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Microenvironmental cues in 3D cancer models to inform targeted PDT combinations (Conference Presentation) 三维癌症模型中的微环境线索为靶向PDT组合提供信息(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526078
S. Nath, Huang‐Chiao Huang, M. Pigula, Christina Conrad, Amjad P. Khan, William Hanna, Sepideh Afsar, W. Franco, G. Scarcelli, U. Demirci, T. Hasan, I. Rizvi
{"title":"Microenvironmental cues in 3D cancer models to inform targeted PDT combinations (Conference Presentation)","authors":"S. Nath, Huang‐Chiao Huang, M. Pigula, Christina Conrad, Amjad P. Khan, William Hanna, Sepideh Afsar, W. Franco, G. Scarcelli, U. Demirci, T. Hasan, I. Rizvi","doi":"10.1117/12.2526078","DOIUrl":"https://doi.org/10.1117/12.2526078","url":null,"abstract":"A range of cellular, architectural, and physical cues in the tumor microenvironment influence the intrinsic and acquired resistance mechanisms that lead to treatment failure. Strategies that leverage photodynamic therapy (PDT), a photochemistry-based biophysical treatment modality, to regionally target and prime stubborn tumor populations may be essential to realizing durable improvements in cancer management while minimizing toxicity from traditional agents. Capturing these attributes in rationally-designed combinations has shown promise by synergistically reducing tumor area in 3D models, and durably controlling tumor burden in vivo. Among the areas that remain understudied is the influence of mechanical forces, such as hydrodynamic shear stress, on resistance, and the development of 3D tumor models and in vivo models that account for physical stress. To evaluate and optimize PDT regimens, and PDT-based combinations, designed to overcome resistance to conventional therapies due to physical stress, a multi-faceted approach is needed. Here the impact of hydrodynamic stress is evaluated in bioengineered 3D tumor models in the context of ovarian cancer. The potential value of using biologically inspired in vitro models to guide customized, rationally-designed PDT-based combination regimens will be presented.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84068716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combinatorial approaches with vascular photodynamic therapy with redaporfin and immune checkpoint blockers (Conference Presentation) 血管光动力疗法联合瑞泊芬和免疫检查点阻滞剂(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526034
Ana Catarina Sousa Lobo, L. C. Gomes‐da‐Silva, L. Arnaut
{"title":"Combinatorial approaches with vascular photodynamic therapy with redaporfin and immune checkpoint blockers (Conference Presentation)","authors":"Ana Catarina Sousa Lobo, L. C. Gomes‐da‐Silva, L. Arnaut","doi":"10.1117/12.2526034","DOIUrl":"https://doi.org/10.1117/12.2526034","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87594181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoactivated chemotherapy in hypoxic cancer cells (Conference Presentation) 缺氧癌细胞的光活化化疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528324
S. Bonnet
{"title":"Photoactivated chemotherapy in hypoxic cancer cells (Conference Presentation)","authors":"S. Bonnet","doi":"10.1117/12.2528324","DOIUrl":"https://doi.org/10.1117/12.2528324","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86344027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel photodynamic therapy technique for peripheral lung tumor (Conference Presentation) 一种新的光动力治疗外周性肺肿瘤的技术(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525629
Y. Hsieh, Hwailuh Chang, K. Liao
{"title":"A novel photodynamic therapy technique for peripheral lung tumor (Conference Presentation)","authors":"Y. Hsieh, Hwailuh Chang, K. Liao","doi":"10.1117/12.2525629","DOIUrl":"https://doi.org/10.1117/12.2525629","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76682397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vandetanib sensitises oral squamous cell carcinoma to photodynamic therapy through NHEJ impairment and modulation of tumour microenvironment (Conference Presentation) Vandetanib通过NHEJ损伤和肿瘤微环境调节使口腔鳞状细胞癌对光动力治疗敏感(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527990
P. Chu, W. A. Shihabudeen, K. Low, D. Poon, B. Ramaswamy, Zhongguo Liang, W. Nei, K. Chua, P. Thong, K. Soo, E. Yeo, M. Chua
{"title":"Vandetanib sensitises oral squamous cell carcinoma to photodynamic therapy through NHEJ impairment and modulation of tumour microenvironment (Conference Presentation)","authors":"P. Chu, W. A. Shihabudeen, K. Low, D. Poon, B. Ramaswamy, Zhongguo Liang, W. Nei, K. Chua, P. Thong, K. Soo, E. Yeo, M. Chua","doi":"10.1117/12.2527990","DOIUrl":"https://doi.org/10.1117/12.2527990","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76005616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutants of E. coli, which lack antioxidant enzymes, are more susceptible towards type-1 mechanism of action of photoantimicrobials compared to type-2 photoantimicrobials (Conference Presentation) 缺乏抗氧化酶的大肠杆菌突变体比2型光抗菌剂更容易受到1型光抗菌剂作用机制的影响(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525799
T. Maisch, Pouriya Faraj Tabrizi, S. Wennige
{"title":"Mutants of E. coli, which lack antioxidant enzymes, are more susceptible towards type-1 mechanism of action of photoantimicrobials compared to type-2 photoantimicrobials (Conference Presentation)","authors":"T. Maisch, Pouriya Faraj Tabrizi, S. Wennige","doi":"10.1117/12.2525799","DOIUrl":"https://doi.org/10.1117/12.2525799","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72674140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tom Dougherty, PDT, and myself (Conference Presentation) Tom Dougherty, PDT和我自己(会议演讲)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525474
Kevin M. Smith
{"title":"Tom Dougherty, PDT, and myself (Conference Presentation)","authors":"Kevin M. Smith","doi":"10.1117/12.2525474","DOIUrl":"https://doi.org/10.1117/12.2525474","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75015065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a personalized aminolevulinic acid (ALA)-based therapy (Conference Presentation) 以个性化氨基乙酰丙酸(ALA)为基础的治疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526183
Bin Chen
{"title":"Towards a personalized aminolevulinic acid (ALA)-based therapy (Conference Presentation)","authors":"Bin Chen","doi":"10.1117/12.2526183","DOIUrl":"https://doi.org/10.1117/12.2526183","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87404544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Initial clinical studies with PCI (Conference Presentation) PCI的初步临床研究(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527886
C. Hopper
{"title":"Initial clinical studies with PCI (Conference Presentation)","authors":"C. Hopper","doi":"10.1117/12.2527886","DOIUrl":"https://doi.org/10.1117/12.2527886","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76500967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular targeted photodynamic therapy with Tookad: from local ablation to systemic cancer treatment (Conference Presentation) Tookad血管靶向光动力治疗:从局部消融到全身癌症治疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527629
A. Scherz, L. Agemy, D. Preise, Rachel Elmoalem-Hamri, J. Coleman
{"title":"Vascular targeted photodynamic therapy with Tookad: from local ablation to systemic cancer treatment (Conference Presentation)","authors":"A. Scherz, L. Agemy, D. Preise, Rachel Elmoalem-Hamri, J. Coleman","doi":"10.1117/12.2527629","DOIUrl":"https://doi.org/10.1117/12.2527629","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79075815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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