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Antimicrobial photodynamic therapy mediated by chlorin e-6 photosensitizer against Streptococcus mutans biofilm (Conference Presentation) 氯e-6光敏剂对变形链球菌生物膜的抗菌光动力治疗(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528235
A. Rastelli, A. C. Bernardi, C. Rodero, M. Chorilli, Kleber T. de Oliveira, D. Deng, V. Bagnato
{"title":"Antimicrobial photodynamic therapy mediated by chlorin e-6 photosensitizer against Streptococcus mutans biofilm (Conference Presentation)","authors":"A. Rastelli, A. C. Bernardi, C. Rodero, M. Chorilli, Kleber T. de Oliveira, D. Deng, V. Bagnato","doi":"10.1117/12.2528235","DOIUrl":"https://doi.org/10.1117/12.2528235","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82171365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive oxygen species goes beyond photodynamic therapy (Conference Presentation) 活性氧超越光动力疗法(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525919
Xiaoyuan Chen
{"title":"Reactive oxygen species goes beyond photodynamic therapy (Conference Presentation)","authors":"Xiaoyuan Chen","doi":"10.1117/12.2525919","DOIUrl":"https://doi.org/10.1117/12.2525919","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80742793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the first steps towards immune-modulation triggered by nanobody-targeted photodynamic therapy (Conference Presentation) 了解纳米体靶向光动力疗法引发免疫调节的第一步(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526108
Irati Beltrán Hernández, Tommaso Del Buono D’Ondes, Alessia Di Maggio, S. Oliveira
{"title":"Understanding the first steps towards immune-modulation triggered by nanobody-targeted photodynamic therapy (Conference Presentation)","authors":"Irati Beltrán Hernández, Tommaso Del Buono D’Ondes, Alessia Di Maggio, S. Oliveira","doi":"10.1117/12.2526108","DOIUrl":"https://doi.org/10.1117/12.2526108","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81105983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using x-ray in photodynamic therapy (Conference Presentation) x射线在光动力治疗中的应用(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525588
C. Frochot, P. Arnoux, S. Acherar, F. Baros, F. Lux, M. Verelst, O. Tillement, M. Barberi-Heyob
{"title":"Using x-ray in photodynamic therapy (Conference Presentation)","authors":"C. Frochot, P. Arnoux, S. Acherar, F. Baros, F. Lux, M. Verelst, O. Tillement, M. Barberi-Heyob","doi":"10.1117/12.2525588","DOIUrl":"https://doi.org/10.1117/12.2525588","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79835488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EGFR-targeted fluorescence guided surgery in head and neck cancer (Conference Presentation) egfr靶向荧光引导头颈癌手术(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2530659
J. Warram
{"title":"EGFR-targeted fluorescence guided surgery in head and neck cancer (Conference Presentation)","authors":"J. Warram","doi":"10.1117/12.2530659","DOIUrl":"https://doi.org/10.1117/12.2530659","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77827082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination therapy with photodynamic therapy in lung cancer (Conference Presentation) 联合光动力治疗肺癌(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2527891
K. Furukawa, J. Usuda, M. Kimura, K. Miyajima, T. Matsubara, Shotaro Ono, E. Nakajima, N. Ikeda, H. Kato
{"title":"Combination therapy with photodynamic therapy in lung cancer (Conference Presentation)","authors":"K. Furukawa, J. Usuda, M. Kimura, K. Miyajima, T. Matsubara, Shotaro Ono, E. Nakajima, N. Ikeda, H. Kato","doi":"10.1117/12.2527891","DOIUrl":"https://doi.org/10.1117/12.2527891","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86882428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy followed by abraxane chemotherapy can significantly suppress pancreatic cancer metastasis (Conference Presentation) 光动力治疗配合abraxane化疗可显著抑制胰腺癌转移(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2528195
Zhiming Mai, Myung-Gyu Choi, T. Hasan
{"title":"Photodynamic therapy followed by abraxane chemotherapy can significantly suppress pancreatic cancer metastasis (Conference Presentation)","authors":"Zhiming Mai, Myung-Gyu Choi, T. Hasan","doi":"10.1117/12.2528195","DOIUrl":"https://doi.org/10.1117/12.2528195","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89651055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photosensitizing biomolecules and nanocrystals for anti-glioma photodynamic therapy (Conference Presentation) 用于抗胶质瘤光动力治疗的光敏生物分子和纳米晶体(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525904
Collin T. Inglut, Yan Baglo, Barry J. Liang, Jillian Stabile, Yahya Cheema, G. Woodworth, Huang‐Chiao Huang
