cas12a trans-cleavage activity, a cascaded signal amplification strategy is established, which significantly improves the detection sensitivity. Under optimized conditions, the platform shows a distinct negative correlation between transient photocurrent and the logarithm of piR-823 concentration (1.0-1.0 × 10⁶ fM), with an ultralow detection limit of 0.34 fM (S/N = 3). It also demonstrates high specificity, good reproducibility, and satisfactory recovery (96.87%-103.41%) in exosome lysate. This work not only presents an efficient PEC biosensing platform for piRNA analysis but also offers guidance for the rational construction of S-scheme heterojunctions in high-performance PEC biosensors, holding great promise for early colorectal cancer diagnosis and prognostic monitoring.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5510-5517"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profiling reveals subtype-specific responses to jerantinine A acetate in breast cancer cells.","authors":"Haneen Abuzaid, Salah Abdelrazig, Alaa Abuawad, Lama Hamadneh, Lyudmila Turyanska, Dong-Hyun Kim, Tracey D Bradshaw","doi":"10.1039/d6an00497k","DOIUrl":"10.1039/d6an00497k","url":null,"abstract":"<p><p>Jerantinines are natural indole alkaloids with promising anticancer activity in breast cancer cells <i>via</i> mechanisms of action involving tubulin binding and disruption of microtubule dynamics, with growth inhibition values, GI₅₀ < 0.4 µM. However, metabolic responses of different breast cancer phenotypes are not yet understood. In this work, LC-MS-based untargeted metabolomics was used to investigate the response of four selected breast cancer cell lines representing different subtypes (MCF-7, BT-474, MDA-MB-231, and SKBR-3) to treatment with Jerantinine A acetate (JAa). Based on univariate, multivariate and pathway analyses, the results showed metabolic perturbations in amino-acid metabolism, fatty acid oxidation, and redox homeostasis. In breast cancer cells treated with 0.4 µM of JAa for 72 h, the elevated levels of oxidation-related metabolites, including 2-oxoglutarate, butyryl carnitine, propionyl carnitine, and 5-oxo-L-proline, indicated increased oxidative stress. Interestingly, only MCF-7 cells accumulated the antioxidants glutathione and taurine relative to untreated controls, and this response was accompanied by upregulation of wild-type p53 in this cell line. This p53-associated antioxidant capacity offers a mechanistic explanation for the difference in observed GI₅₀ values: GI₅₀ of 0.37 µM in MCF-7 compared to 0.19 µM and 0.14 µM in SKBR-3 and BT-474 cells, respectively, both of which harbour mutant p53 and did not mount an equivalent antioxidant response. These findings provide new insights into the metabolic effects of JAa on breast cancer cells and further support its potential as an anticancer agent. The observed metabolic differences between cell lines may inform future strategies for personalized therapy.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5459-5469"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Detection of Heart Failure: Development of a Sensitive Fluorescent Kit for Clinical sST2 Detection","authors":"Ping Zhou,Menghan Chen,Ya-ge Jin,Mengke Gu,Liang Pan,Jinzhi Zang,Shanshan Nai,Ting Song,Miaoyuan Liu,Kaidi Ren,Huijie Zhao,Yang Yang","doi":"10.1039/d6an00857g","DOIUrl":"https://doi.org/10.1039/d6an00857g","url":null,"abstract":"Heart failure, the terminal stage of various cardiovascular diseases, typically presents with subtle early symptoms that are difficult to detect. Consequently, developing fast and accurate diagnostic tools is essential for effective early diagnosis and disease management. Soluble suppression of tumorigenicity 2 (sST2) is recognized as a valuable biomarker for predicting disease severity and mortality in cardiovascular disease, making it a promising target for developing a detection kit for early heart failure diagnosis. Recently, the CRISPR-Cas12a system has been increasingly used for quick and sensitive nucleic acid detection. However, its application in protein detection remains limited. In this study, we combined nanotechnology-mediated protein capture with the CRISPR-Cas12a system and developed a fluorescence-based method for rapid and sensitive detection of sST2. The presence of sST2 triggers the formation of a ternary complex, which can activate the trans-cleavage activity of Cas12a, resulting in cleavage of the response DNA single strand and the production of a fluorescent signal. Importantly, when tested on serum samples, this method can effectively distinguish patients with heart failure from healthy controls. This method offers a promising alternative to traditional enzyme-linked immunosorbent assays (ELISAs), with potential advantages in operational simplicity and detection speed. Therefore, this innovative fluorescence-based sST2 detection technique has significant potential for the clinical diagnosis of heart failure.","PeriodicalId":63,"journal":{"name":"Analyst","volume":"25 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148973255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear modification-enhanced electrochemiluminescence of naphthalimide for copper ion detection in traditional Chinese medicine <i>Astragalus membranaceus</i>.","authors":"Hai Wang, Ting Zhang, Qi Zhang, Yifan Zhang, Zhengang