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17th International Photodynamic Association World Congress最新文献

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Vandetanib sensitises oral squamous cell carcinoma to photodynamic therapy through NHEJ impairment and modulation of tumour microenvironment (Conference Presentation) Vandetanib通过NHEJ损伤和肿瘤微环境调节使口腔鳞状细胞癌对光动力治疗敏感(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527990
P. Chu, W. A. Shihabudeen, K. Low, D. Poon, B. Ramaswamy, Zhongguo Liang, W. Nei, K. Chua, P. Thong, K. Soo, E. Yeo, M. Chua
{"title":"Vandetanib sensitises oral squamous cell carcinoma to photodynamic therapy through NHEJ impairment and modulation of tumour microenvironment (Conference Presentation)","authors":"P. Chu, W. A. Shihabudeen, K. Low, D. Poon, B. Ramaswamy, Zhongguo Liang, W. Nei, K. Chua, P. Thong, K. Soo, E. Yeo, M. Chua","doi":"10.1117/12.2527990","DOIUrl":"https://doi.org/10.1117/12.2527990","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76005616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combinatorial approaches with vascular photodynamic therapy with redaporfin and immune checkpoint blockers (Conference Presentation) 血管光动力疗法联合瑞泊芬和免疫检查点阻滞剂(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526034
Ana Catarina Sousa Lobo, L. C. Gomes‐da‐Silva, L. Arnaut
{"title":"Combinatorial approaches with vascular photodynamic therapy with redaporfin and immune checkpoint blockers (Conference Presentation)","authors":"Ana Catarina Sousa Lobo, L. C. Gomes‐da‐Silva, L. Arnaut","doi":"10.1117/12.2526034","DOIUrl":"https://doi.org/10.1117/12.2526034","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87594181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel photodynamic therapy technique for peripheral lung tumor (Conference Presentation) 一种新的光动力治疗外周性肺肿瘤的技术(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525629
Y. Hsieh, Hwailuh Chang, K. Liao
{"title":"A novel photodynamic therapy technique for peripheral lung tumor (Conference Presentation)","authors":"Y. Hsieh, Hwailuh Chang, K. Liao","doi":"10.1117/12.2525629","DOIUrl":"https://doi.org/10.1117/12.2525629","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76682397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microenvironmental cues in 3D cancer models to inform targeted PDT combinations (Conference Presentation) 三维癌症模型中的微环境线索为靶向PDT组合提供信息(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526078
S. Nath, Huang‐Chiao Huang, M. Pigula, Christina Conrad, Amjad P. Khan, William Hanna, Sepideh Afsar, W. Franco, G. Scarcelli, U. Demirci, T. Hasan, I. Rizvi
{"title":"Microenvironmental cues in 3D cancer models to inform targeted PDT combinations (Conference Presentation)","authors":"S. Nath, Huang‐Chiao Huang, M. Pigula, Christina Conrad, Amjad P. Khan, William Hanna, Sepideh Afsar, W. Franco, G. Scarcelli, U. Demirci, T. Hasan, I. Rizvi","doi":"10.1117/12.2526078","DOIUrl":"https://doi.org/10.1117/12.2526078","url":null,"abstract":"A range of cellular, architectural, and physical cues in the tumor microenvironment influence the intrinsic and acquired resistance mechanisms that lead to treatment failure. Strategies that leverage photodynamic therapy (PDT), a photochemistry-based biophysical treatment modality, to regionally target and prime stubborn tumor populations may be essential to realizing durable improvements in cancer management while minimizing toxicity from traditional agents. Capturing these attributes in rationally-designed combinations has shown promise by synergistically reducing tumor area in 3D models, and durably controlling tumor burden in vivo. Among the areas that remain understudied is the influence of mechanical forces, such as hydrodynamic shear stress, on resistance, and the development of 3D tumor models and in vivo models that account for physical stress. To evaluate and optimize PDT regimens, and PDT-based combinations, designed to overcome resistance to conventional therapies due to physical stress, a multi-faceted approach is needed. Here the impact of hydrodynamic stress is evaluated in bioengineered 3D tumor models in the context of ovarian cancer. The potential value of using biologically inspired in vitro models to guide customized, rationally-designed PDT-based combination regimens will be presented.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84068716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoactivated chemotherapy in hypoxic cancer cells (Conference Presentation) 缺氧癌细胞的光活化化疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528324
S. Bonnet
