临床病例讨论杂志(英文版)最新文献

{"title":"Generalized lymphadenopathy as an atypical initial clinical manifestation in rheumatoid arthritis and a possible hypothetical mechanism","authors":"José Eugenio Vázquez‐Meraz, C. Duarte-Salazar, R. Franco-Cendejas, David Antonio Argüelles-Pérez, G. Aristi-Urista, J. Arellano-Galindo","doi":"10.5430/dcc.v9n1p13","DOIUrl":"https://doi.org/10.5430/dcc.v9n1p13","url":null,"abstract":"Objective: To describe a 60-year-old male with diffuse generalized lymphadenopathy preceding a diagnosis of rheumatoid arthritis.Case presentation: The patient was admitted on suspicion of lymphoma. Chest positron emission/computed tomography showed enlarged lymph nodes bilaterally, mediastinum in the perihilar, retroperitoneum, and inguinal regions, with normal hematopoiesis of bone marrow. Lymph node biopsy revealed reactive follicular lymphadenopathy. Polyarthritis was present, and a rheumatoid factor test was positive eight months after the initial medical evaluation. A diagnosis of rheumatoid arthritis associated with generalized lymph node involvement was made. The patient was treated with leflunomide and corticosteroids and showed complete recovery without recurrence at 18 months of follow-up.Conclusions: Once histological findings of reactive lymph node hyperplasia are established as primarily related to rheumatic disease activity, clinicians should consider a possible diagnosis of rheumatoid arthritis.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"2 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82444796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of plasma homocysteine, soluble intercellular adhesion molecule-1, high mobility group box 1 protein with carotid intima-media thickness in elderly patients with type 2 diabetes mellitus","authors":"Zhijie Cai, J-F Xue, Xiaohui Ma, Pei-pei Chen, B. Ge, Yuying Zhang, Zhihui Dong","doi":"10.5430/dcc.v9n1p9","DOIUrl":"https://doi.org/10.5430/dcc.v9n1p9","url":null,"abstract":"Objective: To explore the relationship of plasma homocysteine (Hcy), soluble intercellular adhesion molecule-1 (sICAM-1) and high mobility group box 1 protein (HMGB1) with carotid intima-media thickness (c-IMT) in elderly patients with type 2 diabetes mellitus.Methods: A total of 100 elderly patients who were diagnosed as type 2 diabetes mellitus in Baogang Hospital of Inner Mongolia from June 2017 to May 2020 were chosen as research objects. According to c-IMT, they were divided into the normal group (n = 35), the mild to moderate group (n = 41) and the severe group (n = 24). The expression levels of plasma Hcy, sICAM-1 and HMGB1 were compared between groups respectively. Pearson’s correlation coefficient was used to analyze the relationship of plasma Hcy, sICAM-1, HMGB1 with c-IMT.Results: The comparison in plasma Hcy, sICAM-1, HMGB1 and c-IMT among the three groups of patients was of statistical significance (p < .05). The results of correlation analysis showed that the expression levels of plasma Hcy, sICAM-1 and HMGB1 were positively correlated with c-IMT in elderly patients with type 2 diabetes mellitus (r = .627, .598, .614; p < .05).Conclusions: The expression levels of plasma Hcy, sICAM-1 and HMGB1 are abnormally increased in elderly patients with type 2 diabetes mellitus, and related to c-IMT, which can provide a strong evidence for clinical diagnosis and treatment by detecting their levels in clinical practice.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85680924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of stem cell-derived exosomes in injury repair","authors":"Fengrui Cui, Fang Li, Tiening Zhang, Quan Li","doi":"10.5430/dcc.v9n1p5","DOIUrl":"https://doi.org/10.5430/dcc.v9n1p5","url":null,"abstract":"After organ and tissue injury, the proliferation and differentiation of stem cells themselves play only a small role in the repair of injury, and their repair role is mainly played through the paracrine function of stem cells. Exosomes are nano-scale vesicles that are secreted into the extracellular space in an exocytic manner, and its own function will be regulated after the target cells absorb the exosomes. Stem cell-derived exosomes communicate between cells by transmitting proteins, lipids and micro-RNAs (miRNAs). The targeting and biological properties of stem cell-derived exosomes are determined by the level of miRNAs that they carry. After the exosomes reach the target cells and undergo fusion, the gene expression of the target cells is changed by degradation and expression. In addition, the RNA and protein of stem cell-derived exosomes can also limit the development of injury through cell homing. This article will review the mechanism of stem cell-derived exosomes in wound healing, joint injury, fracture healing and cardiac injury.