临床病例讨论杂志(英文版)最新文献

{"title":"Clinical study of different immune induction and BK virus infection after renal transplantation","authors":"Lizhong Han, Haochen Zhong, Zhi-zhong Liu, Yan-ping Feng, G. Sun","doi":"10.5430/dcc.v9n4p12","DOIUrl":"https://doi.org/10.5430/dcc.v9n4p12","url":null,"abstract":"Objective: To monitor the incidence of BK virus infection in hematuria of renal transplant recipients induced by different immunizations.Methods: A total of 109 patients who underwent renal transplantation in Baogang Hospital of Inner Mongolia from January 2019 to December 2022 were analyzed retrospectively. The results of BK virus DNA detection in urine and blood were observed after operation. They were divided into three groups according to different immunosuppressive induction regimens; 35 patients in group A, 42 patients in group B, and 32 patients in group C (basiliximab). To explore the effect of different immune induction regimens on BK virus infection in renal transplant recipients.Results: The positive rate of urine BK virus in all patients in 1 month after operation was 10.09% (11/109), which was significantly higher than that of blood BK virus 0% (0/109), and the difference had a statistical significance (p < .05). The positive rate of urine BK virus in all patients in 6 months after operation was 31.19% (34/109), which was significantly higher than that of blood BK virus 3.67% (4/109), and the difference had a statistical significance (p < .05). The positive rate of urine BK virus in all patients in 12 months after operation was 35.79% (39/109), which was significantly higher than that of blood BK virus 5.50% (6/109), and the difference had a statistical significance (p < .05). The urinary BK virus infection rate was increased significantly from 1 month to 6 months after operation, but was not increased significantly from 6 months to 12 months after operation. There was a statistically significant difference between the two groups (p < .05). The BK virus infection rate in renal transplant recipients induced by basiliximab within the first month was significantly lower than that in patients using polyclonal antibodies, but the urinary BK virus infection rate after one year was not significantly different from that in patients using polyclonal antibodies.Conclusions: There are slight differences in BK virus infection after early renal transplantation with different immune induction therapies, but there is no significant difference in the long-term. It is recommended to strengthen the early monitoring of BK virus after renal transplantation, timely adjust  immunosuppressive regimens to achieve the early detection and early treatment.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"53 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75994999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial effect of povidone iodine disinfectant and antibiotic eye drops before cataract surgery","authors":"Qing-an Zhao","doi":"10.5430/dcc.v9n3p5","DOIUrl":"https://doi.org/10.5430/dcc.v9n3p5","url":null,"abstract":"Objective: Investigate the distribution of bacteria in the conjunctival sac of two groups of cataract patients with different preoperative aseptic treatments, and compare the clinical effects of 0.5% povidone-iodine (PI) and antibiotic eye drops on killing conjunctival sac bacteria.Methods: 400 cases of patients (400 eyes) who underwent cataract surgery in the Department of Ophthalmology of Baogang Hospital in Inner Mongolia from October 2019 to October 2020 were selected in a randomized controlled study. They were randomly divided into the experimental group (group A) and the control group (group B), with 200 cases in each group. Group A: the patients were given Gatifloxacin Eye Gel (3 times/day, 1 drop/time) combined with Diclofenac Sodium Eye Drops (4 times/day, 1 drop/time) before the operation; 0.5% PI was administered to irrigate the conjunctival sac, with 0.9% SodiumChloride Injection washing after 3 min; 0.5% PI was administered to irrigate the conjunctival sac after operation. The corneal epithelium was observed after each irrigation. Group B: the patients were given Gatifloxacin Eye Gel (3 times/day, 1 drop/time) combined with Diclofenac Sodium Eye Drops (4 times/day, 1 drop/time) 2 days and 1 day before the operation; 0.9% Sodium Chloride Injection was administered to irrigate the conjunctival sac before and after surgical disinfection. Conjunctival sac specimens were collected for bacterial culture 2 hours before the operation, after irrigation, and after the procedure. The positive rate and the distribution of bacteria were compared between the two groups.Results: The difference in the positive rate of bacteria in the conjunctival sac between the two groups at different time points had a statistical significance (χ2 = 11.498, p < .022). Conjunctival sac specimens were collected on admission and 2 hours before the operation. There was no significant difference in the pathogens with positive results between the two groups (p = .955; p = .073); there was a substantial difference in the distribution of positive pathogens between the two groups before and after surgical disinfection (p < .001); there was a significant difference in the distribution of pathogens between the two groups after the operation (p = .005). For Staphylococcus epidermidis, Corynebacterium, Enterococcus faecalis, Streptococcus, and other Gram-positive bacteria, there was a significant difference in the disinfection methods between the two groups at different time points (p < .001); for Staphylococcus