{"title":"Photoactivated chemotherapy in hypoxic cancer cells (Conference Presentation)","authors":"S. Bonnet","doi":"10.1117/12.2528324","DOIUrl":"https://doi.org/10.1117/12.2528324","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86344027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a personalized aminolevulinic acid (ALA)-based therapy (Conference Presentation) 以个性化氨基乙酰丙酸(ALA)为基础的治疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526183
Bin Chen
{"title":"Towards a personalized aminolevulinic acid (ALA)-based therapy (Conference Presentation)","authors":"Bin Chen","doi":"10.1117/12.2526183","DOIUrl":"https://doi.org/10.1117/12.2526183","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87404544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Epidermal growth factor receptor: targeted photoimmunotherapy is fluence rate dependent in-vivo (Conference Presentation) 表皮生长因子受体:靶向光免疫治疗是体内影响率依赖(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525595
H. S. Bruijn, Wei Peng, T. Hagen, G. M. Dam, J. Roodenburg, M. Witjes, D. Robinson
{"title":"Epidermal growth factor receptor: targeted photoimmunotherapy is fluence rate dependent in-vivo (Conference Presentation)","authors":"H. S. Bruijn, Wei Peng, T. Hagen, G. M. Dam, J. Roodenburg, M. Witjes, D. Robinson","doi":"10.1117/12.2525595","DOIUrl":"https://doi.org/10.1117/12.2525595","url":null,"abstract":"Photodynamic therapy (PDT) has been used clinically for the treatment of head and neck cancer. The effectiveness of PDT is often strongly dependent on fluence rate. Targeted photo-immunotherapy (PIT) may reduce the adverse effects of non-targeted PDT. The in-vivo distribution of the anti-EGFR targeted conjugate Cetuximab-IRDye700DX was investigated. Vascular and tumor responses were determined with respect to fluence rate. \u0000Intra-vital confocal microscopy of skin-fold chambers with the EGFR-overexpressing OSC-19 tumor showed peak tumor fluorescence 24 hrs after administration. Tumor to normal ratio was 3.1±1.6 (n=8). Tumor vascular responses were determined by imaging rhodamine-dextran extravasation. Two hrs after illumination (24 hr DLI, 100 J.cm-2 at 50 mW.cm-2) showed no leakage in 3 of 4 animals and stasis in 1. Normal vasculature showed mild to severe constriction of larger vessels up to 48 hrs after illumination. Subcutaneous OSC-19 tumors were transdermally illuminated with 100 J.cm-2 at 20, 50 and 150 mW.cm-2. Control tumors took 5.3±1.1 days to grow to 200%. All animals treated with 20 mW.cm-2 showed no tumor up to 90 days post treatment (n=4) compared to 1 of 4 in the 50 and 150 mW.cm-2 groups. The remaining tumors reached 200% after 17.9±5.2 and 19.5±7.4 days. Crust formation of the overlying skin was observed at low fluence rate.\u0000Cetuximab-IRDye700DX showed significant tumor to normal ratio. Normal tissue responses like vascular effects and crust formation of the skin was observed and may be caused by conjugate still present in the circulation. The effect of targeted-PIT is strongly dependent on fluence rate.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80468316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutants of E. coli, which lack antioxidant enzymes, are more susceptible towards type-1 mechanism of action of photoantimicrobials compared to type-2 photoantimicrobials (Conference Presentation) 缺乏抗氧化酶的大肠杆菌突变体比2型光抗菌剂更容易受到1型光抗菌剂作用机制的影响(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525799
T. Maisch, Pouriya Faraj Tabrizi, S. Wennige
{"title":"Mutants of E. coli, which lack antioxidant enzymes, are more susceptible towards type-1 mechanism of action of photoantimicrobials compared to type-2 photoantimicrobials (Conference Presentation)","authors":"T. Maisch, Pouriya Faraj Tabrizi, S. Wennige","doi":"10.1117/12.2525799","DOIUrl":"https://doi.org/10.1117/12.2525799","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72674140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red-light-responsive Ru-containing polymers for deep-tissue biomedical applications (Conference Presentation) 用于深层生物医学应用的红光响应性含ru聚合物(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525181
Si-Tong Wu
{"title":"Red-light-responsive Ru-containing polymers for deep-tissue biomedical applications (Conference Presentation)","authors":"Si-Tong Wu","doi":"10.1117/12.2525181","DOIUrl":"https://doi.org/10.1117/12.2525181","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74178738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular imaging of gastrointestinal tumors (Conference Presentation) 胃肠道肿瘤的分子影像学(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525894
J. Park
{"title":"Molecular imaging of gastrointestinal tumors (Conference Presentation)","authors":"J. Park","doi":"10.1117/12.2525894","DOIUrl":"https://doi.org/10.1117/12.2525894","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74944316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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