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77120045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-piece implant-supported overdenture in fully edentulous patients: Report of two cases","authors":"N. Hassine, Alexandre Perez","doi":"10.5430/dcc.v9n1p1","DOIUrl":"https://doi.org/10.5430/dcc.v9n1p1","url":null,"abstract":"Dental implants with a reduced diameter can be placed in regions that lack adequate bone volume enabling functional and aesthetic oral rehabilitation without the complicated bone augmentation procedures.This article describes surgical and prosthetic procedures used in oral rehabilitation using Straumann ® one-piece Mini Implants (2.4-mm diameter with Optiloc ® prosthetic connection system) in two fully edentulous women aged 57 and 74. Both patients presented with severe ridge resorption. Ten one-piece mini dental implants (six on maxillary arch and four on mandibular arch) were placed in each patient to support new complete overdentures. Both patients were delighted with the results and regained their social lives. In addition, stabilized dentures allowed the patients to regain fundamental functions of the mouth: chewing and verbal (speech) and non-verbal (smiling) communication without the fear or difficulty experienced while wearing dentures that can move.In conclusion, mini implants offer an efficient, economical, and less invasive solution, especially for edentulous patients with atrophic bone structure or who cannot undergo complex surgical procedures.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83215534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culturally tailored DSMES: A new key for South Asian patients with Type 2 Diabetes Mellitus","authors":"Hongxiu Luo, A. Kuriakose, G. Thota, Naveen Naveen Mehrotra","doi":"10.5430/dcc.v8n4p14","DOIUrl":"https://doi.org/10.5430/dcc.v8n4p14","url":null,"abstract":"South Asians have an exceptionally high risk for developing Type 2 diabetes mellitus. It is very challenging for healthcare providers to successfully manage diabetes and control glucose levels at target due to the unique lifestyle of the South Asian population. Culturally tailored diabetes self-management education and support (DSMES) can be more effective in guiding South Asian patients with Type 2 diabetes. Unique considerations to address lifestyle modification for South Asians include a diet that typically consists of a high carbohydrate to lipids/proteins ratio, preference for high glucose index fruits, regular intake of traditional sweets or desserts, late afternoon tea break followed by late dinner, lack of vigorous exercise (yoga or walking being the preferred activity), lack of DSMES knowledge and skills, and poor access to culturally appropriate resources for diabetes care. We present a 38-year-old male diagnosed with diabetes four years ago who showed poor glucose control before our intervention. Our interventions included education on the importance of blood glucose monitoring, exercise, and diet. Based on our experience with this case, we propose the following recommendations for a tailored approach to DSMES for South Asian patients with Type 2 diabetes: make appropriate dietary changes (decrease total daily caloric intake, decrease the percentage of carbohydrates, addlow glucose index fruits and vegetables, avoid late afternoon tea breaks, eat dinner before 8 PM); incorporate appropriate daily physical activity; and monitor blood glucose daily for prompt feedback.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"452 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75113437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival of dental implants in patients with bone dysplasia: A systematic review","authors":"Alexandre Perez, Sarah Dib, Andreij Terzic, D. Courvoisier, P. Scolozzi","doi":"10.5430/dcc.v8n4p8","DOIUrl":"https://doi.org/10.5430/dcc.v8n4p8","url":null,"abstract":"Objective: This study used published studies to assess the survival rate of dental implants placed in patients with bone dysplasia of the maxillofacial region.Material and methods: An electronic search without a specified date range was performed using the MEDLINE, PubMed, EMBASE, Web of Science, and Cochrane databases. No gender or age restrictions were applied.Results: Eighteen