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Multifunctional polysilsesquioxane nanoparticle-based platform for the treatment of triple-negative breast cancer in vitro and in vivo using chemo and photodynamic therapy (Conference Presentation) 基于多功能聚硅氧烷纳米颗粒的三阴性乳腺癌体外和光动力化疗治疗平台(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525973
Juan L. Vivero-Escoto, Zachary Lyles
{"title":"Multifunctional polysilsesquioxane nanoparticle-based platform for the treatment of triple-negative breast cancer in vitro and in vivo using chemo and photodynamic therapy (Conference Presentation)","authors":"Juan L. Vivero-Escoto, Zachary Lyles","doi":"10.1117/12.2525973","DOIUrl":"https://doi.org/10.1117/12.2525973","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74171094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation) 靶向pdp联合治疗癌症:亚细胞位点和细胞毒性机制(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525889
I. Rizvi, G. Obaid, S. Nath, M. K. Ruhi, Kaitlin Moore, S. Bano, D. Kessel, T. Hasan
{"title":"Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation)","authors":"I. Rizvi, G. Obaid, S. Nath, M. K. Ruhi, Kaitlin Moore, S. Bano, D. Kessel, T. Hasan","doi":"10.1117/12.2525889","DOIUrl":"https://doi.org/10.1117/12.2525889","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79021116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy as an alternative treatment modality for early stage buccal mucosa malignancy (Conference Presentation) 光动力疗法作为早期口腔黏膜恶性肿瘤的替代治疗方式(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525686
S. Siddiqui, M. Hussain, Amjad P. Khan, K. Akhtar, S. Siddiqui, Shakir Khan, Hui Liu, S. Mallidi, Grant Rudd, L. Daly, Paola L. Alacron, Filip Cuckov, S. C. Sharma, I. Ahmed, S. Bown, C. Hopper, J. Celli, S. Hasan, T. Hasan
{"title":"Photodynamic therapy as an alternative treatment modality for early stage buccal mucosa malignancy (Conference Presentation)","authors":"S. Siddiqui, M. Hussain, Amjad P. Khan, K. Akhtar, S. Siddiqui, Shakir Khan, Hui Liu, S. Mallidi, Grant Rudd, L. Daly, Paola L. Alacron, Filip Cuckov, S. C. Sharma, I. Ahmed, S. Bown, C. Hopper, J. Celli, S. Hasan, T. Hasan","doi":"10.1117/12.2525686","DOIUrl":"https://doi.org/10.1117/12.2525686","url":null,"abstract":"Oral cancers are the 8th most common cancer among males. In India, this corresponds to almost 80,000 new cases per year. With such a disease burden, oral cancers are a prime cause of morbidity and functional disability.\u0000\u0000Conventional treatment for oral cancers is surgery and radiation therapy which are fraught with physical and functional side effects, and the high cost and infrastructure requirements present barriers to timely intervention for patients in rural and/or resource-limited areas. Motivated by these considerations we sought to evaluate photodynamic therapy (PDT) as an approach which is inherently conducive to adaptation for resource-limited settings and has previously shown promising clinical results for early stage oral lesions. In this study we evaluate a low-cost platform for aminolevulinic acid (ALA)-based PDT consisting of a portable 635nm fiber-coupled LED light source integrated with 3D printed applicators for stable intraoral light delivery and smartphone-based fluorescence imaging for treatment guidance.\u0000\u0000Using this technology, we treated 18 subjects with histologically confirmed T1N0M0 lesions of the buccal mucosa with a mean diameter of 1.38 cm2 and micro-invasive (≤ 5mm depth) disease. A total light dose of 100 J/cm2 was delivered in 3 to 5 fractions to the buccal mucosa after oral administration of 60mg/kg ALA (in 3 aliquots of 20mg/kg). The post-PDT investigations showed a 72% success rate (no residual malignancy in follow-up biopsy). \u0000\u0000The treatment was very well tolerated and has potential for broader dissemination into primary care sites and as an early intervention for pre-malignant conditions including submucous fibrosis and leucoplakia.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90671722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy (PDT) based on chlorin e6 in the palliative treatment of head neck malignancies (Conference Presentation) 基于氯e6的光动力疗法(PDT)在头颈部恶性肿瘤姑息性治疗中的应用(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528031
T. Giesen, S. Baumann, J. Buentzel