{"title":"Photosensitizing biomolecules and nanocrystals for anti-glioma photodynamic therapy (Conference Presentation)","authors":"Collin T. Inglut, Yan Baglo, Barry J. Liang, Jillian Stabile, Yahya Cheema, G. Woodworth, Huang‐Chiao Huang","doi":"10.1117/12.2525904","DOIUrl":"https://doi.org/10.1117/12.2525904","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85081347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum dot light emitting diodes (QLEDs) as low-cost PDT light sources (Conference Presentation) 量子点发光二极管(qled)作为低成本PDT光源(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2525829
Hao Chen, Peter K. B. Palomaki, Juan He, R. Lanzafame, I. Stadler, Hamid El-Hamidi, Hui Liu, J. Celli, Michael R Hamblin, Ying-ying Huang, G. Shafirstein, H. Chung, Shin‐Tson Wu, Yajie Dong
{"title":"Quantum dot light emitting diodes (QLEDs) as low-cost PDT light sources (Conference Presentation)","authors":"Hao Chen, Peter K. B. Palomaki, Juan He, R. Lanzafame, I. Stadler, Hamid El-Hamidi, Hui Liu, J. Celli, Michael R Hamblin, Ying-ying Huang, G. Shafirstein, H. Chung, Shin‐Tson Wu, Yajie Dong","doi":"10.1117/12.2525829","DOIUrl":"https://doi.org/10.1117/12.2525829","url":null,"abstract":"Homogeneous, flexible light sources with pure, deep red color and sufficiently high power densities are necessary for more effective and widely used photodynamic therapy (PDT), but have been difficult to achieve with lasers or LED arrays at reasonably low cost. Quantum dot light emitting diodes (QLEDs) have outstanding wavelength tunability, ideal color purity, sufficient power density and unique form factors as thin, flexible, light weight and uniformly large area light sources, which will meet the pressing needs for PDT.\u0000 \u0000Here we report QLEDs fabricated with emission wavelengths precisely tuned to match the absorption peaks of several FDA approved photosensitizers. Preliminary in-vitro studies with rigid on-glass QLEDs as photosensitizer activators demonstrate they can kill cancerous A431 cells or Methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable or better than control LED sources, indicating their potential for PDT treatments of cancers or infections. Computer simulation of light propagation in a tissue mimicking phantom suggests that about 50% of the QLED power can be delivered to a depth of about 4 mm from the treated surface. Recent progress on the fabrication of low-cost flexible QLEDs will be presented. Finally, the perspectives of using these devices for PDT to address medical conditions such as cancer treatment, wound repair or cosmetic dermatology will be discussed.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73145316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interstitial photodynamic therapy (iPDT) of brain tumours (Conference Presentation) 脑肿瘤间质性光动力治疗(iPDT)(会议报告)
17th International Photodynamic Association World Congress Pub Date : 2019-08-14 DOI: 10.1117/12.2526128
H. Stepp, A. Rühm, R. Sroka, W. Stummer
{"title":"Interstitial photodynamic therapy (iPDT) of brain tumours (Conference Presentation)","authors":"H. Stepp, A. Rühm, R. Sroka, W. Stummer","doi":"10.1117/12.2526128","DOIUrl":"https://doi.org/10.1117/12.2526128","url":null,"abstract":"THIS IS FOR THE SESSION \"CAPABILITIES OF 5-ALA\"\u0000\u0000The accumulation of the fluorescent photosensitizer protoporphyrin IX (PpIX) after systemic administration of 5-ALA proved high tumor selectivity and led to intra-operative fluorescence guidance during resection of malignant glioma. 5-ALA therefore also promises to be useful for PDT of malignant glioma. Preclinical investigations resulted in the establishment of an appropriate treatment planning strategy and treatment parameters. This can be outlined as follows: interstitial placement of cylindrical diffuser fibers (1 to 4 cm diffuser length) by stereotaxy after careful planning on CT/MRI scans, such that fibers are approximately 1 cm apart and as close as 3-4 mm from the contrast uptaking tumor border. Aim of the irradiation parameters (200 mW/cm diffuser length for 1 hour) is to reach >95% photobleaching of PpIX in at least one optical penetration depth (approx. 3 mm) from the fibers. The therapeutic penetration depth can be expected to reach significantly deeper and kill glioma cells within parts of the infiltration zone, which are no more highlighted by Gd-contrast uptake. So far, inoperable de novo and recurrent malignant glioma with sizes up to 3 cm in diameter proved amenable in clinical investigations. Intriguing longterm progression free and overall survivals led to the design of prospective clinical trials, which are expected to start recruitment in 2019. \u0000\u0000Further research should focus on individualizing treatment parameters, further improve PpIX accumulation, including the sensitization of cancer stem cells and explore the role of immune stimulation by PDT, including the possible synergistic effect of immune checkpoint inhibitors.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"665 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75941895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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