publications were found that met the study’s criteria, reporting data on 18 patients with bone dysplasia including cleidocranial dysplasia (CDD), fibrous dysplasia (FD), florid cemento-osseous dysplasia (FCOD), and odonto-maxillary segmental dysplasia (SOMD), who received a total of 130 implants, an average of 7.2 implants/patient (range 1 to 16). The mean age of the patients was 36.7 years (range 15 to 70 years). For implants placed in bone dysplasia, the survival rates were 100% for patients with CDD (n = 8), FD (n = 5), SOMD (n = 2), FCOD with implants inserted far from the lesions (n = 2) and 0% for dental implants inserted within FCOD (n = 1). The mean follow-up was 38.2 months (min 6, max 60).Conclusions: Dental implants placed in patients with dysplastic bone lesions show high survival rates, similar to those in the general population for CDD, FD, and SOMD. For FCOD, the failure rate was 100%.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"58 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72445567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical vasovasostomy: An option for men with post vasectomy psychological distress","authors":"S. Elzanaty","doi":"10.5430/dcc.v8n4p5","DOIUrl":"https://doi.org/10.5430/dcc.v8n4p5","url":null,"abstract":"Vasectomy is a practical and straightforward approach to birth control. This paper presented a 31-year-old patient who desired to restore his fertility five years after being vasectomized. He met several obstacles. He developed severe psychological distress with symptoms of stress, anxiety, and aggression. He underwent microsurgical vasovasostomy, and vassal patency was confirmed by return of spermatozoa in semen samples 6 and 10 weeks after surgery, and symptoms of psychological distress disappeared. Preoperative vasectomy counseling should include information about vasectomy reversal. At the most, vasectomy reversal can be considered in selected men with psychological problems due to vasectomy. Microsurgical training should be offered to more urological surgeons, especially those who are interested in andrology.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90695878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of materno-fetal antibody transfer in patients with antiphospholipid syndrome","authors":"M. Carneiro-Sampaio, J. Carvalho","doi":"10.5430/dcc.v8n3p22","DOIUrl":"https://doi.org/10.5430/dcc.v8n3p22","url":null,"abstract":"Introduction: Antiphospholipid syndrome (APS) is characterized by thrombotic events and recurrent pregnancy losses and is considered the most common acquired thrombophilia.Objective: To carry out a narrative review of the transplacental passage and antibodies in patients with APS.Methods: A narrative literature review.Results: When it is not associated with any connective tissue disease, it is said to be primary, and when in association with systemic lupus erythematosus, it is said to be secondary. Gestational morbidity is frequent, and it is crucial to evaluate the passage of these antibodies transplacentally since there are animal models of the syndrome with passive transfer of these antibodies. The transplacental passage of specific antibodies has already been determined in studies, which demonstrated low levels of these antibodies in the maternal serum, but an efficient transplacental passage for the newborn.Conclusions: There are few studies on this maternal-infant passage in patients with APS reviewed here.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90048005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the mechanism of microporous sheep ADM combined with hUCMSC in promoting wound healing","authors":"Xiao-yan Yang, C. Hao, Junliang Li, X. Fu, Ling-feng Wang","doi":"10.5430/dcc.v8n3p15","DOIUrl":"https://doi.org/10.5430/dcc.v8n3p15","url":null,"abstract":"Objective: To explore the therapeutic mechanism of microporous sheep acellular dermal matrix (ADM) combined with human umbilical cord mesenchymal stem cell (hUCMSC) to promote the healing of full-thickness skin defect.Methods: hUCMSC was co-cultured on microporous sheep ADM to form composite biological dressings. Seventy-two nude mice were selected to make full-thickness skin injury models and randomly divided into 3 groups (hUCMSC + microporous sheep ADM group, sheep ADM group and iodophor gauze group), with 24 mice in each group. The wound healing rate of each group was detected at 14 d, 21 d and 28 d after operation, qRT-PCR technique was used to detect the expression of Bax and Bcl-2 in the wound