临床病例讨论杂志(英文版)最新文献

{"title":"Association between polymorphism of optic disc related genes and susceptibility to primary open angle glaucoma in Inner Mongolia","authors":"X. Xin, Peng Chen, Chenlu Liu","doi":"10.14725/DCC.V5N4P30","DOIUrl":"https://doi.org/10.14725/DCC.V5N4P30","url":null,"abstract":"Objective: To explore the relationship between the polymorphism of optic disc related genes and the susceptibility to primary open angle glaucoma (POAG) in Inner Mongolia. Methods: A retrospective study was adopted to include 108 patients who were diagnosed as POAG in six hospitals in Hohhot and Baotou from January of 2014 to December of 2016 (POAG group). At the same time, 120 healthy examinees were included in the control group. 1-2 ml of whole blood was collected by use of EDTA anticoagulation tubes from each patient in these two groups. It was required to fully mix EDTA with whole blood in order to extract genomic DNA and place it in the -20°C refrigerator. Mass spectrometry was used to identify the genotype of single nucleotide polymorphism (SNP) of RFTN1 (rs690037), ATOH7 (rs7916697, rs3858145), CDC7 (rs1192415), CDKN2B (rs1063192) and SIX (rs10483727) in 108 POAG patients and 120 normal controls. χ 2  test and binary logistic regression were used to analyze the relationship between the genetic polymorphism and the occurrence of POAG. Results: The frequency of G allele at CDKN2B (rs1063192) in POAG group was significantly higher than that in the control group (27% vs. 17%), and the difference was of statistical significance [odds ratio (OR) = 1.824, 95% confidence interval (CI): 1.163-2.861, p = .008]; As to the comparison in the frequency of allele at the other 7 SNPs between the two groups, the differences were statistically significant (all p > .05). Additive and dominant models at rs1063192 indicated that the individuals with G allele were more susceptible to POAG, and the difference was of statistical significance ( p .05). There was no statistically significant difference in the distribution of genotypes at other SNPs between POAG group and the control group ( p > .05). Conclusions: The genetic polymorphism of CDKN2B (rs1063192) is associated with the susceptibility to POAG, and G allele may increase the risk for POAG.","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88796340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy","authors":"X. Zou, Zhelin Yun, Sheng-bin Zhang, Jin Zhao, Bing Li","doi":"10.14725/DCC.V5N3P13","DOIUrl":"https://doi.org/10.14725/DCC.V5N3P13","url":null,"abstract":"Objective \u0000To analyze the Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy and investigate the relationship between the major risk factors and Clavien-Dindo classification of complications. \u0000 \u0000 \u0000Methods \u0000The retrospective case-control study was adopted. The clinical data of 200 patients who underwent pancreaticoduodenectomy at the Third Affiliated Hospital of Inner Mongolia Medical University from January 2010 to June 2015 were collected. The patients underwent Whipple surgery or pyloros-preserving pancreaticoduodenectomy according to the tumor location. Observation indicators included: (1) postoperative complications using Clavien-Dindo classification, (2) univariate and multivariate analyses: the basic conditions of patients, surgery-related factors, pancreas-related factors, (3) relationship between independent risk factors and Clavien-Dindo classification of complications after pancreaticoduodenectomy. The univariate analysis and count data were done using the chi-square test. The comparison between groups was done using independent samples nonparametric test (Kolmogorov-Smirnov Z) and multivariate analysis was done using the Logistic regression model. \u0000 \u0000 \u0000Results \u0000(1) Postoperative complication situations: of 200 patients, 122 underwent Whipple surgery and 78 underwent pylorus-preserving pancreatico-duodenectomy, including 6 combined with vascular reconstruction and 1 with radiofrequency ablation of liver tumors. Ninety-eight patients had postoperative complications, including 41 patients with 2 or above kinds of complications. Pancreatic fistula was detected in 80 patients, including 42 with grade A, 28 with grade B and 10 with grade C, wound infection in 29 patients, delayed gastric emptying in 24 patients, postoperative intra-abdominal infection in 16 patients, postoperative intra-abdominal hemorrhage in 10 patients including 8 receiving interventional treatment, postoperative biliary leakage in 7 patients and unintended reoperation in 2 patients. Three patients were dead during hospitalization. The incidence of complications in gradeⅠ, Ⅱ, Ⅲ (Ⅲa and Ⅲb), Ⅳ and V of Clavien-Dindo classification was 28.00%(56/200), 13.00%(26/200), 5.00%(10/200), 1.50%(3/200) and 1.50%(3/200). (2) The univariate and multivariate analyses: the results of univariate analysis showed that body mass index (BMI) and texture of the pancreas were risk factors affecting complications after pancreatico-duodenectomy (χ2=6.483, Z=-3.189, P 23.9 kg/m2 and soft pancreas were independent risk factors affecting complications after pancreaticoduodenectomy (OR=2.044, 1.649, 95% confidence interval: 1.212-3.447, 1.194-2.275). (3) The relationship between independent risk factors and Clavien-Dindo classification of complications after pancreaticoduodenectomy was analyzed, there were statistically significant differences between BMI or texture of the pancreas and Clavien-Dindo classification of complications after pancreaticoduodenect","PeriodicalId":63789,"journal":{"name":"临床病例讨论杂志(英文版)","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76519080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}