aureus, Gram-positive cocci, and Gram-negative bacteria, there was no significant difference in the disinfection methods between the two groups at different time points (p = .113; p = .224; p = .146). There was no significant difference between the two groups with 0-10 and 101-1000 bacterial colonies at different time points (p = .370 and .071, respectively). When there were 11-100 bacterial colonies, there was a significant difference between the two groups at differen","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80138945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of traditional Chinese medicine fumigation in the treatment of allergic rhinitis","authors":"Li Wang, Chunmin Li, Bao-sheng Wang","doi":"10.5430/dcc.v9n3p13","DOIUrl":"https://doi.org/10.5430/dcc.v9n3p13","url":null,"abstract":"Objective: To study the clinical effect of traditional Chinese medicine fumigation on treating allergic rhinitis.Methods: 80 cases of patients with allergic rhinitis in our hospital from August 2020 to August 2021 were selected and then randomly divided into two groups. In this research, the combination of montelukast sodium tablets and cetirizine was used in the control group. Traditional Chinese medicine fumigation was given in addition to oral medication in the treatment group.Results: The total effective rate of the clinical treatment in the treatment group was higher than that in the control group, and the difference was statistically significant (p < .05). It took less time to relieve nasal itching, runny nose, nasal congestion, and sneezing in the treatment group than in the control group, and the difference was statistically significant (p < .05). Besides, the symptoms were much more relieved in the treatment group than in the control group, and the difference was statistically significant.Conclusions: Traditional Chinese medicine fumigation shows a remarkable clinical effect on the treatment of allergic rhinitis, and it is worthy of clinical application.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81061653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of plasma homocysteine levels on methylation and expression of thrombomodulin gene in patients with retinal vein occlusion","authors":"Xin Zhao, Jing Yang, Xiangyang Xin","doi":"10.5430/dcc.v9n4p7","DOIUrl":"https://doi.org/10.5430/dcc.v9n4p7","url":null,"abstract":"Objective: To explore the effect of plasma homocysteine (Hcy) levels on methylation and expression of thrombomodulin (TM) gene in patients with retinal vein occlusion (RVO).Methods: 11 cases of patients who were diagnosed as RVO in Department of Ophthalmology in Baogang Hospital from January 2019 to December 2020 were included in this research. 11 cases of healthy people who came to our physical examination center for physical examination during the same period were included into the control group. Fasting cubital venous blood was collected in the morning, plasma Hcy levels were measured by means of enzyme cycle assay, TM gene methylation was detected by methylation-specificity polymerase chain reaction (MSP), and the correlation between characteristic changes in plasma Hcy and TM gene methylation was analyzed in the research subjects.Results: Plasma Hcy expression levels were higher in the RVO group than those in the control group (p < .01). In the control group, the TM primer set region was basically unmethylated, while in the RVO group, the TM primer set region was partially methylated.Conclusions: Plasma Hcy affects the occurrence and development of RVO through methylation of TM encoding gene.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90888352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biventricular isolated apical hypoplasia: First-time description of a new cardiac abnormality by multimodality imaging","authors":"F. Chirillo, M. Fusaro, G. Balestriero, C. Alderighi, U. Cucchini","doi":"10.5430/dcc.v9n4p1","DOIUrl":"https://doi.org/10.5430/dcc.v9n4p1","url":null,"abstract":"Left ventricular isolated hypoplasia is a seldom-described cardiac abnormality. Right ventricular hypoplasia is usually associated with congenital anomalies of the pulmonary or the tricuspid valve, whereas biventricular isolated apical hypoplasia has never been described. We report the case of a 48-year-old man with no history of known cardiac disease who was found to have a complex cardiac abnormality characterized by: 1) Deficiency of the myocardium within the biventricular apex with adipose tissue infiltration; 2) Truncated right ventricle because of an absent trabecular portion of the inflow tract; 3) Truncated and spherical left ventricular apex; 4) Origin of the mitral papillary muscle in the flattened anterior left ventricular apex. Multimodality imaging was performed to delineate the morphological and functional characteristics of this cardiomyopathy fully. To the best of our knowledge, this is the first description of a new cardiac abnormality characterized by the hypoplasia of the apical region of both ventricles in the absence of valvular or coronary artery disease.