tissues, and the immunohistochemical staining technique was used to detect the expression of Collagen I and vascular endothelial growth factor (VEGF). Data were analyzed with one-way ANOVA and t test.Results: At 14 d after operation, the wound healing rate of the hUCMSC + microporous sheep ADM group was (65.34 ± 14.72)%, which was significantly higher than that of the iodophor gauze group [(37.54 ± 10.21)%], and higher than that of the sheep ADM group [(49.08 ± 11.16)%], the differences were statistically significant (t = 19.52, 14.72; p < .05). With the gradual healing of the wound, at 28 d after operation, the wound healing rate of the hUCMSC + microporous sheep ADM group was (98.63 ± 15.41)%, which was significantly higher than that of the iodophor gauze group [(81.74 ± 16.27)%], and higher than that of the sheep ADM group [(63.47 ± 14.80)%], the differences were statistically significant (t = -16.42, 20.35; p < .05). The expression of Bax in the wound tissues of the hUCMSC + microporous sheep ADM group was significantly reduced, especially at 21 d after operation, the expression level was 0.25 ± 0.06, which was significantly lower than the iodophor gauze group (0.53 ± 0.16) and the sheep ADM group (0.41 ± 0.12), the differences were statistically significant (t = 3.52, -2.83; p < .05). The expression of Bcl-2 in the wound tissues of the hUCMSC + microporous sheep ADM group was significantly higher than those ofthe other two groups, especially at 21 d after operation, the expression level was 0.63 ± 0.19, which was significantly higher than the iodophor gauze group (0.34 ± 0.09) and the sheep ADM group (0.46 ± 0.13), the differences were statistically significant (t = 5.31, -6.07; p < .05). Immunohistochemical detection showed that the expression of Collagen I and VEGF in the hUCMSC + microporous sheep ADM group was slightly more than that of the sheep ADM group and the iodophor gauze group, but the effect was not remarkable.Conclusions: hUCMSC + microporous sheep ADM composite dressing can promote the healing of the full-thickness skin injury and reduce the production of apoptotic cells by carrying hUCMSC.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79866411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presarcopenia and chronic cough due to chronic obstructive pulmonary disease successfully treated with nutraceutical supplements and physical exercise","authors":"J. D. de Carvalho, A. Lerner","doi":"10.5430/dcc.v8n4p1","DOIUrl":"https://doi.org/10.5430/dcc.v8n4p1","url":null,"abstract":"Objective: To describe a patient with presarcopenia and chronic cough secondary to chronic obstructive pulmonary disease (COPD) successfully treated with supplements and physical exercise.Case report: A 75-year-old female patient with a positive past medical history of systemic hypertension, dyslipidemia, heart arrhythmia, and smoking during 20 years evolved with chronic cough due to a chronic obstructive pulmonary disease diagnosed ten years ago. She came to our private clinic due to low weight, low energy. Her weight was 44.8 kg, her height 1.57 m, body mass index of 18.18 kg/m2. Laboratory tests showed SDHEA 76.3, vitamin D of 15.6 ng/ml (nr: > 30 ng/ml), C-reactive protein (CRP) of 55 mg/ml. Computed tomography showed bronchiectasis. She had an skeletal muscle mass index of 5.0 kg/m2 (nr: > 5.5 kg/m2) by DXA. A diagnosis of presarcopenia was determined based on DXA evaluation with low muscle mass but normal gait speed handgrip strength. We suggested to the patient to increase physical exercise and prescribed a supplement formula. After five months, she returned asymptomatic, without cough, marked improvement of fatigue, increased energy levels, and weight increased to 50 kg, BMI of 20.28 kg/m2. Laboratory tests showed SDHEA to 140, vitamin D3 to 64.5 ng/ml, reduced CRP reduced to 5 mg/dl, and amlodipine was excluded due to better blood pressure control. Currently, two years later, the patient continues without cough and has dyspnea only with high efforts, without fatigue, and her weight is 52 kg and BMI 21.1 kg/m2. She also reduced her conventional treatment for COPD, using only a bronchodilator on-demand, without topical corticoids.Conclusions: This case illustrates an interesting case of a patient with presarcopenia and chronic cough, refractory to conventional approach, successfully treated with a combination of nutraceuticals and physical exercises.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82649978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}