17th International Photodynamic Association World Congress最新文献_第10页

Analysis of cell death and immune response in metronomic versus conventional photodynamic therapy of actinic keratosis in a murine model (Conference Presentation) 节律与常规光动力治疗光化性角化病小鼠模型的细胞死亡和免疫反应分析(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525567

S. Anand, Anton Yasinchak, Mukul Govande, S. Shakya, E. Maytin

引用次数: 0

Red-light-responsive Ru-containing polymers for deep-tissue biomedical applications (Conference Presentation) 用于深层生物医学应用的红光响应性含ru聚合物(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525181

Si-Tong Wu

引用次数: 0

Single-agent liposomal chemophototherapy for rat mammary tumors (Conference Presentation) 单药脂质体光化学治疗大鼠乳腺肿瘤(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526214

J. Lovell

引用次数: 0

Management of multiple primary lung cancer in patients with centrally located early lung cancer lesions (Conference Presentation) 多发原发肺癌合并中心位置早期肺癌病变的处理(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527439

Takumi Sonokawa, Takuma Matsui, K. Takegahara, Tatsuya Inoue, J. Usuda

引用次数: 0

ROS explicit dosimetry for photodynamic therapy (Conference Presentation) 光动力疗法的ROS显式剂量测定(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525996

T. Zhu

引用次数: 0

Photodynamic therapy of brain tumor stem cells overcomes drug-resistance in preclinical models (Conference Presentation) 光动力治疗脑肿瘤干细胞克服临床前模型耐药(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527769

Bryan Q. Spring

引用次数: 1

Dual function antibody conjugates (DFACs) for drug quantification and therapy (Conference Presentation) 用于药物定量和治疗的双功能抗体偶联物(DFACs)(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528162

M. A. Saad, Marvin Xavierselvan, H. A. Sharif, S. Mallidi, T. Hasan

{"title":"Dual function antibody conjugates (DFACs) for drug quantification and therapy (Conference Presentation)","authors":"M. A. Saad, Marvin Xavierselvan, H. A. Sharif, S. Mallidi, T. Hasan","doi":"10.1117/12.2528162","DOIUrl":"https://doi.org/10.1117/12.2528162","url":null,"abstract":"Imaging technologies such as Ultrasound, OCT, MRI and CT are useful for diagnostics and tomographic assessment of therapy response. Fluorescence imaging with its high sensitivity is a promising approach and is extensively used for lesion localization, surgical guidance and monitoring response to therapies. While conjugating fluorophores to antibodies improves specificity, further conjugation of drugs provides a dual function, where fluorescence monitoring may simultaneously reveal drug pharmacokinetics. Fluorescence imaging, however, is limited by low penetration of light, which can be partially overcome by photoacoustic imaging (PAI). In this study, by conjugating a fluorophore and photoacoustic molecule to an antibody (Dual Function Antibody Conjugate (DFAC)), we evaluate whether PAI can significantly improve deep-tissue imaging. \u0000To provide a systematic comparison of these imaging modalities we developed a DFAC, comprising of Cetuximab (anti-EGFR antibody) conjugated with a fluorophore (AF647) and a photoacoustic dye (IRDye800) in a 1:2:2 ratio. We hypothesize that, conjugating quantifiable probes to an antibody, would provide information about different depths within the confines of optical approaches. Such quantification is particularly important in photodynamic therapy, for determination of tissue concentration of photosensitizers and in chemotherapy for quantification of drug concentrations non-invasively. The relationship between the photoacoustic and fluorescence signals from the DFAC is demonstrated through spectroscopic techniques and their EGFR specificity along with deep tissue photoacoustic quantification is established using EGFR positive/negative cell lines and tissue mimicking phantoms.\u0000The DFAC, presented in this study, demonstrates a combination of two complimentary imaging modalities for non-invasive determination of pharmacokinetics and in vivo drug quantification.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91408991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oncological PDT in Latin America (Conference Presentation) 拉丁美洲肿瘤PDT(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528015

C. Kurachi, V. Bagnato

引用次数: 0

Developing world applications of PDT in head and neck cancer (Conference Presentation) 发展中国家PDT在头颈癌中的应用(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526613

C. Hopper, B. Tan, T. Hasan, C. Kurachi, V. Bagnato, Eduardo Milanesi, S. Siddiqui

引用次数: 1

Molecular imaging of gastrointestinal tumors (Conference Presentation) 胃肠道肿瘤的分子影像学(会议报告)

17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525894

J. Park

引用次数: 0