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83860268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penicillium marneffei infection involving liver","authors":"F. Afridi, F. Fatima","doi":"10.5430/dcc.v9n3p1","DOIUrl":"https://doi.org/10.5430/dcc.v9n3p1","url":null,"abstract":"Penicillium marneffei (P. marneffei) is a pathogenic fungus that can cause fatal infections in humans, particularly immunocompromised hosts. It is prevalent only in the Southeast Asian region. A 5-year-old boy was presented with diagnosed Acute Lymphoblastic Leukemia undergoing chemotherapy and suffering from high-grade fever for 15 days positively responded to antibiotics on the initial day, but later he became unresponsive. He was found negative for blood cultures of bacterial growth. Ultrasound of the abdomen showed a borderline enlarged liver with multiple small hypoechoic areas of variable sizes seen scattered in both lobes of the liver. Morphological and microscopic analyses of liver tissues showed multiple septate hyphae of P. marneffei. Amphotericin B was found to be effective in treating the child. Appropriate identification is essential to treat the pathogen-causing disease, especially in immuno-compromised conditions like a leukemic patient, and determine underlying mechanisms behind the pathogenesis.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75535068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial tuberculosis: A rare case report","authors":"G. Rawal, S. Yadav, S. Rajamma","doi":"10.5430/dcc.v9n2p13","DOIUrl":"https://doi.org/10.5430/dcc.v9n2p13","url":null,"abstract":"Tuberculosis (TB) is one of the most common causes of mortality and morbidity globally, with Indian subcontinent having quite a large number of TB cases. TB can involve any organ system in humans; however, the disease affecting the cardiovascular system is rare. On the other hand, myocardial tuberculosis is a serious entity and can, unfortunately, be fatal if the diagnosis is missed or delayed. Therefore, the possibility of TB involving the myocardium should always be considered in areas with a high prevalence of TB, like the Indian subcontinent. Anti-TB therapy (with corticosteroids in some cases), along with early detection and suspicion, is proven to be quite effective in management and cure in most cases. We describe a case of sputum AFB (acid-fast bacilli) positive pulmonary TB with dilated cardiomyopathy, and impaired/decreased left ventricular systolic function, which gradually improved after anti-tubercular decongestive therapy.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74365553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent kawasaki disease with intussusception: A case report and a review of the literature","authors":"Yan Pan, Qihong Fan","doi":"10.5430/dcc.v9n2p10","DOIUrl":"https://doi.org/10.5430/dcc.v9n2p10","url":null,"abstract":"Objective: Kawasaki disease (KD) is a multisystemic vasculitic disease that occasionally presents with gastrointestinal tract symptoms.Case presentation: A 2-year-old girl diagnosed with KD 4 months prior was referred to our hospital with complaints of vomiting. She was subsequently diagnosed with intussusception, which was efficiently alleviated through air insufflation. However, despite her improved clinical status, she had a fever unresponsive to antibiotic therapy. Four days later, the patient exhibited typical symptoms of Kawasaki disease. Thus, intravenous immunoglobulin and high-dose aspirin were administrated, and the outcome was satisfactory.Conclusions: In young children who present with crying, vomiting, and passage of bloody stools, color ultrasonography should be performed promptly to avoid missed diagnosis and misdiagnosis.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90304605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful surgical extraction of an impacted mandibular third molar in a patient treated with head & neck radiotherapy and chemotherapy for oral cancer","authors":"Alexandre Perez, Vera Rita Ferreira Da Cunha, T. Lombardi","doi":"10.5430/dcc.v9n2p4","DOIUrl":"https://doi.org/10.5430/dcc.v9n2p4","url":null,"abstract":"Osteoradionecrosis (ORN), a pathological condition characterized by a nonvital bone occurring in the site of radiation injury, is one of the significant risks following extraction of highly impacted third molar teeth in patients treated with head & neck radiotherapy for oral cancer. Therefore, the surgery’s meticulous planning is essential to avoid such complications. This case report describes a 63-year-old male patient diagnosed with an impacted lower third molar (tooth #38) with concurrent basal cell carcinoma of the right ear and squamous cell carcinoma of the right vocal cord treated with radiotherapy. Taking into account the patient’s health status, a minimally invasive osteotomy and a corono-radicular separation procedure were performed. This procedure allowed us to reduce the risk of mandibular ORN. Three years later, the healing was complete, and the situation was stable.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75152757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spindle cell tumor of the lung: A rare case","authors":"G. Rawal, S. Yadav, S. Rajamma","doi":"10.5430/dcc.v9n2p1","DOIUrl":"https://doi.org/10.5430/dcc.v9n2p1","url":null,"abstract":"Spindle cell carcinoma of the lung is a rare, aggressive lung malignancy (non-small cell carcinoma) with a poor prognosis. This tumor accounts for approximately 0.4% of all lung malignancies, and due to its rarity, standard therapy is yet to be established for its management and treatment. The prevalence of this tumor is more common in males as compared to females (ratio of 4:1) and usually occurs in the sixth/seventh decade of life, more so in smokers. The authors report a case of a 79-year-old male patient who was incidentally detected and diagnosed with this rare lung carcinoma proven with a lung biopsy.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88989461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}