Han","doi":"10.1039/d6an00782a","DOIUrl":"10.1039/d6an00782a","url":null,"abstract":"<p><p>This work designs and synthesizes three core-modified naphthalimide derivatives (NCD-B, NDI-I, and NDI-H). Benefiting from efficient intramolecular charge transfer and suppressed intermolecular π-π stacking, all three compounds exhibit remarkable electrochemiluminescence (ECL) performance. In particular, NDI-H functionalized with imidazole substituents delivers a strong ECL signal up to 17 000 a.u. and excellent long-term stability with an RSD of 0.32%. An ECL sensor for Cu²⁺ was further constructed based on NDI-H, which displays a favorable linear response in the range of 0-5000 μM and a low detection limit of 3.56 μM. With advantages of low background interference, simple operation, low probe and instrument costs, and excellent selectivity, this method has been successfully applied to the determination of Cu²⁺ in <i>Astragalus membranaceus</i>, providing a reliable ECL analytical strategy for heavy metal monitoring in traditional Chinese medicines.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5377-5386"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant Nus-organophosphorus hydrolase (OPH) immobilized carbon quantum dot (CQD) loaded thin films for efficient detection of OP compounds in environmental samples.","authors":"Tanmay Vyas, Surbhi Jaiswal, Prashant Kodgire, Abhijeet Joshi","doi":"10.1039/d6an00145a","DOIUrl":"10.1039/d6an00145a","url":null,"abstract":"<p><p>The toxicity of organophosphate (OP) insecticides and pesticides is increasing in the human population owing to their indiscriminate use globally. The need to achieve food security for the rising population is the main reason for the excessive use of such chemical compounds. The hazardous effects of OP pesticides can be mitigated only through conscientious efforts in detecting them in various food and water resources. In the present study, we developed carbon quantum dots (CQDs) and recombinant Nus-organophosphorus hydrolase (Nus-OPH) enzyme co-immobilized chitosan polymer film-based biosensors for the detection of OP compounds, such as coumaphos (CP), methyl parathion (MP) and ethyl paraoxon (EP), present in river water and household water resources using a fiber optic spectrophotometer. The <i>E. coli</i> strains were utilized for the expression of the Nus-OPH enzyme, purified and subsequently immobilized on the chitosan thin films containing CQDs that were synthesized from triethylene diamine and phthalic acid through microwave irradiation. The thin-film biosensors composed of CQDs-Nus-OPH were characterized utilizing several methods like XRD, XPS, TEM, CLSM, and enzyme activity measurements. The biosensing studies of CP, EP, and MP were performed by recording fluorescence changes using reflectance probe-mediated measurements in a fiber optic spectrophotometer. This study determined that the CQDs-Nus-OPH thin film-based biosensor has the potential to detect/analyze EP, CP, and MP in the 0-100 µM range with the limits of detection of 145 ppb, 178 ppb, and 188 ppb, respectively, within a time frame of 5 minutes. The accuracy of the biosensor in the OP-spiked water matrices was found to be 100%-102%, indicating that the CQDs-Nus-OPH thin-film biosensors can detect the analyte accurately. These results indicate that this biosensor platform shows potential for organophosphate detection, although further studies are needed to improve specificity and analyte discrimination.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5244-5257"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photosynthetic starch characterization using terahertz spectroscopy with a bolometer.","authors":"Shusaku Nakajima, Ryutaro Morita","doi":"10.1039/d6an00578k","DOIUrl":"10.1039/d6an00578k","url":null,"abstract":"<p><p>Recent studies have demonstrated that terahertz spectroscopy can identify starch absorption peaks in solid pellets containing powdered plant samples with minimal interference of other plant matrices. Here, we applied this analytical method to assess photosynthetic capacity in plant leaves with a relatively low starch content. To monitor starch produced through photosynthesis, rice leaves were measured in the frequency range of 3.0-9.5 THz using a Fourier-transform spectrometer equipped with a bolometer. A starch over-accumulation mutant (<i>α-glucan water dikinase1</i>) and wild type (cv. Nipponbare) were harvested after 2 and 3 months of cultivation. In the terahertz measurements, all leaves exhibited an absorption peak at 9.0 THz attributed to starch and the peak intensities were consistent with starch contents obtained by chemical analysis. Furthermore, correlations were found between second derivative signals and starch content (<i>R</i>² = 0.86-0.87). However, a higher accuracy model was developed using peak height calculated using the peak top at 9.0 THz and a baseline between 8.65 and 9.35 THz (<i>R</i>² = 0.91). These results indicate that just three frequencies are sufficient on behalf of the full range spectra, suggesting the feasibility of a starch sensor for future applications. Therefore, terahertz technology can serve as a valuable analytical method for assessing starch accumulation and photosynthetic capacity in unpurified plant leaves.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" ","pages":"5482-5489"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}