{"title":"Photodynamic therapy (PDT) based on chlorin e6 in the palliative treatment of head neck malignancies (Conference Presentation)","authors":"T. Giesen, S. Baumann, J. Buentzel","doi":"10.1117/12.2528031","DOIUrl":"https://doi.org/10.1117/12.2528031","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73133977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining immunooncology agents and PDT in thoracic oncology: once more back to the bench, dear friends (Conference Presentation) 联合免疫肿瘤药物和PDT治疗胸部肿瘤:亲爱的朋友们，再一次回到长凳上(会议发言)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528220
K. Cengel
{"title":"Combining immunooncology agents and PDT in thoracic oncology: once more back to the bench, dear friends (Conference Presentation)","authors":"K. Cengel","doi":"10.1117/12.2528220","DOIUrl":"https://doi.org/10.1117/12.2528220","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72572744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic priming and VDR activation modulate tumor-stroma interactions and permeability for durable control and enhanced treatment tolerability (Conference Presentation) 光动力启动和VDR激活调节肿瘤-基质相互作用和渗透性，以实现持久控制和增强治疗耐受性(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526104
M. Pigula, Sriram Anbil, Huang‐Chiao Huang, Yan Baglo, M. Broekgaarden, D. Simeone, G. Dotto, T. Hasan
{"title":"Photodynamic priming and VDR activation modulate tumor-stroma interactions and permeability for durable control and enhanced treatment tolerability (Conference Presentation)","authors":"M. Pigula, Sriram Anbil, Huang‐Chiao Huang, Yan Baglo, M. Broekgaarden, D. Simeone, G. Dotto, T. Hasan","doi":"10.1117/12.2526104","DOIUrl":"https://doi.org/10.1117/12.2526104","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73768922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor targeting vitamin B12 derivatives for x-ray activated chemotherapy (Conference Presentation) 肿瘤靶向维生素B12衍生物用于x射线激活化疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528263
Jennifer R. Shell, Thomas A. Shell, B. Pogue, Liberty N. Gendron, Colter G. Sheveland
{"title":"Tumor targeting vitamin B12 derivatives for x-ray activated chemotherapy (Conference Presentation)","authors":"Jennifer R. Shell, Thomas A. Shell, B. Pogue, Liberty N. Gendron, Colter G. Sheveland","doi":"10.1117/12.2528263","DOIUrl":"https://doi.org/10.1117/12.2528263","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74852213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the clinical application of photodynamic action for pharyngotonsillitis treatment (Conference Presentation) 光动力作用治疗咽扁桃体炎的临床应用进展(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525934
K. Blanco, Jennifer M. Soares, N. Inada, V. Bagnato
{"title":"Advances in the clinical application of photodynamic action for pharyngotonsillitis treatment (Conference Presentation)","authors":"K. Blanco, Jennifer M. Soares, N. Inada, V. Bagnato","doi":"10.1117/12.2525934","DOIUrl":"https://doi.org/10.1117/12.2525934","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73962772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of photomedicine and anti-microRNA combination therapies in 3D cell culture models of pancreatic ductal adenocarcinoma (Conference Presentation) 光电医学与抗microrna联合治疗在胰腺导管腺癌三维细胞培养模型中的应用(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526199
L. Petrovic, T. Materdey, Eric Struth, Maud-Emmanuelle Gilles, Meirav Segal, F. Slack, J. Celli
{"title":"Evaluation of photomedicine and anti-microRNA combination therapies in 3D cell culture models of pancreatic ductal adenocarcinoma (Conference Presentation)","authors":"L. Petrovic, T. Materdey, Eric Struth, Maud-Emmanuelle Gilles, Meirav Segal, F. Slack, J. Celli","doi":"10.1117/12.2526199","DOIUrl":"https://doi.org/10.1117/12.2526199","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74069649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers (Conference Presentation) 光动力疗法作为抗生素治疗感染性腿部溃疡的替代疗法(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525525
A. Kawczyk-Krupka, Anna Król-Zybura, A. Sieroń, G. Cieślar
{"title":"Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers (Conference Presentation)","authors":"A. Kawczyk-Krupka, Anna Król-Zybura, A. Sieroń, G. Cieślar","doi":"10.1117/12.2525525","DOIUrl":"https://doi.org/10.1117/12.2525525","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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